Games |
- LaunchControl 1.2 - Manage running services on your Mac. (Demo)
- Dial!Fritz 1.7 - Call manager for Fritz!Box. (Shareware)
- OnyX 2.6.8 - Maintenance and optimization tool. (Free)
- GameCrib: TSM Snapdragon - Episode 7 Enter the Turtle
- Nanomaterials, Vol. 3, Pages 221-228: Separation of Short Single- and Double-Stranded DNA Based on Their Adsorption Kinetics Difference on Graphene Oxide
- Molecules, Vol. 18, Pages 4026-4053: The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity
- Molecules, Vol. 18, Pages 4018-4025: Effect of a Combination of Low Level Ozone and Metal Ions on Reducing Escherichia coli O157:H7 and Listeria monocytogenes
- Molecules, Vol. 18, Pages 4002-4017: Steroidal Triterpenes of Cholesterol Synthesis
- Molecules, Vol. 18, Pages 3972-4001: Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
- Molecules, Vol. 18, Pages 3962-3971: Macrocyclic Spermidine Alkaloids from Androya decaryi L. Perrier
- Now Playing: One Piece Pirate Warriors 2
- Pandora's Tower launching in North America in April
- GameCenter - April 3, 2013
- Business insider: Go online to play offline
- Adobe Lightroom 4.4 - Import, develop, and showcase volumes of digital images. (Updater)
- Parallels Desktop 8.0.18483 - Run Windows app without rebooting. (Demo)
- iFFmpeg 3.6.5 - Convert multimedia files between formats. (Shareware)
- Art Text 2.4.4 - Create high quality headings, logos, icons, banners and buttons. (Shareware)
- Powerball Winning Numbers for 04/03/2013
- Powerball Estimated Jackpot for 04/06/2013
| LaunchControl 1.2 - Manage running services on your Mac. (Demo) Posted: 04 Apr 2013 03:15 AM PDT  LaunchControl is a launchd(8) frontend allowing you to manage and debug system and user services on your Mac. All documented features of launchd(8) are supported. It reports potential problems even before a job is started and makes sure you always create valid configurations. Sophisticated interface Absolute freedom Everything you need Discover what's possible Version 1.2: New features
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| Dial!Fritz 1.7 - Call manager for Fritz!Box. (Shareware) Posted: 04 Apr 2013 02:59 AM PDT  Dial!Fritz is a call manager for the Mac, for use with the Fritz!Box Fon of AVM. Incoming calls are displayed on the Mac with caller details from Address Book. If these are missing, it tries to get the name by reverse search. With Dial!Fritz you also have the ability to display the call list from Fritz!Box, make a memo, or, for example, create a new contact in Address Book. Many additional functions make Dial!Fritz a complete CTI solution for the Mac in connection with the Fritz!Box Fon of AVM. Version 1.7:
Download Now This posting includes an audio/video/photo media file: Download Now |
| OnyX 2.6.8 - Maintenance and optimization tool. (Free) Posted: 04 Apr 2013 02:47 AM PDT  OnyX is a multifunctional utility for OS X. It allows you to verify the startup disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock, Spotlight, and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome, and more. Version 2.6.8:
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| GameCrib: TSM Snapdragon - Episode 7 Enter the Turtle Posted: 03 Apr 2013 11:00 AM PDT Follow TSM Snapdragon as they go to GDC and back down to LA for week 7 of LCS.
