Games |
- EyeTV 3.6.1 - Watch, record, edit, and timeshift TV. (Updater)
- SilverFast (Plustek) 8.0.1r22 - Powerful drivers for Plustek scanners. (Demo)
- SilverFast (Nikon) 8.0.1r22 - Powerful drivers for Nikon scanners. (Demo)
- SilverFast (Epson) 8.0.1r22 - Powerful drivers for Epson scanners. (Demo)
- SilverFast (Canon) 8.0.1r22 - Powerful drivers for Canon scanners. (Demo)
- fp Plugin 6.1 - Adds BigInteger, BigFloat, and BigComplex to REALbasic. (Free)
- IJMS, Vol. 14, Pages 9126-9167: Targeting the Redox Balance in Inflammatory Skin Conditions
- Dishonored: The Knife of Dunwall - GR Review
- Sleipnir 4.2.0.2 - Gesture-focused Web browser. (Free)
- IJMS, Vol. 14, Pages 9111-9125: Tumour Cell Labelling by Magnetic Nanoparticles with Determination of Intracellular Iron Content and Spatial Distribution of the Intracellular Iron
- Molecules, Vol. 18, Pages 4972-4985: A Lead (II) 3D Coordination Polymer Based on a Marine Cyclic Peptide Motif
- Molecules, Vol. 18, Pages 4955-4971: 2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine
- The Bureau: XCOM Declassified arrives in August
- The Bureau: XCOM Declassified Screens
- The Bureau: XCOM Declassified Live Action Trailer
- MapleStory Season 2 update available in Asia
- Molecules, Vol. 18, Pages 4942-4954: Phenolic Constituents, Antioxidant and Preliminary Antimycoplasmic Activities of Leaf Skin and Flowers of Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain)
- Molecules, Vol. 18, Pages 4929-4941: Structural Characterization by NMR of a Double Phosphorylated Chimeric Peptide Vaccine for Treatment of Alzheimer’s Disease
- Games, Vol. 4, Pages 163-181: The Dynamics of Costly Signaling
- Now Playing - Monaco: What's Yours Is Mine
| EyeTV 3.6.1 - Watch, record, edit, and timeshift TV. (Updater) Posted: 26 Apr 2013 03:20 AM PDT  EyeTV products lets you watch, record, edit, timeshift, and archive TV on your Mac. With solutions for analog and digital television, and video quality options to meet differing customer needs, Elgato has an EyeTV to fit your Mac. Version 3.6.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| SilverFast (Plustek) 8.0.1r22 - Powerful drivers for Plustek scanners. (Demo) Posted: 26 Apr 2013 03:13 AM PDT  SilverFast (Plustek) is LaserSoft's software for Plustek scanners. LaserSoft Imaging has gained 25 years experience in the development of imaging software that has now been incorporated in the redevelopment of SilverFast scanner software. In combination with a variety of innovative ideas and the usage of current software technology, SilverFast 8 has evolved into what we can proudly present as the best scanner software. The WorkflowPilot, a unique feature, is a core element of the new software. As a kind of assistant, it guides you in the correct order through all the processing steps required for your individual workflow. Turning your analog originals into convincing scans is very simple, with complex operations becoming like child's play. The SilverFast Preview Concept allows you to see the result of any adjusted setting in the preview window immediately. The user interface of SilverFast 8 is newly developed to current standards so that you can access all major functions quickly and easily. SilverFast 8 supports the latest 64-bit hardware, and is therefore extremely fast and efficient.
Version 8.0.1r22:
Download Now This posting includes an audio/video/photo media file: Download Now |
| SilverFast (Nikon) 8.0.1r22 - Powerful drivers for Nikon scanners. (Demo) Posted: 26 Apr 2013 03:07 AM PDT  SilverFast (Nikon) is LaserSoft's software for Nikon scanners. LaserSoft Imaging has gained 25 years experience in the development of imaging software that has now been incorporated in the redevelopment of SilverFast scanner software. In combination with a variety of innovative ideas and the usage of current software technology, SilverFast 8 has evolved into what we can proudly present as the best scanner software. The WorkflowPilot, a unique feature, is a core element of the new software. As a kind of assistant, it guides you in the correct order through all the processing steps required for your individual workflow. Turning your analog originals into convincing scans is very simple, with complex operations becoming like child's play. The SilverFast Preview Concept allows you to see the result of any adjusted setting in the preview window immediately. The user interface of SilverFast 8 is newly developed to current standards so that you can access all major functions quickly and easily. SilverFast 8 supports the latest 64-bit hardware, and is therefore extremely fast and efficient.
