Games |
- Vitamin-R 1.97 - Personal productivity tool. (Shareware)
- Smultron 5.3 - Text editor with easy document selection. (Commercial)
- Sync Folders Pro 2.8.2 - Automatically sync any number of folders. (Commercial)
- VideoUpLink 1.5.3 - Drag-and-drop video upload to Facebook. (Demo)
- fp 6.0 - Unlimited length integers and more for Xcode C++. (Free)
- IJMS, Vol. 14, Pages 8740-8774: The Brassinosteroid Signaling Pathway—New Key Players and Interconnections with Other Signaling Networks Crucial for Plant Development and Stress Tolerance
- IJMS, Vol. 14, Pages 8719-8739: Improving Pharmaceutical Protein Production in Oryza sativa
- IJMS, Vol. 14, Pages 8708-8718: Surgical Resection of Brain Metastases—Impact on Neurological Outcome
- Two Due 3.10 - ToDo list manager handles recurring items. (Free)
- BOINC 7.0.65 - Donate your idle computer time to research. (Free)
- Psychic Cheryl Merz
- IJMS, Vol. 14, Pages 8698-8707: Porous Polyimide Membranes Prepared by Wet Phase Inversion for Use in Low Dielectric Applications
- IJMS, Vol. 14, Pages 8684-8697: Characterization, Purification of Poncirin from Edible Citrus Ougan (Citrus reticulate cv. Suavissima) and Its Growth Inhibitory Effect on Human Gastric Cancer Cells SGC-7901
- The Zoom: great satirical comic created by 12-year-old British schoolboy
- UK Home Office commissions a super villain-catching-machine from Prof. Elemental
- Indie Hour - Don't Starve!
- Free of Charge - Uncharted 3
- Powerball Winning Numbers for 04/20/2013
- Powerball Estimated Jackpot for 04/24/2013
- Mega Millions Winning Numbers for 04/23/2013
| Vitamin-R 1.97 - Personal productivity tool. (Shareware) Posted: 24 Apr 2013 03:28 AM PDT  Vitamin-R creates the optimal conditions for your brain to work at its best by structuring your work into short bursts of distraction-free, highly focused activity alternating with opportunities for renewal, reflection and intuition. The built-in task logging and statistics features create a positive momentum towards productivity by providing visible feedback on your progress and achievements. Time Slice Your Work Get Started Find Your Rhythm Get It Out of Your Head Quickly Make It Your Own Now With Cloud Synching! Recapture the lost of art of joyful concentration. Overcome procrastination. Rediscover the motivation within yourself. Version 1.97:
OS X 10.7 or later Download Now | ||
| Smultron 5.3 - Text editor with easy document selection. (Commercial) Posted: 24 Apr 2013 03:23 AM PDT  Smultron is an elegant and powerful text editor that is easy to use. Use Smultron to create and edit everything from a web page, a script, a list, to every kind of text or code.
(Please note that Smultron 5 is only for OS X 10.8 Mountain Lion -- if you have OS X 10.7 Lion, you can use Smultron 4 instead.) Version 5.3:
Download Now | ||
| Sync Folders Pro 2.8.2 - Automatically sync any number of folders. (Commercial) Posted: 24 Apr 2013 03:17 AM PDT  Sync Folders Pro synchronizes any number of folders on the fly at the same time when there are changes, or connecting external drives at a set time or manually. The app synchronizes folders with or without filter for folder names and / or file names. Sync Folders Pro is perfect for backup to USB, memory cards, disks on remote computers on your network, folders on Cloud services (Dropbox, etc.) TRY IT FOR FREE with the free version which is available on the website and compare the sync speed and stability vs the similar apps (for the number of files > 50 000). Version 2.x is a new application vs version 1.x from a technical point of view. Completely changed the core of the application and algorithm of comparison of files structure which increased the speed of comparing 4-10 times for folders with many files and improved stability of the application. Left unchanged only the application interface that was liked many customers by an easy-to-use. Implemented a parallel analysis of all tasks. The comparison of two folders (6.24 GB and 92 470 files in each folder) is one minute. Video help for Sync Folders Pro on www.greenworldsoft.com:
Version 2.8.2:
Download Now | ||
| VideoUpLink 1.5.3 - Drag-and-drop video upload to Facebook. (Demo) Posted: 24 Apr 2013 03:11 AM PDT  VideoUpLink provides a drag and drop interface for uploading one or more videos to any Facebook page. Video files can be dragged from an iPhoto library, the Media Browser, or from the Finder anywhere on your drive. A title and description for each video can be added using the table view. Login to Facebook with the Login button, and then click Upload. An accurate progress bar will appear for each video as it is processed. Free trial now supports unlimited personal profile uploads. With $9.99 in-app purchase VideoUpLink becomes a flexible, powerful uploader for fan, business, and other Facebook pages. Click 'Load Pages' and a complete list of all the pages you manage pre-loads for easy menu access.
