Games |
- Cefipx 2.00 - Transfer media from an iOS device to your Mac.. (Shareware)
- UK-wide workshops on how to talk to your MP about Internet spying and censorship
- Tories divided over UK spying bill, Home Secretary dismisses critics as "conspiracy theorists" who want to protect freedom for "criminals, terrorists and paedophiles"
- Birds of Steel - Screenshots
- AASync 3.6.4.8 - File backup and folder sync utility.. (Demo)
- Molecules, Vol. 17, Pages 7379-7386: Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription
- Molecules, Vol. 17, Pages 7356-7378: A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids
- IJMS, Vol. 13, Pages 7383-7392: Aroma Volatile Compounds from Two Fresh Pineapple Varieties in China
- IJMS, Vol. 13, Pages 7375-7382: New Antifungal Pyranoisoflavone from Ficus tikoua Bur.
- IJMS, Vol. 13, Pages 7365-7374: Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System
- Rex Verbi 1.0 - Multi-player virtual vocabulary board game.. (Commercial)
- Shimo 3.0.6 - Advanced VPN client for Mac.. (Shareware)
- Symphony of the Origin - Screenshots
- Archiver 1.2.1 - Open, create, and convert archives.. (Shareware)
- Odysseus: Long Way Home 1.0 - Adventure puzzle game.. (Demo)
- FAX90 Client 1.2.0.3.0 - Hylafax desktop client.. (Free)
- IJMS, Vol. 13, Pages 7354-7364: Solution NMR Structure of Hypothetical Protein CV_2116 Encoded by a Viral Prophage Element in Chromobacterium violaceum
- TuneupMyMac 1.3.540 - Clean, secure and optimize your Mac.. (Shareware)
- PlugSpy 1.2.7 - Protect your Mac from unauthorised access.. (Commercial)
- Big in Japan June 4-10: Tokyo Jungle
Cefipx 2.00 - Transfer media from an iOS device to your Mac.. (Shareware) Posted: 14 Jun 2012 03:37 AM PDT Cefipx is an iPod and iOS device to Mac transfer, iPhone file browser, iPad file explorer. Cefipx transfers music and videos from iPod and iOS devices to mac computer, which is for recover music library from an iPod or iOS device. With Cefipx, you can copy all music songs and videos on your iDevice to any folder on mac and iTunes with one click. Additionally, you can preview and play songs on iDevice with Cefipx. Cefipx helps you to explore file system on iPhone, iPad and iPod Touch. You can easily move files from iOS device to mac computer. And the disk mode makes it possible to use an iOS device as USB flash disk, move files by easy drag and drop. Cefipx works great with iOS 5. Version 2.00:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
UK-wide workshops on how to talk to your MP about Internet spying and censorship Posted: 14 Jun 2012 03:41 AM PDT As the UK government ramps up to pass the snooper's charter -- a sweeping, unaccountable regime of tax-funded, warrantless snooping on all online activity -- the Open Rights Group is offering workshops across the country on how to talk to your MP about this proposal. Workshops are coming up in London, Edinburgh, Manchester, Sheffield, Birmingham and Bristol.
Censorship and Surveillance Campaign Training (Disclosure: I am proud to have co-founded the Open Rights Group and to volunteer on its advisory board) |
Posted: 14 Jun 2012 03:35 AM PDT Alan Travis writes in The Guardian:
38 Degrees has an online petition to stop the proposal, which stands at over 164,000 right now. 'Snoopers' charter' proposal sparks Tory row (Image: Home Secretary meets police in South London, a Creative Commons Attribution (2.0) image from 49956354@N04's photostream) |
Posted: 14 Jun 2012 04:32 AM PDT Birds of Steel offers 20 historical and a wealth of fictitious missions, spanning eight world-famous campaigns, and users are given access to over 100 famous planes from the entire axis and allied forces rosters. A number of planes ideal for each campaign can be selected, and have been faithfully recreated in terms of handling, capabilities and weaponry. The classic Spitfire, P-51D Mustangs, and Messerschmidt 109 are all lined up for combat, as players opt to player opt to fight for the Allies, Japanese or Axis forces. The game features a breath-taking level of detail, with the weather effects of each war zone brilliantly brought to life, while the handling and battle-scarred planes are susceptible to damage and will suffer in terms of control accordingly. Similarly, a series of camera views allow users to witness their skills from a series of external views, or within the varied cockpits of the 100 planes. The missions are presented in a pre-conflict briefing, and players can also see how their contributions related to the overall path of the scenario, with new planes available on the completion of specific goals. Birds of Steel also offers the user a number of control systems, ranging from simplistic arcade-style movements, to entirely faithful control systems that offer total control over every aspect of flight. |
