Games

TotalSpaces 0.9.10 - Brings grid spaces back to Mac OS X 10.7 (beta).. (Shareware)
Genes, Vol. 3, Pages 291-319: The Chlamydiales Pangenome Revisited: Structural Stability and Functional Coherence
IJMS, Vol. 13, Pages 5972-5981: Multiplex PCR for 17 Y-Chromosome Specific Short Tandem Repeats (STR) to Enhance the Reliability of Fetal Sex Determination in Maternal Plasma
IJMS, Vol. 13, Pages 5952-5971: Biological Properties of Acidic Cosmetic Water from Seawater
IJMS, Vol. 13, Pages 5933-5951: Combinatorial Signal Integration by APETALA2/Ethylene Response Factor (ERF)-Transcription Factors and the Involvement of AP2-2 in Starvation Response
IJMS, Vol. 13, Pages 5917-5932: Diversity and Biosynthetic Potential of Culturable Actinomycetes Associated with Marine Sponges in the China Seas
Tinderbox 5.11.0 - Store and organize your notes, ideas, and plans.. (Demo)
HoudahGeo 3.1 - Geotag your photos.. (Demo)
IJMS, Vol. 13, Pages 5899-5916: In Vitro Inhibition of Histamine Release Behavior of Cetirizine Intercalated into Zn/Al- and Mg/Al-Layered Double Hydroxides
IJMS, Vol. 13, Pages 5878-5898: A Comparative Study on the Mechanical, Thermal and Morphological Characterization of Poly(lactic acid)/Epoxidized Palm Oil Blend
TrailRunner 3.7.676 - Route planning for hiking, biking, more.. (Free)
Templates for MS Excel 1.0 - Convenient, quality templates for Excel.. (Commercial)
Max Payne 3 Review
Find the Differences Screens
Original Gangstaz Screens
iMob Online Screens
Baseball Manager 2010 Screens
Race or Die Screens
Dinky Ball Screens
Girl Wars Screens

TotalSpaces 0.9.10 - Brings grid spaces back to Mac OS X 10.7 (beta).. (Shareware)

Posted: 16 May 2012 02:51 AM PDT

TotalSpaces is a desktop manager that brings back grid Spaces to Mac OS X 10.7 Lion and more!

Define your grid - and navigate left, right, up and down between your desktops
Choose your transitions - Cube, slide and other effects, or turn them off altogether to really speed up your mac
Manage your desktops and windows from the Overview Grid - a birds-eye view of your grid
Hotkeys, hot-corners, circulation options and more

Version 0.9.10:

Fixed: Registration reminder should not show during beta period.

Mac OS X 10.7 or later

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Genes, Vol. 3, Pages 291-319: The Chlamydiales Pangenome Revisited: Structural Stability and Functional Coherence

Posted: 16 May 2012 12:00 AM PDT

The entire publicly available set of 37 genome sequences from the bacterial order Chlamydiales has been subjected to comparative analysis in order to reveal the salient features of this pangenome and its evolutionary history. Over 2,000 protein families are detected across multiple species, with a distribution consistent to other studied pangenomes. Of these, there are 180 protein families with multiple members, 312 families with exactly 37 members corresponding to core genes, 428 families with peripheral genes with varying taxonomic distribution and finally 1,125 smaller families. The fact that, even for smaller genomes of Chlamydiales, core genes represent over a quarter of the average protein complement, signifies a certain degree of structural stability, given the wide range of phylogenetic relationships within the group. In addition, the propagation of a corpus of manually curated annotations within the discovered core families reveals key functional properties, reflecting a coherent repertoire of cellular capabilities for Chlamydiales. We further investigate over 2,000 genes without homologs in the pangenome and discover two new protein sequence domains. Our results, supported by the genome-based phylogeny for this group, are fully consistent with previous analyses and current knowledge, and point to future research directions towards a better understanding of the structural and functional properties of Chlamydiales.

