| Taxxit 2.0.3 - Manages Italian tax modules F23 and F24. (Demo) Posted: 27 Jun 2013 02:48 AM PDT  Taxxit is available only in Italian. Taxxit is an application that manages (archives, calculates, and prints) Italian tax modules F23 and F24, and stores the info and calculations into a database so you can retrieve the data for future use. It allows you to print the entire module directly on blank paper, with graphics and tax data. Version 2.0.3: - Corretta la formattazione di alcuni campi nei modelli F24 semplificati
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| PS3 firmware update now safe to download Posted: 27 Jun 2013 02:54 AM PDT Sony has released a new version of PS3's firmware to fix the issues caused by the 4.45 update, which bricked some |
| Future Internet, Vol. 5, Pages 317-335: eHealth Service Support in Future IPv6 Vehicular Networks Posted: 27 Jun 2013 12:00 AM PDT Recent vehicular networking activities include novel automotive applications, such as public vehicle to vehicle/infrastructure (V2X), large scale deployments, machine-to-machine (M2M) integration scenarios, and more. The platform described in this paper focuses on the integration of eHealth in a V2I setting. This is to allow the use of Internet from a vehicular setting to disseminate health-related information. From an eHealth viewpoint, the use of remote healthcare solutions to record and transmit a patient's vital signs is a special telemedicine application that helps hospital resident health professionals to optimally prepare the patient's admittance. From the automotive perspective, this is a typical vehicle-to-infrastructure (V2I) communication scenario. This proposal provides an IPv6 vehicular platform, which integrates eHealth devices and allows sending captured health-related data to a personal health record (PHR) application server in the IPv6 Internet. The collected data is viewed remotely by a doctor and supports his diagnostic decision. In particular, our work introduces the integration of vehicular and eHealth testbeds, describes related work and presents a lightweight auto-configuration method based on a DHCPv6 extension to provide IPv6 connectivity with a few numbers of messages. |
| Viruses, Vol. 5, Pages 1607-1632: Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense Posted: 27 Jun 2013 12:00 AM PDT Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection. |
| Behavioral Sciences, Vol. 3, Pages 330-347: Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies Posted: 27 Jun 2013 12:00 AM PDT Schizophrenia is a complex chronic mental illness that is characterized by positive, negative and cognitive symptoms. Cognitive deficits are most predictive of long-term outcomes, with abnormalities in memory being the most robust finding. The advent of functional magnetic resonance imaging (fMRI) has allowed exploring neural correlates of memory deficits in vivo. In this article, we will give a selective review of fMRI studies probing brain regions and functional networks that are thought to be related to abnormal memory performance in two memory systems prominently affected in schizophrenia; working memory and episodic memory. We revisit the classic "hypofrontality" hypothesis of working memory deficits and explore evidence for frontotemporal dysconnectivity underlying episodic memory abnormalities. We conclude that fMRI studies of memory deficits in schizophrenia are far from universal. However, the current literature does suggest that alterations are not isolated to a few brain regions, but are characterized by abnormalities within large-scale brain networks. |
| Molecules, Vol. 18, Pages 7549-7556: Characterization of Total Phenolic Constituents from the Stems of Spatholobus suberectus Using LC-DAD-MSn and Their Inhibitory Effect on Human Neutrophil Elastase Activity Posted: 27 Jun 2013 12:00 AM PDT Spatholobus suberectus Dunn, belonging to the legume family (Fabaceae), has been used as a Traditional Chinese Medicine for the treatment of anemia, menoxenia and rheumatism. A limited number of studies report that various types of flavonoids are the main characteristic constituents of this herb. We have now found that S. suberectus contains about 2% phenolic components and characterized the major phenolic components as homogeneous B-type procyanidin conjugates using a liquid chromatography with diode-array detection-ESI mass spectrometry (LC-DAD/ESI-MS) method. This is the first report on occurrence of most B-type procyanidins in this herb. Moreover, the total phenolics extract was assayed for inhibitory activity on human neutrophil elastase and its IC50 was found to be 1.33 μg/mL. |
