Games |
- Micromachines, Vol. 4, Pages 272-285: On-Chip Enucleation of Bovine Oocytes using Microrobot-Assisted Flow-Speed Control
- Marine Drugs, Vol. 11, Pages 2230-2238: Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
- Laws, Vol. 2, Pages 150-172: Tunisian Migrant Journeys: Human Rights Concerns for Tunisians Arriving by Sea
- JDB, Vol. 1, Pages 47-63: Microsurgical Procedures for Studying the Developmental Significance of the Proepicardium and Epicardium in Avian Embryos: PE-Blocking, PE-Photoablation, and PE-Grafting
- JDB, Vol. 1, Pages 32-46: Epicardial Lineages
- IJERPH, Vol. 10, Pages 2596-2605: Impact of Chlorine Dioxide Gas Sterilization on Nosocomial Organism Viability in a Hospital Room
- Entropy, Vol. 15, Pages 2448-2463: A Maximum Entropy Approach to the Realizability of Spin Correlation Matrices
- iFFmpeg 3.7.2 - Convert multimedia files between formats. (Shareware)
- Batch Image Resizer 1.5.7 - Resize and edit multiple images for Web publishing and sharing. (shareware)
- FontNuke 1.2.0 - Removes font cache files. (Free)
- DjVuReader 1.4.0 - Fully featured reader for DjVu files. (Commercial)
- Life Goes On - Screenshots
- MLB Live Challenge - Screenshots
- Brain Sciences, Vol. 3, Pages 992-1012: Neuromolecular Imaging Shows Temporal Synchrony Patterns between Serotonin and Movement within Neuronal Motor Circuits in the Brain
- Coatings, Vol. 3, Pages 98-107: Uniform and Robust Peptoid Microsphere Coatings
- Behavioral Sciences, Vol. 3, Pages 298-315: Hippocampal Physiology, Structure and Function and the Neuroscience of Schizophrenia: A Unified Account of Declarative Memory Deficits, Working Memory Deficits and Schizophrenic Symptoms
- Atoms, Vol. 1, Pages 13: Special Issue on Critical Assessment of Theoretical Calculations of Atomic Structure and Transition Probabilities
- Slot Revolution - Screenshots
- Balloon Blowout - Screenshots
- Wiggle Web - Screenshots
| Posted: 21 Jun 2013 12:00 AM PDT In this study, we developed a microfluidic chip with a magnetically driven microrobot for oocyte enucleation. A microfluidic system was specially designed for enucleation, and the microrobot actively controls the local flow-speed distribution in the microfluidic chip. The microrobot can adjust fluid resistances in a channel and can open or close the channel to control the flow distribution. Analytical modeling was conducted to control the fluid speed distribution using the microrobot, and the model was experimentally validated. The novelties of the developed microfluidic system are as follows: (1) the cutting speed improved significantly owing to the local fluid flow control; (2) the cutting volume of the oocyte can be adjusted so that the oocyte undergoes less damage; and (3) the nucleus can be removed properly using the combination of a microrobot and hydrodynamic forces. Using this device, we achieved a minimally invasive enucleation process. The average enucleation time was 2.5 s and the average removal volume ratio was 20%. The proposed new system has the advantages of better operation speed, greater cutting precision, and potential for repeatable enucleation. |
| Posted: 21 Jun 2013 12:00 AM PDT Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM. |
| Posted: 21 Jun 2013 12:00 AM PDT In part due to its location on the North African coast, in conjunction with its history of being a former French protectorate, Tunisia has become an important country of emigration to the European Union. In particular, maritime arrivals have become a concern for European states, for both humanitarian and security reasons. The experiences of Tunisian irregular migrants arriving to the EU by sea, who are then detained and returned, highlights the multitude of human rights issues that arise across their journey as they interact with the various stakeholders involved—Tunisian and Libyan smugglers, EU and Tunisian authorities and NGOs, amongst others. The situation for these migrants at sea and during rescue and interception operations can most directly involve such issues as the right to life, access to food and water, access to emergency healthcare and access to information. The next stages of detention and return (either immediately or when later identified on EU territory) can most directly involve human rights issues related to the identification and referral mechanisms for groups at risk, access to information and legal remedy, the right of "non-refoulement" and prohibition of torture, inhuman and degrading treatment and punishment. By examining Tunisian migrant experiences along the entirety of their trajectory, one can see the specific human rights issues that arise at each stage for maritime arrivals—from departure to return. The article will examine these human rights concerns in the context of the Tunisian migrant journey, focusing on the four identified stages of the situation at sea, rescue or interception, detention and return. The article will present results from qualitative in-depth interviews conducted for the EU Fundamental Rights Agency in 2011 with 15 Tunisian migrants who had arrived by sea to Italy between 2005 and 2011 and were returned to Tunisia between 2008 and 2011, complemented by interviews with two Tunisian fishermen and an anonymous Tunisian non-governmental stakeholder. |
