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- Budget greetings cards chain Card Factory plans to float
- SEO PowerSuite 32 - Optimize websites in all major search engines. (Shareware)
- Plethora 1.1 - Unit-conversion calculator. ()
- Sensors, Vol. 13, Pages 7250-7278: An Integral Model for Target Tracking Based on the Use of a WSN
- Entropy, Vol. 15, Pages 2181-2209: An Automatic Multilevel Image Thresholding Using Relative Entropy and Meta-Heuristic Algorithms
- IJERPH, Vol. 10, Pages 2258-2270: Road Traffic Noise and Annoyance: A Quantification of the Effect of Quiet Side Exposure at Dwellings
- Viruses, Vol. 5, Pages 1395-1413: Regulation of Human Cytomegalovirus Transcription in Latency: Beyond the Major Immediate-Early Promoter
- Molecules, Vol. 18, Pages 6504-6520: The Development, Physicochemical Characterisation and in Vitro Drug Release Studies of Pectinate Gel Beads Containing Thai Mango Seed Kernel Extract
- Molecules, Vol. 18, Pages 6491-6503: The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors
- Molecules, Vol. 18, Pages 6469-6490: 89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges
- Designs for Mail 1.4 - 100+ beautiful templates for Apple's Mail. (Commercial)
- Molecules, Vol. 18, Pages 6455-6468: Bioactive Secondary Metabolites of a Marine Bacillus sp. Inhibit Superoxide Generation and Elastase Release in Human Neutrophils by Blocking Formyl Peptide Receptor 1
- Materials, Vol. 6, Pages 2285-2294: Synthesis of Li2Ti3O7 Anode Materials by Ultrasonic Spray Pyrolysis and Their Electrochemical Properties
- Materials, Vol. 6, Pages 2274-2284: Dynamic Behavior of Nanocomposites Reinforced with Multi-Walled Carbon Nanotubes (MWCNTs)
- Sustainability, Vol. 5, Pages 2442-2456: Genetic Variation and Phenotypic Response of 15 Sweet Corn (Zea mays L.) Hybrids to Population Density
- Metals, Vol. 3, Pages 225-236: Mössbauer Spectroscopy Studies on Magnetic Properties for 57Fe-substituted Ni-Mn-Sn Metamagnetic Shape Memory Alloys
- Future Internet, Vol. 5, Pages 282-300: Comparison of Volunteered Geographic Information Data Contributions and Community Development for Selected World Regions
- Remember Me review
- Matt Reed: State too harsh on mini-casinos?
- aLive discusses having to face his teammate at the NA WCS Final
| Budget greetings cards chain Card Factory plans to float Posted: 03 Jun 2013 02:53 AM PDT The firm, which opened in 1997 in Wakefield, West Yorkshire, and now boasts 650 shops, has been owned by private equity firm Charterhouse since 2010. |
| SEO PowerSuite 32 - Optimize websites in all major search engines. (Shareware) Posted: 03 Jun 2013 03:06 AM PDT  SEO PowerSuite is an all-in-one pack of SEO software for professional website promoters. The 4 component products cover all aspects of website optimization: keyword research, SEO site audit, content optimization, competition research, link building, rankings monitoring and lots more! Fitted with a bunch of brand-new features this SEO toolkit lets you turn any website into an unshakable search results leader. 100% search engine friendly. SEO PowerSuite is available in three different levels: Free, Pro, and Enterprise. The price quoted below is for the Pro version. You can find feature comparisons here, and pricing information here. Version 32:
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| Plethora 1.1 - Unit-conversion calculator. () Posted: 03 Jun 2013 02:41 AM PDT  Plethora is a measurement unit conversions calculator that is more powerful than ANY unit conversion program on any platform or online conversion utility available! Version 1.1: Release notes were unavailable when this listing was updated. OS X 10.4 or later More information |
| Sensors, Vol. 13, Pages 7250-7278: An Integral Model for Target Tracking Based on the Use of a WSN Posted: 03 Jun 2013 12:00 AM PDT The use of wireless sensor networks (WSN) in tracking applications is growing at a fast pace. In these applications, the sensor nodes discover, monitor and track an event or target object. A significant number of proposals relating the use of WSNs for target tracking have been published to date. However, they either focus on the tracking algorithm or on the communication protocol, and none of them address the problem integrally. In this paper, a comprehensive proposal for target detection and tracking is discussed. We introduce a tracking algorithm to detect and estimate a target location. Moreover, we introduce a low-overhead routing protocol to be used along with our tracking algorithm. The proposed algorithm has low computational complexity and has been designed considering the use of a mobile sink while generating minimal delay and packet loss. We also discuss the results of the evaluation of the proposed algorithms. |
