Games |
- TuneupMyMac 1.0.334 - Get your Mac running better, faster, stronger.. (Shareware)
- Chromium 1025.168 - Fast and stable open-source browser.. (Free)
- Crystals, Vol. 2, Pages 362-373: Polyoxotungstate-Surfactant Layered Crystal toward Conductive Inorganic-Organic Hybrid
- Crystals, Vol. 2, Pages 349-361: Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of the H-bonding Influenced Linear Chain Formation in the Solid State
- DockShelf 1.1 - Increase accessibility by creating multiple docks.. (Shareware)
- Energies, Vol. 5, Pages 1309-1320: Evidence of Gas Hydrates in Block 26—Offshore Trinidad
- Molecules, Vol. 17, Pages 5151-5163: A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
- Forests, Vol. 3, Pages 179-189: Improving Woody Biomass Estimation Efficiency Using Double Sampling
- Pablo 1.0.0 - Fantasy weapons and adventure game.. (Commercial)
- Anti-gambling laws on parliament program
- IJMS, Vol. 13, Pages 5375-5405: The Role of Protein Crystallography in Defining the Mechanisms of Biogenesis and Catalysis in Copper Amine Oxidase
- Remote Sensing, Vol. 4, Pages 1190-1207: Advances in Forest Inventory Using Airborne Laser Scanning
- Viruses, Vol. 4, Pages 734-760: Spread of the Emerging Viral Hemorrhagic Septicemia Virus Strain, Genotype IVb, in Michigan, USA
- Nutrients, Vol. 4, Pages 331-342: Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older Adults: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial
- Sustainability, Vol. 4, Pages 863-865: Environmental Literacy in Science and Society: From Knowledge to Decisions. By Roland W. Scholz. Cambridge University Press: New York, USA, 2011; Hardback, 631 pp; ISBN 978-0-521-19271-2; Paperback, ISBN 978-0-521-18333-8
- Sustainability, Vol. 4, Pages 840-862: Sticks and Stones: The Impact of the Definitions of Brownfield in Policies on Socio-Economic Sustainability
- Molecules, Vol. 17, Pages 5139-5150: Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives
- Molecules, Vol. 17, Pages 5126-5138: Comparison of the Simple Cyclic Voltammetry (CV) and DPPH Assays for the Determination of Antioxidant Capacity of Active Principles
- Molecules, Vol. 17, Pages 5108-5125: Absorption and Fluorescence Spectroscopic Properties of 1- and 1,4-Silyl-Substituted Naphthalene Derivatives
- Molecules, Vol. 17, Pages 5095-5107: Synthesis, Molecular Properties Prediction, and Anti-staphylococcal Activity of N-Acylhydrazones and New 1,3,4-Oxadiazole Derivatives
| TuneupMyMac 1.0.334 - Get your Mac running better, faster, stronger.. (Shareware) Posted: 03 May 2012 03:30 AM PDT TuneupMyMac is an expert and easy-to-use solution for your Mac. It offers an easy way to clean, secure and optimize your Mac to keep it running smoothly and faster. TuneupMyMac's advanced features and powerful tools help enhance Mac speed with ease and improve your experience exclusively. Benefits
Version 1.0.334: Release notes were unavailable when this listing was updated.
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| Chromium 1025.168 - Fast and stable open-source browser.. (Free) Posted: 03 May 2012 03:17 AM PDT  Chromium is an open-source browser project that aims to build a safer, faster, and more stable way for all Internet users to experience the web. FreeSMUG-Free OpenSource Mac User Group build is based on the stable Chromium code plus "Check for Updates..." command.
