Games |
- Pimp Your Screen 1.2 - Custom desktop wallpaper.. (Commercial)
- DragonDisk 1.02 - File manager for the Amazon S3 service.. (Free)
- LED Message Board 1.0.0 - Create LED text and animated messages.. (Free)
- PlayStation 4 side-steps PSP Go-shaped landmine as Sony decides against download-only games
- Nutrients, Vol. 4, Pages 436-448: Neonatal Phosphate Nutrition Alters in Vivo and in Vitro Satellite Cell Activity in Pigs
- Applied Sciences, Vol. 2, Pages 535-548: High Performance Shape Memory Polyurethane Synthesized with High Molecular Weight Polyol as the Soft Segment
- Posterino 2.6 - Create posters, calendars and postcards.. (Demo)
- Tough exercises will improve your play
- Molecules, Vol. 17, Pages 6672-6683: Edible Flowers—A New Promising Source of Mineral Elements in Human Nutrition
- Antibodies, Vol. 1, Pages 70-87: Immunocytokines
- Biology, Vol. 1, Pages 81-93: Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease
- Geosciences, Vol. 2, Pages 130-146: Evolving Phytoplankton Stoichiometry Fueled Diversification of the Marine Biosphere
- Molecules, Vol. 17, Pages 6658-6671: Application of Paramagnetic NMR-Validated Molecular Dynamics Simulation to the Analysis of a Conformational Ensemble of a Branched Oligosaccharide
- Ukelele 2.2 - Unicode keyboard layout editor.. (Free)
- USBMate 1.0 - Clean and secure your USB flash drive. . (Commercial)
- DrumSpillage 1.6.0 - Multi-model drum synth plug-in.. (Demo)
- Sensors, Vol. 12, Pages 7451-7467: Intelligent Emergency Stop Algorithm for a Manipulator Using a New Regression Method
- Sensors, Vol. 12, Pages 7438-7450: Aquatic Acoustic Metrics Interface Utility for Underwater Sound Monitoring and Analysis
- Sensors, Vol. 12, Pages 7423-7437: A Urinary Bcl-2 Surface Acoustic Wave Biosensor for Early Ovarian Cancer Detection
- Sensors, Vol. 12, Pages 7410-7422: A Kernel Gabor-Based Weighted Region Covariance Matrix for Face Recognition
| Pimp Your Screen 1.2 - Custom desktop wallpaper.. (Commercial) Posted: 31 May 2012 03:52 AM PDT  Pimp Your Screen , the best-selling and award-winning app for iPhone, iPod touch and iPad comes to the Mac! Pimp Your Screen is here to customize the look of your desktop by giving you an exclusive selection of specially designed background images and wallpapers arranged in categories. Choose from a variety of minimalistic images, abstract backgrounds and truly unique wallpapers that will bring even more beauty to your Mac. Pimp Your Screen is a true pleasure to use due to its neat interface and well thought out design. Finding a wallpaper of your choice has never been so fun and easy! Features:
We add new eye candies daily. Just click on "New" to see the updates. Version 1.2:
Download Now |
| DragonDisk 1.02 - File manager for the Amazon S3 service.. (Free) Posted: 31 May 2012 03:41 AM PDT  DragonDisk is a file manager for the Amazon S3 Service. DragonDisk has lots of useful features and an intuitive graphical user interface. Features include multiple windows, copy / move between Amazon S3 accounts, a fast multi-threaded HTTP/HTTPS engine, folders synchronization, drag and drop; rename files and folders, filename filters, BiTorrent, time limited, and signed URLs, files integrity control, a metadata editor, ACL inheritance, encryption, compression, detailed operations logs; external buckets; CNAMEs; Reduced Redundancy Storage; and support for versioning. Version 1.02:
Download Now This posting includes an audio/video/photo media file: Download Now |
| LED Message Board 1.0.0 - Create LED text and animated messages.. (Free) Posted: 31 May 2012 03:36 AM PDT  LED Message Board was designed to work with the USB device from Dream Cheeky of the same name. The software can work with multiple LED Message Boards or on its own without the hardware. You can turn your Mac monitor into a giant 7 x 21 LED Message Board. You can display text messages, animated sequences that the program allows you to also create, or other images that you might have prepared. You can alter the speed and direction of display.
