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- IJERPH, Vol. 10, Pages 2468-2470: Correction: Chen, Y.-C.; Yeh, H.-C.; Wei, C. Estimation of River Pollution Index in a Tidal Stream Using Kriging Analysis. Int. J. Environ. Res. Public Health 2012, 9, 3085-3100.
- Coatings, Vol. 3, Pages 82-97: Ethylene Methacrylic Acid (EMAA) Single Splat Morphology
- Air Doc 2.0 - Transfer documents, movies, songs and more to your iOS device. (Free)
- Fotor 1.2.0 - Powerful free photo editor. (Free)
- Brain Sciences, Vol. 3, Pages 941-963: Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications
- Atmosphere, Vol. 4, Pages 198-213: Comparative Spectral Analysis and Correlation Properties of Observed and Simulated Total Column Ozone Records
- Agronomy, Vol. 3, Pages 488-496: The Impact of Volunteer Corn on Crop Yields and Insect Resistance Management Strategies
- Marine Drugs, Vol. 11, Pages 2140-2153: Tetrodotoxin Blockade on Canine Cardiac L-Type Ca2+ Channels Depends on pH and Redox Potential
- Marine Drugs, Vol. 11, Pages 2126-2139: Site-Specific Variability in the Chemical Diversity of the Antarctic Red Alga Plocamium cartilagineum
- Secret Ponchos - Preview
- AppViz 2.3.10 - Sales analysis for Mac and iPhone application designers. (Demo)
- Marine Drugs, Vol. 11, Pages 2113-2125: Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428
- Marine Drugs, Vol. 11, Pages 2069-2112: Protease Inhibitors from Marine Venomous Animals and Their Counterparts in Terrestrial Venomous Animals
- UK Pirate Cinema is out!
- Energies, Vol. 6, Pages 2892-2926: Transient Momentum Balance—A Method for Improving the Performance of Mean-Value Engine Plant Models
- Energies, Vol. 6, Pages 2874-2891: Idle Operation with Low Intake Valve Lift in a Port Fuel Injected Engine
- Energies, Vol. 6, Pages 2859-2873: Mitigation Techniques to Reduce the Impact ofWind Turbines on Radar Services
- Energies, Vol. 6, Pages 2840-2858: Can Tidal Current Energy Provide Base Load?
- Secret Ponchos - Screenshots
- Killer Instinct (Xbox One) - Preview
| Posted: 14 Jun 2013 12:00 AM PDT The authors wish to add the following amendments and corrections on their paper published in IJERPH [1]. | ||
| Coatings, Vol. 3, Pages 82-97: Ethylene Methacrylic Acid (EMAA) Single Splat Morphology Posted: 14 Jun 2013 12:00 AM PDT A single splat is the building block of a thermal spray coating; thus, investigating single splats is essential to understanding thermal spray coatings and their properties. In this study, the morphology of flame sprayed ethylene methacrylic acid (EMAA) splats, deposited at various stand-off distances (SODs) onto glass and mild steel substrates were investigated using a scanning electron microscope, Leica M Stereo-microscope, the WYKO surface profiler and the ContourGT surface profiler. This work analyzed the effect of the process variables on EMAA splat morphology. The modeling of the temperature versus velocity (TV) map, the temperature versus stand-off distance (TS) map and the velocity versus stand-off distance (VS) map of EMAA single splat were presented. | ||
| Air Doc 2.0 - Transfer documents, movies, songs and more to your iOS device. (Free) Posted: 14 Jun 2013 02:38 AM PDT  Air Doc is the ultimate solution for transferring documents, movies, songs, etc., to your iPad/iPhone. Simply drag and drop your files into the Air Doc app and they will open up immediately on your iPad or iPhone (iOS app needed on your iPhone/iPad - get it on the App Store). No cloud or Internet access needed - no data leaves your local network. All your devices must have access to the same LAN (or WLAN) - no additional network configuration is needed. The Air Doc Viewer app is available on the iOS App Store. Features:
Version 2.0:
More information Download Now | ||
| Fotor 1.2.0 - Powerful free photo editor. (Free) Posted: 14 Jun 2013 02:21 AM PDT  Fotor for Mac is a mighty photo editor packed with moment-capturing tools. It's fun, versatile, and ideal for creating picturesque memories. Tools for editing. Powered by a cutting edge processing engine, Fotor is well-suited for processing high-quality images. Adjust your image's white balance, exposure, brightness, color contrast, saturation, and sharpness. Or straighten, crop, rotate, and manipulate the image to your heart's content. Perfect your pictures with Fotor, a powerful free alternative for photographers. Version 1.2.0:
OS X 10.6 or later More information Download Now | ||
