| Games Britannia: Replayed brings new games and industry experts to Sheffield Posted: 28 Jun 2012 02:56 AM PDT  Games Britannia: Replayed is bringing some of the latest games and gaming experts to Sheffield, as well as tournaments and a chance to sample some of the greatest games the UK has ever produced. There's plenty more the weekend event is offering as well…
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| Dead or Alive 5 gets new Photo Mode for even better 'photographing'. Also, first shots of new character, Rig Posted: 28 Jun 2012 02:38 AM PDT  Dead or Alive has always been as much about the feminine wiles of its female leads as the fighting. Looks like the former's going to have an even bigger emphasis this time. Free cam replays and improved photo mode, anyone? And just in case you care, there's a new male character too.
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| IJMS, Vol. 13, Pages 8025-8037: High Resolution Crystal Structures of the Cerebratulus lacteus Mini-Hb in the Unligated and Carbomonoxy States Posted: 28 Jun 2012 12:00 AM PDT The nerve tissue mini-hemoglobin from Cerebratulus lacteus (CerHb) displays an essential globin fold hosting a protein matrix tunnel held to allow traffic of small ligands to and from the heme. CerHb heme pocket hosts the distal TyrB10/GlnE7 pair, normally linked to low rates of O2 dissociation and ultra-high O2 affinity. However, CerHb affinity for O2 is similar to that of mammalian myoglobins, due to a dynamic equilibrium between high and low affinity states driven by the ability of ThrE11 to orient the TyrB10 OH group relative to the heme ligand. We present here the high resolution crystal structures of CerHb in the unligated and carbomonoxy states. Although CO binds to the heme with an orientation different from the O2 ligand, the overall binding schemes for CO and O2 are essentially the same, both ligands being stabilized through a network of hydrogen bonds based on TyrB10, GlnE7, and ThrE11. No dramatic protein structural changes are needed to support binding of the ligands, which can freely reach the heme distal site through the apolar tunnel. A lack of main conformational changes between the heme-unligated and -ligated states grants stability to the folded mini-Hb and is a prerequisite for fast ligand diffusion to/from the heme. |
| IJMS, Vol. 13, Pages 7994-8024: Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics Posted: 28 Jun 2012 12:00 AM PDT Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N2 fixation, photorespiration or asparagine breakdown. A small gene family is encoding for different cytosolic (GS1) or plastidic (GS2) isoforms in legumes. We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production. Functional genomic analysis using GS2-minus mutant reveals the key role of GS2 in the metabolic control of the plants and, more particularly, in carbon metabolism. |
| IJMS, Vol. 13, Pages 7980-7993: Adsorption of Sodium Dodecyl Sulfate on Ge Substrate: The Effect of a Low-Polarity Solvent Posted: 28 Jun 2012 12:00 AM PDT This paper describes the adsorption of sodium dodecyl sulfate (SDS) molecules in a low polar solvent on Ge substrate by using Fourier transform infrared-attenuated total reflection (FTIR-ATR) spectroscopy and atomic force microscopy (AFM). The maximum SDS amount adsorbed is (5.0 ± 0.3) × 1014 molecules cm−2 in CHCl3, while with the use of CCl4 as subphase the ability of SDS adsorbed is 48% lower. AFM images show that depositions are highly disordered over the interface, and it was possible to establish that the size of the SDS deposition is around 30–40 nm over the Ge surface. A complete description of the infrared spectroscopic bands for the head and tail groups in the SDS molecule is also provided. |
| Polymers, Vol. 4, Pages 1331-1348: Tailoring Crystallinity of Electrospun Plla Fibres by Control of Electrospinning Parameters Posted: 28 Jun 2012 12:00 AM PDT Poly(L-lactic acid) (PLLA) fibers were fabricated by electrospinning. The effects of various electrospinning process parameters on the thermal properties, especially the crystallinity of the electrospun fibers were investigated. Thermal analysis of the fibers revealed that they exhibited degree of crystallinity ranging from 23% to 46% while that for the as-received granules was approximately 37%, suggesting that the crystallinity of electrospun PLLA fibres can be controlled by optimizing the electrospinning process. This finding is very important because crystallinity affects polymer properties such as degradation, stiffness, yield stress, modulus and tensile strength, solubility, optical and electrical properties which will in turn affect the behavior of these materials when they are utilized in energy, environment, defense and security applications. The results presented in this paper show that the degree of crystallinity of the electrospun fibers decreased with increasing the polymer solution concentration. Furthermore, an optimum electrospinning voltage at which maximum degree of crystallinity can be obtained was observed. At voltages higher or lower than the optimum electrospinning voltage, the degree of crystallinity will decrease or increase, respectively. The effect of the needle tip to collector distance (NTCD) on the degree of crystallinity follows no predictable and consistent pattern. |
| Radi 0.9 - Publish moving images using modern web standards.. (Free) Posted: 28 Jun 2012 03:02 AM PDT  Radi is the Mac application that lets you create visual elements for the web. Images, animations, vector graphics, video clips, realtime visual effects, JavaScript programming... With Radi, publishing moving images using modern web standards is suddenly incredibly easy.
