вторник, 30 апреля 2013 г.

Games

Games


Scott Stuber to produce Gears of War film - Report

Posted: 30 Apr 2013 12:47 AM PDT

Scott Stuber signs on to produce film adaptation of Gears of War.

 

Scott Stuber has signed on to produce and begin work on the script for the Gears of War film, Variety has reported.

Talks to adapt Epic Games' third-person shooter Gears of War for the big screen have been underway for several years. The project, which was revealed in 2007, encountered development troubles in 2010 and was reportedly revived in 2012.

Stuber is no stranger to the action genre, having produced such films such as Safe House and the upcoming 47 Ronin.

Several Hollywood names have been attached to the project in the past, including directors Tony Scott (Top Gun, Man on Fire), Len Wiseman (Underworld: Evolution), and writer Chris Morgan (Wanted; The Fast and the Furious: Tokyo Drift). The Creative Arts Agency, which represents Epic Games, was reportedly eager to meet with producers to discuss the film in October last year.

Lord of the Rings studio New Line originally picked up rights to the movie adaptation, but the project was put on hold in order to focus efforts on the Hobbit trilogy. Stuber reportedly has a first look deal with Universal.

Read and Post Comments | Get the full article at GameSpot


"Scott Stuber to produce Gears of War film - Report" was posted by Zorine Te on Tue, 30 Apr 2013 00:47:18 -0700

Indie Hour - Papers, Please

Posted: 30 Apr 2013 12:05 AM PDT

Ed introduces Jess to the grim and stressful world of 'Papers, Please' and together they secure the borders of fictional communist state Arstotzka in this unique dystopian document thriller!

 

Read and Post Comments | Get the full article at GameSpot


"Indie Hour - Papers, Please" was posted by edmondt on Tue, 30 Apr 2013 00:05:24 -0700

Unreal Indie bundle on sale in Steam

Posted: 29 Apr 2013 11:40 PM PDT

Deal to last until May 5; costs $19.99 and features Dungeon Defenders and Sanctum.

 

Digital distribution service Steam just launched an Unreal Indie Bundle deal that features seven PC games built using the Unreal Engine 3.

The bundle is a joint collaboration between Epic Games and independent developers. The deal costs $19.99 and features the following titles: Sanctum, Dungeon Defenders, Primal Carnage, Q.U.B.E, Unmechanical, Waves, and The Ball.

The sale will last from today until May 5. Visit the official Steam page for more information.

Read and Post Comments | Get the full article at GameSpot


"Unreal Indie bundle on sale in Steam" was posted by Jonathan Toyad on Mon, 29 Apr 2013 23:40:45 -0700

Ableton Live 9.0.3 - Creative, real-time digital music software. (Demo)

Posted: 30 Apr 2013 02:44 AM PDT



Ableton Live is about making music; for composition, songwriting, recording, production, remixing and live performance. Live's nonlinear, intuitive flow, alongside powerful real-time editing and flexible performance options, make it a unique studio tool and a favorite with live performers. If you'd rather be "making music" than just "using music software," Ableton Live is for you.

Version 9.0.3: Release notes were unavailable when this listing was updated.

OS X 10.5 or later

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Fopydo 2.9.2 - Create PDF documents from images. (Free)

Posted: 30 Apr 2013 02:34 AM PDT



Fopydo is short for photocopy documents -- it creates PDF documents from images taken with digital cameras, cell phones, or scanners. Results are very compact in size and can be saved or emailed securely (with 128-bit encryption). In addition to PDF related functions Fopydo can OCR texts in a number of languages and save results in a text document (open source Tesseract OCR engine is embedded in the application).

Visit fopydo.com to learn more about the software and to see tutorials. Please leave your feedback about the program -- this will be very helpful for the author.

Version 2.9.2:

Note: This release brings several changes for scanning batches of documents using barcode separators.

  • Default input folders for captured images, scanned documents and faxes may be set in Tools-Preferences-Defaults.
  • A default file name format for documents may be set to a barcode value, a date/time stamp or a sequence number in Tools-Preferences-Defaults. So now there is a way to assign a unique name for each document automatically even if a copy of the same barcode is used.
  • A document counter is displayed at the bottom of the user interface (doc #K out of #N in the batch) during the document preview.


OS X 10.6 or later

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Online poker back: Legal site to launch in Vegas

Posted: 30 Apr 2013 02:23 AM PDT

A Las Vegas-based social gambling company says it will launch the first legal, real-money poker website in the United States.

Rugby Challenge 2: The Lions Tour Edition - Screenshots

Posted: 30 Apr 2013 02:32 AM PDT

Features include:
- Refined and expanded gameplay with the addition of quick taps, quick lineout's, mauls from lineout's, interceptions, contesting ball at the breakdown, removing players from the ruck, number 8 scrum pickups, and dynamic in game team strategies.
- Revamped Sound and commentary systems, with real-time commentary from Grant Nisbett and former All Black Justin Marshall, along with French language commentary from Eric Bayle and Thomas Lombard.
- 110+ teams and 50+ stadia from around the world featured including official team, competition, and special match licenses.
- More options than ever before to create or customise players, teams, and competitions, and also change game rules and behaviour to shape game play.

GuitarBots - Screenshots

Posted: 30 Apr 2013 02:15 AM PDT

Pool Live Tour - Screenshots

Posted: 30 Apr 2013 01:53 AM PDT

Key features:
- One of the most popular online competitive pool games.
- Free to play – players can download the game absolutely free of charge.
- Challenge your friends through Facebook, Game Center, Bluetooth or play a duel on a single screen.
- Play online matches with real opponents, always on the verge of doubling or losing your bet.
- Smoothest touch control – we took special care to deliver the most natural feeling pool game on the market. You have to try this!
- 10 levels with unique tables for players of all skill. Progress from the cozy Moe's Pub up to the luxurious Manhattan Sky Loft.
- Collect tens of cues, with ever-increasing power, precision and spin range. Wacky Broomstick, proud Elf cue, elegant Mehndi, or mighty and powerful Tutankhamun are waiting for you in the store.