Download Now |
| PlayStation 4 side-steps PSP Go-shaped landmine as Sony decides against download-only games Posted: 31 May 2012 03:45 AM PDT
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| Posted: 31 May 2012 12:00 AM PDT Satellite cell activity is necessary for postnatal skeletal muscle growth. Severe phosphate (PO4) deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains obscure. Twenty-one piglets (1 day of age, 1.8 ± 0.2 kg BW) were pair-fed liquid diets that were either PO4 adequate (0.9% total P), supra-adequate (1.2% total P) in PO4 requirement or deficient (0.7% total P) in PO4 content for 12 days. Body weight was recorded daily and blood samples collected every 6 days. At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured in vitro for 7 days to determine if PO4 nutrition alters their ability to proceed through their myogenic lineage. Dietary PO4 deficiency resulted in reduced (P < 0.05) sera PO4 and parathyroid hormone (PTH) concentrations, while supra-adequate dietary PO4 improved (P < 0.05) feed conversion efficiency as compared to the PO4 adequate group. In vivo satellite cell proliferation was reduced (P < 0.05) among the PO4 deficient pigs, and these cells had altered in vitro expression of markers of myogenic progression. Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing early PO4 nutrition for future lean growth potential is warranted. |
| Posted: 31 May 2012 12:00 AM PDT Shape memory polyurethanes (SMPUs) are typically synthesized using polyols of low molecular weight (MW~2,000 g/mol) as it is believed that the high density of cross-links in these low molecular weight polyols are essential for high mechanical strength and good shape memory effect. In this study, polyethylene glycol (PEG-6000) with MW ~6000 g/mol as the soft segment and diisocyanate as the hard segment were used to synthesize SMPUs, and the results were compared with the SMPUs with polycaprolactone PCL-2000. The study revealed that although the PEG-6000-based SMPUs have lower maximum elongations at break (425%) and recovery stresses than those of PCL-based SMPUs, they have much better recovery ratios (up to 98%) and shape fixity (up to 95%), hence better shape memory effect. Furthermore, PEG-based SMPUs showed a much shorter actuation time of < 10 s for up to 90% shape recovery compared to typical actuation times of tens of seconds to a few minutes for common SMPUs, demonstrated their great potential for applications in microsystems and other engineering components. |
| Posterino 2.6 - Create posters, calendars and postcards.. (Demo) Posted: 31 May 2012 03:06 AM PDT  Posterino offers enhanced customization and flexibility including a variety of new stylish templates featuring grids of identical or odd sized image boxes. You can customize the size and shape of these boxes at any time. And with a single click, the application will automatically fill those boxes with random images drawn from the photos you uploaded. If you prefer to manually select images, you can simply drag and drop images into the template. Sharing your photos is quick and simple as well. You can directly upload your completed collages to your Flickr account from inside the app and export photos to iPhoto and your email. Posterino 2 also lets you create and send custom e-cards with your very own stamps and postmarks. Posterino 2 lets you:
Version 2.6:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Tough exercises will improve your play Posted: 31 May 2012 03:17 AM PDT When It Happens Panel Get involved: send your photos, videos, news & views by texting 'OXFORD NEWS' to 80360 or email The chess problem this week comes without a solution since it is the starter problem of the 2012-13 Winton Capital British Chess Solving Championship. This posting includes an audio/video/photo media file: Download Now |
| Posted: 31 May 2012 12:00 AM PDT On a global scale, people are demanding more attractive and tasty food. Both the quality of foodstuffs and aesthetic aspects contribute to the appearance of consumed meals. The attraction and appeal of individual dishes could be enhanced by edible flowers. New information concerning the composition and nutritional value of edible flowers is also important and represents a sufficient reason for their consumption. The aim of this study is to contribute to the popularization of some selected edible flowers of ornamental plants involving altogether 12 species. The flowers were used to determine their antioxidant capacity, which fluctuated between 4.21 and 6.96 g of ascorbic acid equivalents (AAE)/kg of fresh mass (FM). Correlation coefficients between antioxidant capacity and the contents of total phenolics and flavonoids were r2 = 0.9705 and r2 = 0.7861, respectively. Moreover, the results were supplemented with new data about the mineral composition of edible flowers (mostly, not found in the available literature). The highest levels of mineral elements were observed in the flowers of species Chrysanthemum, Dianthus or Viola. The most abundant element was potassium, the content of which ranged from 1,842.61 to 3,964.84 mg/kg of FM. |
