Games |
- System Lens 2.1 - Quickly manage resource usage. (Commercial)
- DailyDo 1.2.10 - Simple task manager. (Commercial)
- Vaccines, Vol. 1, Pages 225-249: Vector Design for Improved DNA Vaccine Efficacy, Safety and Production
- Molecules, Vol. 18, Pages 7407-7435: Solution NMR Studies on the Orientation of Membrane-Bound Peptides and Proteins by Paramagnetic Probes
- Remote Sensing, Vol. 5, Pages 3156-3171: Targeting Mineral Resources with Remote Sensing and Field Data in the Xiemisitai Area, West Junggar, Xinjiang, China
- Diversity, Vol. 5, Pages 426-460: In Situ Ecophysiology of Microbial Biofilm Communities Analyzed by CMEIAS Computer-Assisted Microscopy at Single-Cell Resolution
- Plants, Vol. 2, Pages 429-440: Growth Media Induces Variation in Cell Wall Associated Gene Expression in Arabidopsis thaliana Pollen Tube
- Plants, Vol. 2, Pages 416-428: SPL8 Acts Together with the Brassinosteroid-Signaling Component BIM1 in Controlling Arabidopsis thaliana Male Fertility
- Plants, Vol. 2, Pages 396-415: Understanding of Leaf Development—the Science of Complexity
- Plants, Vol. 2, Pages 379-395: Homeotic Genes and the ABCDE Model for Floral Organ Formation in Wheat
- The three way all-in with the Inter-Korean Summit transcript
- Plants, Vol. 2, Pages 371-378: In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
- Plants, Vol. 2, Pages 354-370: The Progamic Phase in High-Mountain Plants: From Pollination to Fertilization in the Cold
- Metabolites, Vol. 3, Pages 517-538: The Critical Assessment of Small Molecule Identification (CASMI): Challenges and Solutions
- IJERPH, Vol. 10, Pages 2606-2620: Socioeconomic Status Accounts for Rapidly Increasing Geographic Variation in the Incidence of Poor Fetal Growth
- Brain Sciences, Vol. 3, Pages 1013-1022: Neuroprotective Role of Nerve Growth Factor in Hypoxic-Ischemic Brain Injury
- Antibodies, Vol. 2, Pages 392-414: Antibody Glycosylation and Inflammation
- PS4 reveals planned for Gamescom
- Interview with Richard Matheson
- AU Shippin' Out June 24-29: Company of Heroes 2
| System Lens 2.1 - Quickly manage resource usage. (Commercial) Posted: 25 Jun 2013 02:24 AM PDT  System Lens is a beautiful way to quickly manage resource usage on your Mac. Version 2.1:
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| DailyDo 1.2.10 - Simple task manager. (Commercial) Posted: 25 Jun 2013 02:10 AM PDT  DailyDo is your answer to other complex and expensive to-do apps. DailyDo brings you a fantastic to-do and task manager. You can write your tasks on the beautiful notepad. When you are done just check the box and your tasks will appear on menu bar with Todo Pad. Todo Pad is an easy way to review and check the tasks. You can manage notifications by clicking on the setting icon. DailyDo has a great time-based notification system so you never miss a task! You don't need to install "Growl" to use the notification system! Features:
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| Posted: 25 Jun 2013 12:00 AM PDT DNA vaccination is a disruptive technology that offers the promise of a new rapidly deployed vaccination platform to treat human and animal disease with gene-based materials. Innovations such as electroporation, needle free jet delivery and lipid-based carriers increase transgene expression and immunogenicity through more effective gene delivery. This review summarizes complementary vector design innovations that, when combined with leading delivery platforms, further enhance DNA vaccine performance. These next generation vectors also address potential safety issues such as antibiotic selection, and increase plasmid manufacturing quality and yield in exemplary fermentation production processes. Application of optimized constructs in combination with improved delivery platforms tangibly improves the prospect of successful application of DNA vaccination as prophylactic vaccines for diverse human infectious disease targets or as therapeutic vaccines for cancer and allergy. | ||
| Posted: 25 Jun 2013 12:00 AM PDT Many peptides and proteins are attached to or immersed in a biological membrane. In order to understand their function not only the structure but also their topology in the membrane is important. Solution NMR spectroscopy is one of the most often used approaches to determine the orientation and localization of membrane-bound peptides and proteins. Here we give an application-oriented overview on the use of paramagnetic probes for the investigation of membrane-bound peptides and proteins. The examples discussed range from the large pool of antimicrobial peptides, bacterial toxins, cell penetrating peptides to domains of larger proteins or the calcium regulating protein phospholamban. Topological information is obtained in all these examples by the use of either attached or freely mobile paramagnetic tags. For some examples information obtained from the paramagnetic probes was included in the structure determination. | ||
