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- DEVONagent Pro 3.5 - Maximize Web search efficiency. (Demo)
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- Molecules, Vol. 18, Pages 4816-4843: Theoretical Analysis on the Kinetic Isotope Effects of Bimolecular Nucleophilic Substitution (SN2) Reactions and Their Temperature Dependence
- Pharmaceutics, Vol. 5, Pages 246-260: Development of a Novel Lipophilic, Magnetic Nanoparticle for in Vivo Drug Delivery
- Sustainability, Vol. 5, Pages 1747-1763: Public Values and Community Energy: Lessons from the US and UK
- Sustainability, Vol. 5, Pages 1725-1746: Do We Teach What We Preach? An International Comparison of Problem- and Project-Based Learning Courses in Sustainability
- Marine Drugs, Vol. 11, Pages 1409-1426: PTP1B Inhibitory and Anti-Inflammatory Effects of Secondary Metabolites Isolated from the Marine-Derived Fungus Penicillium sp. JF-55
- Marine Drugs, Vol. 11, Pages 1399-1408: Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
- Marine Drugs, Vol. 11, Pages 1370-1398: Natural Product Research in the Australian Marine Invertebrate Dicathais orbita
- Marine Drugs, Vol. 11, Pages 1351-1369: Unusual Glycosaminoglycans from a Deep Sea Hydrothermal Bacterium Improve Fibrillar Collagen Structuring and Fibroblast Activities in Engineered Connective Tissues
- Cut the Rope: Time Travel HD - Screenshots
- Salt Lake Gallery Stroll: Cindy Bean
- Tink - Screenshots
- Toxin: Zombie Annihilation - Screenshots
- Shiny the Firefly - Screenshots
- Viruses, Vol. 5, Pages 1175-1207: Small Ruminant Lentiviruses: Genetic Variability, Tropism and Diagnosis
- Viruses, Vol. 5, Pages 1153-1174: Characterization of Clade 2.3.2.1 H5N1 Highly Pathogenic Avian Influenza Viruses Isolated from Wild Birds (Mandarin Duck and Eurasian Eagle Owl) in 2010 in Korea
- Viruses, Vol. 5, Pages 1143-1152: Induced Degradation of Tat by Nucleocapsid (NC) via the Proteasome Pathway and Its Effect on HIV Transcription
- Toxins, Vol. 5, Pages 841-864: Effect of Low Dose of Fumonisins on Pig Health: Immune Status, Intestinal Microbiota and Sensitivity to Salmonella
- Toxins, Vol. 5, Pages 821-840: Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins
| DEVONagent Pro 3.5 - Maximize Web search efficiency. (Demo) Posted: 23 Apr 2013 02:57 AM PDT  DEVONagent Pro helps you search more efficiently on the web. It searches multiple sources, frees you from hunting for the really relevant results, and gives you power tools for your research.
DEVONagent Pro is not a simple Google interface. It knows how to talk to search engines, and how to squeeze the best out of them. DEVONagent connects to as many search engines as you want, collects the data, and weeds out the junk that managed to slip through. It also scans your favorite websites and notifies you when it finds something that matches your query. It can even do all of this while you're sleeping; the results will be ready before you pour your first cup of coffee. Get the good stuff, skip the junk DEVONagent Pro doesn't simply trust the search engines. It filters all returned results again, allowing you to use advanced Boolean operators, proximity operators, and wildcards of unlimited complexity, something no single search engine allows you to do. DEVONagent's "scanners" can even find thumbnail galleries or linked PDF or Office documents for you. When you've found what you're looking but want a little more detail, the unique See Also list contains related pages from elsewhere in the search results, online and even from DEVONthink Pro. The information you want, the way you want View the results as a list or as a smart text summary, and explore them with the topics map. Unread results are marked with a blue dot, just like in Apple Mail, so that you don't miss the one important piece of information you're looking for. Finally, for viewing Web pages there's DEVONagent Pro's specialized Web browser. Extract images, RSS feeds, links, email addresses, even linked documents with a single click and save them for reference or reuse. Save your research and come back later DEVONagent Pro exports your filtered and trimmed-to-the-max research results in a variety of formats, from a simple list of bookmarks to comprehensive RTF digests and PDF reports. The built-in, searchable archive keeps them for later reference, or you can send your results to DEVONthink. Finally, you can save your search and continue later on, or even share it with others via email. How DEVONagent Pro can help your research
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| Sleipnir 4.2.0.1 - Gesture-focused Web browser. (Free) Posted: 23 Apr 2013 02:48 AM PDT  Sleipnir is a Web browser for Mac with Smartphone and Web App Linker. Freely browsing the Web without having to think about unnecessary things with the rich selection of functions in Sleipnir. With Sleipnir 3, you can experience Web browsing never seen before such as the extremely simple design, and the powerful operations that can be easily performed with just one hand. Extremely speedy gestures Main functions:
