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- Molecules, Vol. 17, Pages 7217-7231: Synthesis and Biological Evaluation of Thiophene Derivatives as Acetylcholinesterase Inhibitors
- Sensors, Vol. 12, Pages 8157-8175: Improved Iterative Calibration for Triaxial Accelerometers Based on the Optimal Observation
- Sensors, Vol. 12, Pages 8145-8156: Accuracy and Precision of Equine Gait Event Detection during Walking with Limb and Trunk Mounted Inertial Sensors
- Sensors, Vol. 12, Pages 8135-8144: Novel Platform Development Using an Assembly of Carbon Nanotube, Nanogold and Immobilized RNA Capture Element towards Rapid, Selective Sensing of Bacteria
- Sensors, Vol. 12, Pages 8112-8134: Process-in-Network: A Comprehensive Network Processing Approach
- Molecules, Vol. 17, Pages 7206-7216: Liquiritigenin Inhibits Tumor Growth and Vascularization in a Mouse Model of Hela Cells
- Monster Physics
- QuarkXpress Spotlight Plugin 1.0 - Enables Spotlight searching of QuarkXPress Documents.. (Commercial)
- Action Script Spotlight Plugin 1.0 - Enables Spotlight searching of ActionScript and MXML Files.. (Commercial)
- New Little King's Story - Screenshots
- Karaoke Joysound - Screenshots
- Sci-Fi Heroes - Screenshots
- Disk Order 3.22 - Advanced file manager with CD recording.. (Shareware)
- Molecules, Vol. 17, Pages 7195-7205: Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway
- Molecules, Vol. 17, Pages 7183-7194: Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (Saussurea laniceps) Herb
- Molecules, Vol. 17, Pages 7169-7182: Effect of Frozen Storage on Molecular Weight, Size Distribution and Conformation of Gluten by SAXS and SEC-MALLS
- Crystals, Vol. 2, Pages 669-674: Non-Covalent Interactions in the Crystal Structure of Methyl 4-Hydroxy-3-Nitrobenzoate
- Crystals, Vol. 2, Pages 662-668: Single-Component Charge-Transfer Crystals Based on Spin-Carrying TCNQ (7,7,8,8-Tetracyanoquinodimethane) Derivatives
- Entropy, Vol. 14, Pages 1028-1044: Combined Effect of Buoyancy Force and Navier Slip on Entropy Generation in a Vertical Porous Channel
- Antibiotics, Vol. 1, Pages 1-13: Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs
| Posted: 12 Jun 2012 12:00 AM PDT A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman's method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Methoxyphenyl)piperazin-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (IIId) showed 60% inhibition, compared to only 40% inhibition by donepezil. |
| Posted: 12 Jun 2012 12:00 AM PDT This paper presents an improved iterative nonlinear calibration method in the gravitational field for both low-grade and high-grade triaxial accelerometers. This calibration method assumes the probability density function of a Gaussian distribution for the raw outputs of triaxial accelerometers. A nonlinear criterion function is derived as the maximum likelihood estimation for the calibration parameters and inclination vectors, which is solved by the iterative estimation. First, the calibration parameters, including the scale factors, misalignments, biases and squared coefficients are estimated by the linear least squares method according to the multi-position raw outputs of triaxial accelerometers and the initial inclination vectors. Second, the sequence quadric program method is utilized to solve the nonlinear constrained optimization to update the inclination vectors according to the estimated calibration parameters and raw outputs of the triaxial accelerometers. The initial inclination vectors are supplied by normalizing raw outputs of triaxial accelerometers at different positions without any a priori knowledge. To overcome the imperfections of models, the optimal observation scheme is designed according to some maximum sensitivity principle. Simulation and experiments show good estimation accuracy for calibration parameters and inclination vectors. |
| Posted: 12 Jun 2012 12:00 AM PDT The increased variations of temporal gait events when pathology is present are good candidate features for objective diagnostic tests. We hypothesised that the gait events hoof-on/off and stance can be detected accurately and precisely using features from trunk and distal limb-mounted Inertial Measurement Units (IMUs). Four IMUs were mounted on the distal limb and five IMUs were attached to the skin over the dorsal spinous processes at the withers, fourth lumbar vertebrae and sacrum as well as left and right tuber coxae. IMU data were synchronised to a force plate array and a motion capture system. Accuracy (bias) and precision (SD of bias) was calculated to compare force plate and IMU timings for gait events. Data were collected from seven horses. One hundred and twenty three (123) front limb steps were analysed; hoof-on was detected with a bias (SD) of −7 (23) ms, hoof-off with 0.7 (37) ms and front limb stance with −0.02 (37) ms. A total of 119 hind limb steps were analysed; hoof-on was found with a bias (SD) of −4 (25) ms, hoof-off with 6 (21) ms and hind limb stance with 0.2 (28) ms. IMUs mounted on the distal limbs and sacrum can detect gait events accurately and precisely. |
