Games |
- Toolbox for Pages 1.2.1 - Access a collection of Pages templates; in-app purchases available. (Free)
- Sync Folders Free 2.9.4 - Real time sync for folders. (Free)
- XChat Azure 1.15.0 - IRC chat client ported from UNIX (was XChat Aqua). (Free)
- OnStage 1.22 - Transform Logic Pro into a performance tool. (Commercial)
- Exposure 5 5.0.0.687 - Photographic film effects. (Demo)
- Energies, Vol. 6, Pages 2819-2839: Influence of Maintenance Intervals on Performance and Emissions of a 192 kWel Biogas Gas Otto CHP Unit and Results of Lubricating Oil Quality Tests—Outcome from a Continuous Two-Year Measuring Campaign
- Sustainability, Vol. 5, Pages 2557-2588: Effect of Systems to Manage Environmental Aspects on Environmental Performance
- Crystals, Vol. 3, Pages 363-390: Soft Elasticity in Main Chain Liquid Crystal Elastomers
- Animals, Vol. 3, Pages 532-550: A Longitudinal Study on Feeding Behaviour and Activity Patterns of Released Chimpanzees in Conkouati-Douli National Park, Republic of Congo
- Molecules, Vol. 18, Pages 6748-6781: The Development of Aromas in Ruminant Meat
- Macau's casinos thrive on Chinese gamblers' taste for baccarat
- Molecules, Vol. 18, Pages 6734-6747: Eudragit® L100/N-Trimethylchitosan Chloride Microspheres for Oral Insulin Delivery
- Insects, Vol. 4, Pages 230-240: Behavioral Responses of the Bed Bug to Permethrin-Impregnated ActiveGuard™ Fabric
- Genes, Vol. 4, Pages 293-305: RNAi-Mediated Gene Silencing in a Gonad Organ Culture to Study Sex Determination Mechanisms in Sea Turtle
- IJERPH, Vol. 10, Pages 2401-2411: High Dental Caries among Adults Aged 35 to 44 Years: Case-Control Study of Distal and Proximal Factors
- IJERPH, Vol. 10, Pages 2384-2400: Accumulations of Heavy Metals in Roadside Soils Close to Zhaling, Eling and Nam Co Lakes in the Tibetan Plateau
- IJERPH, Vol. 10, Pages 2370-2383: Public Place Smoke-Free Regulations, Secondhand Smoke Exposure and Related Beliefs, Awareness, Attitudes, and Practices among Chinese Urban Residents
- Behavioral Sciences, Vol. 3, Pages 273-297: Discrimination within Recognition Memory in Schizophrenia
- Biology, Vol. 2, Pages 810-831: Adhesion of Diarrheagenic Escherichia coli and Inhibition by Glycocompounds Engaged in the Mucosal Innate Immunity
- Toxins, Vol. 5, Pages 1119-1139: The Pore-Forming Haemolysins of Bacillus Cereus: A Review
| Toolbox for Pages 1.2.1 - Access a collection of Pages templates; in-app purchases available. (Free) Posted: 07 Jun 2013 02:58 AM PDT  Toolbox for Pages is a free download that contains links to the ultimate collection of templates and illustrations for Apple's Pages. The first item in each product category is available free of charge -- just click Open! The toolbox provides countless options for creating professional and exciting content ranging from invoices and business cards to greetings and posters. Whether you choose to purchase a single clipart image or the huge Corporate Style Packs bundle, you will receive a beautiful, easily customizable product, which will make your work more efficient and its results more enjoyable. Toolbox for Pages provides access to six product sets that can be purchased from within the app:
Version 1.2.1:
More information |
| Sync Folders Free 2.9.4 - Real time sync for folders. (Free) Posted: 07 Jun 2013 02:53 AM PDT  Sync Folders Free synchronizes folders on-the-fly whenever there are changes, when connecting external drives, or manually. The application synchronizes folders with or without filters for folder names and / or file names. The Sync Folders Free is perfect for backing up to USB, to memory cards, or to disks on remote computers on your network. Warning! Version 2.x is a new application vs version 1.x from a technical point of view. Completely changed the core of the application and algorithm of comparison of files structure which increased the speed of comparing 4-10 times for folders with many files and improved stability of the application. Left unchanged only the application interface that was liked by many customers as easy-to-use. Install the VPN Server Configurator and you can synchronize folders on a remote Mac from anywhere in the world! Learn more at www.greenworldsoft.com Features:
Version 2.9.4: New features:
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| XChat Azure 1.15.0 - IRC chat client ported from UNIX (was XChat Aqua). (Free) Posted: 07 Jun 2013 02:45 AM PDT  XChat Azure (was XChat Aqua) is an OS X-native front-end of XChat, an IRC chat program that is especially popular in the Linux world. It allows you to join multiple IRC channels (chat rooms) at the same time, talk publicly or in private one-on-one conversations, etc. Even file transfers are possible. We support 41+ locales and xchat 2.8 core features. Version 1.15.0:
OS X 10.6.6 or later More information |
| OnStage 1.22 - Transform Logic Pro into a performance tool. (Commercial) Posted: 07 Jun 2013 02:32 AM PDT  OnStage takes the stress out of your live performance. With OnStage running seamlessly alongside Apple's leading studio application, Logic Studio is transformed into a powerful performance tool. OnStage enables the user to assign a unique MIDI program-change message to 30 different Logic Pro or Logic Express Projects. This allows the performer to recall each project, or song in a set list, via an 'OnStage' MIDI control message.