All phone numbers are clickable when using Sleipnir 3. By simply clicking that phone number, the phone number is sent to your smartphone, and you can start calling from your smartphone straight away. In order to user Smartphone App Linker, it is required to download the free app Sleipnir Linker that can be used on iPhone / iPad and Android, and a Fenrir pass ID that can be obtained for free. Web App Linker Version 4.2.0.1: Gestures that captivate
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 23 Apr 2013 12:00 AM PDT Factors affecting the kinetic isotope effects (KIEs) of the gas-phase SN2 reactions and their temperature dependence have been analyzed using the ion-molecule collision theory and the transition state theory (TST). The quantum-mechanical tunneling effects were also considered using the canonical variational theory with small curvature tunneling (CVT/SCT). We have benchmarked a few ab initio and density functional theory (DFT) methods for their performance in predicting the deuterium KIEs against eleven experimental values. The results showed that the MP2/aug-cc-pVDZ method gave the most accurate prediction overall. The slight inverse deuterium KIEs usually observed for the gas-phase SN2 reactions at room temperature were due to the balance of the normal rotational contribution and the significant inverse vibrational contribution. Since the vibrational contribution is a sensitive function of temperature while the rotation contribution is temperature independent, the KIEs are thus also temperature dependent. For SN2 reactions with appreciable barrier heights, the tunneling effects were predicted to contribute significantly both to the rate constants and to the carbon-13, and carbon-14 KIEs, which suggested important carbon atom tunneling at and below room temperature. |
| Posted: 23 Apr 2013 12:00 AM PDT The aim of the present study was to evaluate the transfection potential of chitosan-coated, green-fluorescent magnetic nanoparticles (MNPs) (chi-MNPs) after encapsulation inside polyethylglycol (PEG)ylated liposomes that produced lipid-encapsulated chitosan-coated MNPs (lip-MNPs), and also to evaluate how these particles would distribute in vivo after systemic injection. The transfection potential of both chi-MNPs and lip-MNPs was evaluated in vitro in rat brain endothelial 4 (RBE4) cells with and without applying a magnetic field. Subsequently, the MNPs were evaluated in vivo in young rats. The in vitro investigations revealed that the application of a magnetic field resulted in an increased cellular uptake of the particles. The lip-MNPs were able to transfect the RBE4 cells with an incidence of approximately 20% of a commercial transfection agent. The in vivo distribution studies revealed that lip-MNPs had superior pharmacokinetic properties due to evasion of the RES, including hepatic Kuppfer cells and macrophages in the spleen. In conclusion, we were able to design a novel lipid-encapsulated MNP with the ability to carry genetic material, with favorable pharmacokinetic properties, and under the influence of a magnetic field with the capability to mediate transfection in vitro. |
| Posted: 23 Apr 2013 12:00 AM PDT This paper examines some of the normative aspects of "community energy" programmes—defined here as decentralized forms of energy production and distributed energy technologies where production decisions are made as close as possible to sources of consumption. Such projects might also display a degree of separation from the formal political process. The development of a community energy system often generates a great deal of debate about both the degree of public support for such programmes and the values around which programmes ought to be organized. Community energy programmes also raise important issues regarding the energy choice problem, including questions of process, that is, by whom a project is developed and the influence of both community and exogenous actors, as well as certain outcome issues regarding the spatial and social distribution of energy. The case studies, drawn from community energy programmes in both the United States and the United Kingdom, allow for a careful examination of all of these factors, considering in particular the complex interplay and juxtaposition between the ideas of "public value" and "public values". |