Download Now This posting includes an audio/video/photo media file: Download Now | ||
| fp 6.0 - Unlimited length integers and more for Xcode C++. (Free) Posted: 24 Apr 2013 03:04 AM PDT fp is an Xcode C++ project which implements unlimited length integers, multi-precision floating point numbers, and multi-precision complex numbers. It can calculate the usual transcendental functions, including the Gamma function and many special functions. I am releasing it without a restrictive license. Version 6.0:
OS X 10.4.11 or later Download Now This posting includes an audio/video/photo media file: Download Now | ||
| Posted: 24 Apr 2013 12:00 AM PDT Brassinosteroids (BRs) are a class of steroid hormones regulating a wide range of physiological processes during the plant life cycle from seed development to the modulation of flowering and senescence. The last decades, and recent years in particular, have witnessed a significant advance in the elucidation of the molecular mechanisms of BR signaling from perception by the transmembrane receptor complex to the regulation of transcription factors influencing expression of the target genes. Application of the new approaches shed light on the molecular functions of the key players regulating the BR signaling cascade and allowed identification of new factors. Recent studies clearly indicated that some of the components of BR signaling pathway act as multifunctional proteins involved in other signaling networks regulating diverse physiological processes, such as photomorphogenesis, cell death control, stomatal development, flowering, plant immunity to pathogens and metabolic responses to stress conditions, including salinity. Regulation of some of these processes is mediated through a crosstalk between BR signalosome and the signaling cascades of other hormones, including auxin, abscisic acid, ethylene and salicylic acid. Unravelling the complicated mechanisms of BR signaling and its interconnections with other molecular networks may be of great importance for future practical applications in agriculture. | ||
| IJMS, Vol. 14, Pages 8719-8739: Improving Pharmaceutical Protein Production in Oryza sativa Posted: 24 Apr 2013 12:00 AM PDT Application of plant expression systems in the production of recombinant proteins has several advantages, such as low maintenance cost, absence of human pathogens, and possession of complex post-translational glycosylation capabilities. Plants have been successfully used to produce recombinant cytokines, vaccines, antibodies, and other proteins, and rice (Oryza sativa) is a potential plant used as recombinant protein expression system. After successful transformation, transgenic rice cells can be either regenerated into whole plants or grown as cell cultures that can be upscaled into bioreactors. This review summarizes recent advances in the production of different recombinant protein produced in rice and describes their production methods as well as methods to improve protein yield and quality. Glycosylation and its impact in plant development and protein production are discussed, and several methods of improving yield and quality that have not been incorporated in rice expression systems are also proposed. Finally, different bioreactor options are explored and their advantages are analyzed. | ||
| Posted: 24 Apr 2013 12:00 AM PDT Brain metastases (BM) develop in about 30% of all cancer patients. Surgery plays an important role in confirming neuropathological diagnosis, relieving mass effects and improving the neurological status. To select patients with the highest benefit from surgical resection, prognostic indices (RPA, GPA) have been formulated which are solely focused on survival without considering neurological improvement. In this study we analyzed the impact of surgical resection on the neurological status in addition to overall survival in 206 BM patients. Surgical mortality and morbidity was 0.0% and 10.3% respectively. New neurologic deficits occurred in 6.3% of all patients. The median overall survival was 6.3 months. Poor RPA class and short time interval between diagnosis of cancer and the occurrence of BM were independent factors predictive for poor survival. Improvement of neurological performance was achieved in 56.8% of all patients, with the highest improvement rate seen in patients presenting with increased intracranial pressure and hemiparesis. Notably, the neurological benefits were independent from RPA class. In conclusion, surgical resection leads to significant neurological improvement despite poor RPA class and short overall survival. Considering the low mortality and morbidity rates, resection should be considered as a valid option to increase neurological function and quality of life for patients with BM. | ||
| Two Due 3.10 - ToDo list manager handles recurring items. (Free) Posted: 24 Apr 2013 02:57 AM PDT Two Due is a to-do list manager capable of managing recurring action items. When you have completed one instance of a recurring item, a new instance will automatically be created for you with a future date, based on the frequency you specify. Your to-do list may be sorted by any of several different fields. Version 3.10:
OS X 10.6 or later Download Now | ||