Version 0.9: - Radi now supports realtime GPU-accelerated filters that are rendered in the browser using WebGL. For a better idea of what this means, check out the demos at: http://radiapp.com/webgl
- Improvements and fixes to event scripting in elements.
- Fixed bug where dragging a selection of multiple layers would only drag one of them.
- Fixed bug where a pattern's offset would not be correctly saved.
- Fixed bugs related to how elements react to document size changes.
Mac OS X 10.5.6 or later Download Now |
| Sleipnir 3.5.0.1 - Gesture focused web browser.. (Free) Posted: 28 Jun 2012 02:58 AM PDT  Sleipnir is a web browser for Mac with Smartphone and Web App Linker. Freely browse the web with the rich selection of functions in Sleipnir. With Sleipnir, you can experience web browsing never seen before. Enjoy the extremely simple design and the powerful operations that can be easily performed with just one hand. Speedy gestures: - You can operate tabs as if magic by using the multi-touch and mouse supported gesture - [TouchPaging]. You do not need to do all your daily browsing by clicking the small buttons on the screen because you can perform gestures such as switching, going to previous, and closing tabs with just one hand.
Main functions: - Switch tabs by swiping tabs left or right, or by right-clicking and moving the mouse.
- Operate tabs using a variety of gestures: Execute using touch operations or while holding down the right-click button.
- TiledTab: Pinch-in on the TrackPad to view a list of tabs.
- Hold And Go: Hold down on a link to open in the background.
- Ad Block.
- Tab groups for managing tabs.
- Sync bookmarks with other devices using Fenrir Pass.
- The standard full-screen with OS X 10.7.
Smartphone App Linker - All phone numbers are clickable when using Sleipnir. By simply clicking that phone number, it is sent to your smartphone, and you can start calling from your smartphone straight away.
- In order to user Smartphone App Linker, it is required that you download the free app Sleipnir Linker that can be used on iPhone / iPad and Android, and a Fenrir pass ID that can be obtained for free.
Web App Linker - Share: Twitter, Facebook, Google+, LinkedIn, Tumblr, Flickr.
- Save: Dropbox, Evernote, SkyDrive, SugarSync Read later: Readability, Instapaper, Pocket.
Version 3.5.0.1: Release notes were unavailable when this listing was updated. Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Totals 2.1.1 - Create stylish invoices and more.. (Demo) Posted: 28 Jun 2012 02:52 AM PDT  Totals is a full-featured invoice application for SOHO or business users. It has been designed from scratch to use the power and beauty of the Mac OS, while making life as easy as possible for its users. Very simple to use.
Totals is the combination of powerful features behind a simple user interface. Every single step, every single process is well-thought-out. Everything in one central location.
Totals has one window for each database. You will write invoices, estimates, create new catalogs, items, add clients, suppliers and even design layouts and many more in the same window. Key Features: - Creating invoices (also recurring, discounts, sequential invoices)
- User defined layouts
- Tracking payments
- Reports (Payments, Documents, Built-in stock count)
- PDF export and emailing (also with email templates)
- Smart Folders
- Write and track estimates
- Reminder for overdue invoices
- Flexible tax settings
- Foreign currency support
- Multiple businesses (multiple databases)
- Inventory management
- Drag & drop invoice creations
- Support for custom document types
- Custom fields
- Custom # (Number) Formatter
- Client specific settings
- Document processing (merge, convert, ...)