| Posted: 25 Jun 2013 12:00 AM PDT The Xiemisitai area, West Junggar, Xinjiang, China, is situated at a potential copper mineralization zone in association with small granitic intrusions. In order to identify the alteration zones and mineralization characteristics of the intrusions, Landsat Enhanced Thematic Mapper (ETM+) and Quickbird data of the study area were evaluated in mapping lithological units, small intrusions, and alteration zones. False color composites of the first principal component analyses (PCA1), PCA2, and PCA4 in red (R), green (G), and blue (B) of the ETM+ image, and relevant hue-saturation-intensity (HSI) color model transformations, were performed. This led to the identification of lithologic units and discrimination of granitic intrusions from wall-rocks. A new geological map was generated by integrating the remote sensing results with two internally published local geologic maps and field inspection data. For the selected region, false color composites from PCA and relevant HSI-transformed images of the Quickbird data delineated the details of small intrusions and identified other unknown similar intrusions nearby. Fifteen separate potash-feldspar granites and three separate hornblende biotite granites were identified using ETM+ and Quickbird data. The principal component analysis-based Crosta technique was employed to discriminate alteration minerals. Some of the mapped alteration zones using the Crosta technique agreed very well with the known copper deposits. Field verification led to the discovery of three copper mineralizations and two gold mineralizations for the first time. The results show that the PCA and HSI transformation techniques proved to be robust in processing remote sensing data with moderate to high spatial resolutions. It is concluded that the utilized methods are useful for mapping lithology and the targeting of small intrusion-type mineral resources within the sparsely vegetated regions of Northwest China. | ||
| Posted: 25 Jun 2013 12:00 AM PDT This paper describes the utility of CMEIAS (Center for Microbial Ecology Image Analysis System) computer-assisted microscopy to extract data from accurately segmented images that provide 63 different insights into the ecophysiology of microbial populations and communities within biofilms and other habitats. Topics include quantitative assessments of: (i) morphological diversity as an indicator of impacts that substratum physicochemistries have on biofilm community structure and dominance-rarity relationships among populations; (ii) morphotype-specific distributions of biovolume body size that relate microbial allometric scaling, metabolic activity and growth physiology; (iii) fractal geometry of optimal cellular positioning for efficient utilization of allocated nutrient resources; (iv) morphotype-specific stress responses to starvation, environmental disturbance and bacteriovory predation; (v) patterns of spatial distribution indicating positive and negative cell–cell interactions affecting their colonization behavior; and (vi) significant methodological improvements to increase the accuracy of color-discriminated ecophysiology, e.g., differentiation of cell viability based on cell membrane integrity, cellular respiratory activity, phylogenetically differentiated substrate utilization, and N-acyl homoserine lactone-mediated cell–cell communication by bacteria while colonizing plant roots. The intensity of these ecophysiological attributes commonly varies at the individual cell level, emphasizing the importance of analyzing them at single-cell resolution and the proper spatial scale at which they occur in situ. | ||