AASync 3.6.4.8 - File backup and folder sync utility.. (Demo) Posted: 14 Jun 2012 03:23 AM PDT AASync is a file backup and folder sync utility. Running a small business and need secure off-site backups for your intellectual property? Need security and easy access to your data at a low cost? Have Macs and PC's in your office and want to avoid the high cost of training on both? We can help you! With AASync, there is no need for any special (read: expensive) server software! Make internet backups of your private data which is available from anywhere, WITHOUT compromising your data security. Perfect for small business and people on the go! AAsync is the only full featured folder sync app that runs on both Mac and Windows. Version 3.6.4.8: For Mac OS X 10.6 use this version (32/64 bit fat)
Download Now |
Posted: 14 Jun 2012 12:00 AM PDT Apolipoprotein A-I (Apo A-I) is the principal protein component of high density lipoprotein (HDL), which is generally considered as a potential therapeutic target against atherosclerosis. The understanding of the Apo A-I regulation mechanism has fuelled the development of novel HDL targeted therapeutic approaches. To identify novel agents that can upregulate Apo A-I expression, we performed a cell-based reporter assay to screen 25,600 small molecules. Based on the dataset obtained from screening, a series of novel analogs of substituted benzamides containing azaspiro rings were assessed for their ability to induce the transcription of the Apo A-I gene, and the structure-activity relationship (SAR) around these analogs was also proposed. The results indicated that the trifluoromethyl substituted benzamide containing an azaspiro ring is a promising backbone for designing Apo A-I transcriptional upregulator and could be viable leads for development of new drugs to prevent and treat atherosclerosis in the future. |
Posted: 14 Jun 2012 12:00 AM PDT We report a new method for the preparation of chiral 2-aryl-2-fluoropropanoic acids, including 2-fluoroibuprofen, a fluorinated analogue of non-steroidal anti-inflammatory drugs (NSAIDs), by the kinetic resolution of racemic 2-aryl-2-fluoropropanoic acids using enantioselective esterification. By applying pivalic anhydride (Piv2O) as a coupling agent, bis(α-naphthyl)methanol [(α-Np)2CHOH] as an achiral alcohol, and (+)-benzotetramisole (BTM) as a chiral acyl-transfer catalyst, a series of racemic 2-aryl-2-fluoropropanoic acids were kinetically separated to afford the optically active carboxylic acids and the corresponding esters with good to high enantiomeric excesses. This technology can provide a convenient approach to furnish the chiral α-fluorinated drugs containing quaternary carbons at the α-positions in the 2-aryl-2-fluoropropanoic acid structure. |
IJMS, Vol. 13, Pages 7383-7392: Aroma Volatile Compounds from Two Fresh Pineapple Varieties in China Posted: 14 Jun 2012 12:00 AM PDT Volatile compounds from two pineapples varieties (Tainong No.4 and No.6) were isolated by headspace solid phase microextraction (HS-SPME) and identified and quantified by gas chromatography-mass spectrometry (GC/MS). In the Tainong No. 4 and No. 6 pineapples, a total of 11 and 28 volatile compounds were identified according to their retention time on capillary columns and their mass spectra, and quantified with total concentrations of 1080.44 µg·kg−1 and 380.66 µg·kg−1 in the Tainong No.4 and No. 6 pineapples, respectively. The odor active values (OAVs) of volatile compounds from pineapples were also calculated. According to the OAVs, four compounds were defined as the characteristic aroma compounds for the Tainong No. 4 pineapple, including furaneol, 3-(methylthio)propanoic acid methyl ester, 3-(methylthio)propanoic acid ethyl ester and δ-octalactone. The OAVs of five compounds including ethyl-2-methylbutyrate, methyl-2-methylbutyrate, 3-(methylthio)propanoic acid ethyl ester, ethyl hexanoate and decanal were considered to be the characteristic aroma compounds for the Tainong No. 6 pineapple. |