| Posted: 14 Jun 2013 12:00 AM PDT Ethanol is the main constituent of alcoholic beverages that exerts toxicity to neuronal development. Ethanol affects synaptogenesis and prevents proper brain development. In humans, synaptogenesis takes place during the third trimester of pregnancy, and in rodents this period corresponds to the initial few weeks of postnatal development. In this period neuronal maturation and differentiation begin and neuronal cells start migrating to their ultimate destinations. Although the neuronal development of all areas of the brain is affected, the cerebellum and cerebellar neurons are more susceptible to the damaging effects of ethanol. Ethanol's harmful effects include neuronal cell death, impaired differentiation, reduction of neuronal numbers, and weakening of neuronal plasticity. Neuronal development requires many hormones and growth factors such as retinoic acid, nerve growth factors, and cytokines. These factors regulate development and differentiation of neurons by acting through various receptors and their signaling pathways. Ethanol exposure during development impairs neuronal signaling mechanisms mediated by the N-methyl-d-aspartate (NMDA) receptors, the retinoic acid receptors, and by growth factors such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-I), and basic fibroblast growth factor (bFGF). In combination, these ethanol effects disrupt cellular homeostasis, reduce the survival and migration of neurons, and lead to various developmental defects in the brain. Here we review the signaling mechanisms that are required for proper neuronal development, and how these processes are impaired by ethanol resulting in harmful consequences to brain development. | ||
| Posted: 14 Jun 2013 12:00 AM PDT We present a statistical analysis of total column ozone records obtained from satellite measurements and from two global climate chemistry models on global scale. Firstly, a spectral weight analysis is performed where the relative strength of semiannual, annual and quasi-biennial oscillations are determined with respect to the integrated power spectra. The comparison reveals some anomalies in the model representations at each spectral component. The tails of the spectra demonstrate that both models underestimate high frequency (daily) ozone variability, which might have a complex origin, since several dynamical processes affect short time changes of the ozone level at a given location. Secondly, detrended fluctuation analysis is exploited to analyze two-point correlations of anomaly time series. Both models reproduce the characteristic geographic dependence of correlation strength over the overlapping area with empirical observations (latitude band between 60 S and 60 N). The values of precise correlation exponents are hard to obtain over regions where quasi-biennial oscillations or other strong nonstationarities (ozone hole) are present. In spite of all the numerical difficulties, significant long range correlations are detected for total ozone over all geographic locations. | ||
| Posted: 14 Jun 2013 12:00 AM PDT Volunteer corn (VC) has reemerged as a problematic weed in corn/soybean rotational cropping systems. This reemergence and increasing prevalence of volunteer corn has been correlated to an increased adoption of herbicide-resistant (HR) corn hybrids and the adoption of conservation tillage. Since the introduction of HR crops, control options, weed/crop competition, and other concerns (i.e., insect resistance management of Bt traits) have increased the amount of attention that volunteer corn is receiving. The objective of this review is to discuss what is known about VC prior to and after the introduction of HR crops, and to discuss new information about this important weed. | ||