| Posted: 03 Jun 2013 12:00 AM PDT Multilevel thresholding has been long considered as one of the most popular techniques for image segmentation. Multilevel thresholding outputs a gray scale image in which more details from the original picture can be kept, while binary thresholding can only analyze the image in two colors, usually black and white. However, two major existing problems with the multilevel thresholding technique are: it is a time consuming approach, i.e., finding appropriate threshold values could take an exceptionally long computation time; and defining a proper number of thresholds or levels that will keep most of the relevant details from the original image is a difficult task. In this study a new evaluation function based on the Kullback-Leibler information distance, also known as relative entropy, is proposed. The property of this new function can help determine the number of thresholds automatically. To offset the expensive computational effort by traditional exhaustive search methods, this study establishes a procedure that combines the relative entropy and meta-heuristics. From the experiments performed in this study, the proposed procedure not only provides good segmentation results when compared with a well known technique such as Otsu's method, but also constitutes a very efficient approach. |
| Posted: 03 Jun 2013 12:00 AM PDT Previous studies indicate that residents may benefit from a "quiet side" to their dwellings. The influence of the level of road traffic noise exposure at the least exposed side on road traffic noise annoyance was studied in Amsterdam, The Netherlands. Road traffic noise exposure was assessed at the most and least exposed façade (Lden,most and Lden,least respectively) of dwellings for subjects in a population based survey (N = 1,967). It was investigated if and to what extent relative quietness at the least exposed façade affected the level of road traffic noise annoyance by comparing two groups: (1) The subgroup with a relatively quiet façade; (2) the subgroup without a relatively quiet façade (large versus small difference in exposure between most and least exposed façade; DIF ≥ 10 dB and DIF < 10 dB respectively). In addition, it was investigated if and to what extent Lden,least affected the level of road traffic noise annoyance. Results indicate a significantly lower road traffic noise annoyance score at a given Lden,most, in the subgroup with DIF ≥ 10 dB versus DIF < 10 dB. Furthermore, results suggest an effect of Lden,least independent of Lden,most. The estimated size of the effect expressed in an equivalent change in Lden,most approximated 5 dB for both the difference between the two subgroups (DIF ≥ 10 dB and DIF < 10 dB), and for a 10 dB change in Lden,least. |
| Posted: 03 Jun 2013 12:00 AM PDT Lytic infection of differentiated cell types with human cytomegalovirus (HCMV) results in the temporal expression of between 170–200 open reading frames (ORFs). A number of studies have demonstrated the temporal regulation of these ORFs and that this is orchestrated by both viral and cellular mechanisms associated with the co-ordinated recruitment of transcription complexes and, more recently, higher order chromatin structure. Importantly, HCMV, like all herpes viruses, establishes a lifelong latent infection of the host—one major site of latency being the undifferentiated haematopoietic progenitor cells resident in the bone marrow. Crucially, the establishment of latency is concomitant with the recruitment of cellular enzymes that promote extensive methylation of histones bound to the major immediate early promoter. As such, the repressive chromatin structure formed at the major immediate early promoter (MIEP) elicits inhibition of IE gene expression and is a major factor involved in maintenance of HCMV latency. However, it is becoming increasingly clear that a distinct subset of viral genes is also expressed during latency. In this review, we will discuss the mechanisms that control the expression of these latency-associated transcripts and illustrate that regulation of these latency-associated promoters is also subject to chromatin mediated regulation and that the instructive observations previously reported regarding the negative regulation of the MIEP during latency are paralleled in the regulation of latent gene expression. |
