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- Molecules, Vol. 17, Pages 7709-7721: A Further Contribution to the Study of Sagittamide A: Synthesis of a Pivotal Intermediate Belonging to a Rare L-Series
- Molecules, Vol. 17, Pages 7695-7708: Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components
- Molecules, Vol. 17, Pages 7666-7694: Residue-Ligand Interaction Energy (ReLIE) on a Receptor-Dependent 3D-QSAR Analysis of S- and NH-DABOs as Non-Nucleoside Reverse Transcriptase Inhibitors
- Molecules, Vol. 17, Pages 7645-7665: Butylated Hydroxytoluene Analogs: Synthesis and Evaluation of Their Multipotent Antioxidant Activities
- Movavi Video Converter 3.0.0 - Easy-to-use video & audio file converter.. (Demo)
- ESRB ratings for GTA3 and Vice City suggest imminent PS3 releases. But where's San Andreas?
- gfxCardStatus 2.2.1 - Keeps track of which graphics card your MacBook Pro is using.. (Free)
- Molecules, Vol. 17, Pages 7637-7644: A New Benzofuran Derivative from Flemingia philippinensis Merr. et Rolfe
- Molecules, Vol. 17, Pages 7629-7636: Terpene Glycosides from the Roots of Sanguisorba officinalis L. and Their Hemostatic Activities
- Molecules, Vol. 17, Pages 7612-7628: Thiadiazines, N,N-Heterocycles of Biological Relevance
- FontCat 5.2.3 - Font viewer/printer.. (Shareware)
- Bundle for MS Office 1.2 - Enhance your MS Office experience.. (Commercial)
- Multisite for iWeb 3.1 - Manage websites in iWeb.. (Shareware)
- Eastern Developers Find Their Footing At E3
- Dragon's Dogma global shipments top one million
- Big in Japan June 11-17: Persona 4 The Golden, PS Vita
- Klondike Screens
- Sticky Balls Screens
- Meghan's WordFlash Audio Flashcards - Kindergarten Screens
- Chuggington: Roundhouse Romp Screens
| Posted: 25 Jun 2012 12:00 AM PDT A key saggitamide intermediate corresponding to a rare sugar framework has been obtained. This approach should help to establish the overall configuration of more complex structures of the sagittamide family. |
| Posted: 25 Jun 2012 12:00 AM PDT The immunomodulatory effects of the ethanol extract of Gynostemma pentaphyllum (GP-EX) were examined in electric footshock (EFS)-stressed mice. The mice were orally administered various doses of GP-EX for 7 days before exposure to EFS (duration: 3 min, interval: 10 s, intensity: 2 mA) once a day from day 8 for 14 days with continuous daily feeding of GP-EX. Oral administration of GP-EX to mice prevented EFS stress-induced immunosuppression as determined by the lymphoid organ (thymus and spleen) weight and cellularity. In addition, oral administration of GP-EX restored EFS-suppressed functional properties of mature lymphocytes in terms of concanavalin A-induced proliferation of splenocytes and lipopolysaccharide-induced cytokine production (TNF-α, IL-1β). Furthermore, we found that mice that were orally administered with GP-EX generated much more potent ovalbumin-specific cytotoxic T lymphocyte responses upon intravenous ovalbumin injection compared to the untreated controls. These results demonstrate that oral administration of the ethanol extract of Gynostemma pentaphyllum could increase host defense in immunocompromised situations such as stress-induced immunosuppression. |
| Posted: 25 Jun 2012 12:00 AM PDT A series of 74 dihydroalkoxybenzyloxopyrimidines (DABOs), a class of highly potent non-nucleoside reverse transcriptase inhibitors (NNRTIs), was retrieved from the literature and studied by receptor-dependent (RD) three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis to derive RD-3D-QSAR models. The descriptors in this new method are the steric and electrostatic interaction energies of the protein-ligand complexes (per residue) simulated by molecular dynamics, an approach named Residue-Ligand Interaction Energy (ReLIE). This study was performed using a training set of 59 compounds and the MKC-442/RT complex structure as reference. The ReLIE-3D-QSAR models were constructed and evaluated by genetic algorithm (GA) and partial least squares (PLS). In the best equations, at least one term is related to one of the amino acid residues of the p51 subunit: Asn136, Asn137, Glu138, and Thr139. This fact implies the importance of interchain interaction (p66-p51) in the equations that best describe the structure-activity relationship for this class of compounds. The best equation shows q2 = 0.660, SEcv = 0.500, r2 = 0.930, and SEE = 0.226. The external predictive ability of this best model was evaluated using a test set of 15 compounds. In order to design more potent DABO analogues as anti-HIV/AIDS agents, substituents capable of interactions with residues like Ile94, Lys101, Tyr181, and Tyr188 should be selected. Also, given the importance of the conserved Asn136, this residue could become an attractive target for the design of novel NNRTIs with improved potency and increased ability to avoid the development of drug-resistant viruses. |
| Posted: 25 Jun 2012 12:00 AM PDT A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and lipid peroxidation assays to verify the predictions obtained by the PASS program. Compounds 3 and 5 showed more inhibition of DPPH stable free radical at 10−4 M than the well-known standard antioxidant, butylated hydroxytoluene (BHT). Compound 5 exhibited promising in vitro inhibition of Fe2+-induced lipid peroxidation of the essential egg yolk as a lipid-rich medium (83.99%, IC50 16.07 ± 3.51 µM/mL) compared to a-tocopherol (a-TOH, 84.6%, IC50 5.6 ± 1.09 µM/mL). The parameters for drug-likeness of these BHT analogues were also evaluated according to the Lipinski's "rule-of-five" (RO5). All the BHT analogues were found to violate one of the Lipinski's parameters (LogP > 5), even though they have been found to be soluble in protic solvents. The predictive polar surface area (PSA) and absorption percent (% ABS) data allow us to conclude that they could have a good capacity for penetrating cell membranes. Therefore, one can propose these new multipotent antioxidants (MPAOs) as potential antioxidants for tackling oxidative stress and lipid peroxidation processes. |