| Posted: 12 Jun 2012 12:00 AM PDT This study examines the creation of a nano-featured biosensor platform designed for the rapid and selective detection of the bacterium Escherichia coli. The foundation of this sensor is carbon nanotubes decorated with gold nanoparticles that are modified with a specific, surface adherent ribonucleiuc acid (RNA) sequence element. The multi-step sensor assembly was accomplished by growing carbon nanotubes on a graphite substrate, the direct synthesis of gold nanoparticles on the nanotube surface, and the attachment of thiolated RNA to the bound nanoparticles. The application of the compounded nano-materials for sensor development has the distinct advantage of retaining the electrical behavior property of carbon nanotubes and, through the gold nanoparticles, incorporating an increased surface area for additional analyte attachment sites, thus increasing sensitivity. We successfully demonstrated that the coating of gold nanoparticles with a selective RNA sequence increased the capture of E. coli by 189% when compared to uncoated particles. The approach to sensor formation detailed in this study illustrates the great potential of unique composite structures in the development of a multi-array, electrochemical sensor for the fast and sensitive detection of pathogens. |
| Sensors, Vol. 12, Pages 8112-8134: Process-in-Network: A Comprehensive Network Processing Approach Posted: 12 Jun 2012 12:00 AM PDT A solid and versatile communications platform is very important in modern Ambient Intelligence (AmI) applications, which usually require the transmission of large amounts of multimedia information over a highly heterogeneous network. This article focuses on the concept of Process-in-Network (PIN), which is defined as the possibility that the network processes information as it is being transmitted, and introduces a more comprehensive approach than current network processing technologies. PIN can take advantage of waiting times in queues of routers, idle processing capacity in intermediate nodes, and the information that passes through the network. |
| Posted: 12 Jun 2012 12:00 AM PDT Angiogenesis is one of the crucial steps in the transition of a tumor from a small, harmless cluster of mutated cells to a large, malignant growth, capable of spreading to other organs throughout the body. Vascular endothelial growth factor (VEGF) that stimulates vasculogenesis and angiogenesis is thought to be as an anti-angiogenic target for cancer therapy. Liquiritigenin (LQ), a flavanone existing in Radix glycyrrhiza, shows extensive biological activities, such as anti-inflammatory and anti-cancer properties. In our studies, liquiritigenin effectively inhibited the growth of tumors xenografted in nude mice from human cervical cancer cell line HeLa cells, and microvascular density (MVD) of the tumor exposed to liquiritigenin was reduced in a dose dependent manner, especially in the high dose group. Moreover, the expression and secretion of VEGF were down-regulated by the drug in vivo and in vitro. Therefore, liquiritigenin can be further studied on cancer and other diseases associated with VEGF up-regulation. |
| Posted: 10 Jun 2012 04:50 PM PDT Platform: iOS —  Monster Physics is a bright colorful physics game for the whole family. Create a unique creature and propel it through level after level of physics puzzles. Using the intuitive controls, grab parts to create anything from a simple car to a complex rocket ship to help you reach the level goal. There are endless combinations of parts, and many different ways to solve each level, which means hours of great gameplay. Tagged as: drussellpinson, game, ios, ipad, iphone, mobile, physics, puzzle, rating-g |
| Posted: 12 Jun 2012 03:00 AM PDT  QuarkXpress Spotlight Plugin extends the default set of file types supported by SpotLight to include QuarkXpress Documents. SpotLightQXP would enable you to search contents of QuarkXPress documents such as text, font names, style sheets, and layouts. All features are available to users of QuarkXPress 6 and later. Performs searches for the following matches:
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| Posted: 12 Jun 2012 02:57 AM PDT  Action Script Spotlight Plugin extends the default set of file types supported by SpotLight to include ActionScript and MXML Files. SpotlightAS would enable you to search within contents of ActionScript and MXML Files. Features:
Version 1.0:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| New Little King's Story - Screenshots Posted: 12 Jun 2012 03:48 AM PDT Key Features: • A Brand New Storyline – Fans and new players alike can experience a reimagining of Little King's Story, featuring King Corobo! Save royal princesses, travel unknown lands and conquer your new enemy, "The Nightmare." • Enhanced PS Vita Graphics and Features – Experience an ever-changing 24-hour world filled with upgraded 2D and 3D visuals and utilizes intuitive touch controls, including the PS Vita rear touch pad. • Lead Massive Armies and Build Your Kingdom – Make your plan of attack! Use your scouting ability to organize your citizens based on their job skills and lead your army's battle formations. • New Online Functionality to Enhance Your Game play Experience – Enjoy a myriad of newly added online features including downloadable content, item combining co-operative play, and online leader boards! |
