Games |
- Games Britannia: Replayed brings new games and industry experts to Sheffield
- Dead or Alive 5 gets new Photo Mode for even better 'photographing'. Also, first shots of new character, Rig
- IJMS, Vol. 13, Pages 8025-8037: High Resolution Crystal Structures of the Cerebratulus lacteus Mini-Hb in the Unligated and Carbomonoxy States
- IJMS, Vol. 13, Pages 7994-8024: Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics
- IJMS, Vol. 13, Pages 7980-7993: Adsorption of Sodium Dodecyl Sulfate on Ge Substrate: The Effect of a Low-Polarity Solvent
- Polymers, Vol. 4, Pages 1331-1348: Tailoring Crystallinity of Electrospun Plla Fibres by Control of Electrospinning Parameters
- Radi 0.9 - Publish moving images using modern web standards.. (Free)
- Sleipnir 3.5.0.1 - Gesture focused web browser.. (Free)
- Totals 2.1.1 - Create stylish invoices and more.. (Demo)
- PDF Nomad 1.4.1 - PDF editor built for Mac.. (Demo)
- Membranes, Vol. 2, Pages 346-366: Pure and Modified Co-Poly(amide-12-b-ethylene oxide) Membranes for Gas Separation Studied by Molecular Investigations
- Cycle PDF Converter 1.5.0 - Convert PDF's to other formats.. (Shareware)
- Molecules, Vol. 17, Pages 7864-7886: Tebrophen — An Old Polyphenol Drug with Anticancer Potential †
- Fortora Fresh Finance 1.7.6 - Personal finance solution.. (Demo)
- Big in Japan June 18-24: Pokemon Black/White 2
- DayZ Diaries - Part 1
- Game Masters: Peter Molyneux
- ACMI Game Masters - Peter Molyneux
- Macsome iTunes Converter for Mac 1.5.6 - Convert DRM protected music to unprotected formats.. (Shareware)
- Staff Security Training: Be Original
Games Britannia: Replayed brings new games and industry experts to Sheffield Posted: 28 Jun 2012 02:56 AM PDT |
Posted: 28 Jun 2012 02:38 AM PDT |
Posted: 28 Jun 2012 12:00 AM PDT The nerve tissue mini-hemoglobin from Cerebratulus lacteus (CerHb) displays an essential globin fold hosting a protein matrix tunnel held to allow traffic of small ligands to and from the heme. CerHb heme pocket hosts the distal TyrB10/GlnE7 pair, normally linked to low rates of O2 dissociation and ultra-high O2 affinity. However, CerHb affinity for O2 is similar to that of mammalian myoglobins, due to a dynamic equilibrium between high and low affinity states driven by the ability of ThrE11 to orient the TyrB10 OH group relative to the heme ligand. We present here the high resolution crystal structures of CerHb in the unligated and carbomonoxy states. Although CO binds to the heme with an orientation different from the O2 ligand, the overall binding schemes for CO and O2 are essentially the same, both ligands being stabilized through a network of hydrogen bonds based on TyrB10, GlnE7, and ThrE11. No dramatic protein structural changes are needed to support binding of the ligands, which can freely reach the heme distal site through the apolar tunnel. A lack of main conformational changes between the heme-unligated and -ligated states grants stability to the folded mini-Hb and is a prerequisite for fast ligand diffusion to/from the heme. |
Posted: 28 Jun 2012 12:00 AM PDT Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N2 fixation, photorespiration or asparagine breakdown. A small gene family is encoding for different cytosolic (GS1) or plastidic (GS2) isoforms in legumes. We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production. Functional genomic analysis using GS2-minus mutant reveals the key role of GS2 in the metabolic control of the plants and, more particularly, in carbon metabolism. |
Posted: 28 Jun 2012 12:00 AM PDT This paper describes the adsorption of sodium dodecyl sulfate (SDS) molecules in a low polar solvent on Ge substrate by using Fourier transform infrared-attenuated total reflection (FTIR-ATR) spectroscopy and atomic force microscopy (AFM). The maximum SDS amount adsorbed is (5.0 ± 0.3) × 1014 molecules cm−2 in CHCl3, while with the use of CCl4 as subphase the ability of SDS adsorbed is 48% lower. AFM images show that depositions are highly disordered over the interface, and it was possible to establish that the size of the SDS deposition is around 30–40 nm over the Ge surface. A complete description of the infrared spectroscopic bands for the head and tail groups in the SDS molecule is also provided. |
Posted: 28 Jun 2012 12:00 AM PDT Poly(L-lactic acid) (PLLA) fibers were fabricated by electrospinning. The effects of various electrospinning process parameters on the thermal properties, especially the crystallinity of the electrospun fibers were investigated. Thermal analysis of the fibers revealed that they exhibited degree of crystallinity ranging from 23% to 46% while that for the as-received granules was approximately 37%, suggesting that the crystallinity of electrospun PLLA fibres can be controlled by optimizing the electrospinning process. This finding is very important because crystallinity affects polymer properties such as degradation, stiffness, yield stress, modulus and tensile strength, solubility, optical and electrical properties which will in turn affect the behavior of these materials when they are utilized in energy, environment, defense and security applications. The results presented in this paper show that the degree of crystallinity of the electrospun fibers decreased with increasing the polymer solution concentration. Furthermore, an optimum electrospinning voltage at which maximum degree of crystallinity can be obtained was observed. At voltages higher or lower than the optimum electrospinning voltage, the degree of crystallinity will decrease or increase, respectively. The effect of the needle tip to collector distance (NTCD) on the degree of crystallinity follows no predictable and consistent pattern. |
Radi 0.9 - Publish moving images using modern web standards.. (Free) Posted: 28 Jun 2012 03:02 AM PDT Radi is the Mac application that lets you create visual elements for the web. Images, animations, vector graphics, video clips, realtime visual effects, JavaScript programming... With Radi, publishing moving images using modern web standards is suddenly incredibly easy.
