Games |
- Ukiyo Link
- IJMS, Vol. 13, Pages 6073-6088: Evaluation of Antioxidant and Free Radical Scavenging Capacities of Polyphenolics from Pods of Caesalpinia Pulcherrima
- IJMS, Vol. 13, Pages 6053-6072: Design and Synthesis of Binding Growth Factors
- IJMS, Vol. 13, Pages 6040-6052: Molecular Characterization of Cultivated Bromeliad Accessions with Inter-Simple Sequence Repeat (ISSR) Markers
- IJMS, Vol. 13, Pages 6026-6039: Beta-Glucans Improve Growth, Viability and Colonization of Probiotic Microorganisms
- IJMS, Vol. 13, Pages 6009-6025: Quantitative Structure-Activity Relationship Studies on Indenoisoquinoline Topoisomerase I Inhibitors as Anticancer Agents in Human Renal Cell Carcinoma Cell Line SN12C
- IJMS, Vol. 13, Pages 5998-6008: Immobilization of Laccase for Oxidative Coupling of Trans-Resveratrol and Its Derivatives
- $22,000 routers "economical"
- HP to axe 30k jobs
- Magican 1.0.0 - Optimize your Mac.. (Free)
- Shapes 2.5 - Simple diagramming app.. (Demo)
- Bros MKV Converter Mac 1.7.12 - Convert videos into Mac-supported formats.. (Shareware)
- Sponsor Shout-Out: Watchismo
- 5 movies adapted from odd sources
- Multi Threaded TCP Port Scanner 4.0 - Scan any IP address for open ports.. (Free)
- cf/x photo mosaic 2.0.0 - Convert images into a mosaic.. (Demo)
- IJMS, Vol. 13, Pages 5982-5997: The Role of Receptor for Advanced Glycation End Products (RAGE) in the Proliferation of Hepatocellular Carcinoma
- Molecules, Vol. 17, Pages 6001-6010: Metathesis Transformations of Natural Products: Cross-Metathesis of Natural Rubber and Mandarin Oil by Ru-Alkylidene Catalysts
- Molecules, Vol. 17, Pages 5988-6000: A Sandwich HIV p24 Amperometric Immunosensor Based on a Direct Gold Electroplating-Modified Electrode
- Molecules, Vol. 17, Pages 5972-5987: Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics
| Posted: 18 May 2012 02:46 AM PDT
Jed Henry paints Nintendo heroes in Ukiyo-e style. Here's Link about to find out that arrows are futile against enenra. [via Gamovr] |
| Posted: 18 May 2012 12:00 AM PDT Thirteen polyphenolics were isolated from fresh pods of Caesalpinia pulcherrima using various methods of column chromatography. The structures of these polyphenolics were elucidated as gallic acid (1), methyl gallate (2), 6-O-galloyl-D-glucoside (3), methyl 6-O-galloyl-β-D-glucoside (4), methyl 3,6-di-O-galloyl-α-D-glucopyranoside (5), gentisic acid 5-O-α-D-(6'-O-galloyl)glucopyranoside (6), guaiacylglycerol 4-O-β-D-(6'-O-galloyl)glucopyranoside (7), 3-methoxy-4-hydroxyphenol 1-O-β-D-(6'-O-galloyl)glucopyranoside (8), (+)-gallocatechin (9), (+)-catechin (10), (+)-gallocatechin 3-O-gallate (11), myricetin 3-rhamnoside (12), and ampelopsin (13). All isolated compounds were tested for their antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and peroxynitrite radicals scavenging assays. Among those compounds, 11, 12, and 2 exhibited the best DPPH-, hydroxyl-, and peroxynitrite radical-scavenging activities, respectively. Compound 7 is a new compound, and possesses better scavenging activities towards DPPH but has equivalent hydroxyl radical scavenging activity when compared to BHT. The paper is the first report on free radical scavenging properties of components of the fresh pods of Caesalpinia pulcherrima. The results obtained from the current study indicate that the free radical scavenging property of fresh pods of Caesalpinia pulcherrima may be one of the mechanisms by which this herbal medicine is effective in several free radical mediated diseases. |
| IJMS, Vol. 13, Pages 6053-6072: Design and Synthesis of Binding Growth Factors Posted: 18 May 2012 12:00 AM PDT Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches. |
| Posted: 18 May 2012 12:00 AM PDT Bromeliads are of great economic importance in flower production; however little information is available with respect to genetic characterization of cultivated bromeliads thus far. In the present study, a selection of cultivated bromeliads was characterized via inter-simple sequence repeat (ISSR) markers with an emphasis on genetic diversity and population structure. Twelve ISSR primers produced 342 bands, of which 287 (~84%) were polymorphic, with polymorphic bands per primer ranging from 17 to 34. The Jaccard's similarity ranged from 0.08 to 0.89 and averaged ~0.30 for the investigated bromeliads. The Bayesian-based approach, together with the un-weighted paired group method with arithmetic average (UPGMA)-based clustering and the principal coordinate analysis (PCoA), distinctly grouped the bromeliads from Neoregelia, Guzmania, and Vriesea into three separately clusters, well corresponding with their botanical classifications; whereas the bromeliads of Aechmea other than the recently selected hybrids were not well assigned to a cluster. Additionally, ISSR marker was proven efficient for the identification of hybrids and bud sports of cultivated bromeliads. The findings achieved herein will further our knowledge about the genetic variability within cultivated bromeliads and therefore facilitate breeding for new varieties of cultivated bromeliads in future as well. |