| Posted: 14 Jun 2013 12:00 AM PDT Tetrodotoxin (TTX) is believed to be one of the most selective inhibitors of voltage-gated fast Na+ channels in excitable tissues. Recently, however, TTX has been shown to block L-type Ca2+ current (ICa) in canine cardiac cells. In the present study, the TTX-sensitivity of ICa was studied in isolated canine ventricular myocytes as a function of (1) channel phosphorylation, (2) extracellular pH and (3) the redox potential of the bathing medium using the whole cell voltage clamp technique. Fifty-five micromoles of TTX (IC50 value obtained under physiological conditions) caused 60% ± 2% inhibition of ICa in acidic (pH = 6.4), while only a 26% ± 2% block in alkaline (pH = 8.4) milieu. Similarly, the same concentration of TTX induced 62% ± 6% suppression of ICa in a reductant milieu (containing glutathione + ascorbic acid + dithiothreitol, 1 mM each), in contrast to the 31% ± 3% blockade obtained in the presence of a strong oxidant (100 μM H2O2). Phosphorylation of the channel protein (induced by 3 μM forskolin) failed to modify the inhibiting potency of TTX; an IC50 value of 50 ± 4 μM was found in forskolin. The results are in a good accordance with the predictions of our model, indicating that TTX binds, in fact, to the selectivity filter of cardiac L-type Ca channels. | ||
| Posted: 14 Jun 2013 12:00 AM PDT Plocamium cartilagineum is a common red alga on the benthos of Antarctica and can be a dominant understory species along the western Antarctic Peninsula. Algae from this region have been studied chemically, and like "P. cartilagineum" from other worldwide locations where it is common, it is rich in halogenated monoterpenes, some of which have been implicated as feeding deterrents toward sympatric algal predators. Secondary metabolites are highly variable in this alga, both qualitatively and quantitatively, leading us to probe individual plants to track the possible link of variability to genetic or other factors. Using cox1 and rbcL gene sequencing, we find that the Antarctic alga divides into two closely related phylogroups, but not species, each of which is further divided into one of five chemogroups. The chemogroups themselves, defined on the basis of Bray-Curtis similarity profiling of GC/QqQ chromatographic analyses, are largely site specific within a 10 km2 area. Thus, on the limited geographical range of this analysis, P. cartilagineum displays only modest genetic radiation, but its secondary metabolome was found to have experienced more extensive radiation. Such metabogenomic divergence demonstrated on the larger geographical scale of the Antarctic Peninsula, or perhaps even continent-wide, may contribute to the discovery of cryptic speciation. | ||
| Posted: 14 Jun 2013 03:04 AM PDT Two things are certain: death and bourbon. What drew me instantly to Secret Ponchos was its style. There's not much that beats an old Western game or movie. So for my first taste of E3 2013, I decided to try out Switchblade Monkeys' newest title in development. Currently working off the Unity Engine (not yet set in stone), movement and game play has shown to be very responsive. Before even getting into actual combat, simply running around, firing weapons into the air, and getting a feel for the controls is smooth. At first glance, this reminded me of Renegade Ops except, obviously, for cowboys (and cowgirls respectively) instead of cars. And that it is catering specifically for online play only. What stands out particularly about this downloadable title is the artistic graphics centered around each character and the backgrounds surrounding them. The animations, though at times cartoonish, have a particular flair that still allow for immersion. It's a joy to watch, particularly at the end of a match when the main protagonist twirls his gun, in badass form, gracefully into his holster. So far the idea is for Secret Ponchos to be continually updated so that it will be ready for play anytime we get the hankering, an experience that keeps itself fresh even after hours and hours of play. New characters, and possibly weapons, will be available for download every few weeks or so, in order to keep the palate satisfied. Secret Ponchos also sports swanky game modes that are sure to keep fans interested. You can [lay anywhere from 1-vs-1 to 4-vs-4, as well as an 8-player free-for-all. Fight settings will also allow you to tweak ... | ||
| AppViz 2.3.10 - Sales analysis for Mac and iPhone application designers. (Demo) Posted: 14 Jun 2013 02:04 AM PDT  AppViz helps Mac and iPhone developers download and visualize their application sales. Avoid the hassle of manual daily downloads. Instead, download your data from the Web with the click of a button. Spend your time building applications, not spreadsheets. Version 2.3.10: Fixes