| Movavi Video Converter 3.0.0 - Easy-to-use video & audio file converter.. (Demo) Posted: 25 Jun 2012 02:59 AM PDT  Movavi Video Converter is a video & audio file converter. Convert video & audio on your Mac. Save videos for watching on your portable device. Extract soundtracks from video. And much more... Here's just a taste of what you can do with Movavi Video Converter for Mac:
Version 3.0.0:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| ESRB ratings for GTA3 and Vice City suggest imminent PS3 releases. But where's San Andreas? Posted: 25 Jun 2012 02:40 AM PDT
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| gfxCardStatus 2.2.1 - Keeps track of which graphics card your MacBook Pro is using.. (Free) Posted: 25 Jun 2012 02:50 AM PDT  gfxCardStatus is a free menu bar application that keeps track of which graphics card your MacBook Pro is using at any given time. Features: Simple, clean "i" and "n" icons that signify Intel® HD Graphics, and NVIDIA® GeForce GT 330M graphics, respectively Automatically updates when the GPU switches, in real time Dependent process list - see which applications are currently using the 330M, if it's the active GPU! Growl support - so you know right when the GPU switches Tiny footprint - doesn't sit in your menu bar and hog RAM or CPU cycles Automatic application updating - checks for, downloads and installs new versions of gfxCardStatus automatically! New in this version: 2012 + Retina MacBook Pro support!
Known Issues:
Thanks so much to everyone who contributed to this release in some way, shape or form. You're all awesome.
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| Posted: 25 Jun 2012 12:00 AM PDT A new prenylated benzofuran derivative, named flemiphilippinone A, was isolated together with ten known flavonoids from the roots of Flemingia philippinensis. Flemiphilippinone A was identified as (2S,3aS)-5-(1-hydroxy-3-(4-methoxyphenyl)- propylidene)-2-(2-hydroxypropan-2-yl)-3a,7-bis(3-methylbut-2-en-1-yl)tetrahydrobenzo- furan-4,6(2H,5H)-dione, and its structure was established by a combination of HR EIMS, 1H-NMR, 13C-NMR, HMQC, HMBC and NOESY spectra data. |
| Posted: 25 Jun 2012 12:00 AM PDT Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-O-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (1), geraniol-1-O-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (2), geraniol-1-O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (3), 3β-[(α-l-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (4), 3β-[(α-l-arabinopyranosyl)-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I, 5), 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (6) and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (7). Compound 1 is a new mono-terpene glycoside and compounds 2, 3 and 5 were isolated from the Sanguisorba genus for the first time. Compounds 1–7 were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (5) showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity. |
| Molecules, Vol. 17, Pages 7612-7628: Thiadiazines, N,N-Heterocycles of Biological Relevance Posted: 25 Jun 2012 12:00 AM PDT The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed. |
| FontCat 5.2.3 - Font viewer/printer.. (Shareware) Posted: 25 Jun 2012 02:21 AM PDT  FontCat makes it easy to view fonts without having to install them first. You can print out a listing of your fonts, or view them on-screen. You can create custom layouts to print font specimen sheets or entires font catalogs. You can list any Mac OS X supported font type. Version 5.2.3:
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| Bundle for MS Office 1.2 - Enhance your MS Office experience.. (Commercial) Posted: 25 Jun 2012 01:43 AM PDT  Bundle for MS Office is the ultimate helping hand for users of MS Office; it provides you with 511 original designs for Word documents, 50 spreadsheet templates for Excel, and 30 impressive slideshow themes for PowerPoint. Save time and achieve the best results with Bundle for MS Office! Version 1.2:
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| Multisite for iWeb 3.1 - Manage websites in iWeb.. (Shareware) Posted: 25 Jun 2012 01:23 AM PDT  Multisite for iWeb is a Mac OS X utility for users of iWeb. Whether you need to build 2 or 200 sites Multisite makes iWeb even better. First of all it keeps iWeb uncluttered by focusing it on just the site you want to work with. It also speeds up iWeb since iWeb no longer has to keep every site in the same data file. This way, when you edit or publish, iWeb just works on the site you want rather than every site each time. This helps to reduce memory usage and improve load and save times too. Multisite Features:
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| Eastern Developers Find Their Footing At E3 Posted: 24 Jun 2012 09:50 PM PDT Jessica McDonell speaks to Eastern developers who are having their first E3 experiences. They discuss fierce competition, eastern integration and whether booth size really matters.