- Automatic margin calculation
Version 2.1.1: - ENHANCEMENT: Added DATE placeholder for account statements.
- ENHANCEMENT: Red marker for unsupported placeholder in Layout Designer.
- BUGFIX: Fixed the date format bug which was introduced in 2.1.
Mac OS X 10.6.8 or later Download Now |
| PDF Nomad 1.4.1 - PDF editor built for Mac.. (Demo) Posted: 28 Jun 2012 02:11 AM PDT  PDF Nomad is a modern, carefully styled PDF editor, built from the ground up for Mac OS X 10.7 Lion and later (it is Gatekeeper ready for OS X 10.8 Mountain Lion). It features a multitude of ways to take your PDF documents from one place to the next, through an easy to use interface. It provides often used operations like merging multiple documents, as well as more exotic ones like exporting the document's text as a spoken sound file. Tutorial videos are available on the SintraWorks website. Easily resize whole documents to a different page size with a single command, or resize individual pages with drag and drop, shifting page contents as needed. Export individual pages as bitmaps (jpg, png etc.) or create spoken audio files from the document's text. Split documents into even/odd pages, or explode documents into single page PDFs or even into individual chapters. Merge pages side by side or on top of each other. Split pages in half or tile them to print them onto multiple pages to be assembled into posters. Merge documents, interleave documents and even overlay documents on top of each other. Create and fill out PDF forms. Markup text and annotate pages with rectangles, ovals, arrows, lines and more. Add watermarks. Create books and magazines ready for printing. Add finishing/proofing marks if needed. Ever wanted to print a manual into a small booklet for easy reference, or need to prepare your novel or essay for your publisher? With PDF Nomad you'll have your document ready within a matter of minutes. Partial Feature List - Resize, merge, delete, reorder, split and tile pages.
- Merge, interleave and overlay PDF documents.
- Split and explode documents.
- Export pages as bitmap files or text as an audio file.
- Create and fill out PDF forms.
- Markup text and annotate pages.
- Create books and magazines.
- Create and edit outlines (including batch edits and automatic creation from table of contents.
- Stamp page labels onto pages.
- Shift page contents.
- Add finishing and proofing marks.
- Link index table and cross-document references to their corresponding pages.
Speed PDF Nomad is blindingly fast, even documents with thousands of pages are laid out in less than a second. Play with margin settings, or any other layout options: PDF Nomad's instant previews make it cheap to experiment.
Version 1.4.1: - Fixes an issue that could occasionally cause a crash when saving a file while the preview canvas is redrawing.
Mac OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Membranes, Vol. 2, Pages 346-366: Pure and Modified Co-Poly(amide-12-b-ethylene oxide) Membranes for Gas Separation Studied by Molecular Investigations Posted: 28 Jun 2012 12:00 AM PDT This paper deals with a theoretical investigation of gas transport properties in a pure and modified PEBAX block copolymer membrane with N-ethyl-o/p-toluene sulfonamide (KET) as additive molecules. Molecular dynamics simulations using COMPASS force field, Gusev-Suter Transition State Theory (TST) and Monte Carlo methods were used. Bulk models of PEBAX and PEBAX/KET in different copolymer/additive compositions were assembled and analyzed to evaluate gas permeability and morphology to characterize structure-performance relationships. |
| Cycle PDF Converter 1.5.0 - Convert PDF's to other formats.. (Shareware) Posted: 28 Jun 2012 02:01 AM PDT  Cycle PDF Converter, the powerful, easy-to-use, fast application has everything you need to convert PDF files to other document formats. It starts with an extremely simple and clear interface that lets you easily convert unlimited PDF files into 4 common document formats. You can convert PDF to Word to reuse the content more easily without typing or formatting the content manually; or convert PDF to PowerPoint for better presentation. Whatever you convert, Cycle PDF Converter will preserve the original text content, layouts, formatting, graphics as accurate as possible. Extremely simple - Preview PDF files within the application before conversion
- Clear interface guides you from the beginning to the end
- It takes only 3 steps to convert PDF.