| Posted: 25 Jun 2013 12:00 AM PDT The influence of three different pollen germination media on the transcript profile of Arabidopsis pollen tubes has been assessed by real-time PCR on a selection of cell wall related genes, and by a statistical analysis of microarray Arabidopsis pollen tube data sets. The qPCR assays have shown remarkable differences on the transcript levels of specific genes depending upon the formulation of the germination medium used. With the aid of principal component analysis performed on existing microarray data, a subset of genes has been identified that is more prone to produce diverging transcript levels. A functional classification of those genes showed that the clusters with higher number of members were those for hydrolase activity (based in molecular function) and for cell wall (based in cellular component). Taken together, these results may indicate that the nutrient composition of the pollen germination media influences pollen tube metabolism and that caution must be taken when interpreting transcriptomic data of pollen tubes. | ||
| Posted: 25 Jun 2013 12:00 AM PDT The non-miR156 targeted SBP-box gene SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 8 (SPL8), plays an important role in Arabidopsis anther development, where its loss-of-function results in a semi-sterile phenotype. Fully male-sterile plants are obtained when a spl8 loss-of-function mutation is introduced into a 35S:MIR156 genetic background, thereby revealing functional redundancy between SPL8 and miR156-targeted SBP-box genes. Here, we show that BIM1, a gene encoding a bHLH protein involved in brassinosteroid signaling and embryonic patterning, functions redundantly with SPL8 in its requirement for male fertility. Although bim1 single mutants displayed a mild fertility problem due to shortened filaments in some flowers, mutation of BIM1 significantly enhanced the semi-sterile phenotype of the spl8 mutant. Expression of both SPL8 and BIM1 was detected in overlapping expression domains during early anther developmental stages. Our data suggest that in regulating anther development, SPL8 and BIM1 function cooperatively in a common complex or in synergistic pathways. Phylogenetic analysis supports the idea of an evolutionary conserved function for both genes in angiosperm anther development. | ||
| Plants, Vol. 2, Pages 396-415: Understanding of Leaf Development—the Science of Complexity Posted: 25 Jun 2013 12:00 AM PDT The leaf is the major organ involved in light perception and conversion of solar energy into organic carbon. In order to adapt to different natural habitats, plants have developed a variety of leaf forms, ranging from simple to compound, with various forms of dissection. Due to the enormous cellular complexity of leaves, understanding the mechanisms regulating development of these organs is difficult. In recent years there has been a dramatic increase in the use of technically advanced imaging techniques and computational modeling in studies of leaf development. Additionally, molecular tools for manipulation of morphogenesis were successfully used for in planta verification of developmental models. Results of these interdisciplinary studies show that global growth patterns influencing final leaf form are generated by cooperative action of genetic, biochemical, and biomechanical inputs. This review summarizes recent progress in integrative studies on leaf development and illustrates how intrinsic features of leaves (including their cellular complexity) influence the choice of experimental approach. | ||
| Posted: 25 Jun 2013 12:00 AM PDT Floral organ formation has been the subject of intensive study for over 20 years, particularly in the model dicot species Arabidopsis thaliana. These studies have led to the establishment of a general model for the development of floral organs in higher plants, the so-called ABCDE model, in which floral whorl-specific combinations of class A, B, C, D, or E genes specify floral organ identity. In Arabidopsis, class A, B, C, D, E genes encode MADS-box transcription factors except for the class A gene APETALA2. Mutation of these genes induces floral organ homeosis. In this review, I focus on the roles of these homeotic genes in bread wheat (Triticum aestivum), particularly with respect to the ABCDE model. Pistillody, the homeotic transformation of stamens into pistil-like structures, occurs in cytoplasmic substitution (alloplasmic) wheat lines that have the cytoplasm of the related wild species Aegilops crassa. This phenomenon is a valuable tool for analysis of the wheat ABCDE model. Using an alloplasmic line, the wheat ortholog of DROOPING LEAF (TaDL), a member of the YABBY gene family, has been shown to regulate pistil specification. Here, I describe the current understanding of the ABCDE model for floral organ formation in wheat. | ||
| The three way all-in with the Inter-Korean Summit transcript Posted: 25 Jun 2013 01:17 AM PDT Picture Korea's current political situation with a poker game with three players: the New Frontier Party, the Democratic Party and the National Intelligence Service. | ||