Read and Post Comments | Get the full article at GameSpot "Eastern Developers Find Their Footing At E3" was posted by Jessica McDonell on Sun, 24 Jun 2012 21:50:24 -0700 |
| Dragon's Dogma global shipments top one million Posted: 24 Jun 2012 09:42 PM PDT Publisher Capcom reveals plans to develop the name into a major franchise in the future.
Shipments of Dragon's Dogma for the PlayStation 3 and Xbox 360, across the entire world, have crossed the one million mark. According to Capcom, Dragon's Dogma is the publisher's 55th title to top the one million shipping mark. Based on the game's first week sales of 300,000 units for the PlayStation 3 version, released on May 21, the company is planning on developing the brand into a major franchise. The Xbox 360 version sold 29,024 during its debut week, as well. The game was the highest-selling title in Japan in the month of May, even with just a week's worth of sales. Dragon's Dogma generated positive reviews. The RPG was praised for its combat and boss fights, but was criticized for its backtracking elements and quest events. For more information, check out GameSpot's video review below.
Read and Post Comments | Get the full article at GameSpot "Dragon's Dogma global shipments top one million" was posted by Jonathan Toyad on Sun, 24 Jun 2012 21:42:57 -0700 |
| Big in Japan June 11-17: Persona 4 The Golden, PS Vita Posted: 24 Jun 2012 09:40 PM PDT New Sony handheld doubled in sales units; Vita version of Atlus RPG claims top spot.
You can always count on an RPG series that blends role-playing and social-simulation to push sales for a new console in Japan. Shin Megami Tensei: Persona 4 The Golden did just that for the week of June 11-17 according to a recent Media Create sales update. The portable version of Atlus' fourth Persona game sold 137,076 units in its debut week. This remake of the 2008 PS2 game boasts a number of updates, including a new character named Mary, new animated cutscenes and scenarios, and a new wireless feature that allows players to call for help when near death. Check out GameSpot's review of the PS2 version for more information. Persona 4: The Golden outperformed newcomers such as the PS3 and Xbox 360 versions of Lollipop Chainsaw. The former version came in at third place with 53,347 units sold, while the latter was at ninth place with 14,422 units shifted. The action game pits players in the role of cheerleader zombie-hunter Juliet Starling as she has to fight off the outbreak happening at her school. Critics praised the game for its fun boss battles and gameplay, but criticized it for its lack of depth. For more information, check out GameSpot's full review. Good software drives hardware sales, and as a result of Persona 4: The Golden's success, Vita sales doubled to 34,459 units for the week. Sony's new handheld edged out PS3 and PSP numbers; the former selling 14,673 units and latter 9,740 devices. The 3DS maintained its top spot with 61,793 units sold for the week. Top Japan Game Sales of June 11-17 Software Hardware Read and Post Comments | Get the full article at GameSpot "Big in Japan June 11-17: Persona 4 The Golden, PS Vita" was posted by Jonathan Toyad on Sun, 24 Jun 2012 21:40:11 -0700 |
| Posted: 24 Jun 2012 05:05 PM PDT 5 new shots posted.
Get the full article at GameSpot "Klondike Screens" was posted on Sun, 24 Jun 2012 17:05:28 -0700 |
| Posted: 24 Jun 2012 05:05 PM PDT 5 new shots posted.
Get the full article at GameSpot "Sticky Balls Screens" was posted on Sun, 24 Jun 2012 17:05:00 -0700 |
| Meghan's WordFlash Audio Flashcards - Kindergarten Screens Posted: 24 Jun 2012 05:02 PM PDT 4 new shots posted.
Get the full article at GameSpot "Meghan's WordFlash Audio Flashcards - Kindergarten Screens" was posted on Sun, 24 Jun 2012 17:02:40 -0700 |
| Chuggington: Roundhouse Romp Screens Posted: 24 Jun 2012 05:02 PM PDT 3 new shots posted.
Get the full article at GameSpot "Chuggington: Roundhouse Romp Screens" was posted on Sun, 24 Jun 2012 17:02:22 -0700 |
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