| Molecules, Vol. 18, Pages 7533-7548: Synthesis, Surface Modification and Characterisation of Biocompatible Magnetic Iron Oxide Nanoparticles for Biomedical Applications Posted: 27 Jun 2013 12:00 AM PDT Superparamagnetic iron oxide nanoparticles (MNPs) with appropriate surface chemistry exhibit many interesting properties that can be exploited in a variety of biomedical applications such as magnetic resonance imaging contrast enhancement, tissue repair, hyperthermia, drug delivery and in cell separation. These applications required that the MNPs such as iron oxide Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) having high magnetization values and particle size smaller than 100 nm. This paper reports the experimental detail for preparation of monodisperse oleic acid (OA)-coated Fe3O4 MNPs by chemical co-precipitation method to determine the optimum pH, initial temperature and stirring speed in order to obtain the MNPs with small particle size and size distribution that is needed for biomedical applications. The obtained nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray fluorescence spectrometry (EDXRF), thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), and vibrating sample magnetometer (VSM). The results show that the particle size as well as the magnetization of the MNPs was very much dependent on pH, initial temperature of Fe2+ and Fe3+ solutions and steering speed. The monodisperse Fe3O4 MNPs coated with oleic acid with size of 7.8 ± 1.9 nm were successfully prepared at optimum pH 11, initial temperature of 45 °C and at stirring rate of 800 rpm. FTIR and XRD data reveal that the oleic acid molecules were adsorbed on the magnetic nanoparticles by chemisorption. Analyses of TEM show the oleic acid provided the Fe3O4 particles with better dispersibility. The synthesized Fe3O4 nanoparticles exhibited superparamagnetic behavior and the saturation magnetization of the Fe3O4 nanoparticles increased with the particle size. |
| Molecules, Vol. 18, Pages 7510-7532: Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers Posted: 27 Jun 2013 12:00 AM PDT In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor blockers bearing either the benzyl or the biphenylmethyl moiety at the N-1 or N-3 position, either the (E)-acrylate or the propanoate fragment and their related acids at the C-4 position as well as a halogen atom at the C-5 position of the imidazole ring, were synthesized. The newly synthesized analogues were evaluated for binding to human AT1 receptor. The biological results showed that this class of molecules possesses moderate or no activity, thus not always confirming high docking scores. Nonetheless, important conclusions can be derived for their molecular basis of their mode of action and help medicinal chemists to design and synthesize more potent ones. An aliphatic group as in losartan seems to be important for enhancing binding affinity and activity. |
| Molecules, Vol. 18, Pages 7492-7509: Spectroscopic and Theoretical Studies of Some 3-(4′-Substituted phenylsulfanyl)-1-methyl-2-piperidones Posted: 27 Jun 2013 12:00 AM PDT The analysis of the IR carbonyl bands of some 3-(4′-substituted phenylsulfanyl)-1-methyl-2-piperidones 1–6 bearing substituents: NO2 (compound 1), Br (compound 2), Cl (compound 3), H (compound 4) Me (compound 5) and OMe (compound 6) supported by B3LYP/6-31+G(d,p) and PCM calculations along with NBO analysis (for compound 4) and X-ray diffraction (for 2) indicated the existence of two stable conformations, i.e., axial (ax) and equatorial (eq), the former corresponding to the most stable and the least polar one in the gas phase calculations. The sum of the energy contributions of the orbital interactions (NBO analysis) and the electrostatic interactions correlate well with the populations and the νCO frequencies of the ax and eq conformers found in the gas phase. Unusually, in solution of the non-polar solvents n-C6H14 and CCl4, the more intense higher IR carbonyl frequency can be ascribed to the ax conformer, while the less intense lower IR doublet component to the eq one. The same νCO frequency trend also holds in polar solvents, that is νCO (eq)< νCO (ax). However, a reversal of the ax/eq intensity ratio occurs going from non-polar to polar solvents, with the ax conformer component that progressively decreases with respect to the eq one in CHCl3 and CH2Cl2, and is no longer detectable in the most polar solvent CH3CN. The PCM method applied to compound 4 supports these findings. In fact, it predicts the progressive increase of the eq/ax population ratio as the relative permittivity of the