| Posted: 18 May 2012 12:00 AM PDT Probiotics, prebiotics and synbiotics are frequently-used components for the elaboration of functional food. Currently, most of the commercialized probiotics are limited to a few strains of the genera Bifidobacteria, Lactobacillus and Streptococcus, most of which produce exopolysaccharides (EPS). This suggests that the beneficial properties of these microorganisms may be related to the biological activities of these biopolymers. In this work we report that a 2-substituted-(1,3)-β-D-glucan of non-dairy bacterial origin has a prebiotic effect on three probiotic strains. Moreover, the presence of this β-D-glucan potentiates in vitro adhesion of the probiotic Lactobacillus plantarum WCFS1 to human intestinal epithelial cells. |
| Posted: 18 May 2012 12:00 AM PDT Topoisomerase I is important for DNA replication and cell division, making it an attractive drug target for anticancer therapy. A series of indenoisoquinolines displaying potent Top1 inhibitory activity in human renal cell carcinoma cell line SN12C were selected to establish 3D-QSAR models using CoMFA and CoMSIA methods. Internal and external cross-validation techniques were investigated, as well as some measures taken, including region focusing, bootstrapping and the "leave-group-out" cross-validation method. The satisfactory CoMFA model predicted a q2 value of 0.659 and an r2 value of 0.949, indicating that electrostatic and steric properties play a significant role in potency. The best CoMSIA model, based on a combination of steric, electrostatic and H-bond acceptor descriptors, predicted a q2 value of 0.523 and an r2 value of 0.902. The models were graphically interpreted by contour plots which provided insight into the structural requirements for increasing the activity of a compound, providing a solid basis for future rational design of more active anticancer agents. |
| Posted: 18 May 2012 12:00 AM PDT Trametes villosa Laccase (TVL) was immobilized through physical adsorption on SBA-15 mesoporous silica and the immobilized TVL was used in the oxidative coupling of trans-resveratrol. Higher loading and activity of the immobilized enzyme on SBA-15 were obtained when compared with the free enzyme. The effects of reaction conditions, such as buffer type, pH, temperature and substrate concentration were investigated, and the optimum conditions were screened and resulted in enzyme activity of up to 10.3 μmol/g·h. Furthermore, the oxidative couplings of the derivatives of trans-resveratrol were also catalyzed by immobilized TVL. The immobilized TVL was recyclable and could maintain 78% of its initial activity after reusing it four times. |
| Posted: 18 May 2012 02:37 AM PDT Ultra high-end $22,000 routers were bought in huge quantities by the government in West Virginia, many destined for rural offices with minimal IT footprints. [Ars Technica] |
| Posted: 18 May 2012 02:25 AM PDT At the New York Times, Quentin Hardy writes that HP CEO Meg Whitman is to cut at least 30,000 jobs
Who needs a press office when you have HP's boardrooms? [NYT] |
| Magican 1.0.0 - Optimize your Mac.. (Free) Posted: 18 May 2012 02:06 AM PDT  Magican is an integrated system utility for optimizing Mac OS X, featuring:
Version 1.0.0:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Shapes 2.5 - Simple diagramming app.. (Demo) Posted: 18 May 2012 02:23 AM PDT  Shapes is a simple, elegant Diagramming app for Mac OS X Snow Leopard. Shapes gives you all of the most important features you need in a Diagramming tool without all the extra cruft, and without breaking the bank! Shapes is great for Programmers and Web Designers looking for a simple tool for quickly designing Charts, laying out Wireframes, or visualizing Model Relationships. Shapes lets you get to work quickly by giving you just the basic tools you need in a slick, single-window, thoroughly Mac-native UI. Bonus: Shapes also offers Full-Screen Mode. Woo!