| Posted: 21 Jun 2013 12:00 AM PDT The epicardium is the outer skin of the mature vertebrate heart. Its embryonic origin and its possible roles in the developing and mature heart did not receive much recognition during the 19th and most of the 20th century. During the past 25 years, however, the epicardium came into the focus of developmental biology and regenerative medicine. Clinical researchers usually prefer genetically modified mouse models when they want to gain insight into developmental or pathological processes. The story of research on the embryonic epicardium, however, nicely demonstrates the value of non-mammalian species, namely avian species, for elucidating fundamental processes in embryonic and fetal development. Studies on chick and quail embryos have not only led to the identification of the primarily extracardiac source of the epicardium—presently called the proepicardium (PE)—they have also significantly contributed to our current knowledge about the developmental significance of the embryonic epicardium. In this review article, I describe three "classical" microsurgical experiments that have been developed for studying the developmental significance of the PE/epicardium in avian embryos (mechanical PE-blocking, PE-photoablation, orthotopic PE-grafting). Furthermore, I show how these microsurgical experiments have contributed to our current knowledge about the roles of the PE/epicardium in cardiac development. There are still some unsolved aspects in the physiology of the developing epicardium, which may be clarified with the aid of these "classical" microsurgical experiments. |
| JDB, Vol. 1, Pages 32-46: Epicardial Lineages Posted: 21 Jun 2013 12:00 AM PDT The epicardium is the mono-layered epithelium that covers the outer surface of the myocardium from early in cardiac development. Long thought to act merely passively to protect the myocardium from frictional forces in the pericardial cavity during the enduring contraction and expansion cycles of the heart, it is now considered to be a crucial source of cells and signals that direct myocardial growth and formation of the coronary vasculature during development and regeneration. Lineage tracing efforts in the chick, the mouse and the zebrafish unambiguously identified fibroblasts in interstitial and perivascular locations as well as coronary smooth muscle cells as the two major lineages that derive from epithelial-mesenchymal transition and subsequent differentiation from individual epicardial cells. However, controversies exist about an additional endothelial and myocardial fate of epicardial progenitor cells. Here, we review epicardial fate mapping efforts in three vertebrate model systems, describe their conceptual differences and discuss their methodological limitations to reach a consensus of the potential of (pro-)epicardial cells in vitro and in vivo. |
| Posted: 21 Jun 2013 12:00 AM PDT To evaluate the ability of ClO2 to decontaminate pathogens known to cause healthcare-associated infections in a hospital room strains of Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis, Mycobacterium smegmatis, and Staphylococcus aureus were spot placed in duplicate pairs at 10 sites throughout a hospital room and then exposed to ClO2 gas. Organisms were collected and evaluated for reduction in colony forming units following gas exposure. Six sterilization cycles with varied gas concentrations, exposure limits, and relative humidity levels were conducted. Reductions in viable organisms achieved ranged from 7 to 10-log reductions. Two sterilization cycles failed to produce complete inactivation of organisms placed in a bathroom with the door closed. Reductions of organisms in the bathroom ranged from 6-log to 10-log reductions. Gas leakage between hospital floors did not occur; however, some minor gas leakage from the door of hospital room was measured which was subsequently sealed to prevent further leakage. Novel technologies for disinfection of hospital rooms require validation and safety testing in clinical environments. Gaseous ClO2 is effective for sterilizing environmental contamination in a hospital room. Concentrations of ClO2 up to 385 ppm were safely maintained in a hospital room with enhanced environmental controls. |
| Posted: 21 Jun 2013 12:00 AM PDT Deriving the form of the optimal solution of a maximum entropy problem, we obtain an infinite family of linear inequalities characterizing the polytope of spin correlation matrices. For n ≤ 6, the facet description of such a polytope is provided through a minimal system of Bell-type inequalities. |
| iFFmpeg 3.7.2 - Convert multimedia files between formats. (Shareware) Posted: 21 Jun 2013 02:18 AM PDT  iFFmpeg is a graphical front-end for FFmpeg, a command-line tool used to convert multimedia files between formats. The command line instructions can be very hard to master/understand, so iFFmpeg does all the hard work for you. This allows you to use FFmpeg without detailed command-line knowledge. Version 3.7.2:
More information Download Now |
| Posted: 21 Jun 2013 02:10 AM PDT  Batch Image Resizer lets you resize, rename, rotate, and add borders to multiple images for Web publishing and sharing. If you have ever needed to resize multiple pictures for your Web page, then this program is for you. With this appliction, you can resize, rotate, add a transparent border, and save pictures with an icon preview. Best of all, it uses batch mode processing - so you can manipulate multiple pictures at once! Also, it allows you to grab the first page of a PDF file, convert it to an image, and resize it. Batch Image Resizer now also allows you to watermark your files. This feature is extremely useful for web developers because you can now resize your images and copy-protect them all in one step! The workflow is far easier and faster than bulky, monthly subscription applications such as Adobe Photoshop.