| Karaoke Joysound - Screenshots Posted: 12 Jun 2012 03:15 AM PDT Key Features: • Access Streaming Music Content to Extend Your Game Experience – Utilizing Joysound's internet streaming service where players can purchase Wii "rental" tickets to access over 1,000 songs, with new songs added monthly! • 24 hour Ticket: 500 Wii Points • 3 Day Ticket: 1000 Wii Points • 30 Day Ticket: 3000 Wii Points • Sing to Today's Hits and Popular Classics – Play through over 30 songs from every genre! • Enjoy Extensive Customizations – Select your avatar and set the stage for your performances. Earn points as you sing so that you can customize outfits, stages, and backgrounds! • Battle in Multiplayer Mic Competitions – Enjoy mini-games for up to 8 players using the mic and Wii remotes to control your avatar, and participate in interactive mini-games using your voice! |
| Posted: 12 Jun 2012 03:06 AM PDT Key Features - Socialize in Space: Outer-space explorers can fight alongside friends in Sci-Fi Heroes' innovative Social Raids. Select a friend to help complete a quest and share in the spoils. Send them rare items as gifts, invite friends to join Social Raids, or compare high scores from the Arena. - Fight through Outer-Space: Battle across more than 40 levels on four different planets each containing unique enemies, landscapes and bosses! - Many Will Enter; One Will Win: Players will pit their skills against seemingly never-ending waves of enemy forces in arena battles. If players want their rare loot, they are going to have to fight for it! - Choose a Hero: Players can choose from eight hero classes including Space Marine, Priest, Space Cowboy and Futuristic Healbot. - Space Loot: Players will have the ability to save the galaxy the way they want to with an endless amount of upgrades that can be unlocked with coins or credits including: Weapons/Armor/Trinkets: Players can outfit their entire party with customizable weapons, armors, and trinkets to wipe out the bad guys in true heroic fashion. Boosts: Players can purchase a variety of in-game boosts to help take on the next level of foes. Buffs: Heroes will want to stock up on in-game buffs so they won't be caught in a sticky situation without a resurrection pill or skill recharge. |
| Disk Order 3.22 - Advanced file manager with CD recording.. (Shareware) Posted: 12 Jun 2012 02:19 AM PDT  Disk Order makes file management easy, fast and fun on your Mac . It allows to save time on every step and gives you a great file-management power. Disk Order is an advanced Finder replacement with built-in FTP client and ability to handle archives like plain folders. This makes file management much faster then it has been before, because now you don't have to launch separate applications to connect to FTP server, batch rename files, or extract some data out of .zip, .gz, .tgz archive. All these tasks may be performed within Disk Order with just few mouse clicks. Also, Disk Order offers all usual features, such as Get Info, Copy/Move/Delete, View, Edit and so on. Disk Order is fast and stable, works great on both Intel-based and PowerPC Macs. Use the double-pane interface to:
Version 3.22:
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| Posted: 12 Jun 2012 12:00 AM PDT Intestinal ischemia reperfusion (IIR) is a serious clinical condition associated with simultaneous multiple organ dysfunction. The aim of this study was to investigate the effects of ginsenoside Rb1 on IIR induced renal injury in mice. An intestinal ischemia reperfusion mouse model was established by superior mesenteric artery (SMA) occlusion for 45 min, followed by reperfusion for 2 h. IIR induced renal injury characterized by increase of BUN, Cr and NGAL in serum, MDA levels and decrease of SOD levels in the renal tissues. Ginsenoside Rb1 (30, 60 mg/kg) given intraperitoneally before reperfusion attennuated renal injury, which was associated with decrease of BUN, Cr and NGAL in serum, MDA levels and increase of SOD levels in the renal tissues. Furthermore, the immunohistochemistry and Western blot data showed that ginsenoside Rb1 dramatically reversed IIR induced renal injury, associated with upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in renal tissues. Our data suggests that ginsenoside Rb1 attenuates acute renal injury induced by intestinal ischemia reperfusion by activating the Nrf2/ARE pathway. |