| Posted: 03 Jun 2013 12:00 AM PDT Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar 'Fahlun') were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate beads were prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentrations, and concentrations of two cross-linkers (calcium chloride and zinc acetate). The formulated beads were spherical in shape and ranged in size between 1.13 mm and 1.88 mm. Zinc-pectinate (ZPG) beads containing high amounts of MSKE showed complete entrapment efficiency (EE) of MSKE (100%), while calcium-pectinate (CPG) beads demonstrated 70% EE. The in vitro release tests indicated that MSKE-loaded CPG beads were unstable in both simulated gastric medium (SGM) and simulated intestinal medium (SIM), while MSKE-loaded ZPG beads were stable in SIM but unable to prevent the release of MSKE in SGM. The protection of ZPG beads with gastro-resistant capsules (Eudragit® L 100-55) resulted in stability in both SGM and SIM; they disintegrated immediately in simulated colonic medium containing pectinolytic enzymes. MSKE-loaded ZPG beads were stable at 4, 25 and 45 °C during the study period of four months. The present study revealed that ZPG beads in enteric-coated capsules might be a promising carrier for delivering MSKE to the colon. |
| Posted: 03 Jun 2013 12:00 AM PDT Over the years, the development of targeted medicines has made significant achievements. As a typical example, receptor tyrosine kinases (RTK) inhibitors have become important chemotherapy drugs for a variety of cancers. However, the effectiveness of these agents is always hindered by poor response rates and acquired drug resistance. In order to overcome these limitations, several dual-targeted inhibitors with quinazoline core were designed and synthesized. Though these compounds can simultaneously inhibit histone deacetylases (HDAC) as well as RTK, the structure-activity relationship (SAR) is still not clear enough. To further explore this type of dual-targeted inhibitors, a new class of quinazoline derivatives were designed and synthesized. Their activity evaluations include in vitro inhibitory activity of HDAC, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). The SAR study indicated that the introduction of polar group such as hydroxamate on the 4-position of the quinazoline core is more likely to provide a potent HDACi/HER2i hybrid rather than HDACi/EGFRi molecule. |
| Posted: 03 Jun 2013 12:00 AM PDT Molecular imaging—and especially Positron Emission Tomography (PET)—is of increasing importance for the diagnosis of various diseases and thus is experiencing increasing dissemination. Consequently, there is a growing demand for appropriate PET tracers which allow for a specific accumulation in the target structure as well as its visualization and exhibit decay characteristics matching their in vivo pharmacokinetics. To meet this demand, the development of new targeting vectors as well as the use of uncommon radionuclides becomes increasingly important. Uncommon nuclides in this regard enable the utilization of various selectively accumulating bioactive molecules such as peptides, antibodies, their fragments, other proteins and artificial structures for PET imaging in personalized medicine. Among these radionuclides, 89Zr (t1/2 = 3.27 days and mean Eβ+ = 0.389 MeV) has attracted increasing attention within the last years due to its favorably long half-life, which enables imaging at late time-points, being especially favorable in case of slowly-accumulating targeting vectors. This review outlines the recent developments in the field of 89Zr-labeled bioactive molecules, their potential and application in PET imaging and beyond, as well as remaining challenges. |
