| Civilization V: Brave New World - Launch Trailer Posted: 28 Jun 2013 02:00 AM PDT |
| Double Fine's Massive Chalice Kickstarter campaign ends with $1.2 million raised Posted: 28 Jun 2013 12:28 AM PDT Campaign for strategy game exceeds initial $725,000 goal. 
Double Fine Production's Kickstarter campaign to fund an upcoming strategy game called Massive Chalice recently ended with a total of $1,229,015 raised. The company created the Kickstarter page on May and initially had a funding goal of $725,000. The goal was surpassed in early June. Project lead Brad Muir will now lead a separate team within Double Fine to create Massive Chalice, following the success of the campaign. Massive Chalice was billed as a tactical strategy game that will be a hybrid between X-COM and Final Fantasy Tactics, coupled with a bloodlines and breeding mechanic. This is the second game Double Fine Productions has created a Kickstarter campaign for, with the first being Broken Age. Read and Post Comments | Get the full article at GameSpot
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| League of Legends Oceanic server opens Posted: 27 Jun 2013 10:12 PM PDT League of Legends introduces Oceanic server to the region; transfers to the server are free for a limited time. 
Riot Games has announced the opening of an Oceanic server for its MOBA game League of Legends. Accompanying the server's open beta launch is a regionalised League of Legends Oceania website. Players can partake in the Oceanic server beta by transferring over from the NA, LATAM, Russia, Turkey, EUNE, and EUW regions. Transfers to the Oceanic server are free for a limited time, and can be done by claiming a free OCE transfer token in the "other" tab via the in-game store. Participants who transfer early earn in-game rewards, including the champion Ziggs and a pool party skin, as well as a boost granting double IP and XP until the conclusion of the beta. A local online tournament has also been announced, scheduled to run from July 6-14. Teams that finish in the top four places will compete for an A$40,000 prize pool at PAX Australia. Additional tournament details are available at the Australian Cyber League website. Riot Games established a Sydney office in February this year. The Australian branch will have staff in marketing, eSports, and community. Read and Post Comments | Get the full article at GameSpot
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| Killer Is Dead gets Fan Edition Posted: 27 Jun 2013 08:21 PM PDT |
| Pokemon Video Game National Championships touring Australia Posted: 27 Jun 2013 06:53 PM PDT The Pokemon Video Game Australian National Championships will take place across the country; winners will compete in 2013 Pokemon Video Game World Championships. 
Get the full article at GameSpot
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| Molecules, Vol. 18, Pages 7584-7599: Anxiolytic-Like and Antinociceptive Effects of 2(S)-Neoponcirin in Mice Posted: 28 Jun 2013 12:00 AM PDT Study aims: 2(S)-neopincirin (NEO) is a constituent from of Clinopodium mexicanum, which is used in traditional Mexican herbal medicine for its tranquilizing and analgesic properties. This study investigated the anxiolytic-like, sedative and antinociceptive effects of NEO in several mice models. Material and methods: The anxiolytic-like effect was evaluated in the hole-board (HBT) and Open Field Tests (OFT); sedative effect was evaluated in sleeping time induced by sodium pentobarbital, and its antinociceptive actions were measured in the hot plate test. To evaluate if the GABA receptor could be involved in the anxiolytic-like effect produced by NEO, in independent experiments, the effects produced by co-administration of NEO plus muscimol (MUS) and NEO plus Pitrotoxin (PTX) were evaluated in the HBT. Results: NEO was isolated from Clinopodium mexicanum leaves. The NMR, MS and optic rotation data helped establish its identity as (2S)-5-hydroxy-4′-methoxyflavanone-7-O-{β-glucopyranosyl-(1→6)-β-rhamnoside}. NEO showed an anxiolytic-like effect and was able to counter the nociception induced by a thermal stimulus in a dose-dependent manner. PTX blocked the anxiolytic-like effect of NEO, while MUS was able to enhance it. Conclusions: The findings of present work demonstrated that NEO possesses anxiolytic-like and antinociceptive effects in mice. Such effects are not associated with changes in the locomotor activity. These results supported the notion that anxiolytic-like effect of NEO involves the participation of GABAergic system. |