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| Posted: 03 May 2012 12:00 AM PDT A polyoxotungstate-surfactant hybrid layered compound was synthesized as a single phase by using decatungstate ([W10O32]4−, W10) and hexadecylpyridinium (C16py). The X-ray structure analysis combined with infrared spectroscopy and elemental analysis revealed the formula to be (C16py)4[W10O32] (C16py-W10). The layered structure consisted of alternative stacking of W10 inorganic monolayers and interdigitated C16py bilayers with layered periodicity of 23.3 Å. Each W10 anion in the W10 inorganic monolayers was isolated by the hydrophilic heads of C16py. The hybrid crystals of C16py-W10 decomposed at around 500 K. The conductivity of the hybrid layered crystal was estimated to be 4.8 × 10−6 S cm−1 at 423 K by alternating current (AC) impedance spectroscopy. |
| Posted: 03 May 2012 12:00 AM PDT Three N-substituted 5-chlorosalicylamides (4-chlorophenyl, 2a; benzyl, 2b; phenethyl 2c) differing in the length of the 'linker' between the benzene ring and the amide moiety were prepared in order to compare their supramolecular architecture. The intramolecular NH···O(H) hydrogen bond and the intermolecular C=O···H–O hydrogen bond were found in the crystal structure of 2a and 2c thus forming an infinite linear chain. Compound 2b had a different arrangement with the intramolecular C=O···H–O hydrogen bond and another intermolecular NH···O(H) hydrogen forming a linear infinite chain. |
| DockShelf 1.1 - Increase accessibility by creating multiple docks.. (Shareware) Posted: 03 May 2012 02:39 AM PDT  DockShelf lets you place unlimited docks around your desktop so you never run out of space again for your commonly used files, folders and applications! We've all seen it and you've probably experienced it yourself - a Dock exploding with files and apps which has been shrunk so small you can barely see what anything is anymore. DockShelf helps you manage the clutter of the Dock by offering another form of "dock shelf" which you can place around any edge of your screen without any restrictions and has more options for customization. With DockShelf launching your favorite documents and apps is faster and more powerful because you control where your docks are positioned, how many are on screen, how they're labeled and when they're visible. Version 1.1: New
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| Energies, Vol. 5, Pages 1309-1320: Evidence of Gas Hydrates in Block 26—Offshore Trinidad Posted: 03 May 2012 12:00 AM PDT Natural gas hydrates are increasingly viewed as a potential economic resource as energy demands rise. In this study, three-dimensional seismic data for Block 26 in the Atlantic Continental Margin offshore Trinidad were evaluated to determine if there is the potential for oceanic hydrate-bearing sediments. The seismic dataset covered an area of approximately 1210 km2 of the continental slope. A bottom simulating reflector which generally ran parallel to the sea floor and cut the dominant stratigraphy was observed and mapped over approximately 43% of the study area. |
| Posted: 03 May 2012 12:00 AM PDT A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step. |
| Forests, Vol. 3, Pages 179-189: Improving Woody Biomass Estimation Efficiency Using Double Sampling Posted: 03 May 2012 12:00 AM PDT Although double sampling has been shown to be an effective method to estimate timber volume in forest inventories, only a limited body of research has tested the effectiveness of double sampling on forest biomass estimation. From forest biomass inventories collected over 9,683 ha using systematic point sampling, we examined how a double sampling scheme would have affected precision and efficiency in these biomass inventories. Our results indicated that double sample methods would have yielded biomass estimations with similar precision as systematic point sampling when the small sample was ≥ 20% of the large sample. When the small to large sample time ratio was 3:1, relative efficiency (a combined measure of time and precision) was highest when the small sample was a 30% subsample of the large sample. At a 30% double sample intensity, there was a < 3% deviation from the original percent margin of error and almost half the required time. Results suggest that double sampling can be an efficient tool for natural resource managers to estimate forest biomass. |
| Pablo 1.0.0 - Fantasy weapons and adventure game.. (Commercial) Posted: 03 May 2012 02:29 AM PDT  Play Pablo and explore a new, exciting fantasy world. Each level has unique traps and obstacles. Choose an axe, pick, hammer, morning star or sword for Pablo to fight his enemies and survive the challenges of each level. With 6 Boss levels, Pablo will meet more and more challenging foes with every advancement. Features :
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| Anti-gambling laws on parliament program Posted: 03 May 2012 01:59 AM PDT The federal government will push ahead with its plan to introduce and pass its laws to tackle problem gambling in the winter session of parliament to start next Tuesday. |