| Posted: 25 Jun 2013 12:00 AM PDT In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro. | ||
| Posted: 25 Jun 2013 12:00 AM PDT In high-mountains, cold spells can occur at any time during the growing season and plants may be covered with snow for several days. This raises the question to what extent sexual processes are impaired by low temperatures. We tested pollen performance and fertilization capacity of high-mountain species with different elevational distribution in the European Alps (Cerastium uniflorum, Gentianella germanica, Ranunculus glacialis, R. alpestris, Saxifraga bryoides, S. caesia, S. moschata) during simulated cold snaps in the laboratory. Plants were exposed to 0 °C (the temperature below the snow) for 12, 36, 60 and 84 h. In S. caesia, the experiment was verified in situ during a cold snap. Sexual processes coped well with large temperature differences and remained functional at near-freezing temperatures for a few days. During the cooling-down phase a high percentage (67–97%) of pollen grains germinated and grew tubes into the style. At zero degrees, tube growth continued slowly both in the laboratory and in situ below the snow. Fertilization occurred in up to 100% of flowers in the nival species and in G. germanica, but was strongly delayed or absent in the alpine species. During rewarming, fertilization continued. Overall, progamic processes in high-mountain plants appear fairly robust toward weather extremes increasing the probability of successful reproduction. | ||
| Posted: 25 Jun 2013 12:00 AM PDT The Critical Assessment of Small Molecule Identification, or CASMI, contest was founded in 2012 to provide scientists with a common open dataset to evaluate their identification methods. In this article, the challenges and solutions for the inaugural CASMI 2012 are presented. The contest was split into four categories corresponding with tasks to determine molecular formula and molecular structure, each from two measurement types, liquid chromatography-high resolution mass spectrometry (LC-HRMS), where preference was given to high mass accuracy data, and gas chromatography-electron impact-mass spectrometry (GC-MS), i.e., unit accuracy data. These challenges were obtained from plant material, environmental samples and reference standards. It was surprisingly difficult to obtain data suitable for a contest, especially for GC-MS data where existing databases are very large. The level of difficulty of the challenges is thus quite varied. In this article, the challenges and the answers are discussed, and recommendations for challenge selection in subsequent CASMI contests are given. | ||
| Posted: 25 Jun 2013 12:00 AM PDT Fetal growth is an important risk factor for infant morbidity and mortality. In turn, socioeconomic status is a key predictor of fetal growth; however, other sociodemographic factors and environmental effects may also be important. This study modelled geographic variation in poor fetal growth after accounting for socioeconomic status, with a fixed effect for socioeconomic status and a combination of spatially-correlated and spatially-uncorrelated random effects. The dataset comprised 88,246 liveborn singletons, aggregated within suburbs in Perth, Western Australia. Low socioeconomic status was strongly associated with an increased risk of poor fetal growth. An increase in geographic variation of poor fetal growth from 1999–2001 (interquartile odds ratio among suburbs = 1.20) to 2004–2006 (interquartile odds ratio = 1.40) indicated a widening risk disparity by socioeconomic status. Low levels of residual spatial patterns strengthen the case for targeting policies and practices in areas of low socioeconomic status for improved outcomes. This study indicates an alarming increase in geographic inequalities in poor fetal growth in Perth which warrants further research into the specific aspects of socioeconomic status that act as risk factors. | ||