Toy Story: Story Theatre - Screenshots

Posted: 30 Apr 2013 01:47 AM PDT

Skim It - Screenshots

Posted: 30 Apr 2013 01:22 AM PDT

Features:
- Accessible 'Skim' mechanic – it's really as simple as flicking your stone in the desired direction to sink boats. Chain multiple boats for extra score!
- Powerful Upgrades – grab a bigger stone bag, or score multiplier for extra score and quicker progression. If smashing wooden or metal boats in one shot is your thing, upgrade your stones for the ultimate boat sinking experience!
- Hungry Frogs – will float by so be warned! They are partial to a stone based snack and will steal your stone in the blink of an eye.
- Skim it! Skills – Use tilt to curl your shots around the pesky frogs and floating logs, or rebound from logs to sink boats and generally show off!
- Multiple missions and achievements – can you complete them all??

Soul Sacrifice review

Posted: 30 Apr 2013 12:27 AM PDT

Any time there's mention of "high fantasy" these days, someone's bound to roll their eyes and scoff. Tolkein's core of orcs, elves, and magic has been so

Deadly Premonition: The Director’s Cut review

Posted: 30 Apr 2013 12:27 AM PDT

Deadly Premonition is the durian fruit of video games. To the average person, it will seem repulsive--about as appealing as a used diaper. But those

Daylite 4.2.1 - Dynamic business organization tool kit. (Demo)

Posted: 29 Apr 2013 08:59 PM PDT



Daylite helps businesses organize themselves with tools such as shared calendars, contacts, tasks, projects, notes, and more. Enable easy collaboration with features such as task and project delegation between users, and never let things fall through the cracks. Create smart lists to find meaningful data fast -- including delegated but uncompleted work. Work anywhere -- in a networked office, from home or on the road.

Read the Daylite 4 review at GigaOm



Version 4.2.1:
  • Daylite Mail Assistant 4.2.1 will be compatible with OS X 10.8.4
  • New version of database engine for Daylite Server
  • Addressed a performance issue when loading a calendar sourcelist
  • Updated the version of Postgres included with Daylite to include a security fix made by the Postgres working group
  • Fixed an issue preventing Daylite from detecting an already running Postgres instance
  • Fixed a crash when during a calendar subscription update
  • Added scrolling to the list of notifications in the notifications preference pane




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Mountain Lion Cache Cleaner 7.0.8 - Clear caches, access hidden OS X settings and more. (Demo)

Posted: 29 Apr 2013 08:59 PM PDT



Mountain Lion Cache Cleaner is an award-winning general purpose tool for OS X. MLCC makes system maintenance simple with an easy point-and-click interface to many OS X functions. Novice and expert users alike will appreciate the powerful toolset MLCC provides. Mountain Lion Cache Cleaner is one of the world's leading maintenance tools, with millions of downloads around the globe.

Maintenance

Mountain Lion Cache Cleaner is a one-stop solution for all of your OS X maintenance needs. Intel or PPC, Tiger or Mountain Lion, MLCC has the tools to keep your system running at its best. MLCC Documents and the MLCC Engine maintain system health by providing full automation of common maintenance chores, including virus scanning of Internet downloads. The MLCC Engine can even repair permissions automatically after software installations. With the MLCC Engine, powerful system maintenance and antivirus can be completely transparent or as close as your menu bar.

Optimization

Mountain Lion Cache Cleaner can improve system performance by tuning Internet and file cache settings, implementing RAM disks, and cleaning out various cached and stale data. MLCC includes tools to help optimize files and memory. MLCC can recover wasted disk space by eliminating language localization files and slimming Universal Binaries.

Customization

Mountain Lion Cache Cleaner lets you control your OS X experience. Turn off Spotlight or Dashboard, or turn on a Login Items folder. MLCC can tweak many OS X features to suit your tastes. All without permanently altering or harming your system.

Disaster Planning

Mountain Lion Cache Cleaner lets you create a bootable installer dvd from your Mountain Lion download that will boot and install Mountain Lion on any supported machine. Mountain Lion Cache Cleaner lets you create bootable emergency disks that include system repair utilities and MLCC's powerful cache cleaning functions. If disaster strikes, the power of Mountain Lion Cache Cleaner is available at the command prompt in Single User mode. Registered users of MLCC can install a portable version on a flash drive or iPod. Mountain Lion Cache Cleaner Portable runs on any supported Mac, and is a great tool for testing hard drives, screen pixels, batteries, RAM, and more before buying a machine.

Antivirus

Mountain Lion Cache Cleaner helps protect your system from malware. MLCC adds three additional layers of malware protection to Lion, and ships with the powerful ClamAV antivirus built in. MLCC can scan your downloads on the fly providing industrial strength virus protection from Mac and Windows threats.

Version 7.0.8:

New features:

  • Makes improvements to the System log cleaning.
  • Adds the ability clean user activity logs.
  • The MLCC Engine reports to its own dedicated log instead of the Console log.
  • Updates ClamAV to version 0.97.8
  • Minor optimizations and improvements.


OS X 10.4 or later

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Little Snitch 3.1 - Alerts you to outgoing network connections. (Demo)

Posted: 29 Apr 2013 08:59 PM PDT



Little Snitch sees what happens under the hood.

A firewall protects your computer against unwanted guests from the Internet. But who protects your private data from being sent out? Little Snitch does!

As soon as you're connected to the Internet, applications can potentially send whatever information they want to wherever they want.

Sometimes they do this for good reason, on your explicit request. But often they don't. Little Snitch allows you to intercept these unwanted connection attempts, and lets you decide how to proceed.

Little Snitch informs you whenever a program attempts to establish an Internet connection. You can then choose to allow or deny this connection, or define a rule how to handle similar, future connection attempts. This reliably prevents private data from being sent out without your knowledge. Little Snitch runs inconspicuously in the background and it can also detect network related activity of viruses, trojans and other malware.



