Games |
- Contenta Converter BASIC 5.97 - Batch convert your photos.. (Free)
- ClipBuddy 1.07.2 - Organize all your text and image clippings. (Shareware)
- Forests, Vol. 3, Pages 283-299: Site Productivity and Forest Carbon Stocks in the United States: Analysis and Implications for Forest Offset Project Planning
- Applied Sciences, Vol. 2, Pages 549-557: Effects of Nonlinear Chirp on the Self-Phase Modulation of Ultrashort Optical Pulses
- Sensors, Vol. 12, Pages 7529-7547: Estimating Sugarcane Yield Potential Using an In-Season Determination of Normalized Difference Vegetative Index
- Sensors, Vol. 12, Pages 7518-7528: Satellite- and Epoch Differenced Precise Point Positioning Based on a Regional Augmentation Network
- Sensors, Vol. 12, Pages 7496-7517: Study of LZ-Based Location Prediction and Its Application to Transportation Recommender Systems
- Pharmaceuticals, Vol. 5, Pages 553-590: Gene Therapy for the Treatment of Parkinson’s Disease: The Nature of the Biologics Expands the Future Indications
- Contenta Converter PREMIUM 5.97 - Java app to batch convert photos for internet use or organization.. (Demo)
- Get Plain Text 1.1 - Convert any text to plain text.. (Commercial)
- MenuMate 1.1 - Display applications menu bar items anywhere on screen.. (Commercial)
- Onde Audio Recorder 2.21.9 - Record sound from numerous sources.. (Shareware)
- Block Rogue
- Marine Drugs, Vol. 10, Pages 1244-1265: Conotoxins that Confer Therapeutic Possibilities
- IJERPH, Vol. 9, Pages 2108-2120: Thermostable Bacterial Bioflocculant Produced by Cobetia Spp. Isolated from Algoa Bay (South Africa)
- IJMS, Vol. 13, Pages 6772-6799: Mechanistic Insights into Neurotoxicity Induced by Anesthetics in the Developing Brain
- IJMS, Vol. 13, Pages 6757-6771: 3β-Acetyl Tormentic Acid (3ATA) a Novel Modulator of ABCC Proteins Activity
- IJMS, Vol. 13, Pages 6747-6756: Opuntia humifusa Supplementation Increased Bone Density by Regulating Parathyroid Hormone and Osteocalcin in Male Growing Rats
- Marine Drugs, Vol. 10, Pages 1225-1243: Microbial Regulation in Gorgonian Corals
- Molecules, Vol. 17, Pages 6808-6820: Synthesis, Radiolabeling and Biological Evaluation of Propylene Amine Oxime Complexes Containing Nitrotriazoles as Hypoxia Markers
| Contenta Converter BASIC 5.97 - Batch convert your photos.. (Free) Posted: 04 Jun 2012 02:10 AM PDT  Contenta Converter BASIC lets you batch convert your photos. Optimize photos for internet, batch rename and organize in subfolders. Handles many image formats (jpg, jpeg2000, gif, png, tiff, bmp, wbmp, targa, ppm, pgm, pbm, xpm, ico, cut, g3, dds, iff, jng, koa, mng, pcd, pcx, ras, sgi). Select your images, setup your conversion parameters, preview quality and file sizes and press Start! It does batch file renaming (Ex: CameraModel_Date_Filename.Extension),organize into sub-folders automatically (Ex: CameraModelCreationYearYearmonthday). Optimized for multi-core processors. Speed up your conversions by using 100% of your CPU. Best of all, it is FREE.
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| ClipBuddy 1.07.2 - Organize all your text and image clippings. (Shareware) Posted: 04 Jun 2012 02:12 AM PDT  ClipBuddy...Don't think of it as a clipboard - it's a personal assistant.
Version 1.07.2: Release notes were unavailable when this listing was updated.