IJMS, Vol. 13, Pages 5972-5981: Multiplex PCR for 17 Y-Chromosome Specific Short Tandem Repeats (STR) to Enhance the Reliability of Fetal Sex Determination in Maternal Plasma

Posted: 16 May 2012 12:00 AM PDT

The aim of the study was to demonstrate the influence of target gene and amplification product length on the performance of fetal gender determination systems using maternal plasma. A total of 40 pairs of plasma DNA samples from pregnant women and genomic DNA samples from maternal blood, amniotic fluid and paternal blood were isolated for gender determination by amplification of the amelogenin gene and 17 Y-chromosome STR loci, using three different commercial kits. The gender of the fetuses was confirmed by cytogenetic analysis or phenotype at birth. Both the AmpFℓSTR-Identifiler amplification kit and the Mini-STR Amplification kit for amelogenin gene detection were reliable in determining fetal gender (92.0% and 96.0%, respectively), but false negatives were present in both systems. AmpFℓSTR-Yfiler was found to be fully reliable as it amplified Y-STR in all cases of pregnancies with male fetuses and thus was 100% correct in determining fetal gender. The results demonstrated that multiple fluorescent PCR for 17 Y-STR loci was more reliable than AMELY gene testing in fetal sex determination with maternal plasma. We also found that the shorter amplification products could improve the performance of fetal gender determination systems.

IJMS, Vol. 13, Pages 5952-5971: Biological Properties of Acidic Cosmetic Water from Seawater

Posted: 16 May 2012 12:00 AM PDT

This current work was to investigate the biological effects of acidic cosmetic water (ACW) on various biological assays. ACW was isolated from seawater and demonstrated several bio-functions at various concentration ranges. ACW showed a satisfactory effect against Staphylococcus aureus, which reduced 90% of bacterial growth after a 5-second exposure. We used cultured human peripheral blood mononuclear cells (PBMCs) to test the properties of ACW in inflammatory cytokine release, and it did not induce inflammatory cytokine release from un-stimulated, normal PBMCs. However, ACW was able to inhibit bacterial lipopolysaccharide (LPS)-induced inflammatory cytokine TNF-α released from PBMCs, showing an anti-inflammation potential. Furthermore, ACW did not stimulate the rat basophilic leukemia cell (RBL-2H3) related allergy response on de-granulation. Our data presented ACW with a strong anti-oxidative ability in a superoxide anion radical scavenging assay. In mass spectrometry information, magnesium and zinc ions demonstrated bio-functional detections for anti-inflammation as well as other metal ions such as potassium and calcium were observed. ACW also had minor tyrosinase and melanin decreasing activities in human epidermal melanocytes (HEMn-MP) without apparent cytotoxicity. In addition, the cell proliferation assay illustrated anti-growth and anti-migration effects of ACW on human skin melanoma cells (A375.S2) indicating that it exerted the anti-cancer potential against skin cancer. The results obtained from biological assays showed that ACW possessed multiple bioactivities, including anti-microorganism, anti-inflammation, allergy-free, antioxidant, anti-melanin and anticancer properties. To our knowledge, this was the first report presenting these bioactivities on ACW.

IJMS, Vol. 13, Pages 5933-5951: Combinatorial Signal Integration by APETALA2/Ethylene Response Factor (ERF)-Transcription Factors and the Involvement of AP2-2 in Starvation Response

Posted: 16 May 2012 12:00 AM PDT

Transcription factors of the APETALA 2/Ethylene Response Factor (AP2/ERF)-family have been implicated in diverse processes during development, stress acclimation and retrograde signaling. Fifty-three leaf-expressed AP2/ERFs were screened for their transcriptional response to abscisic acid (ABA), 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), methylviologen (MV), sucrose and high or low light, respectively, and revealed high reactivity to these effectors. Six of them (AP2-2, ARF14, CEJ1, ERF8, ERF11, RAP2.5) were selected for combinatorial response analysis to ABA, DCMU and high light. Additive, synergistic and antagonistic effects demonstrated that these transcription factors are components of multiple signaling pathways. AP2-2 (At1g79700) was subjected to an in depth study. AP2-2 transcripts were high under conditions linked to limited carbohydrate availability and stress and down-regulated in extended light phase, high light or in the presence of sugar. ap2-2 knock out plants had unchanged metabolite profiles and transcript levels of co-expressed genes in extended darkness. However, ap2-2 revealed more efficient germination and faster early growth under high sugar, osmotic or salinity stress, but the difference was abolished in the absence of sugar or during subsequent growth. It is suggested that AP2-2 is involved in mediating starvation-related and hormonal signals.