Version 3.1:
  • Automatic Profile Switching This new feature allows you to assign networks (for example your Wi-Fi network at home, a public hotspot, etc.) to certain profiles. Whenever you join one of these networks, Little Snitch detects the network change and switches to the associated profile automatically.
       When you join a network for the first time, Little Snitch shows an alert window allowing you to choose the desired profile. Alternatively you can configure a default profile that will be used for all unknown networks.
       The mappings between profiles and networks can be reviewed and edited later in Little Snitch Configuration, either in the profiles section of the sidebar, or in the new "Known Networks" window (⇧⌘K).
       Automatic Profile Switching is off by default. To use it, it must be enabled in Little Snitch Configuration > Preferences > Automatic Profile Switching.
  • In the menu bar item "Silent Mode" and "Start/Stop Network Filter" entries are now hidden if "Allow Preferences Editing" is disabled.
  • Improved "Restore Factory Defaults" feature.
  • Updated help section to reflect changes mentioned above.
  • Fixed a bug which caused a kernel panic in some rare cases.
  • Minor other bugfixes and improvements.


OS X 10.6.8 or later

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Supreme Court says states can limit freedom-of-information requests from out-of-state, Muckrock hacks around it with your help

Posted: 29 Apr 2013 11:06 PM PDT

Michael from MuckRock sez,

The Supreme Court ruled this morning that states have the right to restrict public records access to locals, meaning one more hurdle to would-be muckrakers everywhere. Even in-state requesters are harmed: It means one more bureaucratic hurdle and another excuse for agencies to respond in paper rather than electronically.

MuckRock has helped file requests in all 50 states -- important for projects like the Drone Census -- and we're looking for more volunteers to help ensure transparency from sea to shining sea.

States impacted:

* Alabama
* Arkansas
* Delaware
* Georgia
* New Hampshire
* New Jersey
* Tennessee
* Virginia

If you live in one of the above, fill out a simple form and we can help ensure that sunshine isn't restricted depending on where you live:

To keep filing in all 50 states, MuckRock needs your help (Thanks, Michael!)

    


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Playboy Prince Made Good

Posted: 29 Apr 2013 10:08 PM PDT

Bell Shakespeare's latest production fuses Henry IV Parts one and two into one play, set against the backdrop of the modern-day London riots, writes Garrett Bithell.

The Vault

Posted: 29 Apr 2013 09:52 PM PDT

The Vault Games featured this week: Magnetism; Industrial Place Thingy; Reelz — Get ready to be metagrobolized, lovers of ludo, by this week's collection of confounding complexities in the JayIsGames Vault. Whether you like your puzzles with sides of strategy, adventure, or luck, this selection from the archives is sure to satisfy! Tagged as: blog, browser, thevault

Layoffs hit Square Enix Europe

Posted: 29 Apr 2013 09:07 PM PDT

Square Enix layoffs to hit European and UK offices; exact employee numbers unknown.

 

Square Enix has begun a round of layoffs in its UK and European offices.

In a statement to MCV UK, the company confirmed the news. The announcement comes after the publisher saw an "extraordinary loss" for the financial year ended March 31.

Speaking to the trade publication, Square Enix said, "We are reviewing our business in Europe to ensure we have the right structure, content, and skills for the changing entertainment landscape."

"We do expect changes to the UK office, which will affect personnel. We will update you when the time is right, but our priority right now is for the people within the business.'

Last month, Square Enix president Yoichi Wada resigned from the company following the announcement of an expected 10 billion yen loss for the 2012-2013 financial year. Despite being well-received critically, sales for big-budget Square Enix titles Tomb Raider, Hitman: Absolution, and Sleeping Dogs failed to meet expectations in the North American market.

Read and Post Comments | Get the full article at GameSpot


"Layoffs hit Square Enix Europe" was posted by Zorine Te on Mon, 29 Apr 2013 21:07:53 -0700

понедельник, 29 апреля 2013 г.

Games

Games


Dust 514 launches May 14

Posted: 28 Apr 2013 10:54 PM PDT

PlayStation-exclusive MMO from Eve Online developer to launch on May 14.

 

Console MMO Dust 514 will launch on May 14, according to a status update from the game's official Twitter account.

The project was first unveiled at the Game Developers Conference (GDC) in 2009, and will be CCP Games' first new title since 2003's Eve Online. Exclusive to the PlayStation 3, the game will be linked with the wider Eve Online universe.

The two games were officially connected on January 10 this year, and allowed players of both titles to interact with one another.

CEO Hilmar Veigar Petursson has described Dust 514 as a first-person shooter/real-time strategy hybrid that will take place on the planets within Eve Online.

Dust 514 will be free to play and utilises a micro-transaction model. For more information on the game, be sure to check out GameSpot's previous coverage.

Read and Post Comments | Get the full article at GameSpot


"Dust 514 launches May 14" was posted by Zorine Te on Sun, 28 Apr 2013 22:54:31 -0700

Pr0lly talks about the LCS Mid Season Playoffs on Day 3

Posted: 28 Apr 2013 10:22 PM PDT

Travis chats with Pr0lly to find out his thoughts on the matches so far at the Mid Season Playoffs.

 

Read and Post Comments | Get the full article at GameSpot


"Pr0lly talks about the LCS Mid Season Playoffs on Day 3" was posted by Erick Tay on Sun, 28 Apr 2013 22:22:53 -0700

Dan Dinh talks about Leading TSM Snapdragon to Victory

Posted: 28 Apr 2013 10:17 PM PDT

Travis chats with Dan Dinh about TSM Snapdragon's performance and his influences on them.

 

Read and Post Comments | Get the full article at GameSpot


"Dan Dinh talks about Leading TSM Snapdragon to Victory" was posted by Erick Tay on Sun, 28 Apr 2013 22:17:29 -0700

Zuna talks Vulcun's Performance on Day 3 of the LCS Playoffs

Posted: 28 Apr 2013 10:13 PM PDT

Zuna and Travis talk about Vulcun's performance and recent success at the LCS Playoffs.