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| Posted: 04 Jun 2012 12:00 AM PDT The documented role of United States forests in sequestering carbon, the relatively low cost of forest-based mitigation, and the many co-benefits of increasing forest carbon stocks all contribute to the ongoing trend in the establishment of forest-based carbon offset projects. We present a broad analysis of forest inventory data using site quality indicators to provide guidance to managers planning land acquisition for forest-based greenhouse gas mitigation projects. Specifically, we summarize two condition class indicators of site productivity within the FIA forest inventory database—physclcd and siteclcd—as they relate to current aboveground live tree carbon stocks. Average carbon density is higher on more productive sites, but compared to the overall variability among sites, the differences are relatively small for all but the highest and lowest site classes. Some minor differences in eastern- versus western-forests were apparent in terms of how carbon on the least productive sites differed from most other forest land over time. Overall results suggest that xeric sites in most regions as well as sites that correspond to the lowest, non-productive classifications of forest land should preferentially not be used forestry-based greenhouse gas mitigation projects, but all other forest areas appear to be suitable. |
| Posted: 04 Jun 2012 12:00 AM PDT In this article, we analytically investigate the spectral broadening by self-phase modulation of strongly chirped optical pulses. The dispersion due to the nonlinear optical process is expressed as functions of a linear and a nonlinear initial chirp. As a result, it is found that the third-order dispersion strongly depends on the initial linear chirp and the nonlinearity for self-phase modulation. |
| Posted: 04 Jun 2012 12:00 AM PDT Estimating crop yield using remote sensing techniques has proven to be successful. However, sugarcane possesses unique characteristics; such as, a multi-year cropping cycle and plant height-limiting for midseason fertilizer application timing. Our study objective was to determine if sugarcane yield potential could be estimated using an in-season estimation of normalized difference vegetative index (NDVI). Sensor readings were taken using the GreenSeeker® handheld sensor from 2008 to 2011 in St. Gabriel and Jeanerette, LA, USA. In-season estimates of yield (INSEY) values were calculated by dividing NDVI by thermal variables. Optimum timing for estimating sugarcane yield was between 601–750 GDD. In-season estimated yield values improved the yield potential (YP) model compared to using NDVI. Generally, INSEY value showed a positive exponential relationship with yield (r2 values 0.48 and 0.42 for cane tonnage and sugar yield, respectively). When models were separated based on canopy structure there was an increase the strength of the relationship for the erectophile varieties (r2 0.53 and 0.47 for cane tonnage and sugar yield, respectively); however, the model for planophile varieties weakened slightly. Results of this study indicate using an INSEY value for predicting sugarcane yield shows potential of being a valuable management tool for sugarcane producers in Louisiana. |
| Posted: 04 Jun 2012 12:00 AM PDT Precise Point Positioning (PPP) has been demonstrated as a simple and effective approach for user positioning. The key issue in PPP is how to shorten convergence time and improve positioning efficiency. Recent researches mainly focus on the ambiguity resolution by correcting residual phase errors at a single station. The success of this approach (referred to hereafter as NORM-PPP) is subject to how rapidly one can fix wide-lane and narrow-lane ambiguities to achieve the first ambiguity-fixed solution. The convergence time of NORM-PPP is receiver type dependent, and normally takes 15–20 min. Different from the general algorithm and theory by which the float ambiguities are estimated and the integer ambiguities are fixed, we concentrate on a differential PPP approach: the satellite- and epoch differenced (SDED) approach. In general, the SDED approach eliminates receiver clocks and ambiguity parameters and thus avoids the complicated residual phase modeling procedure. As a further development of the SDED approach, we use a regional augmentation network to derive tropospheric delay and remaining un-modeled errors at user sites. By adding these corrections and applying the Robust estimation, the weak mathematic properties due to the ED operation is much improved. Implementing this new approach, we need only two epochs of data to achieve PPP positioning converging to centimeter-positioning accuracy. Using seven days of GPS data at six CORS stations in Shanghai, we demonstrate the success rate, defined as the case when three directions converging to desired positioning accuracy of 10 cm, reaches 100% when the interval between the two epochs is longer than 15 min. Comparing the results of 15 min' interval to that of 10 min', it is observed that the position RMS improves from 2.47, 3.95, 5.78 cm to 2.21, 3.93, 4.90 cm in the North, East and Up directions, respectively. Combining the SDED coordinates at the starting point and the ED relative coordinates thereafter, we demonstrate the performance of RTK PPP with standard deviation of 0.80, 1.34, 0.97 cm in the North, East and Up directions. |