| Designs for Mail 1.4 - 100+ beautiful templates for Apple's Mail. (Commercial) Posted: 03 Jun 2013 02:02 AM PDT  Designs for Mail brings you a diverse collection of templates for creating customized email messages in Apple Mail. Choose a lively seasonal template for a family newsletter. Or select a sharp, sophisticated design for a business proposal. Designs for Mail's selection is constantly expanding, so you'll always have access to the latest templates. Strong communication with signature style. That's Designs for Mail. Version 1.4:
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| Posted: 03 Jun 2013 12:00 AM PDT It is well known that overwhelming neutrophil activation is closely related to acute and chronic inflammatory injuries. Formyl peptide receptor 1 (FPR1) plays an important role in activation of neutrophils and may represent a potent therapeutic target in inflammatory diseases. In the present study, we demonstrated that IA-LBI07-1 (IA), an extract of bioactive secondary metabolites from a marine Bacillus sp., has anti-inflammatory effects in human neutrophils. IA significantly inhibited superoxide generation and elastase release in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated neutrophils, but failed to suppress the cell responses activated by non-FPR1 agonists. IA did not alter superoxide production and elastase activity in cell-free systems. IA also attenuated the downstream signaling from FPR1, such as the Ca2+, MAP kinases and AKT pathways. In addition, IA inhibited the binding of N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein, a fluorescent analogue of FMLP, to FPR1 in human neutrophils and FPR1-transfected HEK293 cells. Taken together, these results show that the anti-inflammatory effects of IA in human neutrophils are through the inhibition of FPR1. Also, our data suggest that IA may have therapeutic potential to decrease tissue damage induced by human neutrophils. |
| Posted: 03 Jun 2013 12:00 AM PDT Ramsdellite-type lithium titanate (Li2Ti3O7) powders were synthesized by performing ultrasonic spray pyrolysis, and their chemical and physical properties were characterized by performing Scanning Electron Microscope (SEM), powder X-ray Diffraction (XRD), and Inductively Coupled Plasma (ICP) analyses. The as-prepared Li2Ti3O7 precursor powders had spherical morphologies with hollow microstructures, but an irregularly shaped morphology was obtained after calcination above 900 °C. The ramsdellite Li2Ti3O7 crystal phase was obtained after the calcination at 1100 °C under an argon/hydrogen atmosphere. The first rechargeable capacity of the Li2Ti3O7 anode material was 168 mAh/g at 0.1 C and 82 mAh/g at 20 C, and the discharge capacity retention ratio was 99% at 1 C after the 500th cycle. The cycle performance of the Li2Ti3O7 anode was also highly stable at 50 °C, demonstrating the superiority of Li2Ti3O7 anode materials reported previously. |
| Posted: 03 Jun 2013 12:00 AM PDT The influence of multi-walled carbon nanotubes (MWCNT) on the structural dynamic behavior of MWCNT/epoxy nanocomposites was investigated. Two different types of MWCNTs, pristine MWCNT and functionalized MWCNT, were used in this study. Carboxylic acid-functionalized MWCNTs (MWCNT-COOH) were obtained by oxidation pristine MWCNTs via sonication in sulfuric-nitric acid and characterized by Fourier transform infrared spectroscopy (FTIR). Dynamic behaviors of the MWCNT reinforced nanocomposite including the natural frequency and damping ratio were determined using free vibration test. Experimental results showed that the damping ratio of the nanocomposite decreases with the increase of the MWCNT addition, while the natural frequency is increasing with the increase of the MWCNT addition. Functionalized MWCNTs improved the interfacial bonding between the nanotubes and epoxy resin resulting in the reduction of the interfacial energy dissipation ability and enhancement of the stiffness. |
| Posted: 03 Jun 2013 12:00 AM PDT Planting sweet corn at higher densities may increase the canopy cover, reducing light transmission to the understory and suppressing weed growth. High planting densities can also negatively impact the crop, however, by decreasing ear size and overall yield. The objective of this study was to determine the potential for increased density tolerance of 15 sweet corn hybrids by estimating the general combining ability (GCA) and specific combining ability (SCA) for traits of interest. In 2010 and 2011, a half-diallel of six historic sweet corn inbreds was evaluated in a split-block randomized complete block design in four Wisconsin environments, with four replicates in each environment. Hybrids were planted at a low density of 29,936 plants ha−1, a medium density of 63,615 plants ha−1, and a high density of 97,293 plants ha−1. Significant differences between hybrids were found for phenomorphological traits and ear characteristics. Inbreds C68, C40 and Ia5125 produced the progeny most tolerant of the highest population density. Among these genotypes, tolerance to high density is a heritable trait, indicating the feasibility of breeding sweet corn for density tolerance and potential weed competitiveness. |