OS X 10.6.6 or later More information |
| Exposure 5 5.0.0.687 - Photographic film effects. (Demo) Posted: 07 Jun 2013 02:20 AM PDT  Exposure 5 lets you enjoy all the creative tools of film photography, such as discontinued films, dark room tricks, and lo-fi camera quirks. We accurately simulate classic films, like Kodachrome, Polaroid, and Panatomic-X. The result is a photo that looks like it was made by a human, not by a computer. There is careful research under the hood, but we keep the controls simple so you can focus on your art. Exposure 5 has a completely redesigned user interface that helps you quickly develop your own look. Across the board, everything is faster and much easier to use. Version 5.0.0.687: Release notes were unavailable when this listing was updated.
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| Posted: 07 Jun 2013 12:00 AM PDT In the present work, we focus on long-term and permanent measurements of approximately two years on a 192 kWel Gas Otto CHP (combined heat and power) unit at a full-scale research biogas plant. In detail the influence of 600 h and 1800 h maintenance intervals on electrical efficiency consumption and exhaust gas emissions such as NOx and CO have been studied under real life conditions. Lubricating oil quality analyses throughout the CHP operation time are presented to show the destructive changes in property and its influence on condition based maintenance. The results confirm the well-known fact that after readjustment of the air-fuel ratio after 1800 h maintenance the emission values for NOx decline while CO increases. The emission-optimized operation mode leads to lower engine efficiency. The maintenance tasks carried out at 600 h intervals lead to lower NOx emissions in nine cases while in 14 cases the emissions remained unchanged. The permanent measurements proved their legitimacy showing various emission deviations from the limiting values prior and post maintenance. The results show that by monitoring the lubricating oil quality, the oil change intervals can be maximized while ensuring that engine performance is not endangered, and a longer engine lifespan can be expected. The oil analyses allow the operator to reduce maintenance expenditures while minimizing wear. |
| Posted: 07 Jun 2013 12:00 AM PDT This paper analyzes the effect of systems to manage environmental aspects on environmental performance at individual polluting facilities. Regulated polluting facilities are increasingly embracing pollution minimization strategies that involve the adoption of broadly defined systems to manage environmental aspects. Despite a meaningful empirical literature, whether or not these systems lead to better environmental performance remains an open question. This study seeks to assess the possible connection between systems to manage environmental aspects and improved environmental performance. It also seeks to identify the factors determining the extent of the adopted system of management and the factors' direct effects on environmental performance. For this empirical analysis, the study examines the extent of systems to manage environmental aspects employed by and the level of wastewater discharged by U.S. chemical manufacturing facilities during 2001. |
| Crystals, Vol. 3, Pages 363-390: Soft Elasticity in Main Chain Liquid Crystal Elastomers Posted: 07 Jun 2013 12:00 AM PDT Main chain liquid crystal elastomers exhibit several interesting phenomena, such as three different regimes of elastic response, unconventional stress-strain relationship in one of these regimes, and the shape memory effect. Investigations are beginning to reveal relationships between their macroscopic behavior and the nature of domain structure, microscopic smectic phase structure, relaxation mechanism, and sample history. These aspects of liquid crystal elastomers are briefly reviewed followed by a summary of the results of recent elastic and high-resolution X-ray diffraction studies of the shape memory effect and the dynamics of the formation of the smectic-C chevron-like layer structure. A possible route to realizing auxetic effect at molecular level is also discussed. |