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Sleipnir 3.5.0.1 - Gesture focused web browser.. (Free) Posted: 28 Jun 2012 02:58 AM PDT Sleipnir is a web browser for Mac with Smartphone and Web App Linker. Freely browse the web with the rich selection of functions in Sleipnir. With Sleipnir, you can experience web browsing never seen before. Enjoy the extremely simple design and the powerful operations that can be easily performed with just one hand. Speedy gestures:
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Totals 2.1.1 - Create stylish invoices and more.. (Demo) Posted: 28 Jun 2012 02:52 AM PDT Totals is a full-featured invoice application for SOHO or business users. It has been designed from scratch to use the power and beauty of the Mac OS, while making life as easy as possible for its users. Very simple to use. Everything in one central location. Key Features:
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PDF Nomad 1.4.1 - PDF editor built for Mac.. (Demo) Posted: 28 Jun 2012 02:11 AM PDT PDF Nomad is a modern, carefully styled PDF editor, built from the ground up for Mac OS X 10.7 Lion and later (it is Gatekeeper ready for OS X 10.8 Mountain Lion). It features a multitude of ways to take your PDF documents from one place to the next, through an easy to use interface. It provides often used operations like merging multiple documents, as well as more exotic ones like exporting the document's text as a spoken sound file. Tutorial videos are available on the SintraWorks website. Easily resize whole documents to a different page size with a single command, or resize individual pages with drag and drop, shifting page contents as needed. Export individual pages as bitmaps (jpg, png etc.) or create spoken audio files from the document's text. Split documents into even/odd pages, or explode documents into single page PDFs or even into individual chapters. Merge pages side by side or on top of each other. Split pages in half or tile them to print them onto multiple pages to be assembled into posters. Merge documents, interleave documents and even overlay documents on top of each other. Create and fill out PDF forms. Markup text and annotate pages with rectangles, ovals, arrows, lines and more. Add watermarks. Create books and magazines ready for printing. Add finishing/proofing marks if needed. Ever wanted to print a manual into a small booklet for easy reference, or need to prepare your novel or essay for your publisher? With PDF Nomad you'll have your document ready within a matter of minutes. Partial Feature List
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Posted: 28 Jun 2012 12:00 AM PDT This paper deals with a theoretical investigation of gas transport properties in a pure and modified PEBAX block copolymer membrane with N-ethyl-o/p-toluene sulfonamide (KET) as additive molecules. Molecular dynamics simulations using COMPASS force field, Gusev-Suter Transition State Theory (TST) and Monte Carlo methods were used. Bulk models of PEBAX and PEBAX/KET in different copolymer/additive compositions were assembled and analyzed to evaluate gas permeability and morphology to characterize structure-performance relationships. |
Cycle PDF Converter 1.5.0 - Convert PDF's to other formats.. (Shareware) Posted: 28 Jun 2012 02:01 AM PDT Cycle PDF Converter, the powerful, easy-to-use, fast application has everything you need to convert PDF files to other document formats. It starts with an extremely simple and clear interface that lets you easily convert unlimited PDF files into 4 common document formats. You can convert PDF to Word to reuse the content more easily without typing or formatting the content manually; or convert PDF to PowerPoint for better presentation. Whatever you convert, Cycle PDF Converter will preserve the original text content, layouts, formatting, graphics as accurate as possible. Extremely simple
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Molecules, Vol. 17, Pages 7864-7886: Tebrophen — An Old Polyphenol Drug with Anticancer Potential † Posted: 28 Jun 2012 12:00 AM PDT In vitro high-throughput screening was carried out in order to detect new activities for old drugs and to select compounds for the drug development process comprising new indications. Tebrophen, a known antiviral drug, was found to inhibit activities on inflammation and cancer related targets. In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 µM and 16 µM, respectively), as well as hydrolase DPPIV (at 80 µM 41% inhibition). Next, it showed no cytotoxic effects on standard cell lines within 24 h. However, tebrophen slowed propagation of breast cancer (MDA-MB-231), osteosarcoma (U2OS) and cervical carcinoma (HeLa), through at least 35 population doublings in a dose-dependent manner. It completely stopped the division of the prostate cancer (PC3) cell line at 50 µM concentration and the cells entered massive cell death in less than 20 days. On the other hand, tebrophen did not influence the growth of normal fibroblasts. According to the measured oxidative burst and estimated in silico parameters its direct antioxidative ability is limited. The obtained results indicate that tebrophen can be considered a promising lead molecule for generating more soluble derivatives with specific anticancer efficacy. |
Fortora Fresh Finance 1.7.6 - Personal finance solution.. (Demo) Posted: 28 Jun 2012 01:35 AM PDT Fortora Fresh Finance is the straightforward personal finance software for everyone, simple yet powerful. Easily manage your personal finances, such as balancing the checkbook, keeping track of credit cards, bill reminders, budgeting and more. Generate reports to see where your money is going, and make tax time easy. The streamlined user interface has an easy learning curve, and you will be up and running in a matter of minutes. Version 1.7.6: New Features:
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Big in Japan June 18-24: Pokemon Black/White 2 Posted: 28 Jun 2012 01:13 AM PDT New iteration to Pokemon Black/White bumps PS Vita RPG from top spot; PS Vita sales cool down.