OS X 10.4 or later More information Download Now |
| FontNuke 1.2.0 - Removes font cache files. (Free) Posted: 21 Jun 2013 02:01 AM PDT  FontNuke is a utility application that removes corrupt or troublesome font cache files. I created this application as a tool for my personal use at the office, and has become very useful for me. To grant individual non-admin users the ability to remove font cache files, without my involvement--is huge! Not to mention intelligent application quitting, plus a guaranteed reboot, makes my life easier. FontNuke removes system font caches, Adobe font caches (*.lst), Microsoft Office font caches, and now also (as of version 1.1.9) all versions of QuarkXPress font cache files. Not to mention it's free. I have recently added an option which purges spotlight indexes on startup volume from /.Spotlight-V100. This has been added due to some intermittent unresponsiveness when searching network volumes for some of my MCX clients. Please use this feature with caution. See the FontNuke homepage for more details.
OS X 10.6 or later More information Download Now |
| DjVuReader 1.4.0 - Fully featured reader for DjVu files. (Commercial) Posted: 21 Jun 2013 01:54 AM PDT  DjVu Reader is the most fully featured reader for DjVu files available on the Mac store. Features:
DjVu is a new image compression technology to solve the problem of bulky image files that are simply too large for acceptable download speeds when used on the Web. For companies or individuals who deal with large numbers of image documents this not only considerably reduces the storage space required but also makes the distribution of these documents far more efficient. DjVu typically achieves compression ratios between 5 and 10 times better than JPEG and GIF files for color documents, and 3 to 8 times better than TIFF for black and white images. Decompression is also far more efficient, with an image that would usually require 25Mb RAM to decompress only needing about 2Mb. Version 1.4.0:
More information Download Now |
| Posted: 21 Jun 2013 02:47 AM PDT In order to reach this coveted prize, you must sacrifice the knights one by one in order to progress. Impale a knight on a spike to provide a safe platform needed to cross a pit. Catch another knight on a saw blade so their body falls on a button to solve a puzzle. Fling your knights heroically into the flames to allow those that follow to reach new heights. Discover hidden monsters that linger in the depths and hunger for the satisfying crunch of an unfortunate former champion. Life Goes On gives players a fresh look at life and death in video games through comically morbid puzzles and challenges that can only be overcome by dying. |
| MLB Live Challenge - Screenshots Posted: 21 Jun 2013 02:33 AM PDT KEY FEATURES Build, train and perfect your custom team! Over 2,000 collectible real MLB Player Tickets from all 30 Major League teams! Your team's success is directly impacted by daily updates from players' real MLB performances. Earn coins based on real-world Player results. Compete in Season Mode against other Live Challenge users and real MLB Teams! 3D Players and stadiums featured in game-changing Key Moments! Cross-platform gameplay allows you to enjoy MLB Live Challenge on both Facebook and iOS. |
| Posted: 21 Jun 2013 12:00 AM PDT The present discourse links the electrical and chemical properties of the brain with neurotransmitters and movement behaviors to further elucidate strategies to diagnose and treat brain disease. Neuromolecular imaging (NMI), based on electrochemical principles, is used to detect serotonin in nerve terminals (dorsal and ventral striata) and somatodendrites (ventral tegmentum) of reward/motor mesocorticolimbic and nigrostriatal brain circuits. Neuronal release of serotonin is detected at the same time and in the same animal, freely moving and unrestrained, while open-field behaviors are monitored via infrared photobeams. The purpose is to emphasize the unique ability of NMI and the BRODERICK PROBE® biosensors to empirically image a pattern of temporal synchrony, previously reported, for example, in Aplysia using central pattern generators (CPGs), serotonin and cerebral peptide-2. Temporal synchrony is reviewed within the context of the literature on central pattern generators, neurotransmitters and movement disorders. Specifically, temporal synchrony data are derived from studies on psychostimulant behavior with and without cocaine while at the same time and continuously, serotonin release in motor neurons within basal ganglia, is detected. The results show that temporal synchrony between the neurotransmitter, serotonin and