| Molecules, Vol. 18, Pages 7570-7583: Hepatotoxicity Evaluation of Aqueous Extract from Scutia buxifolia Posted: 28 Jun 2013 12:00 AM PDT Nowadays there is an increase in the number of people taking herbals worldwide. Scutia buxifolia is used for the treatment of hypertension, but little is known about its action on liver. Thirty-two Wistar rats were divided into four groups: control and groups treated during 30 days with 100, 200 and 400 mg of lyophilized aqueous extract of S. buxifolia (SBSB)/kg of body weight. This study was planned to explore hepatotoxic effect of SBSB, which was assessed by serum transaminases (ALT and AST). Thiobarbituric acid reactive substances (TBARS) levels were determined in liver, along with thiols content (NPSH), catalase (CAT) activity and, superoxide dismutase (SOD) enzymes. Histopathological studies of liver tissue were performed. Flavonoids and phenolics were quantified in SBSB by high performance liquid chromatography with diode array detection (HPLC/DAD). We did not observe alterations on redox status (TBARS, NPSH, CAT and, SOD) in the control and experimental groups. An increase on AST activity was only observed at 200 mg of SBSB, whereas ALT score was not affected by SBSB. Moreover, no morphological alterations were observed on the hepatocytes, matching the analysed biochemical parameters. This way, we conclude that SBSB was not toxic. |
| Toxins, Vol. 5, Pages 1219-1229: Degradation of Aflatoxin B1 during the Fermentation of Alcoholic Beverages Posted: 28 Jun 2013 12:00 AM PDT Aflatoxin B1 (AFB1) is a contaminant of grain and fruit and has one of the highest levels of carcinogenicity of any natural toxin. AFB1 and the fungi that produce it can also contaminate the raw materials used for beer and wine manufacture, such as corn and grapes. Therefore, brewers must ensure strict monitoring to reduce the risk of contamination. In this study, the fate of AFB1 during the fermentation process was investigated using laboratory-scale bottom and top beer fermentation and wine fermentation. During fermentation, cool wort beer samples and wine must samples were artificially spiked with AFB1 and the levels of AFB1 remaining after fermentation were analyzed. AFB1 levels were unchanged during both types of fermentation used for beer but were reduced to 30% of their initial concentration in wine. Differential analysis of the spiked and unspiked wine samples showed that the degradation compound was AFB2a, a hydrated derivative of AFB1. Thus, the results showed that the risk of AFB1 carryover was still present for both types of beer fermentation but was reduced in the case of wine fermentation because of hydration. |
| Sensors, Vol. 13, Pages 8340-8351: Organic Plasmon-Emitting Diodes for Detecting Refractive Index Variation Posted: 28 Jun 2013 12:00 AM PDT A photo-excited organic layer on a metal thin film with a corrugated substrate was used to generate surface plasmon grating coupled emissions (SPGCEs). Directional emissions corresponded to the resonant condition of surface plasmon modes on the Au/air interface. In experimental comparisons of the effects of different pitch sizes on the plasmonic band-gap, the obtained SPGCEs were highly directional, with intensity increases as large as 10.38-fold. The FWHM emission spectrum was less than 70 nm. This method is easily applicable to detecting refractive index changes by using SP-coupled fluorophores in which wavelength emissions vary by viewing angle. The measurements and calculations in this study confirmed that the color wavelength of the SPGCE changed from 545.3 nm to 615.4 nm at certain viewing angles, while the concentration of contacting glucose increased from 10 to 40 wt%, which corresponded to a refractive index increase from 1.3484 to 1.3968. The organic plasmon-emitting diode exhibits a wider linearity range and a resolution of the experimental is 1.056 × 10−3 RIU. The sensitivity of the detection limit for naked eye of the experimental is 0.6 wt%. At a certain viewing angle, a large spectral shift is clearly distinguishable by the naked eye unaided by optoelectronic devices. These experimental results confirm the potential applications of the organic plasmon-emitting diodes in a low-cost, integrated, and disposable refractive-index sensor. |
| Marine Drugs, Vol. 11, Pages 2293-2313: Strategies for the Development of Conotoxins as New Therapeutic Leads Posted: 28 Jun 2013 12:00 AM PDT Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can be used directly, but in many instances it is desirable to truncate and/or stabilize the peptide to improve its therapeutic properties. A complementary strategy is to display the key residues that make up the pharmacophore of the peptide toxin on a non-peptidic scaffold, thereby creating a peptidomimetic. This review exemplifies these approaches with peptide toxins from marine organisms, with a particular focus on conotoxins. |