Nintendo's Pokemon series never fail to grab Japan by storm sales-wise, and the latest update to the Media Creates sales chart proves to be no exception. Pokemon Black 2 and Pokemon White 2 for the Nintendo DS took first place on the top 10, bumping down former top dog Persona 4: Golden with 1,561,738 units combined. The new versions of Pokemon Black and Pokemon White introduce new locations in the southwest part of the Unova region, a Pokemon World Tournament that lets players fight every gym leader and champion from past generations of the series, and a Pokewood scenario that lets players pit Pokemon in movies. Persona 4: Golden was bumped down to third place with 29,293 units sold. Tokyo Jungle clung onto fifth place with 18,715 units sold to slot in at five, while The PS3 versions of Dragon's Dogma and Lollipop Chainsaw capped off the end of the top 10 list with 9,162 units and 7,898 units sold, putting them at nine and ten respectively. New titles that made their mark for the week were Kenka Bancho Bros. Tokyo Battle Royale for the PSP which sold 21,797 units and took fourth spot, and K-On After School Live!! HD version for the PS3 which sold 13,581 units to place at six. The former is an action game styled like a classic beat-em-up where players control one of the two brothers who has to clean up Tokyo of crime. The latter is an HD update of a PSP rhythm game based on the hit anime series. On the hardware front, the PlayStation Vita lost its momentum from its previous sales record and dropped down to 13,589 units as a result. The 3DS got a slight increase in sales to 68,056 units. Top Game Sales of Japan For June 18 to June 24 Software Hardware Unit Sales Read and Post Comments | Get the full article at GameSpot "Big in Japan June 18-24: Pokemon Black/White 2" was posted by Jonathan Toyad on Thu, 28 Jun 2012 01:13:01 -0700 |
Posted: 27 Jun 2012 08:48 PM PDT Ed and Randy jump into the popular ArmA II mod for the first time and learn how to play the only way they know how: by running. A tension and surprise-filled journey with an ending full of gravitas. Please leave us any tips you have, and follow GameSpot_AU on Twitch!
Read and Post Comments | Get the full article at GameSpot "DayZ Diaries - Part 1" was posted by edmondt on Wed, 27 Jun 2012 20:48:33 -0700 |
Posted: 27 Jun 2012 08:01 PM PDT What's the fabled game designer up to now that he's left Microsoft?
Get the full article at GameSpot "Game Masters: Peter Molyneux" was posted by Laura Parker on Wed, 27 Jun 2012 20:01:38 -0700 |
ACMI Game Masters - Peter Molyneux Posted: 27 Jun 2012 07:59 PM PDT Populous and Fable designer Peter Molyneux speaks about the very idea of his work being exhibited in a museum space for ACMI's Game Masters exhibition in Melbourne, Australia.
Read and Post Comments | Get the full article at GameSpot "ACMI Game Masters - Peter Molyneux" was posted by edmondt on Wed, 27 Jun 2012 19:59:46 -0700 |
Posted: 28 Jun 2012 01:16 AM PDT Macsome iTunes Converter can easily convert DRM protected music and various audio files to unprotected MP3, AAC formats playable on any iPod, iPod Touch, iPhone, Zune, PSP, Creative Zen and other MP3 players at high speed and CD quality. Convert M4P to MP3, AA to MP3 or AAC in 5X fast speed, with ID Tags preserved on Mac OS X. iTunes M4P to MP3 Converter, Audible AA to MP3 or AAC converter. Version 1.5.6:
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Staff Security Training: Be Original Posted: 28 Jun 2012 12:26 AM PDT IT Governance Ltd, the leading expert in ISO27001 and information security management solutions, is advising organisations to strengthen the weakest link in their information security posture by increasing the ability of their staff to recognise and respond to cyber threats. |
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