| Posted: 03 May 2012 12:00 AM PDT Copper amine oxidases (CAOs) are a ubiquitous group of enzymes that catalyze the conversion of primary amines to aldehydes coupled to the reduction of O2 to H2O2. These enzymes utilize a wide range of substrates from methylamine to polypeptides. Changes in CAO activity are correlated with a variety of human diseases, including diabetes mellitus, Alzheimer's disease, and inflammatory disorders. CAOs contain a cofactor, 2,4,5-trihydroxyphenylalanine quinone (TPQ), that is required for catalytic activity and synthesized through the post-translational modification of a tyrosine residue within the CAO polypeptide. TPQ generation is a self-processing event only requiring the addition of oxygen and Cu(II) to the apoCAO. Thus, the CAO active site supports two very different reactions: TPQ synthesis, and the two electron oxidation of primary amines. Crystal structures are available from bacterial through to human sources, and have given insight into substrate preference, stereospecificity, and structural changes during biogenesis and catalysis. In particular both these processes have been studied in crystallo through the addition of native substrates. These latter studies enable intermediates during physiological turnover to be directly visualized, and demonstrate the power of this relatively recent development in protein crystallography. |
| Remote Sensing, Vol. 4, Pages 1190-1207: Advances in Forest Inventory Using Airborne Laser Scanning Posted: 03 May 2012 12:00 AM PDT We present two improvements for laser-based forest inventory. The first improvement is based on using last pulse data for tree detection. When trees overlap, the surface model between the trees corresponding to the first pulse stays high, whereas the corresponding model from the last pulse results in a drop in elevation, due to its better penetration between the trees. This drop in elevation can be used for separating trees. In a test carried out in Evo, Southern Finland, we used 292 forests plots consisting of more than 5,500 trees and airborne laser scanning (ALS) data comprised of 12.7 emitted laser pulses per m2. With last pulse data, an improvement of 6% for individual tree detection was obtained when compared to using first pulse data. The improvement increased with an increasing number of stems per plot and with decreasing diameter breast height (DBH). The results confirm that there is also substantial information for tree detection in last pulse data. The second improvement is based on the use of individual tree-based features in addition to the statistical point height metrics in area-based prediction of forest variables. The commonly-used ALS point height metrics and individual tree-based features were fused into the non-parametric estimation of forest variables. By using only four individual tree-based features, stem volume estimation improved when compared to the use of statistical point height metrics. For DBH estimation, the point height metrics and individual tree-based features complemented each other. Predictions were validated at plot level. |
| Posted: 03 May 2012 12:00 AM PDT In 2003, viral hemorrhagic septicemia virus (VHSV) emerged in the Laurentian Great Lakes causing serious losses in a number of ecologically and recreationally important fish species. Within six years, despite concerted managerial preventive measures, the virus spread into the five Great Lakes and to a number of inland waterbodies. In response to this emerging threat, cooperative efforts between the Michigan Department of Natural Resources (MI DNR), the Michigan State University Aquatic Animal Health Laboratory (MSU-AAHL), and the United States Department of Agriculture-Animal and Plant Health Inspection Services (USDA-APHIS) were focused on performing a series of general and VHSV-targeted surveillances to determine the extent of virus trafficking in the State of Michigan. Herein we describe six years (2005–2010) of testing, covering hundreds of sites throughout Michigan's Upper and Lower Peninsulas. A total of 96,228 fish representing 73 species were checked for lesions suggestive of VHSV and their internal organs tested for the presence of VHSV using susceptible cell lines. Of the 1,823 cases tested, 30 cases from 19 fish species tested positive for VHSV by tissue culture and were confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). Gene sequence analyses of all VHSV isolates retrieved in Michigan demonstrated that they belong to the emerging sublineage "b" of the North American VHSV genotype IV. These findings underscore the complexity of VHSV ecology in the Great Lakes basin and the critical need for rigorous legislation and regulatory guidelines in order to reduce the virus spread within and outside of the Laurentian Great Lakes watershed. |
| Posted: 03 May 2012 12:00 AM PDT Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena® ELFA®955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements. Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement. Result: Chronic WGOE supplementation did not affect any measures of cognition. Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition. It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment. |