| Biology, Vol. 2, Pages 861-871: A Versatile Tool for Stable Inhibition of microRNA Activity Posted: 28 Jun 2013 12:00 AM PDT MicroRNAs (miRNAs) are a class of small RNAs (18–22 nt) that post transcriptionally regulate gene expression by binding to complementary sequences on target mRNAs, resulting in translational repression or target degradation and gene silencing. As aberrant expression of miRNAs is implicated in important diseases including cancer miRNA-based therapies are under intensive investigation. We optimized strategies to stably or conditionally generate miRNA inhibitors for a continuous block of miRNA activity that allows for probing miRNA function in long-term cell culture experiments, cancer xenografts, 3D tissue models and for in vivo studies with transgenic organisms. |
| Viruses, Vol. 5, Pages 1633-1645: Chromatin, Non-Coding RNAs, and the Expression of HIV Posted: 28 Jun 2013 12:00 AM PDT HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual currently remains unattainable. Viral latency and regulation of gene expression is a key consideration when developing effective treatments. While our understanding of these processes remains incomplete new developments suggest that non-coding RNA (ncRNA) mediated regulation may provide an avenue to controlling both viral expression and latency. Here we discuss the importance of known regulatory mechanisms and suggest directions for further study, in particular the use ncRNAs in controlling HIV expression. |
| Remote Sensing, Vol. 5, Pages 3172-3189: Comparison of Typhoon Locations over Ocean Surface Observed by Various Satellite Sensors Posted: 28 Jun 2013 12:00 AM PDT In this study, typhoon eyes have been delineated using wavelet analysis from the synthetic aperture radar (SAR) images of ocean surface roughness and from the warm area at the cloud top in the infrared (IR) images, respectively. Envisat SAR imagery, and multi-functional transport satellite (MTSAT) and Feng Yun (FY)-2 Chinese meteorological satellite IR imagery were used to examine the typhoons in the western North Pacific from 2005 to 2011. Three cases of various typhoons in different years, locations, and conditions have been used to compare the typhoon eyes derived from SAR (on the ocean surface) with IR (at the cloud-top level) images. Furthermore, the best track data from the Joint Typhoon Warning Center (JTWC), Chinese Meteorological Administration (CMA), and the Japan Meteorological Agency (JMA) are checked for the calibration. Because of the vertical wind shear, which acts as an upright tilt, the location of the typhoon eye on the ocean surface differs from that at the top of the clouds. Consequently, the large horizontal distance between typhoon eyes on the ocean surface and on the cloud top implies that the associated vertical wind shear profile is considerably more complex than generally expected. This result demonstrates that SAR can be a useful tool for typhoon monitoring study over the ocean surface. |
| Molbank, Vol. 2013, Article M803: N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide Posted: 28 Jun 2013 12:00 AM PDT N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis. |
| Mathematics, Vol. 1, Pages 76-88: On the Distribution of the spt-Crank Posted: 28 Jun 2013 12:00 AM PDT Andrews, Garvan and Liang introduced the spt-crank for vector partitions. We conjecture that for any n the sequence {NS (m, n)}m is unimodal, where NS (m, n) is the number of S-partitions of size n with crank m weight by the spt-crank. We relate this conjecture to a distributional result concerning the usual rank and crank of unrestricted partitions. This leads to a heuristic that suggests the conjecture is true and allows us to asymptotically establish the conjecture. Additionally, we give an asymptotic study for the distribution of the spt-crank statistic. Finally, we give some speculations about a definition for the spt-crank in terms of "marked" partitions. A "marked" partition is an unrestricted integer partition where each part is marked with a multiplicity number. It remains an interesting and apparently challenging problem to interpret the spt-crank in terms of ordinary integer partitions. |
| 123D Make 1.2.5 - Turn 3D models into 3D creations of any flat material. (Free) Posted: 28 Jun 2013 02:23 AM PDT  123D Make lets you turn 3D models into real world creations made out of any flat material that you can cut! Easily convert any 3D STL or OBJ file into a physical object using automatically generated 2D build plans and animated assembly instructions. Features: - 4 Build Techniques
- Stacked - Create objects by cutting out cross sections and stacking them on top of each other.