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| Posted: 14 Jun 2013 12:00 AM PDT Three new napyradiomycins (1–3) were isolated from the culture broth of a marine-derived actinomycete strain SCSIO 10428, together with six known related analogues napyradiomycin A1 (4), 18-oxonapyradiomycin A1 (5), napyradiomycin B1 (6), napyradiomycin B3 (7), naphthomevalin (8), and napyradiomycin SR (9). The strain SCSIO 10428 was identified as a Streptomyces species by the sequence analysis of its 16S rRNA gene. The structures of new compounds 1–3, designated 4-dehydro-4a-dechlorona pyradiomycin A1 (1), 3-dechloro-3-bromonapyradiomycin A1 (2), and 3-chloro-6, 8-dihydroxy-8-α-lapachone (3), respectively, were elucidated by comparing their 1D and 2D NMR spectroscopic data with known congeners. None of the napyradiomycins 1–9 showed antioxidative activities. Napyradiomycins 1–8 displayed antibacterial activities against three Gram-positive bacteria Staphylococcus and Bacillus strains with MIC values ranging from 0.25 to 32 μg mL−1, with the exception that compound 3 had a MIC value of above 128 μg mL−1 against Staphylococcus aureus ATCC 29213. Napyradiomycins 2, 4, 6, and 7 exhibited moderate cytotoxicities against four human cancer cell lines SF-268, MCF-7, NCI-H460, and HepG-2 with IC50 values below 20 μM, while the IC50 values for other five napyradiomycins 1, 3, 5, 8 and 9 were above 20 μM. | ||
| Posted: 14 Jun 2013 12:00 AM PDT The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms. These inhibitors consist of a chain of ~60 amino acid residues stabilized by three disulfide bridges, and was first observed in the bovine pancreatic trypsin inhibitor (BPTI)-like protease inhibitors, which strongly inhibit trypsin and chymotrypsin. In this review we present the protease inhibitors (PIs) described to date from marine venomous animals, such as from sea anemone extracts and Conus venom, as well as their counterparts in terrestrial venomous animals, such as snakes, scorpions, spiders, Anurans, and Hymenopterans. More emphasis was given to the Kunitz-type inhibitors, once they are found in all these organisms. Their biological sources, specificity against different proteases, and other molecular blanks (being also K+ channel blockers) are presented, followed by their molecular diversity. Whereas sea anemone, snakes and other venomous animals present mainly Kunitz-type inhibitors, PIs from Anurans present the major variety in structure length and number of Cys residues, with at least six distinguishable classes. A representative alignment of PIs from these venomous animals shows that, despite eventual differences in Cys assignment, the key-residues for the protease inhibitory activity in all of them occupy similar positions in primary sequence. The key-residues for the K+ channel blocking activity was also compared. | ||
| Posted: 14 Jun 2013 01:41 AM PDT
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| Posted: 14 Jun 2013 12:00 AM PDT Mean-value engine models (MVEMs) are frequently applied in system-level simulations of vehicle powertrains. In particular, MVEMs are a common choice in engine simulators, where real-time execution is mandatory. In the case of real-time applications with prescribed, fixed sampling times, the use of explicit integration schemes is almost mandatory. Thus the stability of MVEMs is one of the main limitations when it comes to optimizing their performance. It is limited either by the minimum size of the gas volume elements or by the maximum integration time step. An innovative approach that addresses both constraints arises from the fact that the mass flow through the transfer elements of the MVEM is not modelled considering the quasi-steady assumption, but instead the mass-flow is calculated using a single transient momentum balance (TMB) equation. The proposed approach closely resembles phenomena in the physical model, since it considers both the flow-field history and the inertial effects arising from the time variation of the mass flow. It is shown in this paper that a consideration of the TMB equation improves the stability and/or the computational speed of the MVEMs, whereas it also makes it possible to capture physical phenomena in a more physically plausible manner. | ||