| Posted: 23 Apr 2013 12:00 AM PDT Problem- and project-based learning (PPBL) courses in sustainability address real-world sustainability problems. They are considered powerful educational settings for building students' sustainability expertise. In practice, however, these courses often fail to fully incorporate sustainability competencies, participatory research education, and experiential learning. Only few studies exist that compare and appraise PPBL courses internationally against a synthesized body of the literature to create an evidence base for designing PPBL courses. This article introduces a framework for PPBL courses in sustainability and reviews PPBL practice in six programs around the world (Europe, North America, Australia). Data was collected through semi-structured qualitative interviews with course instructors and program officers, as well as document analysis. Findings indicate that the reviewed PPBL courses are of high quality and carefully designed. Each PPBL course features innovative approaches to partnerships between the university and private organizations, extended peer-review, and the role of knowledge brokers. Yet, the findings also indicate weaknesses including paucity of critical learning objectives, solution-oriented research methodology, and follow-up research on implementation. Through the comparative design, the study reveals improvement strategies for the identified challenges and provides guidance for design and redesign of PPBL courses. |
| Posted: 23 Apr 2013 12:00 AM PDT Protein tyrosine phosphatase 1B (PTP1B) plays a major role in the negative regulation of insulin signaling, and is thus considered as an attractive therapeutic target for the treatment of diabetes. Bioassay-guided investigation of the methylethylketone extract of marine-derived fungus Penicillium sp. JF-55 cultures afforded a new PTP1B inhibitory styrylpyrone-type metabolite named penstyrylpyrone (1), and two known metabolites, anhydrofulvic acid (2) and citromycetin (3). Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, and kinetic analyses of PTP1B inhibition suggested that these compounds inhibited PTP1B activity in a competitive manner. In an effort to gain more biological potential of the isolated compounds, the anti-inflammatory effects of compounds 1–3 were also evaluated. Among the tested compounds, only compound 1 inhibited the production of NO and PGE2, due to the inhibition of the expression of iNOS and COX-2. Penstyrylpyrone (1) also reduced TNF-α and IL-1β production, and these anti-inflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of IκB-α, NF-κB nuclear translocation, and NF-κB DNA binding activity. In addition, using inhibitor tin protoporphyrin (SnPP), an inhibitor of HO-1, it was verified that the inhibitory effects of penstyrylpyrone (1) on the pro-inflammatory mediators and NF-κB DNA binding activity were associated with the HO-1 expression. Therefore, these results suggest that penstyrylpyrone (1) suppresses PTP1B activity, as well as the production of pro-inflammatory mediators via NF-κB pathway, through expression of anti-inflammatory HO-1. |
| Posted: 23 Apr 2013 12:00 AM PDT A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. |
| Posted: 23 Apr 2013 12:00 AM PDT The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well as the synthesis of structural analogues, bioactivity testing, biodistributional and biosynthetic studies. Here I also report on how well these compounds conform to Lipinski's rule of five for druglikeness and their predicted receptor binding and enzyme inhibitor activity. The composition of mycosporine-like amino acids, fatty acids and sterols has also been described in the egg masses of D. orbita. The combination of bioactive compounds produced by D. orbita is of interest for further studies in chemical ecology, as well as for future nutraceutical development. Biological insights into the life history of this species, as well as ongoing research on the gene expression, microbial symbionts and biosynthetic capabilities, should facilitate sustainable production of the bioactive compounds. Knowledge of the phylogeny of D. orbita provides an excellent platform for novel research into the evolution of brominated secondary metabolites in marine molluscs. The range of polarities in the brominated indoles produced by D. orbita has also provided an effective model system used to develop a new method for biodistributional studies. The well characterized suite of chemical reactions that generate Tyrian purple, coupled with an in depth knowledge of the ecology, anatomy and genetics of D. orbita provide a good foundation for ongoing natural products research. |
| Posted: 23 Apr 2013 12:00 AM PDT Biopolymers produced by marine organisms can offer useful tools for regenerative medicine. Particularly, HE800 exopolysaccharide (HE800 EPS) secreted by a deep-sea hydrothermal bacterium displays an interesting glycosaminoglycan-like feature resembling hyaluronan. Previous studies demonstrated its effectiveness to enhance in vivo bone regeneration and to support osteoblastic cell metabolism in culture. Thus, in order to assess the usefulness of this high-molecular weight polymer in tissue engineering and tissue repair, in vitro reconstructed connective tissues containing HE800 EPS were performed. We showed that this polysaccharide promotes both collagen structuring and extracellular matrix settle by dermal fibroblasts. Furthermore, from the native HE800 EPS, a low-molecular weight sulfated derivative (HE800 DROS) displaying chemical analogy with heparan-sulfate, was designed. Thus, it was demonstrated that HE800 DROS mimics some properties of heparan-sulfate, such as promotion of fibroblast proliferation and inhibition of matrix metalloproteinase (MMP) secretion. Therefore, we suggest that the HE800EPS family can be considered as an innovative biotechnological source of glycosaminoglycan-like compounds useful to design biomaterials and drugs for tissue engineering and repair. |
