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- Plex Media Server 0.9.7.28 - Seamlessly connect your Plex clients with your local media. (Free)
- Materials, Vol. 6, Pages 2360-2371: Structural Properties of Chemically Functionalized Carbon Nanotube Thin Films
- Sensors, Vol. 13, Pages 7570-7598: Aspects of the Application of Cavity Enhanced Spectroscopy to Nitrogen Oxides Detection
- Sensors, Vol. 13, Pages 7546-7569: Accurate Human Tissue Characterization for Energy-Efficient Wireless On-Body Communications
- Sensors, Vol. 13, Pages 7522-7545: Deployment and Validation of a Smart System for Screening of Language Disorders in Primary Care
- Sensors, Vol. 13, Pages 7505-7521: Early Improper Motion Detection in Golf Swings Using Wearable Motion Sensors: The First Approach
- Molecules, Vol. 18, Pages 6908-6918: Preliminary Biological Evaluation of Novel 99mTc-Cys-Annexin A5 as a Apoptosis Imaging Agent
- Molecules, Vol. 18, Pages 6898-6907: Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
- Molecules, Vol. 18, Pages 6883-6897: Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)
- Molecules, Vol. 18, Pages 6866-6882: Design, Synthesis and Evaluation of the Antibacterial Enhancement Activities of Amino Dihydroartemisinin Derivatives
- Pascalloid Calc 8.1 - Calculate 3D animation and adjustable geometry. ()
- Golden Trails 3: The Guardian's Creed PE 1.0 - Restore the Order of the Knights Templar in this puzzle game. ()
- Ballad of Solar 1.0 - Help Solar fight evil and assist good in this strategy game. ()
- Mail Archiver X 3.0.3 20130606 - Mail archiving, cleaning, and browsing. (Demo)
- Baccarat boom fueling Macau casinos
- Plymouth Herald published Former soldier attacked ex-partner, Plymouth court told
- Molecules, Vol. 18, Pages 6852-6865: Application and Analysis of the Folin Ciocalteu Method for the Determination of the Total Phenolic Content from Limonium Brasiliense L.
- Molecules, Vol. 18, Pages 6829-6851: Exploring the C-X…π Halogen Bonding Motif: An Infrared and Raman Study of the Complexes of CF3X (X = Cl, Br and I) with the Aromatic Model Compounds Benzene and Toluene
- Molecules, Vol. 18, Pages 6804-6828: Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes
- Molecules, Vol. 18, Pages 6792-6803: Reduction of Saltiness and Acrylamide Levels in Palm Sugar-Like Flavouring through Buffer Modification and the Addition of Calcium Chloride
| Plex Media Server 0.9.7.28 - Seamlessly connect your Plex clients with your local media. (Free) Posted: 10 Jun 2013 03:24 AM PDT  Plex Media Server seamlessly connects your Plex clients with all of your local and online media. The combination of centralized library management, streaming of online content, and powerful transcoding functionality provides an unrivaled level of flexibility and ease of use. Plex Media Server runs on your Mac, PC, or compatible NAS device and serves your media to all of your Plex clients including Plex-enabled mobile devices and 2011 LG Smart TVs. Features:
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| Posted: 10 Jun 2013 12:00 AM PDT Buckypapers are thin sheets of randomly entangled carbon nanotubes, which are highly porous networks. They are strong candidates for a number of applications, such as reinforcing materials for composites. In this work, buckypapers were produced from multiwall carbon nanotubes, pre-treated by two different chemical processes, either an oxidation or an epoxidation reaction. Properties, such as porosity, the mechanical and electrical response are investigated. It was found that the chemical pretreatment of carbon nanotubes strongly affects the structural properties of the buckypapers and, consecutively, their mechanical and electrical performance. |
| Posted: 10 Jun 2013 12:00 AM PDT This article presents design issues of high-sensitive laser absorption spectroscopy systems for nitrogen oxides (NOx) detection. Examples of our systems and their investigation results are also described. The constructed systems use one of the most sensitive methods, cavity enhanced absorption spectroscopy (CEAS). They operate at different wavelength ranges using a blue—violet laser diode (410 nm) as well as quantum cascade lasers (5.27 µm and 4.53 µm). Each of them is configured as a one or two channel measurement device using, e.g., time division multiplexing and averaging. During the testing procedure, the main performance features such as detection limits and measurements uncertainties have been determined. The obtained results are 1 ppb NO2, 75 ppb NO and 45 ppb N2O. For all systems, the uncertainty of concentration measurements does not exceed a value of 13%. Some experiments with explosives are also discussed. A setup equipped with a concentrator of explosives vapours was used. The detection method is based either on the reaction of the sensors to the nitrogen oxides directly emitted by the explosives or on the reaction to the nitrogen oxides produced during thermal decomposition of explosive vapours. For TNT, PETN, RDX and HMX a detection limit better than 1 ng has been achieved. |
| Posted: 10 Jun 2013 12:00 AM PDT The demand for Wireless Body Sensor Networks (WBSNs) is rapidly increasing due to the revolution in wearable systems demonstrated by the penetration of on-the-body sensors in hospitals, sports medicine and general health-care practices. In WBSN, the body acts as a communication channel for the propagation of electromagnetic (EM) waves, where losses are mainly due to absorption of power in the tissue. This paper shows the effects of the dielectric properties of biological tissues in the signal strength and, for the first time, relates these effects with the human body composition. After a careful analysis of results, this work proposes a reactive algorithm for power transmission to alleviate the effect of body movement and body type. This policy achieves up to 40.8% energy savings in a realistic scenario with no performance overhead. |
| Posted: 10 Jun 2013 12:00 AM PDT Neuro-evolutive development from birth until the age of six years is a decisive factor in a child's quality of life. Early detection of development disorders in early childhood can facilitate necessary diagnosis and/or treatment. Primary-care pediatricians play a key role in its detection as they can undertake the preventive and therapeutic actions requested to promote a child's optimal development. However, the lack of time and little specific knowledge at primary-care avoid to applying continuous early-detection anomalies procedures. This research paper focuses on the deployment and evaluation of a smart system that enhances the screening of language disorders in primary care. Pediatricians get support to proceed with early referral of language disorders. The proposed model provides them with a decision-support tool for referral actions to trigger essential diagnostic and/or therapeutic actions for a comprehensive individual development. The research was conducted by starting from a sample of 60 cases of children with language disorders. Validation was carried out through two complementary steps: first, by including a team of seven experts from the fields of neonatology, pediatrics, neurology and language therapy, and, second, through the evaluation of 21 more previously diagnosed cases. The results obtained show that therapist positively accepted the system proposal in 18 cases (86%) and suggested system redesign for single referral to a speech therapist in three remaining cases. |
| Posted: 10 Jun 2013 12:00 AM PDT This paper presents an analysis of a golf swing to detect improper motion in the early phase of the swing. Led by the desire to achieve a consistent shot outcome, a particular golfer would (in multiple trials) prefer to perform completely identical golf swings. In reality, some deviations from the desired motion are always present due to the comprehensive nature of the swing motion. Swing motion deviations that are not detrimental to performance are acceptable. This analysis is conducted using a golfer's leading arm kinematic data, which are obtained from a golfer wearing a motion sensor that is comprised of gyroscopes and accelerometers. Applying the principal component analysis (PCA) to the reference observations of properly performed swings, the PCA components of acceptable swing motion deviations are established. Using these components, the motion deviations in the observations of other swings are examined. Any unacceptable deviations that are detected indicate an improper swing motion. Arbitrarily long observations of an individual player's swing sequences can be included in the analysis. The results obtained for the considered example show an improper swing motion in early phase of the swing, i.e., the first part of the backswing. An early detection method for improper swing motions that is conducted on an individual basis provides assistance for performance improvement. |
| Posted: 10 Jun 2013 12:00 AM PDT A novel annexin A5 derivative (cys-annexin A5) with a single cysteine residue at its C-terminal has been developed and successfully labeled in high labeling yield with 99mTc by a ligand exchange reaction. Like the 1st generation 99mTc-HYNIC-annexin A5, the novel 99mTc-cys-annexin A5 derivative shows in normal mice mainly renal and, to a lesser extent, hepatobiliary excretion. In rat models of hepatic apoptosis there was 283% increase in hepatic uptake of 99mTc-cys-annexin A5 as compared to normal mice. The results indicate that the novel 99mTc-cys-annexin A5 is a potential apoptosis imaging agent. |
| Posted: 10 Jun 2013 12:00 AM PDT A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone. |
| Posted: 10 Jun 2013 12:00 AM PDT The apical sodium-dependent bile salt transporter (ASBT) plays a pivotal role in maintaining bile acid homeostasis. Inhibition of ASBT would reduce bile acid pool size and lower cholesterol levels. In this report, a series of novel arylsulfonylaminobenzanilides were designed and synthesized as potential inhibitors of ASBT. Most of them demonstrated great potency against ASBT's bile acid transport activity. In particular, compound 5g2 inhibited ASBT activity with an IC50 value of 0.11 μM. These compounds represent potential cholesterol-lowering drugs. |
| Posted: 10 Jun 2013 12:00 AM PDT Artemisinin (ART) and its derivatives artesunate (AS), dihydroartemisinin (DHA) are a group of drugs containing a sesquiterpene lactone used to treat malaria. Previously, AS was shown to not have antibacterial activity but to significantly increase the antibacterial activities of β-lactam antibiotics against E. coli. Herein, molecular docking experiments showed that ART, AS and DHA could dock into AcrB very well, especially DHA and AS; both DHA and AS had the same docking pose. The affinity between AS and AcrB seemed weaker than that of DHA, while the succinate tail of AS, which was like a "bug", could extend in the binding pocket very well. Imitating the parent nucleus of DHA and the succinate tail of AS, twenty-one DHA derivatives 4a–u were designed and synthesized. Among them, seventeen were new compounds. The synergistic effects against E. coli AG100A/pET28a-AcrB showed among the new structures 4k, 4l, 4m, 4n, and 4r exhibited significant synergism with β-lactam antibiotics although they had no direct antibacterial activities themelves. The bacterial growth assay showed that only 4k in combination with ampicillin or cefuroxime could totally inhibit bacterial growth from 0 to 12 h, demonstrating that 4k had the best antibacterial enhancement effect. In conclusion, our results provided a new idea and several candidate compounds for antibacterial activity enhancers against multidrug resistant E. coli. |
| Pascalloid Calc 8.1 - Calculate 3D animation and adjustable geometry. () Posted: 10 Jun 2013 03:10 AM PDT Pascalloid Calc deals with Pascal's Triangle taken into additional dimensions of Plato's polyhedra. It also aids calculation of three-dimensional animation and adjustable geometry. Version 8.1:
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| Posted: 10 Jun 2013 02:50 AM PDT  Golden Trails 3: The Guardian's Creed, a mix of hidden object and puzzle game, continues the popular Golden Trails series. Intriguing storyline, awe-inspiring mysteries of the Templars, and tons of challenging puzzles await. Are you ready to find out the secrets of the Templar Order? The events take place in France at the end of the 18th century. Golden Trails 3: The Guardian's Creed opens as Jacques is knocked out by a stranger in a Parisian street. When he regains consciousness in a tavern, he finds a strange seal on his shoulder. Where does it come from? Who did it? Why? Join Jacques in his daring and danger-filled adventure as he tries to solve the mysteries of the seal. Scour numerous locations, travel Europe from Paris to the Vatican, explore ancient writings of the monks, and solve tricky puzzles in search of the truth. Help Jacques revive the Order of the Templars and guard its beliefs as you locate hidden items and solve ancient riddles. Struggling against the Black Templars, hunting for the lost treasure of the Order await you in Golden Trails 3! This is a special Premium Edition which includes exclusive extras you won't find in the standard version of the game:
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| Ballad of Solar 1.0 - Help Solar fight evil and assist good in this strategy game. () Posted: 10 Jun 2013 02:38 AM PDT  The Ballad of Solar is the tale of a hero who arrives to save the day in a land of enchantment, torn by evil. He brings courage, bravery, and skill with a sword. No orc can stop him, no troll can trip him up, and no goblin can gobble him for dinner! Guide Solar and his band of helpers as they set out to stop the dark sorcerer Grogan from achieving eternal life and to rescue the fair Lumina. As you go, you'll put your time and resource management skills to work rebuilding towns, completing quests for friends you make along the way, and stopping the enemy from striking. Told with a laugh and a wink, Ballad of Solar is a colorful, challenging, and utterly unforgettable adventure for all ages! Features:
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| Mail Archiver X 3.0.3 20130606 - Mail archiving, cleaning, and browsing. (Demo) Posted: 10 Jun 2013 02:23 AM PDT  Mail Archiver X protects one of your Mac-based small business' most important assets: your email.