IJMS, Vol. 13, Pages 5917-5932: Diversity and Biosynthetic Potential of Culturable Actinomycetes Associated with Marine Sponges in the China Seas

Posted: 16 May 2012 12:00 AM PDT

The diversity and secondary metabolite potential of culturable actinomycetes associated with eight different marine sponges collected from the South China Sea and the Yellow sea were investigated. A total of 327 strains were isolated and 108 representative isolates were selected for phylogenetic analysis. Ten families and 13 genera of Actinomycetales were detected, among which five genera represent first records isolated from marine sponges. Oligotrophic medium M5 (water agar) proved to be efficient for selective isolation, and "Micromonospora–Streptomyces" was proposed as the major distribution group of sponge-associated actinomycetes from the China Seas. Ten isolates are likely to represent novel species. Sponge Hymeniacidon perleve was found to contain the highest genus diversity (seven genera) of actinomycetes. Housekeeping gene phylogenetic analyses of the isolates indicated one ubiquitous Micromonospora species, one unique Streptomyces species and one unique Verrucosispora phylogroup. Of the isolates, 27.5% displayed antimicrobial activity, and 91% contained polyketide synthase and/or nonribosomal peptide synthetase genes, indicating that these isolates had a high potential to produce secondary metabolites. The isolates from sponge Axinella sp. contained the highest presence of both antimicrobial activity and NRPS genes, while those from isolation medium DNBA showed the highest presence of antimicrobial activity and PKS I genes.

Tinderbox 5.11.0 - Store and organize your notes, ideas, and plans.. (Demo)

Posted: 16 May 2012 02:35 AM PDT

Tinderbox is a personal content management assistant. It stores your notes, ideas, and plans. It can help you organize and understand them. And Tinderbox helps you share ideas through Web journals and web logs.

Tinderbox's agents automatically scan your notes, looking for patterns and building relationships. Agents help discover relationships and help make sure important things don't get lost. Agents are easy to make and easy to modify. They're flexible and powerful.

Tinderbox can even gather and update changing information and breaking news from the internet.

When it's time to share your notes, Tinderbox can assemble multiple notes into one page. Updates are a breeze -- even if you update several times a day. Private notes, timestamps, permanent links, archives: everything you want, just the way you want it.

Version 5.11.0:

This Version Goes to 11!

We're running out of versions numbers, but there's too much great stuff here to make you wait. Tinderbox gets better and better!

Read Scrivener Files

Scrivener and Tinderbox are natural friends, and now they're even better together. Have a Scrivener file? Tinderbox will open it! We'll capture the structure, links, references, and notes. Fast, easy, and terrific.

Brilliant with Bookends

Tinderbox and the upcoming Bookends 11.2.9 now cooperate even more closely. Option-drag a reference into Tinderbox and you don't just get a handy link to your reference database: now, Tinderbox grabs a formatted copy of your reference (using your preferred style, naturally) and populates a slew of attributes, too. There's even a new built-in prototype for references.

Sleeker Outlines

Multi-column outlines are now easier to edit. Tabbing between fields is nice. Click-to-edit is nice, too. Smart autocompletion is even better, letting you autocomplete tags, statuses, contexts; they're exactly the things you want and more!
See the release notes (in the Help menu) for details about Tinderbox 5.11. You'll also find updates in Tinderbox Help, to the Tinderbox Cookbook, and to Mark Anderson's invaluable aTbRef Tinderbox Reference.

Mac OS X 10.6 or later

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HoudahGeo 3.1 - Geotag your photos.. (Demo)

Posted: 16 May 2012 02:45 AM PDT

HoudahGeo lets you know where you took that photo!

With HoudahGeo you may "pin" photos to locations where they were taken.

Just like an expensive GPS camera, HoudahGeo may store latitude, longitude and altitude information right within the image file - invisibly with no loss of quality. HoudahGeo writes EXIF, XMP and IPTC tags.

HoudahGeo also lets you to share your geotagged photos in Google Earth or publish them to Flickr, Locr or EveryTrail.com.

One-stop geocoding for the Mac

HoudahGeo caters to two very different needs:

Geocoding for archival purposes using EXIF, XMP and IPTC tags
Geocoding for publishing to Google Earth or Flickr (GPS device: optional)

HoudahGeo offers you many ways of geocoding your favorite photos:

Automatic: Matches photos to GPS track logs and waypoints
iPhone: Matches photos to reference photos taken using iPhone
Using a Google Earth: Point to the desired location
Using a map: Pick locations using the built-in map
Precision: Attach photos to GPS waypoints
Manual: Enter coordinates found on Google Earth, Wikipedia (GPS device: supported)

HoudahGeo connects directly to many brands and models of GPS track loggers. It also reads GPX and NMEA files created by third party software.