Download Now This posting includes an audio/video/photo media file: Download Now |
| Bros MKV Converter Mac 1.7.12 - Convert videos into Mac-supported formats.. (Shareware) Posted: 18 May 2012 02:16 AM PDT  Bros MKV Converter Mac is designed for Mac users to convert MKV video to Mac supported video formats including MKV to AVI Mac, MKV to MOV Mac, MKV to M4V Mac, MKV to MP4 Mac, MKV to HD Video etc. Except from converting MKV to video, here Mac MKV Converter also can extract audio from MKV video and convert MKV to MP3 on Mac. This program can also meet extensive needs, such as trim MKV video length, crop MKV video for different screen display size, add logo or text watermarks and enhance video effect, etc. Other parameter settings like video bit rate, frame rate, audio channel, aspect ratio can also be edited freely. Key features
This posting includes an audio/video/photo media file: Download Now |
| Posted: 18 May 2012 02:10 AM PDT
Three new Limited Edition Mondaine Giant Watches of Switzerland were introduced at Watchismo this week. Check out the perfectly minimal raw steel and anthracite dial follow-ups to the popular 'Giant' collection use the instantly recognizable Swiss Railways clock dial, emulating a time-honored design present in every Swiss train station. The distinct Mondaine design is so easy to read that it serves its purpose at any size, but there is something majestic about these larger, domed-dial giants. |
| 5 movies adapted from odd sources Posted: 18 May 2012 01:57 AM PDT Consider two of this weekend's new movies: the big-budget action blockbuster "Battleship" and the romantic-comedy "What to Expect When You're Expecting." The former is "based" on a board game with next to no back story and the other is inspired by the popular series of advice books. |
| Multi Threaded TCP Port Scanner 4.0 - Scan any IP address for open ports.. (Free) Posted: 18 May 2012 01:43 AM PDT  Multi Threaded TCP Port Scanner has the ability to scan 65535 TCP ports on an IP address. You can specify how many threads to run and the timeout. Further more it will tell you the Mac address of the target and the service running. With the TCP Scanner you can scan any IP address both local and public IP addresses for open ports. It has threaded option as well so you can easily scan many IPs very fast. You can use the TCP Port scanner to scan your public ip, local IPS and for example your firewall. This way you can find out if you have open ports on your network that actually should be firewalled off. Version 4.0:
Download Now This posting includes an audio/video/photo media file: Download Now |
| cf/x photo mosaic 2.0.0 - Convert images into a mosaic.. (Demo) Posted: 18 May 2012 01:51 AM PDT  cf/x photo mosaic is a highly specialized app to create high quality image-from-images type mosaics. It doesn't do anything else, but this one thing it does better than any other application available (and, yes, that even includes our own flagship 'alpha'). In addition to being blindingly fast, photo mosaic comes with special presets that help you create great photo mosaics even out of borderline images. photo mosaic is incredibly easy to use: drop in a picture, choose a tile source (e.g. an iPhoto event), press 'Go'. A few seconds later you have a beautiful photo mosaic. photo mosaic is fully customizable - from the way tiles are processed to the way that colors are matched. As its sister application 'cf/x mosaic', 'cf/x photo mosaic' supports variably-sized tiles, 'messy' assembly, up to 40'000 individual tiles, and high-quality output (up to 30 x 30 inch at 300dpi). And if you want to show off how the mosaic is assembled, just tell photo mosaic to create a movie - it does the rest. DV, HD, iPhone, iPad - just one click. Quality? Broadcast. Yeah, that good. For advanced mosaic creators, photo mosaic provides highly advanced visual image analysis packages that helps you to tweak and perfect your source data base - and can even recommend the preset that will work best. photo mosaic exports to most common image formats, mail, Apple's Preview App, Aperture, iPhoto, social web sites, and even can directly set your desktop picture to your newest creation. Version 2.0.0: New Features