| Posted: 25 Jun 2013 12:00 AM PDT Hypoxic-ischemic brain injuries (HIBI) in childhood are frequently associated with poor clinical and neurological outcome. Unfortunately, there is currently no effective therapy to restore neuronal loss and to determine substantial clinical improvement. Several neurotrophins, such as Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Derived Neurotrophic Factor (GDNF), play a key role in the development, differentiation, and survival of the neurons of the peripheral and central nervous system. Experimental animal studies demonstrated their neuroprotective role in HIBI, while only a few studies examined the neuroprotective mechanisms in patients with severe HIBI. We report two cases of children with HIBI and prolonged comatose state who showed a significant improvement after intraventricular NGF administration characterized by amelioration of electroencephalogram (EEG) and cerebral perfusion at single-photon emission computed tomography (SPECT). The improvement in motor and cognitive functions of these children could be related to the neuroprotective role exerted by NGF in residual viable cholinergic neurons, leading to the restoration of neuronal networks in the damaged brain. | ||
| Antibodies, Vol. 2, Pages 392-414: Antibody Glycosylation and Inflammation Posted: 25 Jun 2013 12:00 AM PDT IgG antibodies are the basis of some of the most effective therapeutics developed over the last 20 years. These antibodies are highly specific, have long serum-half lives, and can be produced relatively routinely, making them ideal drugs for immunotherapy. The degree of regulation on IgG antibody effector functions by the composition of the single, N-linked glycan attached to the Fc is increasingly appreciated. IgG antibodies with identical protein sequences can gain a 50-fold potency, in terms of initiating antibody-dependent cellular cytotoxicity (ADCC) by removal of the single fucose residue from the Fc glycan. Conversely, the addition of sialic acid to the terminus of the Fc glycan converts IgG antibodies into anti-inflammatory mediators, capable of suppressing autoantibody driven inflammation. This review will discuss the contribution of the Fc glycan to IgG antibody effector functions, the regulation of the antibody glycosylation in vivo, implications for the rational design of IgG antibody-based therapeutics, and touch upon the contribution of glycosylation to other immunoglobulin isotypes. | ||
| PS4 reveals planned for Gamescom Posted: 25 Jun 2013 01:06 AM PDT Sony has 30 games in development for the upcoming | ||
| Interview with Richard Matheson Posted: 24 Jun 2013 11:36 PM PDT Rick Kleffel sez, "We'll miss Richard Matheson... he introduced me to the sort of stories he wrote when I was arguably too young to read them. I found an old paperback of The Shores of Space on my parents' shelves and hid behind the couch to read the terrifying stories. I actually had the chance to speak with him in 2011 about his whole career. It was an fascinating and rather intense conversation. Here's the link for those who would like to remember him." (MP3) 
This posting includes an audio/video/photo media file: Download Now | ||
| AU Shippin' Out June 24-29: Company of Heroes 2 Posted: 24 Jun 2013 09:24 PM PDT For gamers who wish to step into the role of War Strategist, the week's release of Company of Heroes 2 should provide ample opportunity.
Long anticipated World War II real-time strategy game Company of Heroes 2 will be released this week for PC.  Developer Relic Entertainment has added a new Theater of War mode in the game, which sees players embark on a string of single-player and co-op missions, each themed around a particular battle across the game's Eastern Front setting. The Theater of War mode will ship with 18 missions set in 1941. More downloadable content will be added post-launch, including a mini-campaign offered to customers who preordered the game. Fans can also pick up the Red Star edition, which includes additional multiplayer features and steelbook packaging. GameSpot scored the original Company of Heroes a 9.0 when it was released in 2006, praising it's inventive gameplay and fully interactive maps. Marvel's wise-cracking anti-hero Deadpool will be getting his own game this week. The third-person action game will feature a new story written by a former Deadpool writer, and employ the character's humour. Players will be able to combat enemies with a combination of melee and shooting attacks, including the character's trademarked swords and guns. Developer High Moon Studio's is no stranger to working with licensed franchises, having worked on Activision's Transformers: War for Cybertron and Transformers: Fall of Cybertron. For more details on games out this week, check out the full list below.
June 25, 2013 June 26, 2013 June 27, 2013 June 28, 2013 June 29, 2013 Read and Post Comments | Get the full article at GameSpot "AU Shippin' Out June 24-29: Company of Heroes 2" was posted by Zorine Te on Mon, 24 Jun 2013 21:24:39 -0700 |
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