IJMS, Vol. 13, Pages 7375-7382: New Antifungal Pyranoisoflavone from Ficus tikoua Bur. Posted: 14 Jun 2012 12:00 AM PDT Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (1H-1H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MSn analyses. The antifungal activities of 1–3 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC50 values were 262.442, 198.153 and 90.365 µg·mL−1, respectively. |
Posted: 14 Jun 2012 12:00 AM PDT The single-stranded RNA encephalomyocarditis virus (EMCV) can replicate in the central nervous system (CNS) and lead to prominent brain lesions in the stratum pyramidale hippocampus and the stratum granulosum cerebelli. Activated microglia cells infected by EMCV produce a massive burst of reactive oxygen species (ROS) via NADPH oxidase 2 (NOX2) activation, leading to neuronal death. Balancing this effect is mechanisms by which ROS are eliminated from the CNS. Cellular prion protein (PrPC) plays an important antioxidant role and contributes to cellular defense against EMCV infection. This review introduces recent knowledge on brain injury induced by EMCV infection via ROS generation as well as the involvement of various mediators and regulators in the pathogenesis. |
Rex Verbi 1.0 - Multi-player virtual vocabulary board game.. (Commercial) Posted: 14 Jun 2012 03:07 AM PDT Rex Verbi is a word game where you compete to build the most valuable words! The board can be changed to fit orthodox players as well as those seeking a new experience! Play against your friends in "hot seat" mode or solo against any of the three computer personalities. You can play on one of the six boards that comes with the game or create your own boards with the board editor. The tile distribution can also be tweaked to fit your boards. Dictionaries for ENGLISH, FRENCH, DANISH, NORWEGIAN, DUTCH, ITALIAN and FINNISH! Mac OS X 10.6 or later Download Now |
Shimo 3.0.6 - Advanced VPN client for Mac.. (Shareware) Posted: 14 Jun 2012 03:02 AM PDT Shimo is the most advanced VPN client for the Mac platform and supports more protocols than any other VPN application out there! CiscoVPN, AnyConnect, IPSec, OpenVPN, PPTP/L2TP, Nortel, Juniper and even SSH are no problem to handle for Shimo. Shimo is able to automate everything around your secure network connections: Establish connections automatically when you change your network location, execute AppleScripts on certain events or get notified about these events. This is just a very small excerpt of Shimo's capabilities. Feel free to download Shimo from our website and find out about its extraordinary feature set. The downloadable version comes without any restrictions and therefore you are able to find out if it suits your personal requirements before you buy a license! Version 3.0.6:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
Symphony of the Origin - Screenshots Posted: 14 Jun 2012 04:00 AM PDT |
Archiver 1.2.1 - Open, create, and convert archives.. (Shareware) Posted: 14 Jun 2012 02:55 AM PDT Archiver makes opening, creating and converting archives easy as pie. Features:
Version 1.2.1:
Mac OS X 10.6 or later Download Now |
Odysseus: Long Way Home 1.0 - Adventure puzzle game.. (Demo) Posted: 14 Jun 2012 02:39 AM PDT Get Odysseus: Long Way Home and plunge yourself into the world of ancient Greek myths! Together with the heroes of Homer's epic Odyssey, set out on a 20-year journey starting from the walls of Troy to Odysseus' home on Ithaca. Visit mysterious islands filled with magical creatures on the way. Some will beg for help, while others might want to eat you, or even turn you into a wild beast! Overcome all of the obstacles on the way, and help Odysseus to finally return to his beloved Penelope. Features:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
FAX90 Client 1.2.0.3.0 - Hylafax desktop client.. (Free) Posted: 14 Jun 2012 02:27 AM PDT FAX90 Client is a free Hylafax desktop client with everything you are looking for! You can fax any document through your Hylafax server by just printing on the virtual printer or through dragging-and-dropping a pdf document on it. The integration with the Mac OS X Adress Book will permit you to directly access the fax number stored in it or input a new fax number on the fly. You will be able to setup email notifications to have your Hylafax notify you when the fax documents are done, and even pre-approve a prefix to access the telephone line if your fax requires it. This application is completely free. From this interface it is possibile to access links to post feedback or requests; any feedback or requests are welcome.