| Antibodies, Vol. 1, Pages 70-87: Immunocytokines Posted: 31 May 2012 12:00 AM PDT A number of cytokines have shown beneficial effects in preclinical animal models of cancer and chronic inflammatory diseases. However, cytokine treatment is often associated with severe side effects, which prevent the administration of clinically relevant doses in humans. Immunocytokines are a novel class of biopharmaceuticals, consisting of a cytokine moiety fused to monoclonal antibodies or to an antibody fragment, which selectively accumulate at the disease site and thereby enhance the therapeutic effects of cytokines. This review surveys the recent preclinical and clinical advances in the field, with a special focus on the impact of antibody formats, target antigen and cytokine moieties on the therapeutic performance in vivo. We also discuss emerging data about the possibility to combine immunocytokines with other pharmacological agents. |
| Posted: 31 May 2012 12:00 AM PDT Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US FDA-approved HIV-1 protease inhibitors and also reduce the substrate recognition ability were examined. A multi-drug resistant HIV-1 protease isolate, MDR 769, was co-crystallized with the p2/NC substrate and the mutated CA/p2 substrate, CA/p2 P1'F. Both substrates display different levels of molecular recognition by the wild-type and multi-drug resistant HIV-1 protease. From the crystal structures, only limited differences can be identified between the wild-type and multi-drug resistant protease. Therefore, a wild-type HIV-1 protease and four multi-drug resistant HIV-1 proteases in complex with the two peptides were modeled based on the crystal structures and examined during a 10 ns-molecular dynamics simulation. The simulation results reveal that the multi-drug resistant HIV-1 proteases require higher desolvation energy to form complexes with the peptides. This result suggests that the desolvation of the HIV-1 protease active site is an important step of protease-ligand complex formation as well as drug resistance. Therefore, desolvation energy could be considered as a parameter in the evaluation of future HIV-1 protease inhibitor candidates. |
| Posted: 31 May 2012 12:00 AM PDT The availability of nutrients and the quantity and quality of food at the base of food webs have largely been ignored in discussions of the Phanerozoic record of biodiversity. We examine the role of nutrient availability and phytoplankton stoichiometry (the relative proportions of inorganic nutrients to carbon) in the diversification of the marine biosphere. Nutrient availability and phytoplankton stoichiometry played a critical role in the initial diversification of the marine biosphere during the Neoproterozoic. Initial biosphere expansion during this time resulted in the massive sequestration of nutrients into biomass which, along with the geologically slow input of nutrients from land, set the stage for severe nutrient limitation and relatively constant marine biodiversity during the rest of the Paleozoic. Given the slow nutrient inputs from land and low recycling rates, the growth of early-to-middle Paleozoic metazoans remained limited by their having to expend energy to first "burn off" (respire) excess carbon in food before the associated nutrients could be utilized for growth and reproduction; the relative equilibrium in marine biodiversity during the Paleozoic therefore appears to be real. Limited nutrient availability and the consequent nutrient imbalance may have delayed the appearance of more advanced carnivores until the Permo-Carboniferous, when widespread orogeny, falling sea level, the spread of forests, greater weathering rates, enhanced ocean circulation, oxygenation, and upwelling all combined to increase nutrient availability. During the Meso-Cenozoic, rising oxygen levels, the continued nutrient input from land, and, especially, increasing rates of bioturbation, enhanced nutrient availability, increasing the nutrient content of phytoplankton that fueled the diversification of the Modern Fauna. |
| Posted: 31 May 2012 12:00 AM PDT Oligosaccharides of biological importance often exhibit branched covalent structures and dynamic conformational multiplicities. Here we report the application of a method that we developed, which combined molecular dynamics (MD) simulations and lanthanide-assisted paramagnetic NMR spectroscopy, to evaluate the dynamic conformational ensemble of a branched oligosaccharide. A lanthanide-chelating tag was attached to the reducing end of the branched tetrasaccharide of GM2 ganglioside to observe pseudocontact shifts as the source of long distance information for validating the conformational ensemble derived from MD simulations. By inspecting the results, the conformational space of the GM2 tetrasaccharide was compared with that of its nonbranched derivative, the GM3 trisaccharide. |
| Ukelele 2.2 - Unicode keyboard layout editor.. (Free) Posted: 31 May 2012 02:12 AM PDT  Ukelele is a Unicode keyboard layout editor for the XML-format keyboard layout files in OS X (".keylayout" files). It provides a graphical interface to the layout files with support for drag-and-drop character assignments, creation of dead keys, and assignment of multi-character strings. By the way, the name of this software is intentionally misspelled. Call it a case of 'artistic license'.
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| USBMate 1.0 - Clean and secure your USB flash drive. . (Commercial) Posted: 31 May 2012 01:58 AM PDT  USBMate is an app which optimizes and accelerates the operation of USB Flash drives, external hard disks and Flash memory cards. Use USBMate every time before ejecting your USB Flash drive and:
When you erase files from a USB Flash drive, they're only moved to the trash. The data itself isn't erased. Use USBMate and see how much free space is really left in your USB Flash drive. It's one of the most practical utility apps to use every day with Mac OS X 10.6/10.7.