| Posted: 04 Jun 2012 12:00 AM PDT Predicting users' next location allows to anticipate their future context, thus providing additional time to be ready for that context and react consequently. This work is focused on a set of LZ-based algorithms (LZ, LeZi Update and Active LeZi) capable of learning mobility patterns and estimating the next location with low resource needs, which makes it possible to execute them on mobile devices. The original algorithms have been divided into two phases, thus being possible to mix them and check which combination is the best one to obtain better prediction accuracy or lower resource consumption. To make such comparisons, a set of GSM-based mobility traces of 95 different users is considered. Finally, a prototype for mobile devices that integrates the predictors in a public transportation recommender system is described in order to show an example of how to take advantage of location prediction in an ubiquitous computing environment. |
| Posted: 04 Jun 2012 12:00 AM PDT The pharmaceutical industry's development of therapeutic medications for the treatment of Parkinson's disease (PD) endures, as a result of the continuing need for better agents, and the increased clinical demand due to the aging population. Each new drug offers advantages and disadvantages to patients when compared to other medical offerings or surgical options. Deep brain stimulation (DBS) has become a standard surgical remedy for the effective treatment of select patients with PD, for whom most drug regimens have failed or become refractory. Similar to DBS as a surgical option, gene therapy for the treatment of PD is evolving as a future option. In the four different PD gene therapy approaches that have reached clinical trials investigators have documented an excellent safety profile associated with the stereotactic delivery, viral vectors and doses utilized, and transgenes expressed. In this article, we review the clinically relevant gene therapy strategies for the treatment of PD, concentrating on the published preclinical and clinical results, and the likely mechanisms involved. Based on these presentations, we advance an analysis of how the nature of the gene therapy used may eventually expand the scope and utility for the management of PD. |
| Posted: 04 Jun 2012 01:55 AM PDT  Contenta Converter PREMIUM is an app can be used to batch convert your photos. Optimize photos for internet, batch rename and organize in subfolders. Handles 50+ image formats (jpg, jpeg2000, gif, png, tiff, bmp, wbmp, targa, ppm, pgm, pbm, xpm, ico, cut, g3, dds, iff, jng, koa, mng, pcd, pcx, ras, sgi, svg, ps, eps, pdf, psd, raw, dng, crw, cr2, orf, mrw, thm, nef, pef, srf, arw, 3fr, erf, kdc, sr2, raf, x3f, dcr, drf, mef, mos, ptx). Select your images, setup your conversion parameters, preview quality and file sizes and press Start! It does batch file renaming (Ex: CameraModel_Date_Filename.Extension),organize into sub-folders automatically (Ex: CameraModelCreationYearYearmonthday). It also has the capability to transform your images into a nice PDF album. Configure the layout, how many images per page and you get an e-book with your photos ready for sharing or publishing. For power users, there is batch RAW processing so that you can set the parameters to develop your RAW images: brightness, white balance, denoising. Optimized for multi-core processors. Speed up your conversions by using 100% of your CPU. Get one year of update protection and technical support with the purchase of a license.
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| Get Plain Text 1.1 - Convert any text to plain text.. (Commercial) Posted: 04 Jun 2012 01:33 AM PDT  Get Plain Text is a practical utility program to process text within Mac OS X: It converts copied text into plain text. It instantly removes everything unneeded: colors, typeface size, style (for example, boldface/italics), hyper-links, images, etc. In other words, everything that isn't plain text! Now you can put plain text in your letters and documents using the copy/paste functions, without having to clean it up manually. Get Plain Text will convert any bit of text into plain text, no matter where you copied it from (a website, PDF document or elsewhere). You can activate the feature manually, or check "automatically remove formatting". Version 1.1: Now available in:
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| MenuMate 1.1 - Display applications menu bar items anywhere on screen.. (Commercial) Posted: 04 Jun 2012 01:42 AM PDT  MenuMate displays a copy of an app's menu bar items whenever you want, right next to the cursor! Works seamlessly with most other apps! You're tired of straining your wrist from mousing back to the menu bar all the time, especially if you have a big screen, twin screens or a tablet+screen combo. Waste less time, get more work done! All you need to do is assign a hotkey or mouse button (other than left or right) to it. If you have a Magic Mouse or Magic Trackpad, you can use Magic Prefs (free) to create a virtual centre button for them. To access MenuMate's preferences, just click on the octopus icon in the menu bar. Now available in:
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| Onde Audio Recorder 2.21.9 - Record sound from numerous sources.. (Shareware) Posted: 04 Jun 2012 01:25 AM PDT  Onde Audio Recorder, a sound recording program for Mac, allows you to record sound directly from microphone, CD player, line-in devices or sound being played by other applications including Skype, iTunes, or DVD Player, etc. Recording files are saved as WAV, ACC, AIFF and so on. It can also extract music from movie. Advanced recording scheduler, various settings options, intuitive interface, hotkey options, and real-time recording are some noteworthy features. Limited time offer: free onde audio recorder Tip : This Anniversary Edition is distributed for free. It is not accompanied by free upgrade and tech support services. Expires on June 6th. We welcome all users to try our free full version audio recorder! Version 2.21.9: Release notes were unavailable when this listing was updated.