| Posted: 14 Jun 2013 12:00 AM PDT Reducing fuel consumption is a prime objective in the automotive industry in order to meet regulatory and customer demands. Variable valve actuation offers many opportunities for improving the spark ignition engine's performance in areas such as fuel economy and pollutant emissions. Our studies revealed that the ability to control maximum intake valve lift does indeed offer the ability to control intake air mass, but also has the added benefit that it improves the fuel-air mixing process thanks to an increased turbulence, caused by the increased intake flow velocity. This is particularly important at idle and low part loads when low maximum lifts are to be used for improving the fuel economy or for achieving the required power. The paper focuses on the experimental results obtained when approaching idle operation with different intake valve laws. Results indicating the potential of using low intake valve lift for fuel economy and cyclic dispersion improvement are presented in this paper. | ||
| Posted: 14 Jun 2013 12:00 AM PDT Radar services are occasionally affected by wind farms. This paper presents a comprehensive description of the effects that a wind farm may cause on the different radar services, and it compiles a review of the recent research results regarding the mitigation techniques to minimize this impact. Mitigation techniques to be applied at the wind farm and on the radar systems are described. The development of thorough impact studies before the wind farm is installed is presented as the best way to analyze in advance the potential for interference, and subsequently identify the possible solutions to allow the coexistence of wind farms and radar services. | ||
| Energies, Vol. 6, Pages 2840-2858: Can Tidal Current Energy Provide Base Load? Posted: 14 Jun 2013 12:00 AM PDT Tidal energy belongs to the class of intermittent but predictable renewable energy sources. In this paper, we consider a compact set of geographically diverse locations, which have been assessed to have significant tidal stream energy, and attempt to find the degree to which the resource in each location should be exploited so that the aggregate power from all locations has a low variance. An important characteristic of the locations chosen is that there is a good spread in the peak tidal flow times, though the geographical spread is relatively small. We assume that the locations, all on the island of Ireland, can be connected together and also assume a modular set of tidal turbines. We employ multi-objective optimisation to simultaneously minimise variance, maximise mean power and maximise minimum power. A Pareto front of optimal solutions in the form of a set of coefficients determining the degree of tidal energy penetration in each location is generated using a genetic algorithm. While for the example chosen the total mean power generated is not great (circa 100 MW), the case study demonstrated a methodology that can be applied to other location sets that exhibit similar delays between peak tidal flow times. | ||
| Posted: 14 Jun 2013 02:26 AM PDT Fact sheet pending. | ||
| Killer Instinct (Xbox One) - Preview Posted: 14 Jun 2013 02:09 AM PDT Oh, you have piqued my interest. That's… Rare? (rimshot) Ah, Killer Instinct. I was never any good at you, but you helped in defining one of the summers of my life with your B-movie-styled villains and over-the-top WTF combo system. When even I can pull off a 20 -combo without much trouble and can figure out how to break the combo of somebody else, that's a pretty open game! KI's last formal release was KI Gold in 1996, so any fans of the series have reached middle-age since then (at 28 and nearly 29... I know I have), so it's been… holy crap, 17 years? And after nearly two decades, not only is it still the craziness from my old super-tiny arcade from the summer of 1996, but a new way of marketing a fighting game. Little was talked about on the floor (beyond obligatory "HOLY CRAP, IT'S BAAAACK!" talk), but here's what I was able to find out. KI is on schedule to be a launch-day release for the Xbox One, and it will be free to download. It's not going to be a boxed store product, but download-only, and it will be free. And by "free," I mean you can play Jago. And he's it. Everything else is said to be handled as DLC, and that's everything… the story mode, other characters, presumably other stages to fight in. and any other modes Rare might come up with. With the focus starting on Jago it'll be easy to try out, but buying piecemeal is bound to turn off more than a few players. Especially so with some in the fighting game community, or anyone who enjoys experimenting with new characters and ... |
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