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 18 May 2012 12:00 AM PDT The receptor for advanced glycation end products (RAGE) is oncogenic and overexpressed in human cancers, but its role in hepatocellular carcinoma remains unclear. Here we demonstrated that RAGE is overexpressed in primary hepatocellular carcinoma (PHC) compared to adjacent para-neoplastic liver samples. Serum endogenous secretory RAGE levels were also increased in PHC patients (p < 0.01). Moreover, we demonstrated that RAGE regulates cellular proliferation in Hepatocellular carcinoma (HCC). Knockdown of RAGE by specific siRNA inhibited cellular growth in the hepatocellular carcinoma cell line, Huh7, whereas the RAGE ligand, high mobility group box 1 protein (HMGB1) increased cellular proliferation. In addition, knockdown of RAGE by siRNA arrested cells in the G1 phase and inhibited DNA synthesis (p < 0.01), while HMGB1 protein decreased the number of cells in the G1 phase and increased the number in the S phase (p < 0.05). Furthermore, quantitative real time RT-PCR (qRT-PCR) and Western Blot results demonstrated that RAGE and HMGB1 positively regulate NF-κB p65 expression in Huh7 cells. These studies suggest that RAGE and RAGE ligands are important targets for therapeutic intervention in hepatocellular carcinoma. |
| Posted: 18 May 2012 12:00 AM PDT This study reports on the degradation of natural rubber (NR) via cross-metathesis with mandarin oil and d-limonene, an abundant compound in essential oils; that were used as chain transfer agents (CTAs) and green solvents. Reactions were performed in the presence of the ruthenium-alkylidene catalysts (PCy3)2(Cl)2Ru=CHPh (I) and (1,3-dimesityl-4,5-dihydroimidazol-2-ylidene) (PCy3)Cl2Ru=CHPh (II), respectively. Catalyst II bears an N-heterocyclic carbene ligand (NHC) bounded to the ruthenium atom, which has a strong basic character; therefore it is more active toward trisubstituted olefins in comparison with catalyst I. In both cases, isolated monoterpene-terminated isoprene oligomers were obtained as products of the cross-metathesis degradation of NR. In the presence of catalyst II molecular weight values around Mn × 102 and yields of 80% were obtained; whereas with catalyst I, the molecular weights of products were about Mn × 104 with yields ranging 70 to 74%. The composition and yield of NR degradation products were determined by GC/MS (EI) analysis and it was found that the oligomers obtained have primarily one vinyl group and one terpene-monocyclic group at the chain end, with isoprene units Am = 2, 3 y 4. |
| Posted: 18 May 2012 12:00 AM PDT Acquired immune deficiency syndrome (AIDS) is a severe communicable immune deficiency disease caused by the human immune deficiency virus (HIV). The analysis laboratory diagnosis of HIV infection is a crucial aspect of controlling AIDS. The p24 antigen, the HIV-1 capsid protein, is of considerable diagnostic interest because it is detectable several days earlier than host-generated HIV antibodies following HIV exposure. We present herein a new sandwich HIV p24 immunosensor based on directly electroplating an electrode surface with gold nanoparticles using chronoamperometry, which greatly increased the conductivity and reversibility of the electrode. Under optimum conditions, the electrochemical signal showed a linear relationship with the concentration of p24, ranging from 0.01 ng/mL to 100 ng/mL (R > 0.99), and the detection limit was 0.008 ng/mL. Compared with ELISA, this method increased the sensitivity by more than two orders of magnitude (the sensitivity of ELISA for p24 is about 1 ng/mL). This immunosensor may be broadly applied to clinical samples, being distinguished by its ease of use, mild reaction conditions, guaranteed reproducibility, and good anti-interference ability. |
| Posted: 18 May 2012 12:00 AM PDT This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumin-loaded SPC liposomes), C-EPC-L (curcumin-loaded EPC liposomes), and C-HSPC-L (curcumin-loaded HSPC liposomes). The physical properties of different lipsomes were investigated as follows: photon correlation spectroscopy revealed that the average particle sizes of the three types of curcumin-loaded liposomes were 82.37 ± 2.19 nm (C-SPC-L), 83.13 ± 4.89 nm (C-EPC-L), and 92.42 ± 4.56 nm (C-HSPC-L), respectively. The encapsulation efficiency values were found to be 82.32 ± 3.91%, 81.59 ± 2.38%, and 80.77 ± 4.12%, respectively. An in vitro skin penetration study indicated that C-SPC-L most significantly promoted drug permeation and deposition followed by C-EPC-L, C-HSPC-L, and curcumin solution. Moreover, C-SPC-L displayed the greatest ability of all loaded liposomes to inhibit the growth of B16BL6 melanoma cells. Therefore, the C-SPC-L were chosen for further pharmacodynamic evaluation. A significant effect on antimelanoma activity was observed with C-SPC-L, as compared to treatment with curcumin solution in vivo. These results suggest that C-SPC-L would be a promising transdermal carrier for curcumin in cancer treatment. |
Our thanks go to | You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий