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- Molecules, Vol. 18, Pages 6919-6935: Application of a Rapid and Efficient Quantitative Analysis Method for Traditional Chinese Medicines: The Case Study of Quality Assessment of Salvia miltiorrhiza Bunge
- Toxins, Vol. 5, Pages 1140-1166: Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue
- Sensors, Vol. 13, Pages 7652-7667: CrossVit: Enhancing Canopy Monitoring Management Practices in Viticulture
- Sensors, Vol. 13, Pages 7633-7651: Development of a Control System for the Teat-End Vacuum in Individual Quarter Milking Systems
- Sensors, Vol. 13, Pages 7618-7632: Novel Magnetic Sensing Approach with Improved Linearity
- Sensors, Vol. 13, Pages 7599-7617: Two Phase Non-Rigid Multi-Modal Image Registration Using Weber Local Descriptor-Based Similarity Metrics and Normalized Mutual Information
- Shadowland Online
- GrabIt 4.4 - Screen capture utility. (Commercial)
- Reddit Notifier 2.6 - Menubar notifier for Reddit users. (Commercial)
- IJERPH, Vol. 10, Pages 2412-2426: Characteristics of Antibiotic Resistance of Airborne Staphylococcus Isolated from Metro Stations
- Remote Sensing, Vol. 5, Pages 2973-3006: Removal of Optically Thick Clouds from Multi-Spectral Satellite Images Using Multi-Frequency SAR Data
- Metabolites, Vol. 3, Pages 506-516: Molecular Formula Identification with SIRIUS
- Entropy, Vol. 15, Pages 2398-2414: On the Use of Information Theory to Quantify Parameter Uncertainty in Groundwater Modeling
- Fantasia: Music Evolved - Directing the Music Demo E3 2013
- Black Gold: There Will Be Blood
- Sonic Lost World: The Very Best of Sonic
- Lost Planet 3: It's a Bug Hunt
- Payday 2 - Developer Demo E3 2013
- Bandai Namco: Three Steps Forward, One Step Back
- Phoenix Wright Dual Destinies: Lie To me
| Posted: 13 Jun 2013 12:00 AM PDT A reference extractive, containing multiple active known compounds, has been considered to be an alternative to individual reference standards. However, in the Chinese Pharmacopoeia (ChP) the great majority of reference extractives have been primarily used for qualitative identification by thin-layer chromatography (TLC) and few studies on the applicability of reference extractives for quantitative analysis have been presented. Using Salvia miltiorrhiza Bunge as an example in this paper, we first present a preliminary discussion on the feasibility and applicability of reference extractives for the quantitative analysis of TCMs. The reference extractive of S. miltiorrhiza Bunge, comprised of three pharmacological marker compounds, namely cryptotanshinone, tanshinone I and tanshinone IIA, was prepared from purchased Salvia miltiorrhiza Bunge by extraction with acetone under reflux, followed by silica gel column chromatography with stepwise elution with petroleum ether-ethyl acetate (25:1, v/v, 4.5 BV) to remove the non-target components and chloroform-methanol (10:1, v/v; 3 BV) to yield a crude reference extractive solution. After concentration, the solution was further purified by preparative reversed-phase HPLC on a C18 column with isocratic elution with 77% methanol aqueous solution to yield the total reference extractive of S. miltiorrhiza Bunge. Thereafter, the reference extractive was applied to the quality assessment of S. miltiorrhiza Bunge using high-performance liquid chromatography (HPLC) coupled with diode array detection (DAD). The validation of the method, including linearity, sensitivity, repeatability, stability and recovery testing, indicated that this method was valid, reliable and sensitive, with good reproducibility. The developed method was successfully applied to quantify seven batches of samples collected from different regions in China and the results were also similar to those obtained using reference standards, with relative standard deviation (RSD) <3%. Preparation of a reference extractive of S. miltiorrhiza Bunge was significantly less expensive and time consuming than preparation of a corresponding reference standard. Quantitative analysis using a reference extractive was shown to be simple, low-cost, time-saving and practical, with high sensitivity and good stability; and is, therefore, a strong alternative to the use of reference standards. |
| Toxins, Vol. 5, Pages 1140-1166: Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue Posted: 13 Jun 2013 12:00 AM PDT Staphylococcus aureus secretes a number of host-injurious toxins, among the most prominent of which is the small β-barrel pore-forming toxin α-hemolysin. Initially named based on its properties as a red blood cell lytic toxin, early studies suggested a far greater complexity of α-hemolysin action as nucleated cells also exhibited distinct responses to intoxication. The hemolysin, most aptly referred to as α-toxin based on its broad range of cellular specificity, has long been recognized as an important cause of injury in the context of both skin necrosis and lethal infection. The recent identification of ADAM10 as a cellular receptor for α-toxin has provided keen insight on the biology of toxin action during disease pathogenesis, demonstrating the molecular mechanisms by which the toxin causes tissue barrier disruption at host interfaces lined by epithelial or endothelial cells. This review highlights both the historical studies that laid the groundwork for nearly a century of research on α-toxin and key findings on the structural and functional biology of the toxin, in addition to discussing emerging observations that have significantly expanded our understanding of this toxin in S. aureus disease. The identification of ADAM10 as a proteinaceous receptor for the toxin not only provides a greater appreciation of truths uncovered by many historic studies, but now affords the opportunity to more extensively probe and understand the role of α-toxin in modulation of the complex interaction of S. aureus with its human host. |
| Posted: 13 Jun 2013 12:00 AM PDT A new wireless sensor network (WSN), called CrossVit, and based on MEMSIC products, has been tested for two growing seasons in two vineyards in Italy. The aims are to evaluate the monitoring performances of the new WSN directly in the vineyard and collect air temperature, air humidity and solar radiation data to support vineyard management practices. The WSN consists of various levels: the Master/Gateway level coordinates the WSN and performs data aggregation; the Farm/Server level takes care of storing data on a server, data processing and graphic rendering; Nodes level is based on a network of peripheral nodes consisting of a MDA300 sensor board and Iris module and equipped with thermistors for air temperature, photodiodes for global and diffuse solar radiation, and an HTM2500LF sensor for relative humidity. The communication levels are: WSN links between gateways and sensor nodes by ZigBee, and long-range GSM/GPRS links between gateways and the server farm level. The system was able to monitor the agrometeorological parameters in the vineyard: solar radiation, air temperature and air humidity, detecting the differences between the canopy treatments applied. The performance of CrossVit, in terms of monitoring and reliability of the system, have been evaluated considering: its handiness, cost-effective, non-invasive dimensions and low power consumption. |
| Posted: 13 Jun 2013 12:00 AM PDT Progress in sensor technique and electronics has led to a decrease in the costs of electronic and sensor components. In modern dairy farms, having udders in good condition, a lower frequency of udder disease and an extended service life of dairy cows will help ensure competitiveness. The objective of this study was to develop a teat-end vacuum control system with individual quarter actor reaction. Based on a review of the literature, this system is assumed to protect the teat tissue. It reduces the mean teat-end vacuum in the maximum vacuum phase (b) to a level of 20 kPa at a flow rate of 0.25 L/min per quarter. At flow rates higher than 1.50 L/min per quarter, the teat-end vacuum can be controlled to a level of 30 kPa, because in this case it is desirable to have a higher vacuum for the transportation of the milk to the receiver. With this system it is possible for the first time to supply the teat end with low vacuum at low flow rates and with higher vacuum at increasing flow rates in a continuous process with a three second reaction-rate on individual quarter level. This system is completely automated. |
| Sensors, Vol. 13, Pages 7618-7632: Novel Magnetic Sensing Approach with Improved Linearity Posted: 13 Jun 2013 12:00 AM PDT This paper introduces a novel contactless sensing principle conceived for measuring the rotation angle of a shaft. The sensor is based on a smart combination of low-cost components that can be effectively integrated in a mechanical assembly of a rotary joint. The working principle is based on the relative rotation of a small diametrically magnetized cylindrical or annular magnet and at least one Hall effect sensor. One of the main strengths of the new sensing principle is to be adaptable to any assigned dimensions and encumbrances without typical design limitations given by the use of standard components. A numerical model is developed for predicting the sensor output characteristic on the base of the concept of magnetic charge. Such a model is validated against results from laboratory experiments. The parameters that define the geometry and layout of the sensor are optimized in order to maximize linearity over an assigned angular range of measurement. Two examples of mechatronic systems that employ the new sensing principle are presented in order to show the possibility of obtaining with the new principle a compact/integrated sensor-design. |
| Posted: 13 Jun 2013 12:00 AM PDT Non-rigid multi-modal image registration plays an important role in medical image processing and analysis. Existing image registration methods based on similarity metrics such as mutual information (MI) and sum of squared differences (SSD) cannot achieve either high registration accuracy or high registration efficiency. To address this problem, we propose a novel two phase non-rigid multi-modal image registration method by combining Weber local descriptor (WLD) based similarity metrics with the normalized mutual information (NMI) using the diffeomorphic free-form deformation (FFD) model. The first phase aims at recovering the large deformation component using the WLD based non-local SSD (wldNSSD) or weighted structural similarity (wldWSSIM). Based on the output of the former phase, the second phase is focused on getting accurate transformation parameters related to the small deformation using the NMI. Extensive experiments on T1, T2 and PD weighted MR images demonstrate that the proposed wldNSSD-NMI or wldWSSIM-NMI method outperforms the registration methods based on the NMI, the conditional mutual information (CMI), the SSD on entropy images (ESSD) and the ESSD-NMI in terms of registration accuracy and computation efficiency. |
| Posted: 13 Jun 2013 02:42 AM PDT Shadowland Online is a free massively multiplayer game where you can farm, build, role-play and quest. Search for the lost St. Eloi gem. This myster.. |
| GrabIt 4.4 - Screen capture utility. (Commercial) Posted: 13 Jun 2013 02:17 AM PDT  GrabIt grabs anywhere on the screen as an image and shows you instantly. Features:
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| Reddit Notifier 2.6 - Menubar notifier for Reddit users. (Commercial) Posted: 13 Jun 2013 02:12 AM PDT  Reddit Notifier is Orangered mail, delivered straight to your menu bar. It notifies you when someone replies to one of your comments or sends you a private message. The icon sits next to your clock, visible from any app.
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| Posted: 13 Jun 2013 12:00 AM PDT This study focused on the presence of antibiotic-resistant bacteria in a metro system as an example of a public transportation system. The molecular characteristics of Staphylococcus were investigated to discern which strains were isolated from metro stations in Shanghai. These were compared with strains isolated from hospital treatment rooms and parks. Airborne Staphylococcus samples in the metro were resistant to an average of 2.64 antibiotic types, and 58.0% of the strain samples were resistant to at least three antibiotics; this was a significantly higher rate than strains from the park, but was lower than those from hospitals. The presence of two antibiotic resistance genes of Staphylococcus strains, mecA (28.0%) and qac (40.0%), were also found at significantly higher levels in metro samples than park samples, but did not differ significantly from hospital samples. Furthermore, 22.0% of the metro Staphylococcus samples were found to be biofilm-positive. The high rate of antibiotic resistance found in Staphylococcus samples collected from metro stations, and the discovery of antibiotic-resistant genes, indicate that the closed indoor environment and crowded passengers may accelerate the spread of antibiotic resistant strains. More attention should be paid to the inspection and control of antibiotic resistant strains in public transportation systems. |
| Posted: 13 Jun 2013 12:00 AM PDT This study presents a method for the reconstruction of pixels contaminated by optical thick clouds in multi-spectral Landsat images using multi-frequency SAR data. A number of reconstruction techniques have already been proposed in the scientific literature. However, all of the existing techniques have certain limitations. In order to overcome these limitations, we expose the Closest Spectral Fit (CSF) method proposed by Meng et al. to a new, synergistic approach using optical and SAR data. Therefore, the term Closest Feature Vector (CFV) is introduced. The technique facilitates an elegant way to avoid radiometric distortions in the course of image reconstruction. Furthermore the cloud cover removal is independent from underlying land cover types and assumptions on seasonality, etc. The methodology is applied to mono-temporal, multi-frequency SAR data from TerraSAR-X (X-Band), ERS (C-Band) and ALOS Palsar (L-Band). This represents a way of thinking about Radar data not as foreign, but as additional data source in multi-spectral remote sensing. For the assessment of the image restoration performance, an experimental framework is established and a statistical evaluation protocol is designed. The results show the potential of a synergistic usage of multi-spectral and SAR data to overcome the loss of data due to cloud cover. |
| Metabolites, Vol. 3, Pages 506-516: Molecular Formula Identification with SIRIUS Posted: 13 Jun 2013 12:00 AM PDT We present results of the SIRIUS2 submission to the 2012 CASMI contest. Only results for Category 1 (molecular formula identification) were submitted. The SIRIUS method and the parameters used are briefly described, followed by detailed analysis of the results and a discussion of cases where SIRIUS2 was unable to come up with the correct molecular formula. SIRIUS2 returns consistently high quality results, with the exception of fragmentation pattern analysis of time-of-flight data. We then discuss possibilities for further improving SIRIUS2 in the future. |
| Posted: 13 Jun 2013 12:00 AM PDT We applied information theory to quantify parameter uncertainty in a groundwater flow model. A number of parameters in groundwater modeling are often used with lack of knowledge of site conditions due to heterogeneity of hydrogeologic properties and limited access to complex geologic structures. The present Information Theory-based (ITb) approach is to adopt entropy as a measure of uncertainty at the most probable state of hydrogeologic conditions. The most probable conditions are those at which the groundwater model is optimized with respect to the uncertain parameters. An analytical solution to estimate parameter uncertainty is derived by maximizing the entropy subject to constraints imposed by observation data. MODFLOW-2000 is implemented to simulate the groundwater system and to optimize the unknown parameters. The ITb approach is demonstrated with a three-dimensional synthetic model application and a case study of the Kansas City Plant. Hydraulic heads are the observations and hydraulic conductivities are assumed to be the unknown parameters. The applications show that ITb is capable of identifying which inputs of a groundwater model are the most uncertain and what statistical information can be used for site exploration. |
| Fantasia: Music Evolved - Directing the Music Demo E3 2013 Posted: 13 Jun 2013 12:10 AM PDT In order to understand Fantasia, you just have to watch this demo.
Read and Post Comments | Get the full article at GameSpot "Fantasia: Music Evolved - Directing the Music Demo E3 2013" was posted by Aaron Sampson on Thu, 13 Jun 2013 00:10:48 -0700 |
| Black Gold: There Will Be Blood Posted: 12 Jun 2013 11:24 PM PDT Black Gold is an MMO that features sever factions warring over the world's most precious resource: oil. Read and Post Comments | Get the full article at GameSpot "Black Gold: There Will Be Blood" was posted by Tyler Winegarner on Wed, 12 Jun 2013 23:24:55 -0700 |
| Sonic Lost World: The Very Best of Sonic Posted: 12 Jun 2013 11:18 PM PDT Sonic's latest outing combines the very best gameplay that Sonic games have had to offer - to great effect.
Read and Post Comments | Get the full article at GameSpot "Sonic Lost World: The Very Best of Sonic" was posted by Tyler Winegarner on Wed, 12 Jun 2013 23:18:35 -0700 |
| Lost Planet 3: It's a Bug Hunt Posted: 12 Jun 2013 11:12 PM PDT Maxwell McGee describes some of the tedium to be found in Lost Planet 3.
Read and Post Comments | Get the full article at GameSpot "Lost Planet 3: It's a Bug Hunt" was posted by Tyler Winegarner on Wed, 12 Jun 2013 23:12:33 -0700 |
| Payday 2 - Developer Demo E3 2013 Posted: 12 Jun 2013 11:08 PM PDT David Goldfarb shows off heists, masks, and gun customization at E3.
Read and Post Comments | Get the full article at GameSpot "Payday 2 - Developer Demo E3 2013" was posted by Aaron Sampson on Wed, 12 Jun 2013 23:08:33 -0700 |
| Bandai Namco: Three Steps Forward, One Step Back Posted: 12 Jun 2013 10:41 PM PDT With Dark Souls II and Tekken Revolution, Bandai Namco has an impressive E3 lineup. But it isn't all good news.
Read and Post Comments | Get the full article at GameSpot "Bandai Namco: Three Steps Forward, One Step Back" was posted by Tyler Winegarner on Wed, 12 Jun 2013 22:41:57 -0700 |
| Phoenix Wright Dual Destinies: Lie To me Posted: 12 Jun 2013 10:32 PM PDT Phoenix Wright's latest case tests his ability to read the emotional state of is antagonists.
Read and Post Comments | Get the full article at GameSpot "Phoenix Wright Dual Destinies: Lie To me" was posted by Tyler Winegarner on Wed, 12 Jun 2013 22:32:59 -0700 |
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