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| Baccarat boom fueling Macau casinos Posted: 10 Jun 2013 02:27 AM PDT Chinese gamblers have a growing taste for baccarat, which last year provided Macau with nearly all of its $38 billion in gambling revenue. This posting includes an audio/video/photo media file: Download Now |
| Plymouth Herald published Former soldier attacked ex-partner, Plymouth court told Posted: 10 Jun 2013 02:27 AM PDT A FORMER soldier stood over his ex-partner and punched her five or six times around the face and head, a court heard. This posting includes an audio/video/photo media file: Download Now |
| Posted: 10 Jun 2013 12:00 AM PDT Limonium brasiliense is a common plant on the southern coast of Brazil. The roots are traditionally used for treatment of premenstrual syndrome, menstrual disturbances and genito-urinary infections. Pharmaceutical preparations obtained from its roots and used for these purposes were marketed in Brazil in the 1980s and 1990s. Currently, the Brazilian Drug Agency (National Health Surveillance Agency, ANVISA) has canceled the registration of these products, and their use was discontinued because of a lack of studies to characterize the plant raw material and ensure the effectiveness and safety of its use. The aim of the present study was to develop and validate an analytical method to determine the content of total polyphenols (TP) in an extract from L. brasiliense roots, by the UV/Vis spectrophotometric method. L. brasiliense roots were extracted in acetone:water (7:3, v/v-10% w/v). The crude extract was used to develop a method for TP assay. The method was validated according to national and international guidelines. The optimum conditions for analysis time, wavelength, and standard substance were 30 min, 760 nm, and pyrogallol, respectively. Under these conditions, validation by UV/Vis spectrophotometry proved the method to be linear, specific, precise, accurate, reproducible, robust, and easy to perform. This methodology complies with the requirements for analytical application and to ensure the reliability of the results. |
| Posted: 10 Jun 2013 12:00 AM PDT The formation of halogen bonded complexes formed between the trifluorohalomethanes CF3Cl, CF3Br and CF3I and the Lewis bases benzene and toluene at temperatures below 150K was investigated using FTIR and Raman spectroscopy. Experiments using liquid krypton as solvent show that for both CF3Br and CF3I substantial fractions of the monomers can be involved in 1:1 complexes. In addition, weak absorptions illustrating the formation of 2:1 complexes between CF3I and benzene are observed. Using spectra recorded at temperatures between 120 and 140 K, observed information on the relative stability was obtained for all complexes by determining the complexation enthalpies in solution. The resulting values for CF3Br.benzene, CF3I.benzene and (CF3I)2.benzene are −6.5(3), −7.6(2) and −14.5(9) kJ mol−1. The values for CF3Br.toluene and CF3I.toluene are −6.2(5) and −7.4(5) kJ mol−1. The experimental complexation enthalpies are compared with theoretical data obtained by combining results from MP2/aug-cc-pVDZ(-PP) and MP2/aug-cc-pVTZ(-PP) ab initio calculations, from statistical thermodynamical calculations and from Monte Carlo Free Energy Perturbation simulations. The data are also compared with results derived for other C-X···π halogen bonded complexes involving unsaturated Lewis bases such as ethene and ethyne. |
| Posted: 10 Jun 2013 12:00 AM PDT This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included. |
| Posted: 10 Jun 2013 12:00 AM PDT Palm sugar-like flavouring (PSLF) is a type of flavour product that is formed by heating amino acids and sugar under specific heating conditions. Unfortunately, PSLF has a salty taste and contains high amounts of acrylamide. Hence, the objective of this research was to reduce saltiness and acrylamide without negatively affecting the aroma properties of PSLF. A decrease in the sodium phosphate (NaHPO4) buffer concentration from 0.20 to 0.02 M was found to reduce sodium to approximately 15% of the level found in original PSLF. A further decrease (~25%) in the sodium content was achieved by removing monobasic sodium phosphate (NaH2PO4) from the buffer system. Meanwhile, the addition of CaCl2 at 20–40 mg/L reduced the acrylamide content in PSLF by as much as 58%. A CaCl2 concentration of 20 mg/mL was most favourable as it most efficiently suppressed acrylamide formation while providing an acceptably high flavour yield in PSLF. In view of the high acrylamide content in PSLF, additional work is necessary to further reduce the amount of acrylamide by controlling the asparagine concentration in the precursor mixture. |
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