Various output formats - Convert PDF to Microsoft Word (.docx) for flexible editing or content reusing
- Convert PDF files to stunning presentations (.pptx) in minutes
- Extract PDF to images (.jpg) for printing or reusing
- Copy text content from PDF to Text (.txt) without retyping manually
Fast - Import unlimited PDF files at one time.
- Convert PDF files in extremely high speed.
Accurate - Save your time by reducing the need to reformat or retype the output files by preserving almost all the original layouts, formatting, graphics, text and font styles.
Flexible ways to convert PDF - Convert any particular page range as you want
- Flow and Exact modes are available when converting PDF to Word
- Image quality can be adjusted when you convert PDF to image.
Note: If you only got images instead of editable content after converting PDF to Word or PowerPoint, which means your PDF might be a scanned one. To convert images to editable content requires OCR technology. Cycle PDF Converter does not support OCR now.
Version 1.5.0: What's new: - Optimized output image quality and conversion speed.
- Keep the correct text orientation after conversion.
- Other minor fixes and improvements.
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Molecules, Vol. 17, Pages 7864-7886: Tebrophen — An Old Polyphenol Drug with Anticancer Potential † Posted: 28 Jun 2012 12:00 AM PDT In vitro high-throughput screening was carried out in order to detect new activities for old drugs and to select compounds for the drug development process comprising new indications. Tebrophen, a known antiviral drug, was found to inhibit activities on inflammation and cancer related targets. In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 µM and 16 µM, respectively), as well as hydrolase DPPIV (at 80 µM 41% inhibition). Next, it showed no cytotoxic effects on standard cell lines within 24 h. However, tebrophen slowed propagation of breast cancer (MDA-MB-231), osteosarcoma (U2OS) and cervical carcinoma (HeLa), through at least 35 population doublings in a dose-dependent manner. It completely stopped the division of the prostate cancer (PC3) cell line at 50 µM concentration and the cells entered massive cell death in less than 20 days. On the other hand, tebrophen did not influence the growth of normal fibroblasts. According to the measured oxidative burst and estimated in silico parameters its direct antioxidative ability is limited. The obtained results indicate that tebrophen can be considered a promising lead molecule for generating more soluble derivatives with specific anticancer efficacy. |
| Fortora Fresh Finance 1.7.6 - Personal finance solution.. (Demo) Posted: 28 Jun 2012 01:35 AM PDT  Fortora Fresh Finance is the straightforward personal finance software for everyone, simple yet powerful. Easily manage your personal finances, such as balancing the checkbook, keeping track of credit cards, bill reminders, budgeting and more. Generate reports to see where your money is going, and make tax time easy. The streamlined user interface has an easy learning curve, and you will be up and running in a matter of minutes. Version 1.7.6: New Features: - Now displays current unassigned amount when working with category split items.
Fixes: Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Big in Japan June 18-24: Pokemon Black/White 2 Posted: 28 Jun 2012 01:13 AM PDT New iteration to Pokemon Black/White bumps PS Vita RPG from top spot; PS Vita sales cool down. 