natural movement occurs when the brain is NOT injured via, e.g., trauma, addictive drugs or psychiatric illness. In striking contrast, in the case of serotonin and cocaine-induced psychostimulant behavior, a different form of synchrony and also asynchrony can occur. Thus, the known dysfunctional movement behavior produced by cocaine may well be related to the loss of temporal synchrony, the loss of the ability to match serotonin in brain with motor activity. The empirical study of temporal synchrony patterns in humans and animals may be more relevant to the dynamics of motor circuits and movement behaviors than are studies of static parameters currently relied upon within the realms of science and medicine. There are myriad applications for the use of NMI to discover clinically relevant diagnoses and treatments for brain disease involving the motor system. |
| Coatings, Vol. 3, Pages 98-107: Uniform and Robust Peptoid Microsphere Coatings Posted: 21 Jun 2013 12:00 AM PDT Peptoids that are helical and partially water soluble have been shown to self-assemble into microspheres when the peptoid solution is dried on a silicon substrate. Such microsphere coatings have great potential for use in biosensor technologies, specifically to increase the surface area for binding. However, in order to be useful, the peptoids must consistently form uniform coatings. In this study we investigated the effects of various coating protocol parameters on the uniformity of the resulting peptoid microsphere coatings, including (i) solvent, (ii) administration technique, and (iii) drying environment. In addition, we investigated the robustness of the coatings as well as the potential for using a glass substrate. These studies show that uniform, robust peptoid microsphere coatings can be formed using protic solvents, a full coverage administration technique, and drying in open air on silicon or glass substrates. |
| Posted: 21 Jun 2013 12:00 AM PDT Memory impairment is a consistent feature of the schizophrenic syndrome. Hippocampal dysfunction has also been consistently demonstrated. This review will discuss neurophysiological and neuroanatomical aspects of memory formation and how they relate to memory impairment in schizophrenia. An understanding of the cellular physiology and connectivity of the hippocampus with other regions can also aid in understanding the relationship between schizophrenic declarative or relational memory deficits, working memory deficits and the clinical symptoms of the syndrome. |
| Posted: 21 Jun 2013 12:00 AM PDT There exist several codes in the atomic physics community to generate atomic structure and transition probabilities freely and readily distributed to researchers outside atomic physics community, in plasma, astrophysical or nuclear physics communities. Users take these atomic physics codes to generate the necessary atomic data or modify the codes for their own applications. However, there has been very little effort to validate and verify the data sets generated by non-expert users. |
| Posted: 21 Jun 2013 02:26 AM PDT Features Create your character and embark on a grand quest! Choose between 3 unique classes: Warrior, Ranger, or Wizard. Join forces with other players to increase your might. Spin the reels as you travel and battle your way through spectauclar 3D environments. Match slots to cast spells, use items and deal devastating damage to foes! Earn gold, weapons, and other loot by defeating deadly enemies. Evolve weapons and armor into legendary artifacts with rare materials! Cross-platform gameplay allows you to enjoy Slot Revolution on iOS, Android, and Kindle Platforms. |
| Posted: 21 Jun 2013 02:16 AM PDT It comes with 45 puzzles with popping points and star system goals and an exhilarating super survivor mode that lets you play as long as you can last. Who knew that popping balloons could be so much fun?!? Features: * Beautiful graphics and fun balloons that the entire family can enjoy! * 45 different puzzle levels with each one never being quite the same. * Popping point and star system designed to help keep you focused. * Special "Survivor Mode" where the only limit is your ability to pop all of the balloons before 20 get away! * Super funny sounds and wacky balloon faces! |
| Posted: 21 Jun 2013 02:06 AM PDT Features • 5 worlds to explore and 100 levels to play! • Get mega bonus points for long jumps, wall dodges, plenty o' pins and kingpins! • Fill your trophy room with collectible flies like the Fruit Fly, Supa Fly, Butter Fly, and more! • Beat your best score and replay any level to achieve 3 stars |
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