solvent increases. Moreover, it indicates that the computed νCO frequencies of the ax and eq conformers do not change in the non–polar solvents n-C6H14 and CCl4, while the νCO frequencies of the eq conformer become progressively lower than that of the ax one going from CHCl3 to CH2Cl2 and to CH3CN, in agreement with the experimental IR values. The analysis of the geometries of the ax and eq conformers shows that the carbonyl oxygen atom of the eq conformer is free for solvation, while the O[CO]…H[o-Ph] hydrogen bond that takes place in the ax conformer partially hinders the approach of the solvent molecules to the carbonyl oxygen atom. Therefore, the larger solvation that occurs in the carbonyl oxygen atom of the eq conformer is responsible for the observed and calculated decrease of the corresponding frequency. The X-ray single crystal analysis of 2 indicates that this compound adopts the most polar eq geometry in the solid. In fact, in order to obtain the largest energy gain, the molecules are arranged in the crystal in a helical fashion due to dipole moment coupling along with C-H…O and C-H…πPh hydrogen bonds. |
| Landscaper's Companion 1.5 - Gardening reference guide. (Commercial) Posted: 27 Jun 2013 02:31 AM PDT  Landscaper's Companion, enjoyed by thousands of gardeners, is your reference guide to trees, shrubs, annuals, perennials, and all sorts of plants. Containing information on over 26,000 plants and 21,000 pictures, it makes an excellent resource for the casual gardener, landscaper, aspiring botanist, or anyone looking for a simple, easy-to-use plant guide. Browse over 26,000 different plants by their scientific name and common names. View information such as water usage, size, and sun requirements. Most have a short description of the plant along with cultivation information, common uses, and any problems they may have. Each plant entry includes beautiful pictures. You can also add your own picture to each plant. Additional plants and images are added periodically for FREE! Landscaper's Companion is also available of for the iPhone and iPad. Those version are loved by thousands of people, and are highly rated: Version 1.5: - Now you can add your own plants!
- New database with over 3,000 updates.
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| Sensors, Vol. 13, Pages 8303-8330: Energy Consumption and Control Response Evaluations of AODV Routing in WSANs for Building-Temperature Control Posted: 27 Jun 2013 12:00 AM PDT The main objective of this paper is to investigate the effects of routing protocols on wireless sensor and actuator networks (WSANs), focusing on the control system response and the energy consumption of nodes in a network. We demonstrate that routing algorithms designed without considering the relationship between communication and control cannot be appropriately used in wireless networked control applications. For this purpose, an ad-hoc on-demand distance vector (AODV) routing, an IEEE 802.15.4, and a building-temperature control system are employed for this exploration. The findings from our scenarios show that the AODV routing can select a path with a high traffic load for data transmission. It takes a long time before deciding to change a new route although it experiences the unsuccessful transmission of packets. As a result, the desirable control target cannot be achieved in time, and nodes consume more energy due to frequent packet collisions and retransmissions. Consequently, we propose a simple routing solution to alleviate these research problems by modifying the original AODV routing protocol. The delay-threshold is considered to avoid any congested connection during routing procedures. The simulation results demonstrate that our solution can be appropriately applied in WSANs. Both the energy consumption and the control system response are improved. |
| Sensors, Vol. 13, Pages 8285-8302: ADVICE: A New Approach for Near-Real-Time Monitoring of Surface Displacements in Landslide Hazard Scenarios Posted: 27 Jun 2013 12:00 AM PDT We present a new method for near-real-time monitoring of surface displacements due to landslide phenomena, namely ADVanced dIsplaCement monitoring system for Early warning (ADVICE). The procedure includes: (i) data acquisition and transfer protocols; (ii) data collection, filtering, and validation; (iii) data analysis and restitution through a set of dedicated software; (iv) recognition of displacement/velocity threshold, early warning messages via SMS and/or emails; (v) automatic publication of the results on a dedicated webpage. We show how the system evolved and the results obtained by applying ADVICE over three years into a real early warning scenario relevant to a large earthflow located in southern Italy. ADVICE has speed-up and facilitated the understanding of the landslide phenomenon, the communication of the monitoring results to the partners, and consequently the decision-making process in a critical scenario. Our work might have potential applications not only for landslide monitoring but also in other contexts, as monitoring of other geohazards and of complex infrastructures, as open-pit mines, buildings, dams, etc. |