Nintendo's Pokemon series never fail to grab Japan by storm sales-wise, and the latest update to the Media Creates sales chart proves to be no exception. Pokemon Black 2 and Pokemon White 2 for the Nintendo DS took first place on the top 10, bumping down former top dog Persona 4: Golden with 1,561,738 units combined. The new versions of Pokemon Black and Pokemon White introduce new locations in the southwest part of the Unova region, a Pokemon World Tournament that lets players fight every gym leader and champion from past generations of the series, and a Pokewood scenario that lets players pit Pokemon in movies. Persona 4: Golden was bumped down to third place with 29,293 units sold. Tokyo Jungle clung onto fifth place with 18,715 units sold to slot in at five, while The PS3 versions of Dragon's Dogma and Lollipop Chainsaw capped off the end of the top 10 list with 9,162 units and 7,898 units sold, putting them at nine and ten respectively. New titles that made their mark for the week were Kenka Bancho Bros. Tokyo Battle Royale for the PSP which sold 21,797 units and took fourth spot, and K-On After School Live!! HD version for the PS3 which sold 13,581 units to place at six. The former is an action game styled like a classic beat-em-up where players control one of the two brothers who has to clean up Tokyo of crime. The latter is an HD update of a PSP rhythm game based on the hit anime series. On the hardware front, the PlayStation Vita lost its momentum from its previous sales record and dropped down to 13,589 units as a result. The 3DS got a slight increase in sales to 68,056 units. Top Game Sales of Japan For June 18 to June 24 Software
Rank / Title / Publisher / System / Units
1. Pokemon Black/ White 2 / Nintendo / DS / 1,561,738
2. Dragon Quest Monsters : Terry's Wonderland 3D / Square Enix / 3DS / 58,228
3. Persona 4 The Golden / Atlus / PS Vita / 29,293
4. Kenka Bancho Bros. Tokyo Battle Royale / Spike Chunsoft / PSP / 21,797
5. Tokyo Jungle / Sony / PS3 / 18,715
6. K-ON After School Live!! HD Version / Sega / PS3 / 13,581
7. Mario Party 9 / Nintendo / Wii / 13,339
8. Mario Tennis Open / Nintendo / 3DS / 13,036
9. Dragon's Dogma / Capcom / PS3 / 9,162
10. Lollipop Chainsaw / Kadokawa / PS3 / 7,898 Hardware Unit Sales
3DS: 68,056
PS3: 15,680
PS Vita: 13,589
PSP: 8,954
Wii: 6,127
Xbox 360: 1,073
PS2: 1,065
DSi: 900
DSi XL: 704 Read and Post Comments | Get the full article at GameSpot
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| DayZ Diaries - Part 1 Posted: 27 Jun 2012 08:48 PM PDT Ed and Randy jump into the popular ArmA II mod for the first time and learn how to play the only way they know how: by running. A tension and surprise-filled journey with an ending full of gravitas. Please leave us any tips you have, and follow GameSpot_AU on Twitch! 
Read and Post Comments | Get the full article at GameSpot
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| Game Masters: Peter Molyneux Posted: 27 Jun 2012 08:01 PM PDT |
| ACMI Game Masters - Peter Molyneux Posted: 27 Jun 2012 07:59 PM PDT |
| Macsome iTunes Converter for Mac 1.5.6 - Convert DRM protected music to unprotected formats.. (Shareware) Posted: 28 Jun 2012 01:16 AM PDT  Macsome iTunes Converter can easily convert DRM protected music and various audio files to unprotected MP3, AAC formats playable on any iPod, iPod Touch, iPhone, Zune, PSP, Creative Zen and other MP3 players at high speed and CD quality. Convert M4P to MP3, AA to MP3 or AAC in 5X fast speed, with ID Tags preserved on Mac OS X. iTunes M4P to MP3 Converter, Audible AA to MP3 or AAC converter. Version 1.5.6: - Supports multiple iTunes Libraries
- Minor bugs fixed.
- Mac OS X 10.4 or later
- iTunes 8 or later
Download Now This posting includes an audio/video/photo media file: Download Now |
| Staff Security Training: Be Original Posted: 28 Jun 2012 12:26 AM PDT IT Governance Ltd, the leading expert in ISO27001 and information security management solutions, is advising organisations to strengthen the weakest link in their information security posture by increasing the ability of their staff to recognise and respond to cyber threats. |
The Story of Red Cloud is a massive adventure-style mod for the sandbox building game Terraria. Citing inspiration from The Legend of Zelda and Dark Souls, the mod takes a massive step away from its source, knocking out most of the creative aspects in favor of traditional combat and exploration. This isn't the Terraria you've grown to love, nor is it a happy romp through a flower-filled land of bunnies (though there are bunnies). The Story of Red Cloud is a challenging game filled with secrets to find, items to hoard, dungeons to explore, and gruesome deaths to narrowly avoid. Tagged as: action, adventure, free, game, indie, mod, rating-o, rpg, thjersted, windows
You suddenly wake up in a strange world. Travel through time and collect crystals in various levels!
Abandoned in a lonely space station, do whatever you can in order to escape. Change gravity in order to survive.