| Cut the Rope: Time Travel HD - Screenshots Posted: 23 Apr 2013 03:14 AM PDT With two cute monsters to feed in each level, Cut the Rope: Time Travel is twice the fun but familiar to play. If you like Cut the Rope, you'll love Cut the Rope: Time Travel! There's no time to waste! Visit six exciting locations including the Middle Ages, the Renaissance, a Pirate Ship, Ancient Egypt, Ancient Greece, and the Stone Age. Om Nom's ancestors are waiting – and they're getting really hungry for candy! |
| Salt Lake Gallery Stroll: Cindy Bean Posted: 23 Apr 2013 01:29 AM PDT Gallery Stroll may have had a bit of a chill to it, but it was still a far better way to spend Friday night than bundling up for whatever rain or snow was set to roll in. This posting includes an audio/video/photo media file: Download Now |
| Posted: 23 Apr 2013 03:01 AM PDT Tink highlights: - An action packed campaign over 12 levels - A cartoonish and colorful universe. Multiple swamps and flying insects! - Hand drawn animations. - An endless mode with 4 different levels for swarm madness! - A variety of mysterious artifacts and magic potions to help you out. - Train your frog! Upgrade Tink's insecticide capacities and unleash the frog fury! - Show off your aiming skills by building up devastating combos! |
| Toxin: Zombie Annihilation - Screenshots Posted: 23 Apr 2013 02:49 AM PDT List of Game Features: - Fast, intense Run-n-Gun Action FPS game play - Old-School Arcade inspired visuals and art design - Endless Dynamic Waves of enemies to Face Off - 5 Challenging Rooms to Explore - Unlimited Grenades - Selection of Weapons |
| Shiny the Firefly - Screenshots Posted: 23 Apr 2013 02:41 AM PDT Your reflexes will be tested, as well as your wit and intellect as you navigate through this beautiful, colorful world helping Shiny in his search. All kinds of different animations let you know how Shiny's feeling. So you'll always know if he's feeling happy, concerned, tired or angry. That will help you solve the trickiest situations in the game. Use your ability to shine skillfully: the babies can only follow Shiny when he is lit up, but that also makes him visible to his enemies. Features • Unique "Light on, light off" feature • Great, high-quality graphics • A charismatic character with numerous animations • Three different worlds with a total of 33 levels, teeming with enemies, bosses, puzzles and other game elements • An all-round fully developed and intuitive game experience for everybody • Game Center integration |
| Posted: 23 Apr 2013 12:00 AM PDT Small ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread depends largely on the use of appropriate diagnostic tools, but the existence of a high genetic/antigenic variability among these viruses, the fluctuant levels of antibody against them and the low viral loads found in infected individuals hamper the diagnostic efficacy. SRLV have a marked in vivo tropism towards the monocyte/macrophage lineage and attempts have been made to identify the genome regions involved in tropism, with two main candidates, the LTR and env gene, since LTR contains primer binding sites for viral replication and the env-encoded protein (SU ENV), which mediates the binding of the virus to the host's cell and has hypervariable regions to escape the humoral immune response. Once inside the host cell, innate immunity may interfere with SRLV replication, but the virus develops counteraction mechanisms to escape, multiply and survive, creating a quasi-species and undergoing compartmentalization events. So far, the mechanisms of organ tropism involved in the development of different disease forms (neurological, arthritic, pulmonary and mammary) are unknown, but different alternatives are proposed. This is an overview of the current state of knowledge on SRLV genetic variability and its implications in tropism as well as in the development of alternative diagnostic assays. |