- Interlocked - Create slotted assemblies that go together even without adhesive.
- Curve - Define the sweep of your interlocked slices with an editable spline for curvy shapes.
- Radial - Define an axis of rotation around which interlocked slices are assembled, ideal for rounded shapes like bowls.
Custom Materials - Choose from preset materials or define your own sheet size, thickness and kerf from which to build your project. Your build plans are automatically updated on the fly to maximize the use of your material, while the 3D view always shows you what your finished product will look like.
Object Size - Define the final size of your final real-world object and your build plans are updated automatically. Create objects of any size that you are able to physically cut!
Interactive Slice Direction and Distribution - Adjust the angle and spacing of your construction using intuitive manipulators to get the look you want.
- Adjust the positioning of individual slices to right where you need them.
Modify Form - Hollow - Automatically hollow out your model to cut down on final weight, minimize material use, or to create hidden cavities in which to hide treasures.
- Thicken - Thicken your model interactively to make thin parts more manufacturable or to give your model a more cartoony look.
- Shrinkwrap - Great for closing models that have holes or very fine details.
Assembly Instructions - Animated assembly instructions let you see how your model will fit together prior to cutting out your parts.
- Once you are ready to put your cut parts together, the assembly animation can also be used to guide you step-by-step.
Save 2D build plans - Create a free Autodesk account and export your 2D build plans as EPS or PDF files that are ready for cutting with everything from a laser cutter to a bandsaw.
123D Community - Access the 123D Community Gallery to download models and projects from users all around the world.
- Share your projects with other users to get feedback and iterate with the global 123D community.
Version 1.2.5: - Access the new Autodesk 3D Print Utility from the "3D Print" menu to optimize your model for 3D printing.
- Hollow the model to save print time and material.
- Position the model to minimize the support material.
- See a preview of the support material.
- Use adaptive thickening to adjust details that are otherwise too small to print.
- UI enhancements and bug fixes.
More informationDownload Now |
| Face Noir - Screenshots Posted: 28 Jun 2013 03:14 AM PDT |
| Alarm Clock 1.2.1 - Turn your Mac into an alarm clock. (Free) Posted: 28 Jun 2013 01:50 AM PDT  Alarm Clock turns your Mac into an alarm clock that sings pleasant tunes, a beautiful bedside clock, and a sleep timer that lulls you to sleep at night! Features: - Large collection of sounds: wake up to pleasant tunes
- Nightstand mode: turn your Mac into a gorgeous bedside clock
- White noise: fall asleep quickly and smoothly
- Convenient application settings: get easy access to any option you need!
Alarm Clock provides the functionality of 3 indispensable apps in 1: - Alarm:
- Use built-in alarm sounds
- Add your notes to the alarm!
- Adjust the volume of Sounds
- Snooze option
- Clock:
- 12- or 24-hour time format
- Show/Hide seconds
- Show/Hide day of the week
- Enable/Disable chimes
- Sleep Timer:
- Go to sleep to white noise
- Adjust the volume of White noise
Enjoy a perfect balance of beauty and functionality with Alarm Clock! Version 1.2.1: - Performance and stability improvements
More informationDownload Now |
| The Enchanted Kingdom: Elisa's Adventure - Screenshots Posted: 28 Jun 2013 02:34 AM PDT |
| Cosmic Clean-Up - Screenshots Posted: 28 Jun 2013 02:26 AM PDT Features:
- 5 dangerous new worlds to explore
- 7 new space-junk crushing power-ups
- 9 amazing new ships
- New ship upgrade system
- New challenging enemies
- New explosive objects |