| Posted: 03 Jun 2013 12:00 AM PDT In order to investigate the Fe substituted effects on the magnetic properties of the Ni-Mn-Sn metamagnetic shape memory alloys, magnetization and the Mössbauer spectroscopy measurements were carried out with using 57Fe-doped specimens of Ni2Mn1.48−x57FexSn0.52 (x = 0.02, 0.04 and 0.08). Singlet-type Mössbauer spectra were clearly observed for x = 0.02 and 0.04 just below the martensitic transformation temperature, TM, and above the Curie temperature, TC, in the austenite phase. It was clear that the magnetic state in the martensite phase just below TM was paramagnetic for x = 0.02 and 0.04. In further doped 57Fe to Ni2Mn1.48Sn0.52, TC in the austenite phase slightly increased. However, the value of TM significantly decreased. As a result, martensite phase with small spontaneous magnetization directly transformed to the ferromagnetic austenite phase during heating for x = 0.08. These results obtained from the Mössbauer spectra were consistent with the results of the magnetic measurements in this study and the phase diagram reported by Fukushima et al. for normal Fe-doped Ni2Mn1.48−xFexSn0.52 alloys. The breakdown of the general rule, in which the ferromagnetic shape memory alloys with larger value of the valence electrons per atom, e/a, showed higher TM, was also appeared in Ni2Mn1.48−xFexSn0.52 alloys, being similar to Ni2Mn1−xFexGa alloys. |
| Posted: 03 Jun 2013 12:00 AM PDT Volunteered Geographic Information (VGI) projects and their crowdsourced data have been the focus of a number of scientific analyses and investigations in recent years. Oftentimes the results show that the collaboratively collected geodata of one of the most popular VGI projects, OpenStreetMap (OSM), provides good coverage in urban areas when considering particular completeness factors. However, results can potentially vary significantly for different world regions. In this article, we conduct an analysis to determine similarities and differences in data contributions and community development in OSM between 12 selected urban areas of the world. Our findings showed significantly different results in data collection efforts and local OSM community sizes. European cities provide quantitatively larger amounts of geodata and number of contributors in OSM, resulting in a better representation of the real world in the dataset. Although the number of volunteers does not necessarily correlate with the general population density of the urban areas, similarities could be detected while comparing the percentage of different contributor groups and the number of changes they made to the OSM project. Further analyses show that socio-economic factors, such as income, can have an impact on the number of active contributors and the data provided in the analyzed areas. Furthermore, the results showed significant data contributions by members whose main territory of interest lies more than one thousand kilometers from the tested areas. |
| Posted: 03 Jun 2013 12:11 AM PDT Say goodbye to privacy. In Remember Me's speculative future, mankind gives up this once-cherished ideal in exchange for the digitization of memories. They |
| Matt Reed: State too harsh on mini-casinos? Posted: 02 Jun 2013 10:44 PM PDT In April, Brevard delegates helped fast-track a bill that soon shut down Allied Veterans of the World and other Internet cafes in Florida. |
| aLive discusses having to face his teammate at the NA WCS Final Posted: 02 Jun 2013 10:06 PM PDT Slasher catches up with aLive after his match against his teammate.
Read and Post Comments | Get the full article at GameSpot "aLive discusses having to face his teammate at the NA WCS Final" was posted by Erick Tay on Sun, 02 Jun 2013 22:06:40 -0700 |
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