| Posted: 23 Apr 2013 12:00 AM PDT Starting in late November 2010, the H5N1 highly pathogenic avian influenza (HPAI) virus was isolated from many types of wild ducks and raptors and was subsequently isolated from poultry in Korea. We assessed the genetic and pathogenic properties of the HPAI viruses isolated from a fecal sample from a mandarin duck and a dead Eurasian eagle owl, the most affected wild bird species during the 2010/2011 HPAI outbreak in Korea. These viruses have similar genetic backgrounds and exhibited the highest genetic similarity with recent Eurasian clade 2.3.2.1 HPAI viruses. In animal inoculation experiments, regardless of their originating hosts, the two Korean isolates produced highly pathogenic characteristics in chickens, ducks and mice without pre-adaptation. These results raise concerns about veterinary and public health. Surveillance of wild birds could provide a good early warning signal for possible HPAI infection in poultry as well as in humans. |
| Posted: 23 Apr 2013 12:00 AM PDT Human Immunodeficiency Virus type 1 (HIV-1) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS). HIV-1 Tat protein upregulates transcriptional transactivation. The nucleocapsid protein NC of HIV-1 is a component of virion and plays a key role in genome packaging. Herein, we have demonstrated the interaction between NC and Tat by means of a yeast two-hybrid assay, GST pull-down analysis, co-immunoprecipitation and subcellular colocalization analysis. We observed that the level of Tat was significantly reduced in the presence of NC. But NC did not affect mRNA expression level of Tat. The level of Tat in the presence of NC was increased by treating cells with a proteasome inhibitor, MG132. The ubiquitination state of Tat was not seen to increase in the presence of NC, suggesting the proteasomal degradation was independent of ubiquitination. Lowered level of Tat in the presence of NC led to a decrease in Tat-mediated transcriptional transactivation. |
| Posted: 23 Apr 2013 12:00 AM PDT The objective of this study was to measure the effects of chronic exposure to fumonisins via the ingestion of feed containing naturally contaminated corn in growing pigs infected or not with Salmonella spp. This exposure to a moderate dietary concentration of fumonisins (11.8 ppm) was sufficient to induce a biological effect in pigs (Sa/So ratio), but no mortality or pathology was observed over 63 days of exposure. No mortality or related clinical signs, even in cases of inoculation with Salmonella (5 × 104 CFU), were observed either. Fumonisins, at these concentrations, did not affect the ability of lymphocytes to proliferate in the presence of mitogens, but after seven days post-inoculation they led to inhibition of the ability of specific Salmonella lymphocytes to proliferate following exposure to a specific Salmonella antigen. However, the ingestion of fumonisins had no impact on Salmonella translocation or seroconversion in inoculated pigs. The inoculation of Salmonella did not affect faecal microbiota profiles, but exposure to moderate concentrations of fumonisins transiently affected the digestive microbiota balance. In cases of co-infection with fumonisins and Salmonella, the microbiota profiles were rapidly and clearly modified as early as 48 h post-Salmonella inoculation. Therefore under these experimental conditions, exposure to an average concentration of fumonisins in naturally contaminated feed had no effect on pig health but did affect the digestive microbiota balance, with Salmonella exposure amplifying this phenomenon. |
| Posted: 23 Apr 2013 12:00 AM PDT Clinical features, anatomy and physiology of hyperhidrosis are presented with a review of the world literature on treatment. Level of drug efficacy is defined according to the guidelines of the American Academy of Neurology. Topical agents (glycopyrrolate and methylsulfate) are evidence level B (probably effective). Oral agents (oxybutynin and methantheline bromide) are also level B. In a total of 831 patients, 1 class I and 2 class II blinded studies showed level B efficacy of OnabotulinumtoxinA (A/Ona), while 1 class I and 1 class II study also demonstrated level B efficacy of AbobotulinumtoxinA (A/Abo) in axillary hyperhidrosis (AH), collectively depicting Level A evidence (established) for botulinumtoxinA (BoNT-A). In a comparator study, A/Ona and A/Inco toxins demonstrated comparable efficacy in AH. For IncobotulinumtoxinA (A/Inco) no placebo controlled studies exist; thus, efficacy is Level C (possibly effective) based solely on the aforementioned class II comparator study. For RimabotulinumtoxinB (B/Rima), one class III study has suggested Level U efficacy (insufficient data). In palmar hyperhidrosis (PH), there are 3 class II studies for A/Ona and 2 for A/Abo (individually and collectively level B for BoNT-A) and no blinded study for A/Inco (level U). For B/Rima the level of evidence is C (possibly effective) based on 1 class II study. Botulinum toxins (BoNT) provide a long lasting effect of 3–9 months after one injection session. Studies on BoNT-A iontophoresis are emerging (2 class II studies; level B); however, data on duration and frequency of application is inconsistent. |
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