| Posted: 12 Jun 2012 12:00 AM PDT To understand the impacts of different processing methods on the composition and effects of the herb Saussurea laniceps (SL), the present study report the first comparison of the chemical constituents of aqueous and ethanolic SL extracts using chromatographic analysis, and to compare their pharmacological effects in a mouse anti-inflammatory, anti-nociceptive model and an in vitro anti-oxidant test. Chemical comparison demonstrated that the types of chemicals in the two extracts were identical, but the contents of the main constituents in the aqueous extract were lower than those of the ethanolic extract. A transesterification of dicaffeoylquinic acids took place in the aqueous extract during boiling. As for pharmacological effects, oral administration of aqueous and ethanolic SL extracts significantly inhibited croton oil-induced mice ear edema, and significantly inhibited acetic acid-induced mice writhings, respectively. In the DPPH anti-oxidant activity test, the IC50 values were calculated as 409.6 mg/L and 523.4 mg/L for the ethanolic and aqueous extracts, respectively. The inhibitory effects of the ethanolic extract were more potent than those of the aqueous extract in all pharmacological tests, although there was no significant difference. This study suggests that the two preparations should be distinguished when used. |
| Posted: 12 Jun 2012 12:00 AM PDT In this study, the effects of frozen (−18 °C) storage time on molecular weight, size distribution, conformation, free amino groups and free sulfhydryl groups of gluten were studied by small-angle X-ray scattering (SAXS), multi-angle laser light scattering (MALLS) in conjunction with a size exclusion chromatography (SEC) and spectrophotometrically. The results showed that the gluten dissolved in 50 mM acetic acid appeared to be similar to quasi-spherical of the chain conformation and the slope of the conformation plot decreased during the storage. Both the molecular weight and radius of gyration of the frozen gluten decreased with the storage time showing a depolymerization in the high molecular weight fraction of gluten (105 Da ~ 109 Da). Therefore, at constant molecular weight the change of the chain conformation did not show a clear correlation with the storage time. The free amino groups content changed little and the free sulfhydryl groups content of the gluten increased from 9.8 μmol/g for the control to 12.87 μmol/g for 120-day-stored gluten, indicating that the water redistribution and ice recrystallization lead to the breakage of the disulphide bonds and may be one of the reasons for the depolymerization of gluten polymer. |
| Posted: 12 Jun 2012 12:00 AM PDT Methyl 4-hydroxy-3-nitrobenzoate, (I), C8H7NO5, crystallizes with two unique molecules, A and B, in the asymmetric unit of the triclinic unit cell. The space group was assigned as P-1, with lattice parameters a = 0.72831(15), b = 1.0522(2), c = 1.1410(2) nm, α = 83.38(3), β = 80.83(3), γ = 82.02(3)°, Z = 4, V = 0.8510(3) nm3, Mr = 197.15, Dc = 1.539 g/m3, µ= 0.131 mm−1, F(000) = 408, R = 0.1002 and wR = 0.2519. In the crystal structure, 12 hydrogen bonding and two p-stacking interactions link the molecules into infinite stacked sheets parallel to (101). |
| Posted: 12 Jun 2012 12:00 AM PDT Three TCNQ derivatives carrying nitroxide radicals (3a–3c) were prepared and were found to form single-component charge-transfer (CT) complexes by self-assembly, in which outer nitroxide groups of a couple of different molecules work as donors and the inner TCNQ unit of another molecule as an acceptor. While the CT interactions found for the TEMPO (2,2,6,6-tetramethylpiperidin-1-oxy) derivative 3a and the PROXYL (2,2,5,5-tetramethylpirrolidin-1-oxy) derivative 3b are point-to-face fashion between the oxygen atom of each nitroxide group and the six-membered ring of inner TCNQ unit, the CT interactions found for the PO (2,2,5,5-tetramethyl-3-pyrrolin-1-oxy) derivative 3c are point-to-point contacts between the oxygen atoms of outer nitroxide groups and the carbon atoms of a couple of cyano groups. |
| Posted: 12 Jun 2012 12:00 AM PDT In this paper, we investigate the combined effects of buoyancy force and Navier slip on the entropy generation rate in a vertical porous channel with wall suction/injection. The nonlinear model problem is tackled numerically using Runge–Kutta–Fehlberg method with shooting technique. Both the velocity and temperature profiles are obtained and utilized to compute the entropy generation number. The effects of slip parameter, Brinkmann number, the Peclet number and suction/injection Reynolds number on the fluid velocity, temperature profile, Nusselt number, entropy generation rate and Bejan number are depicted graphically and discussed quantitatively. |
| Posted: 12 Jun 2012 12:00 AM PDT By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research—such as neurology, oncology and virology—the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is to classify the compounds already used in therapy and prepare the schematic structure that includes the next generation of TCs. The second aim of this work is to introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of those drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. The lipophilicity and the conformational interchangeability of the functional groups are employed to develop the rules for TC biological activity. |
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