 

Read and Post Comments | Get the full article at GameSpot


"Zuna talks Vulcun's Performance on Day 3 of the LCS Playoffs" was posted by Erick Tay on Sun, 28 Apr 2013 22:13:32 -0700

Call of Duty: Ghosts running on next-gen engine – Report

Posted: 28 Apr 2013 09:10 PM PDT

Next title in military shooter series to be built on next-generation game engine.

 

Last week, UK retailer Tesco prematurely announced the next game in Activision's Call of Duty franchise, Call of Duty: Ghosts.

As well as outing both the unrevealed game and what is believed to be the official box art, the merchant's product listing also claimed that the sequel will be "built on an entirely new story, setting, and cast, all powered by a next-generation Call of Duty engine".

The original listing, which has since been removed, detailed the game as being in development for the Xbox 360 and PlayStation 3. Mention of a next-generation engine and the game's expected early November ship date aligns with industry expectations of when the next Xbox and PlayStation 4 hardware are predicted to go on sale.

GameSpot contacted Activision for verification of the details in the retailer listing, but the company declined to comment, saying that "Activision does not comment on rumour or speculation".

Read and Post Comments | Get the full article at GameSpot


"Call of Duty: Ghosts running on next-gen engine – Report" was posted by Dan Chiappini on Sun, 28 Apr 2013 21:10:26 -0700

Sensors, Vol. 13, Pages 5649-5670: Fast Nearly ML Estimation of Doppler Frequency in GNSS Signal Acquisition Process

Posted: 29 Apr 2013 12:00 AM PDT

It is known that signal acquisition in Global Navigation Satellite System (GNSS) field provides a rough maximum-likelihood (ML) estimate based on a peak search in a two-dimensional grid. In this paper, the theoretical mathematical expression of the cross-ambiguity function (CAF) is exploited to analyze the grid and improve the accuracy of the frequency estimate. Based on the simple equation derived from this mathematical expression of the CAF, a family of novel algorithms is proposed to refine the Doppler frequency estimate with respect to that provided by a conventional acquisition method. In an ideal scenario where there is no noise and other nuisances, the frequency estimation error can be theoretically reduced to zero. On the other hand, in the presence of noise, the new algorithm almost reaches the Cramer-Rao Lower Bound (CRLB) which is derived as benchmark. For comparison, a least-square (LS) method is proposed. It is shown that the proposed solution achieves the same performance of LS, but requires a dramatically reduced computational burden. An averaging method is proposed to mitigate the influence of noise, especially when signal-to-noise ratio (SNR) is low. Finally, the influence of the grid resolution in the search space is analyzed in both time and frequency domains.

Sensors, Vol. 13, Pages 5630-5648: Garment Counting in a Textile Warehouse by Means of a Laser Imaging System

Posted: 29 Apr 2013 12:00 AM PDT

Textile logistic warehouses are highly automated mechanized places where control points are needed to count and validate the number of garments in each batch. This paper proposes and describes a low cost and small size automated system designed to count the number of garments by processing an image of the corresponding hanger hooks generated using an array of phototransistors sensors and a linear laser beam. The generated image is processed using computer vision techniques to infer the number of garment units. The system has been tested on two logistic warehouses with a mean error in the estimated number of hangers of 0.13%.

Sensors, Vol. 13, Pages 5614-5629: Inertial Sensor-Based Two Feet Motion Tracking for Gait Analysis

Posted: 29 Apr 2013 12:00 AM PDT

Two feet motion is estimated for gait analysis. An inertial sensor is attached on each shoe and an inertial navigation algorithm is used to estimate the movement of both feet. To correct inter-shoe position error, a camera is installed on the right shoe and infrared LEDs are installed on the left shoe. The proposed system gives key gait analysis parameters such as step length, stride length, foot angle and walking speed. Also it gives three dimensional trajectories of two feet for gait analysis.

Materials, Vol. 6, Pages 1566-1583: Comparison of Reactive and Non-Reactive Spark Plasma Sintering Routes for the Fabrication of Monolithic and Composite Ultra High Temperature Ceramics (UHTC) Materials

Posted: 29 Apr 2013 12:00 AM PDT

A wider utilization of ultra high temperature ceramics (UHTC) materials strongly depends on the availability of efficient techniques for their fabrication as dense bodies. Based on recent results reported in the literature, it is possible to state that Spark Plasma Sintering (SPS) technology offers a useful contribution in this direction. Along these lines, the use of two different SPS-based processing routes for the preparation of massive UHTCs is examined in this work. One method, the so-called reactive SPS (R-SPS), consists of the synthesis and densification of the material in a single step. Alternatively, the ceramic powders are first synthesized by Self-propagating High-temperature Synthesis (SHS) and then sintered by SPS. The obtained results evidenced that R-SPS method is preferable for the preparation of dense monolithic products, while the sintering of SHS powders requires relatively milder conditions when considering binary composites. The different kinetic mechanisms involved during R-SPS of the monolithic and composite systems, i.e., combustion-like or gradual solid-diffusion, respectively, provides a possible explanation. An important role is also played by the SHS process, particularly for the preparation of composite powders, since stronger interfaces are established between the ceramic constituents formed in situ, thus favoring diffusion processes during the subsequent SPS step.