| Posted: 07 Jun 2013 12:00 AM PDT Wild chimpanzee populations are still declining due to logging, disease transmission and hunting. The bushmeat trade frequently leads to an increase in the number of orphaned primates. HELP Congo was the first project to successfully release wild-born orphan chimpanzees into an existing chimpanzee habitat. A collection of post monitoring data over 16 years now offers the unique opportunity to investigate possible behavioural adaptations in these chimpanzees. We investigated the feeding and activity patterns in eight individuals via focal observation techniques from 1997–1999 and 2001–2005. Our results revealed a decline in the number of fruit and insect species in the diet of released chimpanzees over the years, whereas within the same period of time, the number of consumed seed species increased. Furthermore, we found a decline in time spent travelling, but an increase in time spent on social activities, such as grooming, as individuals matured. In conclusion, the observed changes in feeding and activity patterns seem to reflect important long-term behavioural and ecological adaptations in wild-born orphan released chimpanzees, demonstrating that the release of chimpanzees can be successful, even if it takes time for full adaptation. |
| Molecules, Vol. 18, Pages 6748-6781: The Development of Aromas in Ruminant Meat Posted: 07 Jun 2013 12:00 AM PDT This review provides an update on our understanding of the chemical reactions (lipid oxidation, Strecker and Maillard reactions, thiamine degradation) and a discussion of the principal aroma compounds derived from those reaction or other sources in cooked meat, mainly focused on ruminant species. This knowledge is essential in order to understand, control, and improve the quality of food products. More studies are necessary to fully understand the role of each compound in the overall cooked meat flavour and their possible effect in consumer acceptability. |
| Macau's casinos thrive on Chinese gamblers' taste for baccarat Posted: 07 Jun 2013 01:29 AM PDT In the nearly three dozen casinos in Macau, the world's biggest gambling market, there's only one game that matters: baccarat. This posting includes an audio/video/photo media file: Download Now |
| Posted: 07 Jun 2013 12:00 AM PDT Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to improve the permeation of insulin across the intestinal epithelium via the paracellular pathway. Insulin loaded microspheres were initially formulated in accordance with a factorial design (23) and manufactured by means of a single water-in-oil emulsification/evaporation method. Based on external and internal morphology two microsphere formulations were selected from the initial formulations for further investigation in terms of particle size, dissolution behaviour and in vitro insulin transport across excised rat intestinal tissue. The initial eight microsphere formulations exhibited drug loading capacities ranging from 27.9–52.4% with different shapes and internal structures. The two selected microsphere formulations had average particle sizes of 157.3 ± 31.74 µm and 135.7 ± 41.05 µm, respectively, and mean dissolution time values for insulin release of 34.47 and 42.63 min, respectively. In vitro transport of insulin across excised rat intestinal tissue from the two selected microsphere formulations was 10.67–fold and 9.68–fold higher than the control group (insulin alone). The microsphere delivery system prepared from Eudragit® L100 containing N-trimethylchitosan chloride is therefore a promising candidate for effective oral insulin delivery. |
| Posted: 07 Jun 2013 12:00 AM PDT ActiveGuard™ Mattress Liners have been used to control house dust mites, and they also are commercially available as an integrated pest management tool for use against bed bugs (Cimex lectularius). The aim of our study was to evaluate responses of numerous populations of the bed bug to the permethrin-impregnated fabric, with particular regard to contact toxicity, repellency, and feeding inhibition. Continuous exposure to ActiveGuard fabric resulted in rapid intoxication for three of four populations, with 87 to 100% of moderately pyrethroid-resistant and susceptible bed bugs succumbing by 1 d. In comparison, a highly resistant population reached 22% mortality at 10 d. Video data revealed that bed bugs readily traversed ActiveGuard fabric and spent a considerable amount of time moving about and resting on it during a 12-h period. ActiveGuard fabric was non-repellent to bed bugs from five tested populations. Furthermore, significantly fewer bed bugs successfully fed to repletion through ActiveGuard fabric than through blank fabric for the five populations. With just 30 min of feeding exposure, mortality ranged from 4% to 83%, depending upon the bed bug strain. These laboratory studies indicate that ActiveGuard liners adversely affected bed bugs from diverse populations. |