| Posted: 03 May 2012 12:00 AM PDT The book Environmental Literacy in Science and Society contributes to the scientific understanding and sustainability-oriented management of Human–Environment Systems (HES) based on processes of transdisciplinarity and mutual learning. It presents a historical analysis, and modern explanations, of crucial concepts and developments regarding environmental literacy in science and society. In addition, it presents an original framework for the analysis of HES in which these are seen as inextricably coupled transactional systems. This framework is applied in the book to sustainability learning and decision making in real-world problem-solving processes with respect to complex, ill-defined problems that pose threads to the balance of certain aspects of HES or to the anthroposphere as a whole. [...] |
| Posted: 03 May 2012 12:00 AM PDT Many countries encourage brownfield regeneration as a means of sustainable development but define "brownfield" differently. Specifically, the definitions of brownfield in the regeneration policies of countries with higher population densities usually promote recycling land that is previously developed, whether or not there is chemical contamination. Further, the de facto definition of brownfield used by the UK government focuses on previously developed land that is unused or underused. The ANOVA in this study revealed that local authorities in England (n = 296) with higher percentages of derelict and vacant land tended to be more deprived based on the English Indices of Multiple Deprivation, which evaluate deprivation from the aspects of income, employment, health, education, housing, crime, and living environment. However, the percentage of previously developed land in use but with further development potential had no significant effect on the deprivation conditions. The Blair-Brown Government (1997~2010) encouraged more than 60% of new dwellings to be established on the previously developed land in England. The analyses in this study showed that this target, combined with the definition of brownfield in the policy, may have facilitated higher densities of residential development on previously developed land but without addressing the deprivation problems. These observations indicate that a definition of brownfield in regeneration policies should focus on previously developed land that is now vacant or derelict if land recycling is to contribute to sustainable communities. |
| Molecules, Vol. 17, Pages 5139-5150: Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives Posted: 03 May 2012 12:00 AM PDT Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests. |
| Posted: 03 May 2012 12:00 AM PDT Antioxidant activity of a number of small (low molecular weight) natural compounds found in spices, condiments or drugs (gallic acid, sesamol, eugenol, thymol, carvacrol, vanillin, salicylaldehyde, limonene, geraniol, 4-hexylresorcinol, etc.) has been evaluated using electrochemical and DPPH• radical scavenging measurements. Structural analysis of the tested compound suggest a remarkable activity for phenol derivatives and the importance of the –R groups located on the phenolic ring in the molecule's ability to act as free radical scavenging as well as their influence in the electrochemical behavior. The voltammetric method can be used for the determination of the antioxidant capability in the same manner as the DPPH• radical scavenging because of the correlation found between oxidation potentials and anti-radical power (ARP = 1/EC50). Such electrochemical determination is fast and cheap and allows making measurements under a variety of experimental conditions. The accuracy of the electrochemical measurements is the same for all the compounds, irrespective of their scavenging activity, the opposite of what occurs in the DPPH• test. |
| Posted: 03 May 2012 12:00 AM PDT Silyl-substituted naphthalene derivatives at the 1- and 1,4-positions were synthesized and their UV absorption, fluorescence spectroscopic properties, and fluorescence lifetimes were determined. Analysis of the results shows that the introduction of silyl groups at these positions of the naphthalene chromophore/fluorophore causes shifts of the absorption maxima to longer wavelengths and increases in fluorescence intensities. Bathochromic shifts of the absorption maxima and increases in fluorescence intensities are also promoted by the introduction of methoxy and cyano groups at the naphthalene 4- and 5-positions. In addition, the fluorescence of 9,10-dicyanoanthracene is efficiently quenched by these naphthalene derivatives with Stern-Volmer plot calculated rate constants that depend on the steric bulk of the silyl groups. |
| Posted: 03 May 2012 12:00 AM PDT Five new 1-(2-(5-nitrofuran-2-yl)-5-(aryl)-1,3,4-oxadiazol-3-(2H)-yl) ethanone compounds 5a–e were synthesized by cyclization of N-acylhydrazones 4a–e with acetic anhydride under reflux conditions. Their structures were fully characterized by IR, 1H-NMR, and 13C-NMR. Furthermore, evaluations of the antibacterial activity of the 1,3,4-oxadiazoles 5a–e and N-acylhydrazones 4a–e showed strong activity against several strains of Staphylococcus aureus, with MICs between 4 μg/mL to 32 μg/mL. In silico studies of the parameters of Lipinski's Rule of Five, as well as the topological polar surface area (TPSA), absorption percentage (% ABS), drug likeness and drug score indicate that these compounds, especially 4a and 5d, have potential to be new drug candidates. |
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