Toxins, Vol. 5, Pages 912-925: The Toxicological Impacts of the Fusarium Mycotoxin, Deoxynivalenol, in Poultry Flocks with Special Reference to Immunotoxicity

Posted: 29 Apr 2013 12:00 AM PDT

Deoxynivalenol (DON) is a common Fusarium toxin in poultry feed. Chickens are more resistant to the adverse impacts of deoxynivalenol (DON) compared to other species. In general, the acute form of DON mycotoxicosis rarely occurs in poultry flocks under normal conditions. However, if diets contain low levels of DON (less than 5 mg DON/kg diet), lower productivity, impaired immunity and higher susceptibility to infectious diseases can occur. The molecular mechanism of action of DON has not been completely understood. A significant influence of DON in chickens is the impairment of immunological functions. It was known that low doses of DON elevated the serum IgA levels and affected both cell-mediated and humoral immunity in animals. DON is shown to suppress the antibody response to infectious bronchitis vaccine (IBV) and to Newcastle disease virus (NDV) in broilers (10 mg DON/kg feed) and laying hens (3.5 to 14 mg of DON/kg feed), respectively. Moreover, DON (10 mg DON/kg feed) decreased tumor necrosis factor alpha (TNF-α) in the plasma of broilers. DON can severely affect the immune system and, due to its negative impact on performance and productivity, can eventually result in high economic losses to poultry producers. The present review highlights the impacts of DON intoxication on cell mediated immunity, humoral immunity, gut immunity, immune organs and pro-inflammatory cytokines in chickens.

IJMS, Vol. 14, Pages 9487-9496: The Role of microRNA in Gastric Malignancy

Posted: 29 Apr 2013 12:00 AM PDT

Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.

Toxins, Vol. 5, Pages 895-911: Structure, Function, and Biology of the Enterococcus faecalis Cytolysin

Posted: 29 Apr 2013 12:00 AM PDT

Enterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen. Highly virulent strains of E. faecalis express a pore-forming exotoxin, called cytolysin, which lyses both bacterial and eukaryotic cells in response to quorum signals. Originally described in the 1930s, the cytolysin is a member of a large class of lanthionine-containing bacteriocins produced by Gram-positive bacteria. While the cytolysin shares some core features with other lantibiotics, it possesses unique characteristics as well. The current understanding of cytolysin biosynthesis, structure/function relationships, and contribution to the biology of E. faecalis are reviewed, and opportunities for using emerging technologies to advance this understanding are discussed.

Toxins, Vol. 5, Pages 884-894: Assessment of Aflatoxin Contamination of Maize, Peanut Meal and Poultry Feed Mixtures from Different Agroecological Zones in Cameroon

Posted: 29 Apr 2013 12:00 AM PDT

Mycotoxins affect poultry production by being present in the feed and directly causing a negative impact on bird performance. Carry-over rates of mycotoxins in animal products are, in general, small (except for aflatoxins in milk and eggs) therefore representing a small source of mycotoxins for humans. Mycotoxins present directly in human food represent a much higher risk. The contamination of poultry feed by aflatoxins was determined as a first assessment of this risk in Cameroon. A total of 201 samples of maize, peanut meal, broiler and layer feeds were collected directly at poultry farms, poultry production sites and poultry feed dealers in three agroecological zones (AEZs) of Cameroon and analyzed for moisture content and aflatoxin levels. The results indicate that the mean of the moisture content of maize (14.1%) was significantly (P < 0.05) higher than all other commodities (10.0%–12.7%). Approximately 9% of maize samples were positive for aflatoxin, with concentrations overall ranging from <2 to 42 µg/kg. Most of the samples of peanut meal (100%), broiler (93.3%) and layer feeds (83.0%) were positive with concentrations of positive samples ranging from 39 to 950 µg/kg for peanut meal, 2 to 52 µg/kg for broiler feed and 2 to 23 µg/kg for layer feed. The aflatoxin content of layer feed did not vary by AEZ, while the highest (16.8 µg/kg) and the lowest (8.2 µg/kg) aflatoxin content of broiler feed were respectively recorded in Western High Plateau and in Rainforest agroecological zones. These results suggest that peanut meal is likely to be a high risk feed, and further investigation is needed to guide promotion of safe feeds for poultry in Cameroon.

IJMS, Vol. 14, Pages 9475-9486: Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway

Posted: 29 Apr 2013 12:00 AM PDT

Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cγ1 (PLCγ1) and the protein kinase Cα (PKCα) signaling cascade.

Toxins, Vol. 5, Pages 865-883: An Ultrasensitive Electrochemiluminescent Immunoassay for Aflatoxin M1 in Milk, Based on Extraction by Magnetic Graphene and Detection by Antibody-Labeled CdTe Quantumn Dots-Carbon Nanotubes Nanocomposite

Posted: 29 Apr 2013 12:00 AM PDT

An ultrasensitive electrochemiluminescent immunoassay (ECLIA) for aflatoxins M1 (ATM1) in milk using magnetic Fe3O4-graphene oxides (Fe-GO) as the absorbent and antibody-labeled cadmium telluride quantum dots (CdTe QDs) as the signal tag is presented. Firstly, Fe3O4 nanoparticles were immobilized on GO to fabricate the magnetic nanocomposites, which were used as absorbent to ATM1. Secondly, aflatoxin M1 antibody (primary antibody, ATM1 Ab1), was attached to the surface of the CdTe QDs-carbon nanotubes nanocomposite to form the signal tag (ATM1 Ab1/CdTe-CNT). The above materials were characterized. The optimal experimental conditions were obtained. Thirdly, Fe-GO was employed for extraction of ATM1 in milk. Results indicated that it can adsorb ATM1 efficiently and selectively within a large extent of pH from 3.0 to 8.0. Adsorption processes reached 95% of the equilibrium within 10 min. Lastly, the ATM1 with a serial of concentrations absorbed on Fe-GO was conjugated with ATM1 Ab1/CdTe-CNT signal tag based on sandwich immunoassay. The immunocomplex can emit a strong ECL signal whose intensity depended linearly on the logarithm of ATM1 concentration from 1.0 to 1.0 × 105 pg/mL, with the detection limit (LOD) of 0.3 pg/mL (S/N = 3). The method was more sensitive for ATM1 detection compared to the ELISA method. Finally, ten samples of milk were tested based on the immunoassay. The method is fast and requires very little sample preparation, which was suitable for high-throughput screening of mycotoxins in food.