| Posted: 07 Jun 2013 12:00 AM PDT The autosomal Sry-related gene, Sox9, encodes a transcription factor, which performs an important role in testis differentiation in mammals. In several reptiles, Sox9 is differentially expressed in gonads, showing a significant upregulation during the thermo-sensitive period (TSP) at the male-promoting temperature, consistent with the idea that SOX9 plays a central role in the male pathway. However, in spite of numerous studies, it remains unclear how SOX9 functions during this event. In the present work, we developed an RNAi-based method for silencing Sox9 in an in vitro gonad culture system for the sea turtle, Lepidochelys olivacea. Gonads were dissected as soon as the embryos entered the TSP and were maintained in organ culture. Transfection of siRNA resulted in the decrease of both Sox9 mRNA and protein. Furthermore, we found coordinated expression patterns for Sox9 and the anti-Müllerian hormone gene, Amh, suggesting that SOX9 could directly or indirectly regulate Amh expression, as it occurs in mammals. These results demonstrate an in vitro method to knockdown endogenous genes in gonads from a sea turtle, which represents a novel approach to investigate the roles of important genes involved in sex determination or differentiation pathways in species with temperature-dependent sex determination. |
| Posted: 07 Jun 2013 12:00 AM PDT The aim of this study was to determine whether a high degree of dental caries severity is associated with the distal and proximal determinants of caries in a group of Brazilian adults aged 35 to 44 years. A population-based case-control study was conducted using two groups—a case group with high caries severity (DMFT ≥ 14) and a control group without high caries severity (DMFT < 14). The sample comprised adults from metropolitan Belo Horizonte, Brazil (180 cases and 180 controls matched for gender and age). The exam was performed by calibrated dentists using the DMFT index. The statistical analysis used the Mann-Whitney test and bivariate and multivariate logistic regression (the conditional backward stepwise method). The mean DMFT was 8.4 ± 3.9 in the control group and 20.1 ± 4.5 in the case group. High caries severity was associated with regular visits to the dentist, low income, use of private/supplementary dental service and not petitioning the authorities for community benefits. The results of the study underscore the importance of considering distal and proximal factors in the assessment of the severity of dental caries. Greater caries severity persists among low-income families and among groups with a low degree of social cohesion. |
| Posted: 07 Jun 2013 12:00 AM PDT Concentrations of four typical heavy metals (Cu; Zn; Cd and Pb) in roadside soils close to three lakes in the Tibetan Plateau were investigated in this study. The hierarchical tree-based regression method was applied to classify concentrations of the heavy metals and analyze their potential influencing factors. It was found that the Tibetan Plateau meadow soils with higher content of sand lead to higher concentrations of Cu; Zn and Pb. The concentrations of Cd and Pb increase with road traffic volume; and for the road segments with higher traffic volume; the Cd and Pb concentrations significantly decrease with the roadside distance. Additionally; the concentrations of Zn and Pb increase as the altitude of sampling site increases. Furthermore; the Hakanson potential ecological risk index method was used to assess the contamination degree of the heavy metals for the study regions. The results show that accumulations of Cu; Zn and Pb in roadside soils remain an unpolluted level at all sites. However; the Cd indices in the regions with higher traffic volume have reached a strong potential ecological risk level; and some spots with peak concentrations have even been severely polluted due to traffic activities. |
| Posted: 07 Jun 2013 12:00 AM PDT Objective: To evaluate the association between smoke-free regulations in public places and secondhand smoke exposure and related beliefs, awareness, attitudes, and behavior among urban residents in China. Methods: We selected one city (Hangzhou) as the intervention city and another (Jiaxing) as the comparison. A structured self-administered questionnaire was used for data collection, and implemented at two time points across a 20-month interval. Both unadjusted and adjusted logistic methods were considered in analyses. Multiple regression procedures were performed in examining variation between final and baseline measures. Results: Smoke-free regulations in the intervention city were associated with a significant decline in personal secondhand smoke exposure in government buildings, buses or taxis, and restaurants, but there was no change in such exposure in healthcare facilities and schools. In terms of personal smoking beliefs, awareness, attitudes, and practices, the only significant change was in giving quitting advice to proximal family members. Conclusions: There was a statistically significant association between implementation of smoke-free regulations in a city and inhibition of secondhand tobacco smoking exposure in public places. However, any such impact was limited. Effective tobacco control in China will require comprehensive laws implemented fully and supported by penalties and a combination of strong public health education. |