Version 8.0.1r22:
Download Now This posting includes an audio/video/photo media file: Download Now |
| SilverFast (Epson) 8.0.1r22 - Powerful drivers for Epson scanners. (Demo) Posted: 26 Apr 2013 02:59 AM PDT  SilverFast (Epson) is LaserSoft's software for Epson scanners. LaserSoft Imaging has gained 25 years experience in the development of imaging software that has now been incorporated in the redevelopment of SilverFast scanner software. In combination with a variety of innovative ideas and the usage of current software technology, SilverFast 8 has evolved into what we can proudly present as the best scanner software. The WorkflowPilot, a unique feature, is a core element of the new software. As a kind of assistant, it guides you in the correct order through all the processing steps required for your individual workflow. Turning your analog originals into convincing scans is very simple, with complex operations becoming like child's play. The SilverFast Preview Concept allows you to see the result of any adjusted setting in the preview window immediately. The user interface of SilverFast 8 is newly developed to current standards so that you can access all major functions quickly and easily. SilverFast 8 supports the latest 64-bit hardware, and is therefore extremely fast and efficient.
Version 8.0.1r22:
Download Now This posting includes an audio/video/photo media file: Download Now |
| SilverFast (Canon) 8.0.1r22 - Powerful drivers for Canon scanners. (Demo) Posted: 26 Apr 2013 02:50 AM PDT  SilverFast (Canon) is LaserSoft's software for Canon scanners. LaserSoft Imaging has gained 25 years experience in the development of imaging software that has now been incorporated in the redevelopment of SilverFast scanner software. In combination with a variety of innovative ideas and the usage of current software technology, SilverFast 8 has evolved into what we can proudly present as the best scanner software. The WorkflowPilot, a unique feature, is a core element of the new software. As a kind of assistant, it guides you in the correct order through all the processing steps required for your individual workflow. Turning your analog originals into convincing scans is very simple, with complex operations becoming like child's play. The SilverFast Preview Concept allows you to see the result of any adjusted setting in the preview window immediately. The user interface of SilverFast 8 is newly developed to current standards so that you can access all major functions quickly and easily. SilverFast 8 supports the latest 64-bit hardware, and is therefore extremely fast and efficient.
Version 8.0.1r22:
Download Now This posting includes an audio/video/photo media file: Download Now |
| fp Plugin 6.1 - Adds BigInteger, BigFloat, and BigComplex to REALbasic. (Free) Posted: 26 Apr 2013 02:34 AM PDT fp Plugin is a Real Studio plugin implementing unlimited-length integers and fractions, multi-precision floating point, and complex numbers. Version 6.1:
This posting includes an audio/video/photo media file: Download Now |
| IJMS, Vol. 14, Pages 9126-9167: Targeting the Redox Balance in Inflammatory Skin Conditions Posted: 26 Apr 2013 12:00 AM PDT Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling. However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage. Oxidative stress has been linked to various inflammatory diseases. Inflammation is an essential response in the protection against injurious insults and thus important at the onset of wound healing. However, hampered resolution of inflammation can result in a chronic, exaggerated response with additional tissue damage. In the pathogenesis of several inflammatory skin conditions, e.g., sunburn and psoriasis, inflammatory-mediated tissue damage is central. The prolonged release of excess ROS in the skin can aggravate inflammatory injury and promote chronic inflammation. The cellular redox balance is therefore tightly regulated by several (enzymatic) antioxidants and pro-oxidants; however, in case of chronic inflammation, the antioxidant system may be depleted, and prolonged oxidative stress occurs. Due to the central role of ROS in inflammatory pathologies, restoring the redox balance forms an innovative therapeutic target in the development of new strategies for treating inflammatory skin conditions. Nevertheless, the clinical use of antioxidant-related therapies is still in its infancy. |
| Dishonored: The Knife of Dunwall - GR Review Posted: 26 Apr 2013 03:13 AM PDT Doing Dirty DLC Deeds in Dunwall. For $9.99 on PC and PS3 or 800 Microsoft Points for Xbox 360, The Knife of Dunwall delivers quite a bit of content: three new missions as Daud, the leader of the assassin group; The Whalers, killer of The Empress; and another individual graced with powers given by The Outsider. This is the first of two pieces of DLC starring Daud, showing his experiences at the same time as the events of the primary game. The game opens with a cinematic of the attack on the Empress from Daud's perspective, after which he is visited by The Outsider and chastised. The story takes up six months later (around the same time that Corvo is escaping from prison) as Daud tracks down the clue that The Outsider left him: the name "Delilah." Because of this, the DLC plays much more like a hard-boiled detective story than the Count of Monte Cristo revenge structure of Corvo's story. Daud, voiced by a gravely Michael Madsen, narrates like a battered private dick who knows from the black-eyed deity that he's only got so long before the world, or perhaps The Outsider, cashes in his chips. Arkane Studios and Bethesda have not skimped on this DLC. The missions have the same amazing amount of content and variability of play as those in the Corvo storyline, with the general plot unfolding as you listen or look through a nearby keyhole (if you want to wait patiently to figure out what's going on). The gameplay is slightly altered to account for Daud's abilities and the lack of necessary player training. Although you could jump in and play The Knife of Dunwall as a stand-alone DLC without playing Dishonored, you'd probably be a little lost in terms of the story, combat, and ... |