| Sensors, Vol. 13, Pages 8239-8284: D-MSR: A Distributed Network Management Scheme for Real-Time Monitoring and Process Control Applications in Wireless Industrial Automation Posted: 27 Jun 2013 12:00 AM PDT Current wireless technologies for industrial applications, such as WirelessHART and ISA100.11a, use a centralized management approach where a central network manager handles the requirements of the static network. However, such a centralized approach has several drawbacks. For example, it cannot cope with dynamicity/disturbance in large-scale networks in a real-time manner and it incurs a high communication overhead and latency for exchanging management traffic. In this paper, we therefore propose a distributed network management scheme, D-MSR. It enables the network devices to join the network, schedule their communications, establish end-to-end connections by reserving the communication resources for addressing real-time requirements, and cope with network dynamicity (e.g., node/edge failures) in a distributed manner. According to our knowledge, this is the first distributed management scheme based on IEEE 802.15.4e standard, which guides the nodes in different phases from joining until publishing their sensor data in the network. We demonstrate via simulation that D-MSR can address real-time and reliable communication as well as the high throughput requirements of industrial automation wireless networks, while also achieving higher efficiency in network management than WirelessHART, in terms of delay and overhead. |
| Sensors, Vol. 13, Pages 8222-8238: On the Use of Simple Geometric Descriptors Provided by RGB-D Sensors for Re-Identification Posted: 27 Jun 2013 12:00 AM PDT The re-identification problem has been commonly accomplished using appearance features based on salient points and color information. In this paper, we focus on the possibilities that simple geometric features obtained from depth images captured with RGB-D cameras may offer for the task, particularly working under severe illumination conditions. The results achieved for different sets of simple geometric features extracted in a top-view setup seem to provide useful descriptors for the re-identification task, which can be integrated in an ambient intelligent environment as part of a sensor network. |
| Xbox One Kinect for Windows developer pre-orders open Posted: 27 Jun 2013 12:16 AM PDT Microsoft is taking applications for Kinect for Windows developer program; $399 payment required. 
The Xbox One Kinect for Windows is now available for pre-order by developers, Microsoft has announced. Revealed on the Microsoft website, the Xbox maker is taking applications from those who wish to take part in the Kinect for Windows developer kit program. Accepted participants will receive a pre-release sensor and tools to assist with building applications when the program kicks off in November this year. The program costs $399 (or "local equivalent") and includes: • Access to the Kinect for Windows engineering team private forum and webcasts
• Early SDK access (alpha, beta, and any updates along the way to release)
• Access to all API and sample documentation
• Pre-release/alpha sensor
• Final sensor at launch
Applications close on July 31, 2013, at 9:00 a.m. PST, with successful participants to be notified in August. The Kinect 2.0 will be included with the Xbox One, Microsoft's next-generation console. For more on the latest Xbox One news, be sure to check out GameSpot's Xbox One hub. Read and Post Comments | Get the full article at GameSpot