| BOINC 7.0.65 - Donate your idle computer time to research. (Free) Posted: 24 Apr 2013 02:48 AM PDT  BOINC is a program that lets you donate your idle computer time to science projects like SETI@home, Climateprediction.net, Rosetta@home, World Community Grid, and many others. After installing BOINC on your computer, you can connect it to as many of these projects as you like. Use the idle time on your computer to cure diseases, study global warming, discover pulsars, and do many other types of scientific research. It's safe, secure, and easy. Although BOINC supports 64-bit Intel project applications on OS X 10.5.0 and above, the only part of the BOINC client package built as a 64-bit executable is the screensaver coordinator for OS X 10.6.x and later. The BOINC libraries also include a 64-bit build so that they can be linked with 64-bit project applications. Version 7.0.65:
OS X 10.4.7 or later Download Now This posting includes an audio/video/photo media file: Download Now | ||
| Posted: 24 Apr 2013 02:11 AM PDT "I'd say this work chose me," Cheryl Merz says of her ability to see dead people and talk to them. This posting includes an audio/video/photo media file: Download Now | ||
| Posted: 24 Apr 2013 12:00 AM PDT A wet phase inversion process of polyamic acid (PAA) allowed fabrication of a porous membrane of polyimide (PI) with the combination of a low dielectric constant (1.7) and reasonable mechanical properties (Tensile strain: 8.04%, toughness: 3.4 MJ/m3, tensile stress: 39.17 MPa, and young modulus: 1.13 GPa), with further thermal imidization process of PAA. PAA was simply synthesized from purified pyromellitic dianhydride (PMDA) and 4,4-oxydianiline (ODA) in two different reaction solvents such as γ-butyrolactone (GBL) and N-methyl-2-pyrrolidinone (NMP), which produce Mw/PDI of 630,000/1.45 and 280,000/2.0, respectively. The porous PAA membrane was fabricated by the wet phase inversion process based on a solvent/non-solvent system via tailored composition between GBL and NMP. The porosity of PI, indicative of a low electric constant, decreased with increasing concentration of GBL, which was caused by sponge-like formation. However, due to interplay between the low electric constant (structural formation) and the mechanical properties, GBL was employed for further exploration, using toluene and acetone vs. DI-water as a coagulation media. Non-solvents influenced determination of the PAA membrane size and porosity. With this approach, insight into the interplay between dielectric properties and mechanical properties will inform a wide range of potential low-k material applications. | ||
| Posted: 24 Apr 2013 12:00 AM PDT Poncirin is a bitter flavanone glycoside with various biological activities. Poncirin was isolated from four different tissues (flavedo, albedo, segment membrane, and juice sac) of Ougan fruit (Citrus reticulate cv. Suavissima). The highest content of poncirin was found in the albedo of Ougan fruit (1.37 mg/g DW). High speed counter-current chromatography (HSCCC) combined with D101 resin chromatography was utilized for the separation and purification of poncirin from the albedo of Ougan fruit. After this two-step purification, poncirin purity increased from 0.14% to 96.56%. The chemical structure of the purified poncirin was identified by both HPLC-PDA and LC-MS. Poncirin showed a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-7901, in a dose-dependent manner. Thus, poncirin from Ougan fruit, may be beneficial for gastric cancer prevention. The purification method demonstrated here will be useful for further studies on the pharmacological mechanism of poncirin activity, as well as for guiding the consumption of Ougan fruit. | ||
| The Zoom: great satirical comic created by 12-year-old British schoolboy Posted: 24 Apr 2013 02:01 AM PDT The Zoom - Comic - UK - Home Page
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| UK Home Office commissions a super villain-catching-machine from Prof. Elemental Posted: 24 Apr 2013 01:34 AM PDT
In this startling debut episode, the renowned Professor Elemental receives a commission from the government to build a marvellous snooping machine with which to catch the badduns. The Home Secretary has the right man for the job -- with the good professor's marvellous device, the Home Office will be able to spy on every communique that traverses the British Information Superhighway! (It's all about the Snooper's Charter, the barmy UK legislative proposal to give nearly unlimited snooping powers to the government and police, and this video is courtesy of the good people at the Open Rights Group. Professor Elemental build a Great Machine for Catching Villains Chapter One (Thanks, Jim!)
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| Posted: 23 Apr 2013 11:27 PM PDT Due to popular request and to celebrate its release, Ed and Jess show off their meagre survival skills in Klei's addictive survival game, Don't Starve!
Read and Post Comments | Get the full article at GameSpot "Indie Hour - Don't Starve!" was posted by edmondt on Tue, 23 Apr 2013 23:27:08 -0700 | ||
| Posted: 23 Apr 2013 10:33 PM PDT GameSpot's Jonathan and Randolph checks out Sony's freemium foray that is Uncharted 3's multiplayer portion. Features plenty of vertical combat and some free F2P model words of wisdom.
Read and Post Comments | Get the full article at GameSpot "Free of Charge - Uncharted 3" was posted by rreydebarros on Tue, 23 Apr 2013 22:33:24 -0700 | ||
| Powerball Winning Numbers for 04/20/2013 Posted: 23 Apr 2013 10:36 PM PDT 6 - 8 - 30 - 39 - 48 Powerball 20 | ||
| Powerball Estimated Jackpot for 04/24/2013 Posted: 23 Apr 2013 10:36 PM PDT Annuitized: $116 Million Cash Value: $75.6 Million | ||
| Mega Millions Winning Numbers for 04/23/2013 Posted: 23 Apr 2013 10:36 PM PDT 9 - 21 - 22 - 32 - 50 MegaBall 10 Megaplier 3 |
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