| Sleipnir 4.2.0.2 - Gesture-focused Web browser. (Free) Posted: 26 Apr 2013 02:27 AM PDT  Sleipnir is a Web browser for Mac with Smartphone and Web App Linker. Freely browsing the Web without having to think about unnecessary things with the rich selection of functions in Sleipnir. With Sleipnir 3, you can experience Web browsing never seen before such as the extremely simple design, and the powerful operations that can be easily performed with just one hand. Extremely speedy gestures Main functions:
All phone numbers are clickable when using Sleipnir 3. By simply clicking that phone number, the phone number is sent to your smartphone, and you can start calling from your smartphone straight away. In order to user Smartphone App Linker, it is required to download the free app Sleipnir Linker that can be used on iPhone / iPad and Android, and a Fenrir pass ID that can be obtained for free. Web App Linker Version 4.2.0.2:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 26 Apr 2013 12:00 AM PDT Magnetically labelled cells are used for in vivo cell tracking by MRI, used for the clinical translation of cell-base therapies. Studies involving magnetic labelled cells may include separation of labelled cells, targeted delivery and controlled release of drugs, contrast enhanced MRI and magnetic hyperthermia for the in situ ablation of tumours. Dextran-coated super-paramagnetic iron oxide (SPIO) ferumoxides are used clinically as an MR contrast agents primarily for hepatic imaging. The material is also widely used for in vitro cell labelling, as are other SPIO-based particles. Our results on the uptake by human cancer cell lines of ferumoxides indicate that electroporation in the presence of protamine sulphate (PS) results in rapid high uptake of SPIO nanoparticles (SPIONs) by parenchymal tumour cells without significant impairment of cell viability. Quantitative determination of cellular iron uptake performed by colorimetric assay is in agreement with data from the literature. These results on intracellular iron content together with the intracellular distribution of SPIONs by magnetic force microscopy (MFM) following in vitro uptake by parenchymal tumour cells confirm the potential of this technique for clinical tumour cell detection and destruction. |
| Posted: 26 Apr 2013 12:00 AM PDT The crystal structure of a naturally occurring cyclic tetrapeptide cyclo(Gly-L-Ser-L-Pro-L-Glu) [cyclo(GSPE)] was obtained. The conformation of synthesized cyclo(GSPE) fixes the coordination to lead ion in a 1:1 ratio. This cyclo(GSPE)-Pb complex was constructed as an asymmetric 3D network in the crystalline state. The polymerization of a heavy metal ion with a rigid asymmetric cyclic tetrapeptide represents the first example of a new class of macrocyclic complexes. |
| Molecules, Vol. 18, Pages 4955-4971: 2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine Posted: 26 Apr 2013 12:00 AM PDT Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used against HIV-1. Currently, NVP is the most widely used anti-HIV drug in developing countries, both in combination therapy and to prevent mother-to-child transmission of HIV. Despite its efficacy against HIV, NVP produces a variety of toxic responses, including hepatotoxicity and skin rash. It is also associated with increased incidences of hepatoneoplasias in rodents. In addition, epidemiological data suggest that NNRTI use is a risk factor for non-AIDS-defining cancers in HIV-positive patients. Current evidence supports the involvement of metabolic activation to reactive electrophiles in NVP toxicity. NVP metabolism includes oxidation to 12-hydroxy-NVP; subsequent Phase II sulfonation produces an electrophilic metabolite, 12-sulfoxy-NVP, capable of reacting with DNA to yield covalent adducts. Since 2'-deoxythymidine (dT) adducts from several alkylating agents are regarded as having significant mutagenic/carcinogenic potential, we investigated the formation of NVP-dT adducts under biomimetic conditions. Toward this goal, we initially prepared and characterized synthetic NVP-dT adduct standards using a palladium-mediated Buchwald-Hartwig coupling strategy. The synthetic standards enabled the identification, by LC-ESI-MS, of 12-(2'-deoxythymidin-N3-yl)-nevirapine (N3-NVP-dT) in the enzymatic hydrolysate of salmon testis DNA reacted with 12-mesyloxy-NVP, a synthetic surrogate for 12-sulfoxy-NVP. N3-NVP-dT, a potentially cytotoxic and mutagenic DNA lesion, was also the only dT-specific adduct detected upon reaction of dT with 12-mesyloxy-NVP. Our data suggest that N3-NVP-dT may be formed in vivo and play a role in the hepatotoxicity and/or putative hepatocarcinogenicity of NVP. |
| The Bureau: XCOM Declassified arrives in August Posted: 26 Apr 2013 12:06 AM PDT XCOM first-person shooter repurposed as full-priced third-person tactical game for Xbox 360, PS3, and PC.