Read and Post Comments | Get the full article at GameSpot "GameCrib: TSM Snapdragon - Episode 7 Enter the Turtle" was posted by erickt on Wed, 03 Apr 2013 11:00:00 -0700 |
| Posted: 04 Apr 2013 12:00 AM PDT Separation of short single- and double-stranded DNA typically requires gel electrophoresis followed by DNA extraction, which is a time consuming process. Graphene oxide adsorbs single-stranded DNA more quickly than double-stranded ones, allowing for selective removal of the former with a simple mixing and centrifugation operation. The effect of DNA length and salt on adsorption selectivity has been characterized and its application in DNA melting curve measurement has been demonstrated. |
| Posted: 04 Apr 2013 12:00 AM PDT Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages/signals in a minimum of space. The sequence and shape of oligosaccharides as well as spatial aspects of multivalent presentation are assumed to underlie the natural specificity/selectivity that cellular glycans have for endogenous lectins. In order to eventually unravel structure-activity profiles cyclic scaffolds have been used as platforms to produce glycoclusters and afford valuable tools. Using adhesion/growth-regulatory galectins and the pan-galectin ligand lactose as a model, emerging insights into the potential of cyclodextrins, cyclic peptides, calixarenes and glycophanes for this purpose are presented herein. The systematic testing of lectin panels with spatially defined ligand presentations can be considered as a biomimetic means to help clarify the mechanisms, which lead to the exquisite accuracy at which endogenous lectins select their physiological counterreceptors from the complexity of the cellular glycome. |
| Posted: 04 Apr 2013 12:00 AM PDT Ozonated water has been used as a strong antimicrobial agent against foodborne pathogens. In this study, the combined effect of low level ozonated water and different added components, including 0.2% starch and metal ions (1 mM CuCl2·2H2O and 0.1 mM AgNO3), on inactivation of Escherichia coli O157:H7 and Listeria monocytogenes was investigated. Treatment with 0.4 ppm ozonated water for 30 min resulted in a maximum log reduction in E. coli O157:H7 and L. monocytogenes compared to initial bacterial counts. The log reductions of bacteria in a starch solution containing ozonated water were slightly higher than those in ozonated water alone. Furthermore, the log reductions of E. coli O157:H7 (2.59 and 4.71 log cfu/mL) and L. monocytogenes (2.53 and 4.28 log cfu/mL) in a metal ion solution containing 0.2 and 0.4 ppm ozone for 30 min were significantly higher than those of the water and starch added groups (p < 0.05). These results indicate that a combination of ozonated water and metal ions may be useful as a antimicrobial agent. |
| Molecules, Vol. 18, Pages 4002-4017: Steroidal Triterpenes of Cholesterol Synthesis Posted: 04 Apr 2013 12:00 AM PDT Cholesterol synthesis is a ubiquitous and housekeeping metabolic pathway that leads to cholesterol, an essential structural component of mammalian cell membranes, required for proper membrane permeability and fluidity. The last part of the pathway involves steroidal triterpenes with cholestane ring structures. It starts by conversion of acyclic squalene into lanosterol, the first sterol intermediate of the pathway, followed by production of 20 structurally very similar steroidal triterpene molecules in over 11 complex enzyme reactions. Due to the structural similarities of sterol intermediates and the broad substrate specificity of the enzymes involved (especially sterol-Δ24-reductase; DHCR24) the exact sequence of the reactions between lanosterol and cholesterol remains undefined. This article reviews all hitherto known structures of post-squalene steroidal triterpenes of cholesterol synthesis, their biological roles and the enzymes responsible for their synthesis. Furthermore, it summarises kinetic parameters of enzymes (Vmax and Km) and sterol intermediate concentrations from various tissues. Due to the complexity of the post-squalene cholesterol synthesis pathway, future studies will require a comprehensive meta-analysis of the pathway to elucidate the exact reaction sequence in different tissues, physiological or disease conditions. A major reason for the standstill of detailed late cholesterol synthesis research was the lack of several steroidal triterpene standards. We aid to this efforts by summarizing commercial and laboratory standards, referring also to chemical syntheses of meiosis-activating sterols. |
| Posted: 04 Apr 2013 12:00 AM PDT A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinities with Ki values in the nanomolar range. JM-39 (compound 39) was the most active of the series (KiCB1 = 0.53 nM), while compounds 31 and 44 exhibited similar affinities to WIN 55212-2. CoMFA analysis was performed based on the biological data obtained and resulted in a statistically significant CoMFA model with high predictive value (q2 = 0.710, r2 = 0.998, r2pred = 0.823). |
| Posted: 04 Apr 2013 12:00 AM PDT Three new spermidine alkaloids and two known compounds were isolated from the leaves of Androya decaryi. Their structures were elucidated on the basis of their spectroscopic data (NMR and mass spectrometry), by X-Ray diffraction and by comparison with literature values. Evaluation of the in vitro antiplamosdial properties of the isolated compounds revealed they did not possess any significant activity. |
| Now Playing: One Piece Pirate Warriors 2 Posted: 03 Apr 2013 09:44 PM PDT Jonathan and Randolph set sail into the New World with the import copy of the One Piece Pirate Warriors sequel.
Read and Post Comments | Get the full article at GameSpot "Now Playing: One Piece Pirate Warriors 2" was posted by rreydebarros on Wed, 03 Apr 2013 21:44:49 -0700 |
| Pandora's Tower launching in North America in April Posted: 03 Apr 2013 09:07 PM PDT The Wii-exclusive RPG will hit North American shelves this month for $39.99.