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| Posted: 03 Jun 2012 02:53 PM PDT Platform: iOS, Android —  Waking up on the floor of a mysterious temple without any memories of who you are or what you're doing might sound scary, but in Buzz Monkey Software's adorable and addictive sokoban puzzler there's no time for tears! Choose Story Mode and play up to 325 levels to find out the truth of your predicament, or play forever with the option for endless randomised puzzles! It's a perfect example of a simple and compelling little mobile title you'll want to take with you wherever you go. Tagged as: android, buzzmonkeysoftware, fantasy, game, ios, ipad, iphone, mobile, puzzle, rating-g, sokoban, tablet |
| Marine Drugs, Vol. 10, Pages 1244-1265: Conotoxins that Confer Therapeutic Possibilities Posted: 04 Jun 2012 12:00 AM PDT Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt®; Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ω-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred. |
| Posted: 04 Jun 2012 12:00 AM PDT A novel bioflocculant-producing bacteria was isolated from sediment samples of Algoa Bay in the Eastern Cape Province of South Africa and the effect of culture conditions on the bioflocculant production was investigated. Analysis of the partial nucleotide sequence of the 16S rDNA of the bacteria revealed 99% similarity to Cobetia sp. L222 and the sequence was deposited in GenBank as Cobetia sp. OAUIFE (accession number JF799092). Cultivation condition studies revealed that bioflocculant production was optimal with an inoculum size of 2% (v/v), initial pH of 6.0, Mn2+ as the metal ion, and glucose as the carbon source. Metal ions, including Na+, K+, Li+, Ca2+and Mg2+ stimulated bioflocculant production, resulting in flocculating activity of above 90%. This crude bioflocculant is thermally stable, with about 78% of its flocculating activity remaining after heating at 100 °C for 25 min. Analysis of the purified bioflocculant revealed it to be an acidic extracellular polysaccharide. |
| Posted: 04 Jun 2012 12:00 AM PDT Compelling evidence has shown that exposure to anesthetics used in the clinic can cause neurodegeneration in the mammalian developing brain, but the basis of this is not clear. Neurotoxicity induced by exposure to anesthestics in early life involves neuroapoptosis and impairment of neurodevelopmental processes such as neurogenesis, synaptogenesis and immature glial development. These effects may subsequently contribute to behavior abnormalities in later life. In this paper, we reviewed the possible mechanisms of anesthetic-induced neurotoxicity based on new in vitro and in vivo findings. Also, we discussed ways to protect against anesthetic-induced neurotoxicity and their implications for exploring cellular and molecular mechanisms of neuroprotection. These findings help in improving our understanding of developmental neurotoxicology and in avoiding adverse neurological outcomes in anesthesia practice. |
| Posted: 04 Jun 2012 12:00 AM PDT Multidrug resistance (MDR) is considered the main cause of cancer chemotherapy failure and patient relapse. The active drug efflux mediated by transporter proteins of the ABC (ATP-binding cassette) family is the most investigated mechanism leading to MDR. With the aim of inhibiting this transport and circumventing MDR, a great amount of work has been dedicated to identifying pharmacological inhibitors of specific ABC transporters. We recently showed that 3β-acetyl tormentic acid (3ATA) had no effect on P-gp/ABCB1 activity. Herein, we show that 3ATA strongly inhibited the activity of MRP1/ABCC1. In the B16/F10 and Ma104 cell lines, this effect was either 20X higher or similar to that observed with MK571, respectively. Nevertheless, the low inhibitory effect of 3ATA on A549, a cell line that expresses MRP1-5, suggests that it may not inhibit other MRPs. The use of cells transfected with ABCC2, ABCC3 or ABCC4 showed that 3ATA was also able to modulate these transporters, though with an inhibition ratio lower than that observed for MRP1/ABCC1. These data point to 3ATA as a new ABCC inhibitor and call attention to its potential use as a tool to investigate the function of MRP/ABCC proteins or as a co-adjuvant in the treatment of MDR tumors. |