After numerous delays and years of silence, 2K has finally announced its intentions for the mysterious XCOM first-person shooter that was originally announced in 2010. The game has evolved into a third-person tactical shooter called The Bureau: XCOM Declassified, a $60 Xbox 360, PlayStation 3, and PC game due out on August 20.  The Bureau: XCOM Declassified--in development at BioShock 2 studio 2K Marin--is set in 1962 America at the end of the Cold War. John F. Kennedy is president and the U.S. public at large is afraid of a nuclear war with Russia. At the same time, the US government is establishing a secret organization to combat this threat. As it turns out, it's not the Russians who invade, it's the aliens. "And so the same organization has to switch gears to combat the aliens. So not only are you combating the aliens for the public physically, but you also have to keep it secret so you're not creating mass hysteria and panic in the streets," explained associate producer Andrew Dutra. "This is where the origin story comes in. The Bureau is one of these organizations and it's the start of how the hero becomes the XCOM organization." Gamers play as agent William Carter, an intelligence operative with a determined resolve. He'll stop at nothing to get the job done "no matter what," 2K explained. Described as a third-person tactical squad-based combat game, The Bureau: XCOM Declassified borrows from the praised XCOM: Enemy Unknown. Specifically, the new game will adopt the pillars of the strategy series--Team, Tactics, Tools, Technology, and Terror--and introduce them to players in a new way.
 Creative director Morgan Gray explained that being tactical is a key component of The Bureau. He said players will only succeed if they work together. "The team and tactics aspect is at the forefront of our gameplay experience," he said. Though the Bureau will be respectful of the tone and atmosphere of the classic strategy game series, the new game--designed for hardcore gamers--puts players on the ground and in the boots of a soldier. This makes for a compelling and novel experience, Gray argues. "When we say tactical third-person squad-based combat game, that has a huge T on that tactical; it should be underlined and printed in bold. Because we're basically trying to get a game that puts you away from the turn-based, God's eye view of the action, and puts you in the boots of the squad leader in the battlefield where the bullets are flying," he said. "You have real-time control of your squad." In terms of strategy and tactics, The Bureau will allow players to flank, perform leap frog procedures, cover and fire, and prioritize targets within their squad. In addition, gamers will be able to unleash powers to squadmates that are unlocked through experience points amassed over the course of the campaign. "This is basically putting you in the heat of battle and asking you to use both your brains and bullets to win," Gray said. The stakes are especially high in The Bureau, Gray explained, because when a squadmate dies, there is no coming back. Permadeath for companions is in place for the game, and Gray believes this is a revolutionary feature for the title. "When they're dead, they're dead for good. Now, this is obviously part of the XCOM DNA, but in the third-person space, this is like a revolution," Gray said. "The concept of 'What? My squadmates are dead and they're gone forever?' Yes. And now you still have a lot of game to go and the clock's ticking. Our plotline is always moving forward. The consequences of that loss are immediate and there's no way to hide from them. The war will not stop for you." The Bureau: XCOM Declassified will arrive in the wake of the well-received XCOM: Enemy Uknown, a turn-based strategy game for consoles and PC. Though The Bureau and Enemy Unknown are dissimilar in genre, Gray said he does not believe this will stretch the brand too far or dilute it in any way. "I figure good games are good games," Gray said. "I don't think myself or 2K is too worried about diluting the brand as much as our goal is…we have a brand, let's find an expression that can bring more people to the table and give more people a chance to experience it in different ways." Overall, the goal of The Bureau: XCOM Declassified is to "expand and open up the franchise" to gamers who may have been turned off by past entries in the series, while also preserving the pillars of the classic strategy franchise, Gray explained.