North American JRPG fans can finally experience the next Nintendo Wii RPG, when Pandora's Tower hits gaming store shelves later this month. Publisher XSeed Games has confirmed that the game will be out on April 16 for $39.99. To coincide with the announcement, a North American website has been revealed. Pandora's Tower originally launched in Japan in 2011, with an English version going on sale in Europe and Australia in April 2012. GameSpot praised its combat and time-management mechanics in its review, but criticised fixed camera angles and a lack of enemy variety. For more information, check out GameSpot's full review here. Read and Post Comments | Get the full article at GameSpot "Pandora's Tower launching in North America in April" was posted by Jonathan Toyad on Wed, 03 Apr 2013 21:07:39 -0700 |
| Posted: 03 Apr 2013 06:58 PM PDT Ryan "Gootecks" Gutierrez, Rod "Slasher" Breslau, and Travis Gafford bring you up to speed on all the news in the world of esports.
Read and Post Comments | Get the full article at GameSpot "GameCenter - April 3, 2013" was posted by benitog on Wed, 03 Apr 2013 18:58:45 -0700 |
| Business insider: Go online to play offline Posted: 04 Apr 2013 12:10 AM PDT The Tip Top Shoe Glove is a protective covering placed over the shoe that protects shoes from the scuffing while accelerating and braking. This posting includes an audio/video/photo media file: Download Now |
| Adobe Lightroom 4.4 - Import, develop, and showcase volumes of digital images. (Updater) Posted: 03 Apr 2013 08:59 PM PDT  Adobe Lightroom software helps you bring out the best in your photographs, whether you're perfecting one image, searching for ten, processing hundreds, or organizing thousands. Create incredible images that move your audience. Experiment fearlessly with state-of-the-art nondestructive editing tools. Easily manage all your images. And showcase your work in elegant print layouts, slide shows, and Web galleries, as well as on popular photo-sharing sites. All from within one fast, intuitive application. Version 4.4:
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| Parallels Desktop 8.0.18483 - Run Windows app without rebooting. (Demo) Posted: 03 Apr 2013 08:59 PM PDT  Parallels Desktop is simply the world's bestselling, top-rated, and most trusted solution for running Windows applications on your Mac. With Parallels Desktop for Mac, you can seamlessly run both Windows and Mac OS X applications side-by-side without rebooting. Drag-and-drop files between Windows and Mac applications, launch Windows applications from your Mac dock, and do much more with speed, control and confidence. Seamless Simplicity Use Run Windows programs like they were native to your Mac. Setting up Parallels Desktop for Mac is simple and quick. Enjoy the best of both worlds - Windows and Mac OS X - on one seamless desktop. Performance and Personalization Experience as much or as little Windows as you want. Multiple view modes make it possible for you to customize the level of integration between Mac and Windows without compromising performance. Version 8.0.18483:
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| iFFmpeg 3.6.5 - Convert multimedia files between formats. (Shareware) Posted: 03 Apr 2013 08:59 PM PDT  iFFmpeg is a graphical front-end for FFmpeg, a command-line tool used to convert multimedia files between formats. The command line instructions can be very hard to master/understand, so iFFmpeg does all the hard work for you. This allows you to use FFmpeg without detailed command-line knowledge. Version 3.6.5:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Art Text 2.4.4 - Create high quality headings, logos, icons, banners and buttons. (Shareware) Posted: 03 Apr 2013 08:59 PM PDT  Art Text is an OS X application for creating high quality textual graphics, headings, logos, icons, Web site elements, and buttons. Thanks to multi-layer support, creating complex graphics is no sweat. Use the result with Apple iWork, iWeb, Microsoft Office, BeLight applications, and various other text-editing and Web-design programs. Take a quick video tour If you're creating a website for a business or for your personal needs, Art Text has all of the tools you need. The 250 editable materials and 600 supplied vector icons and shapes will give you a quick start to getting your site up and running, or create your own Web graphics effortlessly with the help of multiple layers. Why use Art Text?
Whether you're an advertising manager or a small-business owner, you'll find Art Text to be a powerful tool. Create compelling text for your advertisements, brochures, letterheads, newsletters, and more. Spice up these documents by designing decorative graphics that are sure to impress others. Version 2.4.4:
OS X 10.6.8 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Powerball Winning Numbers for 04/03/2013 Posted: 03 Apr 2013 09:53 PM PDT 1 - 6 - 8 - 12 - 35 Powerball 3 |
| Powerball Estimated Jackpot for 04/06/2013 Posted: 03 Apr 2013 09:53 PM PDT Annuitized: $50 Million Cash Value: $31.3 Million |
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