| Posted: 07 Jun 2013 12:00 AM PDT Episodic memory is one of the most affected cognitive domains in schizophrenia. First-degree biological relatives of individuals with schizophrenia also have been found to exhibit a similar, but milder, episodic memory deficit. Unlike most studies that focus on the percent of previously presented items recognized, the current investigation sought to further elucidate the nature of memory dysfunction associated with schizophrenia by examining the discrimination of old and new material during recognition (measured by d') to consider false recognition of new items. Using the Recurring Figures Test and the California Verbal Learning Test (CVLT), we studied a sample of schizophrenia probands and the first-degree biological relatives of patients with schizophrenia, as well as probands with bipolar disorder and first-degree biological relatives to assess the specificity of recognition memory dysfunction to schizophrenia. The schizophrenia sample had poorer recognition discrimination in both nonverbal and verbal modalities; no such deficits were identified in first-degree biological relatives or bipolar disorder probands. Discrimination in schizophrenia and bipolar probands failed to benefit from the geometric structure in the designs in the manner that controls did on the nonverbal test. Females performed better than males in recognition of geometric designs. Episodic memory dysfunction in schizophrenia is present for a variety of stimulus domains and reflects poor use of item content to increase discrimination of old and new items. |
| Posted: 07 Jun 2013 12:00 AM PDT Escherichia coli colonizes the human intestine shortly after birth, with most strains engaging in a commensal relationship. However, some E. coli strains have evolved toward acquiring genetic traits associated with virulence. Currently, five categories of enteroadherent E. coli strains are well-recognized, and are classified in regard to expressed adhesins and the strategy used during the colonization. The high morbidity associated with diarrhea has motivated investigations focusing on E. coli adhesins, as well on factors that inhibit bacterial adherence. Breastfeeding has proved to be the most effective strategy for preventing diarrhea in children. Aside from the immunoglobulin content, glycocompounds and oligosaccharides in breast milk play a critical role in the innate immunity against diarrheagenic E. coli strains. This review summarizes the colonization factors and virulence strategies exploited by diarrheagenic E. coli strains, addressing the inhibitory effects that oligosaccharides and glycocompounds, such as lactoferrin and free secretory components, exert on the adherence and virulence of these strains. This review thus provides an overview of experimental data indicating that human milk glycocompounds are responsible for the universal protective effect of breastfeeding against diarrheagenic E. coli pathotypes. |
| Toxins, Vol. 5, Pages 1119-1139: The Pore-Forming Haemolysins of Bacillus Cereus: A Review Posted: 07 Jun 2013 12:00 AM PDT The Bacillus cereus sensu lato group contains diverse Gram-positive spore-forming bacteria that can cause gastrointestinal diseases and severe eye infections in humans. They have also been incriminated in a multitude of other severe, and frequently fatal, clinical infections, such as osteomyelitis, septicaemia, pneumonia, liver abscess and meningitis, particularly in immuno-compromised patients and preterm neonates. The pathogenic properties of this organism are mediated by the synergistic effects of a number of virulence products that promote intestinal cell destruction and/or resistance to the host immune system. This review focuses on the pore-forming haemolysins produced by B. cereus: haemolysin I (cereolysin O), haemolysin II, haemolysin III and haemolysin IV (CytK). Haemolysin I belongs to the cholesterol-dependent cytolysin (CDC) family whose best known members are listeriolysin O and perfringolysin O, produced by L. monocytogenes and C. perfringens respectively. HlyII and CytK are oligomeric ß-barrel pore-forming toxins related to the α-toxin of S. aureus or the ß-toxin of C. perfringens. The structure of haemolysin III, the least characterized haemolytic toxin from the B. cereus, group has not yet been determined. |
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