IJMS, Vol. 14, Pages 9459-9474: Improved Nutritive Quality and Salt Resistance in Transgenic Maize by Simultaneously Overexpression of a Natural Lysine-Rich Protein Gene, SBgLR, and an ERF Transcription Factor Gene, TSRF1

Posted: 29 Apr 2013 12:00 AM PDT

Maize (Zea mays L.), as one of the most important crops in the world, is deficient in lysine and tryptophan. Environmental conditions greatly impact plant growth, development and productivity. In this study, we used particle bombardment mediated co-transformation to obtain marker-free transgenic maize inbred X178 lines harboring a lysine-rich protein gene SBgLR from potato and an ethylene responsive factor (ERF) transcription factor gene, TSRF1, from tomato. Both of the target genes were successfully expressed and showed various expression levels in different transgenic lines. Analysis showed that the protein and lysine content in T1 transgenic maize seeds increased significantly. Compared to non-transformed maize, the protein and lysine content increased by 7.7% to 24.38% and 8.70% to 30.43%, respectively. Moreover, transgenic maize exhibited more tolerance to salt stress. When treated with 200 mM NaCl for 48 h, both non-transformed and transgenic plant leaves displayed wilting and losing green symptoms and dramatic increase of the free proline contents. However, the degree of control seedlings was much more serious than that of transgenic lines and much more increases of the free proline contents in the transgenic lines than that in the control seedlings were observed. Meanwhile, lower extent decreases of the chlorophyll contents were detected in the transgenic seedlings. Quantitative RT-PCR was performed to analyze the expression of ten stress-related genes, including stress responsive transcription factor genes, ZmMYB59 and ZmMYC1, proline synthesis related genes, ZmP5CS1 and ZmP5CS2, photosynthesis-related genes, ZmELIP, ZmPSI-N, ZmOEE, Zmrbcs and ZmPLAS, and one ABA biosynthesis related gene, ZmSDR. The results showed that with the exception of ZmP5CS1 and ZmP5CS2 in line 9–10 and 19–11, ZmMYC1 in line 19–11 and ZmSDR in line 19–11, the expression of other stress-related genes were inhibited in transgenic lines under normal conditions. After salt treatment, the expressions of the ten stress-related genes were significantly induced in both wild-type (WT) and transgenic lines. However, compared to WT, the increases of ZmP5CS1 in all these three transgenic lines and ZmP5CS2 in line 9–10 were less than WT plants. This study provides an effective approach of maize genetic engineering for improved nutritive quality and salt tolerance.

Pharmaceuticals, Vol. 6, Pages 659-680: FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

Posted: 29 Apr 2013 12:00 AM PDT

Many aspects of intercellular communication are mediated through "sending" and "receiving" packets of information via the secretion and subsequent receptor-mediated detection of biomolecular species including cytokines, chemokines, and even metabolites. Recent evidence has now established a new modality of intercellular communication through which biomolecular species are exchanged between cells via extracellular lipid vesicles. A particularly important class of extracellular vesicles is exosomes, which is a term generally applied to biological nanovesicles ~30–200 nm in diameter. Exosomes form through invagination of endosomes to encapsulate cytoplasmic contents, and upon fusion of these multivesicular endosomes to the cell surface, exosomes are released to the extracellular space and transport mRNA, microRNA (miRNA) and proteins between cells. Importantly, exosome-mediated delivery of such cargo molecules results in functional modulation of the recipient cell, and such modulation is sufficiently potent to modulate disease processes in vivo. It is possible that such functional delivery of biomolecules indicates that exosomes utilize native mechanisms (e.g., for internalization and trafficking) that may be harnessed by using exosomes to deliver exogenous RNA for therapeutic applications. A complementary perspective is that understanding the mechanisms of exosome-mediated transport may provide opportunities for "reverse engineering" such mechanisms to improve the performance of synthetic delivery vehicles. In this review, we summarize recent progress in harnessing exosomes for therapeutic RNA delivery, discuss the potential for engineering exosomes to overcome delivery challenges and establish robust technology platforms, and describe both potential challenges and advantages of utilizing exosomes as RNA delivery vehicles.

IJMS, Vol. 14, Pages 9440-9458: Characterization of Rice NADPH Oxidase Genes and Their Expression under Various Environmental Conditions

Posted: 29 Apr 2013 12:00 AM PDT

Plasma membrane NADPH oxidases (Noxs) are key producers of reactive oxygen species under both normal and stress conditions in plants. We demonstrate that at least eleven genes in the genome of rice (Oryza sativa L.) were predicted to encode Nox proteins, including nine genes (OsNox1–9) that encode typical Noxs and two that encode ancient Nox forms (ferric reduction oxidase 1 and 7, OsFRO1 and OsFRO7). Phylogenetic analysis divided the Noxs from nine plant species into six subfamilies, with rice Nox genes distributed among subfamilies I to V. Gene expression analysis using semi-quantitative RT-PCR and real-time qRT-PCR indicated that the expression of rice Nox genes depends on organs and environmental conditions. Exogenous calcium strongly stimulated the expression of OsNox3, OsNox5, OsNox7, and OsNox8, but depressed the expression of OsFRO1. Drought stress substantially upregulated the expression of OsNox1–3, OsNox5, OsNox9, and OsFRO1, but downregulated OsNox6. High temperature upregulated OsNox5–9, but significantly downregulated OsNox1–3 and OsFRO1. NaCl treatment increased the expression of OsNox2, OsNox8, OsFRO1, and OsFRO7, but decreased that of OsNox1, OsNox3, OsNox5, and OsNox6. These results suggest that the expression profiles of rice Nox genes have unique stress-response characteristics, reflecting their related but distinct functions in response to different environmental stresses.