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
Posted: 14 Jun 2012 12:00 AM PDT CV_2116 is a small hypothetical protein of 82 amino acids from the Gram-negative coccobacillus Chromobacterium violaceum. A PSI-BLAST search using the CV_2116 sequence as a query identified only one hit (E = 2e−07) corresponding to a hypothetical protein OR16_04617 from Cupriavidus basilensis OR16, which failed to provide insight into the function of CV_2116. The CV_2116 gene was cloned into the p15TvLic expression plasmid, transformed into E. coli, and 13C- and 15N-labeled NMR samples of CV_2116 were overexpressed in E. coli and purified for structure determination using NMR spectroscopy. The resulting high-quality solution NMR structure of CV_2116 revealed a novel α + β fold containing two anti-parallel β -sheets in the N-terminal two-thirds of the protein and one α-helix in the C-terminal third of the protein. CV_2116 does not belong to any known protein sequence family and a Dali search indicated that no similar structures exist in the protein data bank. Although no function of CV_2116 could be derived from either sequence or structural similarity searches, the neighboring genes of CV_2116 encode various proteins annotated as similar to bacteriophage tail assembly proteins. Interestingly, C. violaceum exhibits an extensive network of bacteriophage tail-like structures that likely result from lateral gene transfer by incorporation of viral DNA into its genome (prophages) due to bacteriophage infection. Indeed, C. violaceum has been shown to contain four prophage elements and CV_2116 resides in the fourth of these elements. Analysis of the putative operon in which CV_2116 resides indicates that CV_2116 might be a component of the bacteriophage tail-like assembly that occurs in C. violaceum. |
TuneupMyMac 1.3.540 - Clean, secure and optimize your Mac.. (Shareware) Posted: 14 Jun 2012 02:07 AM PDT TuneupMyMac is an expert and easy-to-use solution for your Mac. It offers an easy way to clean, secure and optimize your Mac to keep it running smoothly. TuneupMyMac's advanced features and powerful tools help enhance Mac speed with ease and improve your experience exclusively. Benefits
Version 1.3.540: Improvements:
New Feature:
Download Now This posting includes an audio/video/photo media file: Download Now |
PlugSpy 1.2.7 - Protect your Mac from unauthorised access.. (Commercial) Posted: 14 Jun 2012 02:12 AM PDT PlugSpy provides basic Protection for your MacBook. Plug-Spy is an instant warning system for your MacBook in case that someone try to take it away or is entering a wrong password in the standard OS X login panel. It's easy to setup and integrates seamlessly with Mac OS X and the "Find my Mac" Apple offers with iCloud. There is no additional password or shortcut you have to remember. Plug Spy auto activates when your screen is locked and start an annoying high volume alert sound and send a Growl notification when your MacBook gets unplugged from the MagSafe power adapter. With access protection enabled, you will also get notified when someone enter a wrong password in the login panel, try to access your MacBook with a different user account, or restart your Mac in Safari Guest mode. With Boxcar or Prowl on your iPhone you can receive the notification right on your phone to initiate further steps. Version 1.2.7:
Download Now This posting includes an audio/video/photo media file: Download Now |
Big in Japan June 4-10: Tokyo Jungle Posted: 14 Jun 2012 12:47 AM PDT New PS3 survival action game roars its way to first place; 3DS and PS3 still top sellers on hardware side.
There was a new king of the sales jungle in Japan according to the most recent Media Creates sales update. Tokyo Jungle for the PS3 was the top-selling game for the week of June 4 until June 10, with 110,309 units sold. The action game pits players in the role of animals as they attempt to survive as long as possible in a post-apocalyptic Tokyo. Players will have to kill and feed on other animals and procreate with animals of the same species to prolong their lineage for as many game years as possible to amass the most survival points. In addition, the game has a story mode that chronicles the reason behind the disappearance of humans. For more information, check out GameSpot's gamespace here. The only other new title on the list was StormLover Kai!! for the PSP. The dating simulation was at eighth place with 7,931 units sold. The latest Dragon Quest title was just below Tokyo Jungle last week; the 3DS title Dragon Quest Monsters: Terry no Wonderland 3D sold 83,329 units. Following suite was the PS Vita title Gundam Seed Battle Destiny. The game was at third place with 40,297 units sold. The PS3 version of Dragon's Dogma stood strong with 34,184 units sold. The Xbox 360 version of the game was nowhere to be found in the top twenty list. For more information on the Capcom RPG, check out GameSpot's recent review on the title. Otherwise, the list was mostly occupied by 3DS titles, with Mario Tennis Open at fifth place with 24,030 units sold and Super Mario 3D Land placed seventh with 9,390 units sold. Fire Emblem: Awakening was at ninth place with 7,031 units sold while Mario Kart 7 capped off the top 10 with 6,743 units sold. The hardware sales status quo was unchanged; the 3DS still reigned supreme with 64,875 units, while the PS3 was below with 15,593 units. The PS Vita experienced a slight surge in sales with 13,383 units, possibly due to the Gundam title on the top 10 charts. Top Japan Game Sales of June 4-10 Software 1. Tokyo Jungle / Sony / PS3 / 110,309 Hardware 3DS 64,875 Read and Post Comments | Get the full article at GameSpot "Big in Japan June 4-10: Tokyo Jungle" was posted by Jonathan Toyad on Thu, 14 Jun 2012 00:47:43 -0700 |
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