Download Now |
| DrumSpillage 1.6.0 - Multi-model drum synth plug-in.. (Demo) Posted: 31 May 2012 02:20 AM PDT  DrumSpillage is a pro-quality model based drum synth plugin for Mac OS X. DrumSpillage employs a diverse palette of technologies including elements of physical and analog modeling, additive, subtractive and FM synthesis techniques to create its drum sounds. DrumSpillage is compatible with a wide range of AudioUnit plugin hosts (see below). Pro features like multiple outputs, extensive automation capabilities, native 64-bit support and the new pad freeze and sample export features (in v1.2+) result in an instrument that is perfectly at ease in the modern studio environment. Version 1.6.0: Features:
Changes:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 31 May 2012 12:00 AM PDT In working environments with large manipulators, accidental collisions can cause severe personal injuries and can seriously damage manipulators, necessitating the development of an emergency stop algorithm to prevent such occurrences. In this paper, we propose an emergency stop system for the efficient and safe operation of a manipulator by applying an intelligent emergency stop algorithm. Our proposed intelligent algorithm considers the direction of motion of the manipulator. In addition, using a new regression method, the algorithm includes a decision step that determines whether a detected object is a collision-causing obstacle or a part of the manipulator. We apply our emergency stop system to a two-link manipulator and assess the performance of our intelligent emergency stop algorithm as compared with other models. |
| Posted: 31 May 2012 12:00 AM PDT Fishes and marine mammals may suffer a range of potential effects from exposure to intense underwater sound generated by anthropogenic activities such as pile driving, shipping, sonars, and underwater blasting. Several underwater sound recording (USR) devices have been built to acquire samples of the underwater sound generated by anthropogenic activities. Software becomes indispensable for processing and analyzing the audio files recorded by these USRs. In this paper, we provide a detailed description of a new software package, the Aquatic Acoustic Metrics Interface (AAMI), specifically designed for analysis of underwater sound recordings to provide data in metrics that facilitate evaluation of the potential impacts of the sound on aquatic animals. In addition to the basic functions, such as loading and editing audio files recorded by USRs and batch processing of sound files, the software utilizes recording system calibration data to compute important parameters in physical units. The software also facilitates comparison of the noise sound sample metrics with biological measures such as audiograms of the sensitivity of aquatic animals to the sound, integrating various components into a single analytical frame. The features of the AAMI software are discussed, and several case studies are presented to illustrate its functionality. |
| Posted: 31 May 2012 12:00 AM PDT In this study, the design, fabrication, surface functionalization and experimental characterization of an ultrasonic MEMS biosensor for urinary anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) detection with sub ng/mL sensitivity is presented. It was previously shown that urinary Bcl-2 levels are reliably elevated during early and late stages of ovarian cancer. Our biosensor uses shear horizontal (SH) surface acoustic waves (SAWs) on surface functionalized ST-cut Quartz to quantify the mass loading change by protein adhesion to the delay path. SH-SAWs were generated and received by a pair of micro-fabricated interdigital transducers (IDTs) separated by a judiciously designed delay path. The delay path was surface-functionalized with monoclonal antibodies, ODMS, Protein A/G and Pluronic F127 for optimal Bcl-2 capture with minimal non-specific adsorption. Bcl-2 concentrations were quantified by the resulting resonance frequency shift detected by a custom designed resonator circuit. The target sensitivity for diagnosis and identifying the stage of ovarian cancer was successfully achieved with demonstrated Bcl-2 detection capability of 500 pg/mL. It was also shown that resonance frequency shift increases linearly with increasing Bcl-2 concentration. |
| Posted: 31 May 2012 12:00 AM PDT This paper proposes a novel image region descriptor for face recognition, named kernel Gabor-based weighted region covariance matrix (KGWRCM). As different parts are different effectual in characterizing and recognizing faces, we construct a weighting matrix by computing the similarity of each pixel within a face sample to emphasize features. We then incorporate the weighting matrices into a region covariance matrix, named weighted region covariance matrix (WRCM), to obtain the discriminative features of faces for recognition. Finally, to further preserve discriminative features in higher dimensional space, we develop the kernel Gabor-based weighted region covariance matrix (KGWRCM). Experimental results show that the KGWRCM outperforms other algorithms including the kernel Gabor-based region covariance matrix (KGCRM). |
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