Pharmaceuticals, Vol. 6, Pages 650-658: Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors

Posted: 29 Apr 2013 12:00 AM PDT

Natural products have reemerged in traditional medicine as a potential source of new molecules or phytomedicines to help with health disorders. It has been established that members of the P2X subfamily, ATP-gated ion channels, are crucial to the inflammatory process and pain signalization. As such, several preclinical studies have demonstrated that P2X2R, P2X3R, P2X4R and P2X7R are promising pharmacological targets to control inflammatory and pain disorders. Several studies have indicated that natural products could be a good source of the new specific molecules needed for the treatment of diseases linked to inflammation and pain disorders through the regulation of these receptors. Herein, we discuss and give an overview of the applicability of natural products as a source to obtain P2X receptors (P2XR) selective antagonists for use in clinical treatment, which require further investigation.

IJMS, Vol. 14, Pages 9424-9439: Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents

Posted: 29 Apr 2013 12:00 AM PDT

Several rhein-phosphonate derivatives (5a–c) were synthesized and evaluated for in vitro cytotoxicity against HepG-2, CNE, Spca-2, Hela and Hct-116 cell lines. Some compounds showed relatively high cytotoxicity. Especially compounds 5b exhibited the strongest cytotoxicity against HepG-2 and Spca-2 cells (IC50 was 8.82 and 9.01 µM), respectively. All the synthesized compounds exhibited low cytotoxicity against HUVEC cells. Further experiments proved that 5b could disturb the cell cycle in HepG-2 cells and induce apoptosis. In addition, the binding properties of a model conjugate 5b to DNA were investigated by methods (UV-Vis, fluorescence, CD spectroscopy). Results indicated that 5b showed moderate ability to interact ct-DNA.

воскресенье, 28 апреля 2013 г.

Games

Games


Lumber Island

Posted: 27 Apr 2013 04:21 PM PDT

Platform: Windows — Lumber Island Stranded on an island, alone, with only a flickering campfire and a mysterious teddy-bear... what could go wrong? DeanForge delivers the first installment in a flawed but freaky free indie horror adventure that will have you running (or, uh, walking) for your life from a seemingly unstoppable menace and a hidden legacy of violence. Tagged as: action, adventure, deanforge, download, free, game, horror, indie, rating-o, surreal, windows

When we entertained ourselves

Posted: 28 Apr 2013 01:52 AM PDT

WHEN: Through Aug. 30. Museum hours are from 10 a.m. to 3 p.m. Monday, Tuesday, Thursday and Friday and from 2 to 4 p.m. Saturday and Sunday LANA SWEETEN-SHULTS/TIMES RECORD NEWS Games and toys like Slinky are on display at the Kell House Museum as part of its spring exhibit, "As We Were: Entertaining at Home." Chess and card games like canasta, ... (more)

ZionSpartan and Daydreamin talk match vs Curse and going to Prom

Posted: 27 Apr 2013 09:08 PM PDT

Travis chats with ZionSpartan and Daydreamin after their big match against Curse on day 2 at the LCS playoffs as well as their plans for Prom.

 

Read and Post Comments | Get the full article at GameSpot


"ZionSpartan and Daydreamin talk match vs Curse and going to Prom" was posted by Erick Tay on Sat, 27 Apr 2013 21:08:40 -0700

Jack discusses managing TSM Snapdragon

Posted: 27 Apr 2013 09:02 PM PDT

Travis talks with TSM Snapdragon's manager Jack Etienne about what it's like managing the team.

 

Read and Post Comments | Get the full article at GameSpot


"Jack discusses managing TSM Snapdragon" was posted by Erick Tay on Sat, 27 Apr 2013 21:02:31 -0700

Beyond: Two Souls spans 10 hours

Posted: 27 Apr 2013 08:22 PM PDT

David Cage reveals length of upcoming narrative-focused game, says 75 percent of gamers finished Heavy Rain.

 

Tonight during a special Beyond: Two Souls event at the Tribeca Film Festival in New York City, Quantic Dream head David Cage revealed the narrative-focused game will span ten hours of gameplay.

A thirty-five minute clip of the game's 'Homeless' level was shown, depicting main character Jodie Holmes--played by Juno actress Ellen Page--fighting for her life and to protect her friends.

Beyond: Two Souls launches October 8 exclusively on PlayStation 3. GameSpot will have more coverage of the event, including an interview with Quantic Dream co-CEO Guillaume de Fondaumière.

Cage also said tonight that 75 percent of players finished his last game, Heavy Rain. This figure is up from the 74 percent reported in 2011.

He said typically, just 20 percent of players see a game through to its completion. However, this figure was higher for Heavy Rain because of how its story unfolds.

'But for Heavy Rain for example--that was really story-driven--the figure was 75 percent,' Cage said. 'And so because people wanted to see the end, they wanted to know what would happen next'all this was very important.'

Heavy Rain reportedly grossed $100 million for Sony.

Read and Post Comments | Get the full article at GameSpot


"Beyond: Two Souls spans 10 hours" was posted by Eddie Makuch on Sat, 27 Apr 2013 20:22:16 -0700

Wildturtle talks about life on TSM Snapdragon

Posted: 27 Apr 2013 06:54 PM PDT

Travis chats with Wildturtle about what it's like to be a part of TSM Snapdragon.

 

Read and Post Comments | Get the full article at GameSpot


"Wildturtle talks about life on TSM Snapdragon" was posted by Erick Tay on Sat, 27 Apr 2013 18:54:20 -0700

Skype 6.3.60.602 - Voice-over-internet phone and chat software. (Free)

Posted: 27 Apr 2013 08:59 PM PDT



Skype allows you to talk to friends, family and co-workers across the Internet without the inconvenience of long distance telephone charges. Using peer-to-peer data transmission technology, Skype eliminates the central server as a middle manager.

Today, millions of individuals and businesses are taking advantage of Skype's diverse communication features:

  • Free Skype-to-Skype
  • Landline and cellphone calling
  • SMS and instant messaging
  • Voicemail
  • Free video calls
  • Call forwarding to your phone when you're offline
Skype-to-Skype calls, video calls and instant messaging are free, 24 hours a day, anywhere in the world. Users can make phone calls and send SMS messages at great value Pay-As-You-Go rates, or make unlimited calls to certain countries with a subscription.