 Read and Post Comments | Get the full article at GameSpot "The Bureau: XCOM Declassified arrives in August" was posted by Eddie Makuch on Fri, 26 Apr 2013 00:06:33 -0700 |
| The Bureau: XCOM Declassified Screens Posted: 26 Apr 2013 12:02 AM PDT 3 new shots posted.
Get the full article at GameSpot "The Bureau: XCOM Declassified Screens" was posted on Fri, 26 Apr 2013 00:02:08 -0700 |
| The Bureau: XCOM Declassified Live Action Trailer Posted: 26 Apr 2013 12:01 AM PDT What is seen must be unseen. Check out the live action trailer for The Bureau: XCOM Declassified.
Read and Post Comments | Get the full article at GameSpot "The Bureau: XCOM Declassified Live Action Trailer" was posted by edmondt on Fri, 26 Apr 2013 00:01:00 -0700 |
| MapleStory Season 2 update available in Asia Posted: 25 Apr 2013 11:39 PM PDT New patch to be released in segments starting from this week until July 17; features hyper skills and new character classes.
Get the full article at GameSpot "MapleStory Season 2 update available in Asia" was posted by Jonathan Toyad on Thu, 25 Apr 2013 23:39:41 -0700 |
| Posted: 26 Apr 2013 12:00 AM PDT The methanol extracts of leaf skins and flowers of Aloe vera from the Canary Islands were analyzed for their phenolic profiles and screened for their antioxidant and antimycoplasmic activities. The use of reversed phase high performance liquid chromatography (RP-HPLC) allowed the identification of 18 phenolic constituents. Leaf skin extracts were characterized by the abundance of catechin, sinapic acid and quercitrin. Gentisic acid, epicatechin and quercitrin were the most prominent phenolic compounds of the flowers. The in vitro antioxidant activities determined by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric antioxidant reducing power (FRAP) assays revealed that both extracts exhibited antioxidant activity, being the leaf skin extract the most active fraction. The leaf skin extract was also found to be active against the microbial strains tested. Therefore, A. vera extracts from leaf skin and flowers can be considered as good natural antioxidant sources. |
| Posted: 26 Apr 2013 12:00 AM PDT Rational design of peptide vaccines becomes important for the treatment of some diseases such as Alzheimer's disease (AD) and related disorders. In this study, as part of a larger effort to explore correlations of structure and activity, we attempt to characterize the doubly phosphorylated chimeric peptide vaccine targeting a hyperphosphorylated epitope of the Tau protein. The 28-mer linear chimeric peptide consists of the double phosphorylated B cell epitope Tau229-237[pThr231/pSer235] and the immunomodulatory T cell epitope Ag85B241-255 originating from the well-known antigen Ag85B of the Mycobacterium tuberculosis, linked by a four amino acid sequence -GPSL-. NMR chemical shift analysis of our construct demonstrated that the synthesized peptide is essentially unfolded with a tendency to form a β-turn due to the linker. In conclusion, the -GPSL- unit presumably connects the two parts of the vaccine without transferring any structural information from one part to the other. Therefore, the double phosphorylated epitope of the Tau peptide is flexible and accessible. |
| Games, Vol. 4, Pages 163-181: The Dynamics of Costly Signaling Posted: 26 Apr 2013 12:00 AM PDT Costly signaling is a mechanism through which the honesty of signals can be secured in equilibrium, even in interactions where communicators have conflicting interests. This paper explores the dynamics of one such signaling game: Spence's model of education. It is found that separating equilibria are unlikely to emerge under either the replicator or best response dynamics, but that partially communicative mixed equilibria are quite important dynamically. These mixtures are Lyapunov stable in the replicator dynamic and asymptotically stable in the best response dynamic. Moreover, they have large basins of attraction, in fact larger than those of either pooling or separating equilibria. This suggests that these mixtures may play significant, and underappreciated, roles in the explanation of the emergence and stability of information transfer. |
| Now Playing - Monaco: What's Yours Is Mine Posted: 25 Apr 2013 08:12 PM PDT The GameSpot crew dives into Monaco: What's Yours Is Mine for the first time with 4 player coop action.
Read and Post Comments | Get the full article at GameSpot "Now Playing - Monaco: What's Yours Is Mine" was posted by Dan Mihoerck on Thu, 25 Apr 2013 20:12:15 -0700 |
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