| Posted: 04 Jun 2012 12:00 AM PDT We investigated the effect of Opuntia humifusa (O. humifusa) supplementation on bone density and related hormone secretion in growing male rats. Sixteen six-week-old male Sprague-Dawley rats were randomly divided into two groups; control diet group (CG, n = 8), and experimental diet group (EG, n = 8). The rats in the CG were given a control diet and those in the EG were given 5% O. humifusa added to the control diet for eight weeks. The serum OC level of the EG was significantly higher than that of the CG, and the serum parathyroid hormone (PTH) level of EG was significantly lower than that of the CG. In addition, the femoral and tibial BMD of the EG were significantly higher values than those of the CG, and the tibial BMC of the EG was significantly higher than that of the CG. These results suggest that O. humifusa supplementation has a positive effect on bone density by suppressing PTH and increasing the OC level in growing male rats. |
| Marine Drugs, Vol. 10, Pages 1225-1243: Microbial Regulation in Gorgonian Corals Posted: 04 Jun 2012 12:00 AM PDT Gorgonian corals possess many novel natural products that could potentially mediate coral-bacterial interactions. Since many bacteria use quorum sensing (QS) signals to facilitate colonization of host organisms, regulation of prokaryotic cell-to-cell communication may represent an important bacterial control mechanism. In the present study, we examined extracts of twelve species of Caribbean gorgonian corals, for mechanisms that regulate microbial colonization, such as antibacterial activity and QS regulatory activity. Ethanol extracts of gorgonians collected from Puerto Rico and the Florida Keys showed a range of both antibacterial and QS activities using a specific Pseudomonas aeruginosa QS reporter, sensitive to long chain AHLs and a short chain N-acylhomoserine lactones (AHL) biosensor, Chromobacterium violaceium. Overall, the gorgonian corals had higher antimicrobial activity against non-marine strains when compared to marine strains. Pseudopterogorgia americana, Pseusopterogorgia acerosa, and Pseudoplexuara flexuosa had the highest QS inhibitory effect. Interestingly, Pseudoplexuara porosa extracts stimulated QS activity with a striking 17-fold increase in signal. The stimulation of QS by P. porosa or other elements of the holobiont may encourage colonization or recruitment of specific microbial species. Overall, these results suggest the presence of novel stimulatory QS, inhibitory QS and bactericidal compounds in gorgonian corals. A better understanding of these compounds may reveal insight into coral-microbial ecology and whether a therapeutic potential exists. |
| Posted: 04 Jun 2012 12:00 AM PDT Two propylene amine oxime (PnAO) complexes, 1, containing a 3-nitro-1,2,4-triazole and 2, containing two 3-nitro-1,2,4-triazoles, were synthesized and radiolabeled with 99mTc in high labeling yields. Cellular uptakes of 99mTc-1 and 99mTc-2 were tested using a S180 cells line. Under anoxic conditions, the cellular uptakes of 99mTc-1 and 99mTc-2 were 33.7 ± 0.2% and 35.0 ± 0.7% at 4 h, whereas the normoxic uptakes of the two complexes were 6.0 ± 1.6% and 4.6 ± 0.9%, respectively. Both 99mTc-1 and 99mTc-2 displayed significant anoxic/normoxic differentials. The cellular uptakes were highly dependent on oxygen and temperature. Biodistribution studies revealed that both 99mTc-1 and 99mTc-2 showed a selective localization in tumor and slow clearance from it. At 4 h, the tumor-to-muscle ratios (T/M) were 3.79 for 99mTc-1 and 4.58 for 99mTc-2. These results suggested that 99mTc-labeled PnAO complexes 99mTc-1 and 99mTc-2 might serve as novel hypoxia markers. By introducing a second nitrotriazole redox center, the hypoxic accumulation of the marker was slightly enhanced. |
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