Version 6.3.60.602:

New features:

  • It is now easier to save a new number to any existing contact.
  • Optimized Preferences menus for Korean.
  • You can create a line break by pressing Shift+Enter during message editing.
  • "Add Contact Number" popover will be closed when conversation is switched using Option+Command+Left/Right arrow key on keyboard.
  • The grid contact list will move when scrolling with arrow keys.
  • You can can edit a contact with a full name and a custom nickname.
  • Calling toolbar will stay open while "+" sub menu is expanded.
  • The call monitor will appear in desktop space when Skype is not in focus.
  • The "Add Number" and "Add to list" fields will be aligned in the Contact profile.
  • Your contacts' birthday notifications will appear as expected.


  • OS X 10.5.8 or later
  • Microphone


Download Now

This posting includes an audio/video/photo media file: Download Now

xACT 2.23 - Audio compression toolkit. (Free)

Posted: 27 Apr 2013 08:59 PM PDT



xACT stands for X Audio Compression Toolkit. It is a GUI based front end for the unix applications Shorten (3.6.1), shntool (3.0.10), monkey's audio compressor (3.99), FLAC (1.2.1), wavpack (4.60.1), TTA (3.4.1), Opus 0.1.6, cdda2wav 3.0 (with paranoia support) and dvda-author (v09.05). It also uses sox (14.3.1), LAME 3.98.4, AtomicParsley 0.9.0, TagLib and mp4v2. It executes the basic commands of these applications and adds other features to speed up productivity in creation/use of etree.org standard filesets.

Version 2.23:

New feature:

  • File lists now sort files exactly like the Finder


OS X 10.6 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

ClamXav 2.3.6 - Free virus checker, based on ClamAV. (Free)

Posted: 27 Apr 2013 08:59 PM PDT



ClamXav is a free virus checker for OS X. It uses the tried, tested, and very popular ClamAV open source antivirus engine as a back end.

I hope you like and use ClamXav a lot and that it helps keep you and your friends/colleagues virus-free. Although I'm providing ClamXav for free, I am increasingly spending more and more time developing it and would really appreciate if you would consider making a donation please. All donations (no matter how small) are gratefully received and would be a huge incentive to help me work on future versions of ClamXav, but more importantly I rely on donations to pay for my bandwidth costs. Please consider it, see the ClamXav homepage, click the 'More Information' link above on this page.



Version 2.3.6:
  • Updated engine to ClamAV 0.97.8


OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

GraphicConverter 8.6 - Graphics editor with powerful features. (Demo)

Posted: 27 Apr 2013 08:59 PM PDT



GraphicConverter is an all-purpose image-editing program that can import 200 different graphic-based formats, edit the image, and export it to any of 80 available file formats.

The high-end editing tools are perfect for graphic manipulation as well as the ability to use Photoshop-compatible plug-ins. It offers batch-conversion capabilities, a slide-show window, and so much more.

Version 8.6:

Note: The downloadable version is 8.6. The Mac App Store version is currently 8.5.3.

New features

  • Added layers
  • Added brightness with curve function
  • Added DPHOTO service support
  • Added optional filmstrip display for better visual movie display
  • Added mark as 3d image batch
  • Added shortcuts to slideshow for lossless rotation and mirroring
  • Added shortcuts to slideshow for virtual rotation and mirroring
  • Added option to save RGBA files as TIFF with or without premultiplied alpha
  • Added use last zoom option
Updated features
  • Enabled tab key during slideshow to hide/show file list
  • Enabled command + cursor left/right for back/forward in the browser
  • Fixed translation issues
  • Added option to print filename without extension
  • Recent browsers menu does use system settings for length of list
  • Enhanced delete exif tags dialog
  • Improved sharpen range in operator
  • wpg and wpg 2 import improved
  • Updated ExifTool
  • PDF import resolution supports fractions
  • Improved localization
Bug fixes
  • See a complete list here


OS X 10.6.8 or later

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Harrah`s Tunica

Posted: 27 Apr 2013 09:47 PM PDT

Harrah's Tunica, fomerly Grand Casino Resort Tunica, is the largest casino resort between Las Vegas and Atlantic City.

Powerball Winning Numbers for 04/27/2013

Posted: 27 Apr 2013 10:05 PM PDT

3 - 23 - 48 - 54 - 55 Powerball 5

Powerball Estimated Jackpot for 05/01/2013

Posted: 27 Apr 2013 10:05 PM PDT

Annuitized: $165 Million Cash Value: $107.7 Million

Mega Millions Winning Numbers for 04/26/2013

Posted: 27 Apr 2013 10:05 PM PDT

17 - 42 - 49 - 54 - 55 MegaBall 31 Megaplier 4

Mega Millions Estimated Jackpot for 04/30/2013

Posted: 27 Apr 2013 10:05 PM PDT

Annuitized: $114 Million Cash Value: $86.4 Million

Lotto Texas Winning Numbers for 04/27/2013

Posted: 27 Apr 2013 10:05 PM PDT

14 - 21 - 23 - 26 - 42 - 46

Lotto Texas Estimated Jackpot for 05/01/2013

Posted: 27 Apr 2013 10:05 PM PDT

Annuitized: $6 Million Cash Value: $4.27 Million

Texas Two Step Winning Numbers for 04/25/2013

Posted: 27 Apr 2013 10:05 PM PDT

2 - 7 - 10 - 24 Bonus Ball 17

Texas Two Step Advertised Jackpot for 04/29/2013

Posted: 27 Apr 2013 10:05 PM PDT

$625,000

Pick 3 Day Winning Numbers for 04/27/2013

Posted: 27 Apr 2013 10:05 PM PDT

7 - 4 - 9 Sum It Up = 20