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| Energies, Vol. 6, Pages 3134-3148: The Analysis of the Aerodynamic Character and Structural Response of Large-Scale Wind Turbine Blades Posted: 27 Jun 2013 12:00 AM PDT A process of detailed CFD and structural numerical simulations of the 1.5 MW horizontal axis wind turbine (HAWT) blade is present. The main goal is to help advance the use of computer-aided simulation methods in the field of design and development of HAWT-blades. After an in-depth study of the aerodynamic configuration and materials of the blade, 3-D mapping software is utilized to reconstruct the high fidelity geometry, and then the geometry is imported into CFD and structure finite element analysis (FEA) software for completely simulation calculation. This research process shows that the CFD results compare well with the professional wind turbine design and certification software, GH-Bladed. Also, the modal analysis with finite element method (FEM) predicts well compared with experiment tests on a stationary blade. For extreme wind loads case that by considering a 50-year extreme gust simulated in CFD are unidirectional coupled to the FE-model, the results indicate that the maximum deflection of the blade tip is less than the distance between the blade tip (the point of maximum deflection) and the tower, the material of the blade provides enough resistance to the peak stresses the occur at the conjunction of shear webs and center spar cap. Buckling analysis is also included in the study. |
| Symmetry, Vol. 5, Pages 233-252: Symmetries Shared by the Poincaré Group and the Poincaré Sphere Posted: 27 Jun 2013 12:00 AM PDT Henri Poincaré formulated the mathematics of Lorentz transformations, known as the Poincaré group. He also formulated the Poincaré sphere for polarization optics. It is shown that these two mathematical instruments can be derived from the two-by-two representations of the Lorentz group. Wigner's little groups for internal space-time symmetries are studied in detail. While the particle mass is a Lorentz-invariant quantity, it is shown to be possible to address its variations in terms of the decoherence mechanism in polarization optics. |
| Games, Vol. 4, Pages 329-338: Relative Concerns and Delays in Bargaining with Private Information Posted: 27 Jun 2013 12:00 AM PDT We consider Rubinstein's two-person alternating-offer bargaining model with two-sided incomplete information. We investigate the effects of one party having relative concerns about the bargaining outcome and the delay in reaching an agreement. We find that facing an opponent with stronger relative concerns only hurts the bargainer when she is stronger than her opponent. In addition, we show that an increase of one party's relative concerns will decrease the maximum delay in reaching an agreement. |
| Molecules, Vol. 18, Pages 7486-7491: A New Resveratrol Trimer from the Roots and Stems of Vitis wenchowensis Posted: 27 Jun 2013 12:00 AM PDT Phytochemical constituents of Vitis wenchowensis were investigated for the first time. A new resveratrol trimer, wenchowenol (1), was isolated from the roots and stems of Vitis wenchowensis along with four known stilbenoids 2–5. The structure and relative configuration of 1 were established on the basis of spectral evidence, especially HMBC and NOESY experiments. It showed potent antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical. |
| Molecules, Vol. 18, Pages 7473-7485: Effects of Combined Elicitors on Tanshinone Metabolic Profiling and SmCPS Expression in Salvia miltiorrhiza Hairy Root Cultures Posted: 27 Jun 2013 12:00 AM PDT Tanshinones are abietane-type norditerpenoid quinone natural products found in a well-known traditional Chinese medicinal herb, Salvia miltiorrhiza Bunge. The copalyl diphosphate synthase of S. miltiorrhiza (SmCPS) is the key enzyme in the first step for transformation of geranylgeranyl diphosphate (GGPP) into miltiradiene, which has recently been identified as the precursor of tanshinones. Based on previous gene-to-metabolite network, this study examined the influences of various combined elicitors on the expression of SmCPS and production of tanshinones in S. miltiorrhiza hairy root cultures. Combined elicitors were composed of three classes of elicitors, a heavy metal ion (Ag+), a polysaccharide (yeast extract, YE), and a plant response-signalling compound (methyl jasmonate, MJ). YE + Ag+, Ag+ + MJ, YE + MJ, and YE + Ag+ + MJ were the combinations we tested. The effect of elicitors on the SmCPS expression level was detected by quantitative real-time PCR (qRT-PCR), and the tanshinones accumulation responses to elicitation were analysed by Ultra Performance Liquid Chromatography (UPLC) metabolite profiling. Of these combined elicitors, the expression of SmCPS was significantly enhanced by elicitation, especially at 24 h and 36 h. Of four tanshinones detected, the contents of cryptotanshinone and dihydrotanshinone I were enhanced by treatment with YE + Ag+, Ag+ + MJ, and YE + Ag+ + MJ. Our results indicate that appropriate combined elicitors can enhance tanshinones production in hairy root cultures. |