Version 3.1:

HoudahGeo can now browse Lightroom 4 libraries
Updated bundled version of exiftool
HoudahGeo now handles waypoints having speed values
Improved reliability of writing special characters to IPTC tags

Mac OS X 10.6 or later
A digital camera
Optionally, a GPS track logger
Optionally, an iPhone 3G or better

Download Now

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IJMS, Vol. 13, Pages 5899-5916: In Vitro Inhibition of Histamine Release Behavior of Cetirizine Intercalated into Zn/Al- and Mg/Al-Layered Double Hydroxides

Posted: 16 May 2012 12:00 AM PDT

The intercalation of cetirizine into two types of layered double hydroxides, Zn/Al and Mg/Al, has been investigated by the ion exchange method to form CTZAN and CTMAN nanocomposites, respectively. The basal spacing of the nanocomposites were expanded to 31.9 Å for CTZAN and 31.2 Å for CTMAN, suggesting that cetirizine anion was intercalated into Layered double hydroxides (LDHs) and arranged in a tilted bilayer fashion. A Fourier transform infrared spectroscopy (FTIR) study supported the formation of both the nanocomposites, and the intercalated cetirizine is thermally more stable than its counterpart in free state. The loading of cetirizine in the nanocomposite was estimated to be about 57.2% for CTZAN and 60.7% CTMAN. The cetirizine release from the nanocomposites show sustained release manner and the release rate of cetirizine from CTZAN and CTMAN nanocomposites at pH 7.4 is remarkably lower than that at pH 4.8, presumably due to the different release mechanism. The inhibition of histamine release from RBL2H3 cells by the free cetirizine is higher than the intercalated cetirizine both in CTZAN and CTMAN nanocomposites. The viability in human Chang liver cells at 1000 μg/mL for CTZAN and CTMAN nanocomposites are 74.5 and 91.9%, respectively.

IJMS, Vol. 13, Pages 5878-5898: A Comparative Study on the Mechanical, Thermal and Morphological Characterization of Poly(lactic acid)/Epoxidized Palm Oil Blend

Posted: 16 May 2012 12:00 AM PDT

In this work, poly(lactic acid) (PLA) a fully biodegradable thermoplastic polymer matrix was melt blended with three different epoxidized palm oil (EPO). The aim of this research was to enhance the flexibility, mechanical and thermal properties of PLA. The blends were prepared at various EPO contents of 1, 2, 3, 4 and 5 wt% and characterized. The SEM analysis evidenced successful modification on the neat PLA brittle morphology. Tensile tests indicate that the addition of 1 wt% EPO is sufficient to improve the strength and flexibility compared to neat PLA. Additionally, the flexural and impact properties were also enhanced. Further, DSC analysis showed that the addition of EPO results in a decrease in Tg, which implies an increase in the PLA chain mobility. In the presence of 1 wt% EPO, TGA results revealed significant increase in the thermal stability by 27%. Among the three EPOs used, EPO(3) showed the best mechanical and thermal properties compared to the other EPO's, with an optimum loading of 1 wt%. Conclusively, EPO showed a promising outcome to overcome the brittleness and improve the overall properties of neat PLA, thus can be considered as a potential plasticizer.

TrailRunner 3.7.676 - Route planning for hiking, biking, more.. (Free)

Posted: 16 May 2012 01:57 AM PDT

TrailRunner is the perfect companion for runners, bikers, hikers, and all people wandering under the sky. Plan routes on a geographical map. Import GPS or workout recordings and journalize your activities in a diary.

Features:

View Maps and Elevation Data from Internet mapping services like USGS topo maps.
Import GPS Recordings from Trails, iTrail and 321Run for iPhone.
Import workouts from the Nike + iPod Sport Kit.
Import tracks and workouts from GPS fitness devices like the Garmin ForeRunner or Garmin Edge.
Import/Export TCX, GPX, and KML files.
Describe favorite tracks and rate them with iTunes stars.
Plan routes interactively or automatically for a given distance.
Export route directions onto your iPod.
Journalize workouts in a diary, see your progress in a history chart.
Publish a WebLog to MobileMe.

Version 3.7.676:

Migrated the new Dropbox Synchronizer from TrailRunner mini to TrailRunnerX. So you now can view and follow all ever planned routes on RaceBunny for the iPhone.
Added more debug code to catch route merge issues. Please keep sending crash reports.

Mac OS X 10.6 or later

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Templates for MS Excel 1.0 - Convenient, quality templates for Excel.. (Commercial)

Posted: 16 May 2012 02:06 AM PDT

Templates for MS Excel is a high-quality collection of 50 diverse and practical templates for MS Excel. Use them for your business or personal needs to make your daily tasks a lot more manageable. Personalize the templates to your requirements: create tables, make calculations, draw diagrams, and insert images, attending to your job efficiently and without trouble. Available in the US and international page sizes.