Games |
- Claquette 1.0.3 - Capture your screen, attached cameras, and microphones. (Commercial)
- Bluenote 1.16 - Easily keep track of notes, tasks, and passwords. (Demo)
- LimeChat 2.35 - RubyCocoa IRC client. (Free)
- Sync Folders Pro 2.8 - Automatically sync any number of folders. (Commercial)
- Smart Wall 1.2 - Display useful info as a wallpaper. (Demo)
- Pattern Digger 1.2 - Manage projects with internal notes and reminders. (Demo)
- BookMacster 1.14.5 - Organize and manage bookmarks and sync across browsers. (Demo)
- Remote Sensing, Vol. 5, Pages 1912-1931: Early Detection of Bark Beetle Green Attack Using TerraSAR-X and RapidEye Data
- Remote Sensing, Vol. 5, Pages 1894-1911: On the Variation of NDVI with the Principal Climatic Elements in the Tibetan Plateau
- IJMS, Vol. 14, Pages 8406-8421: Detection of Quantitative Trait Loci (QTLs) for Resistances to Small Brown Planthopper and Rice Stripe Virus in Rice Using Recombinant Inbred Lines
- IJMS, Vol. 14, Pages 8393-8405: A Convolutional Code-Based Sequence Analysis Model and Its Application
- IJMS, Vol. 14, Pages 8381-8392: Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis
- IJMS, Vol. 14, Pages 8367-8380: Loss of SUMOylation on ATF3 Inhibits Proliferation of Prostate Cancer Cells by Modulating CCND1/2 Activity
- IJMS, Vol. 14, Pages 8358-8366: Cholesterol Dependent Uptake and Interaction of Doxorubicin in MCF-7 Breast Cancer Cells
- IJMS, Vol. 14, Pages 8345-8357: Intercellular Signaling Pathway among Endothelia, Astrocytes and Neurons in Excitatory Neuronal Damage
- Molecules, Vol. 18, Pages 4487-4509: Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors
- Boca Raton man was a bookie for 'enormous' Internet gambling operation, feds say
- Molecules, Vol. 18, Pages 4477-4486: Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
- Molecules, Vol. 18, Pages 4467-4476: H/D Isotope Effects in Hydrogen Bonded Systems
- IJMS, Vol. 14, Pages 8328-8344: Two Common Bean Genotypes with Contrasting Response to Phosphorus Deficiency Show Variations in the microRNA 399-Mediated PvPHO2 Regulation within the PvPHR1 Signaling Pathway
| Claquette 1.0.3 - Capture your screen, attached cameras, and microphones. (Commercial) Posted: 16 Apr 2013 03:31 AM PDT  Claquette captures your Mac's screen while it also records video from an attached camera as well as microphone input. The built-in Motion 5 support allows you to create a layered export of the recorded material. Add effects and annotations using Motion's fast and familiar user interface. Recording
Version 1.0.3:
Download Now |
| Bluenote 1.16 - Easily keep track of notes, tasks, and passwords. (Demo) Posted: 16 Apr 2013 03:21 AM PDT  Bluenote is one place for jotting down notes, keeping track of your tasks, and accessing your passwords. A beautiful interface separates your info, lets you assign labels and icons, and search with ease. Bluenote automatically encrypts, saves, and syncs on the fly. It's a fantastic app, exclusively for Mac. Version 1.16: Release notes were unavailable when this listing was updated. OS X 10.7.5 or later Download Now |
| LimeChat 2.35 - RubyCocoa IRC client. (Free) Posted: 16 Apr 2013 03:14 AM PDT  LimeChat is an IRC client for OS X written in RubyCocoa. Version 2.35:
OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Sync Folders Pro 2.8 - Automatically sync any number of folders. (Commercial) Posted: 16 Apr 2013 03:04 AM PDT  Sync Folders Pro synchronizes any number of folders on the fly at the same time when there are changes, or connecting external drives at a set time or manually. The app synchronizes folders with or without filter for folder names and / or file names. Sync Folders Pro is perfect for backup to USB, memory cards, disks on remote computers on your network, folders on Cloud services (Dropbox, etc.) TRY IT FOR FREE with the free version which is available on the website and compare the sync speed and stability vs the similar apps (for the number of files > 50 000). Version 2.x is a new application vs version 1.x from a technical point of view. Completely changed the core of the application and algorithm of comparison of files structure which increased the speed of comparing 4-10 times for folders with many files and improved stability of the application. Left unchanged only the application interface that was liked many customers by an easy-to-use. Implemented a parallel analysis of all tasks. The comparison of two folders (6.24 GB and 92 470 files in each folder) is one minute. Video help for Sync Folders Pro on www.greenworldsoft.com:
Version 2.8: New features:
Download Now |
| Smart Wall 1.2 - Display useful info as a wallpaper. (Demo) Posted: 16 Apr 2013 02:57 AM PDT  Smart Wall allows you to integrate day-to-day information on your desktop wallpaper and customize how it all looks. Smart Wall makes your wallpaper smart by integrating bits of data that you use on a daily basis. The information that you add will remain on your desktop at all times -- kind of like widgets. The only difference is that, unlike widgets, the data will blend right into your desktop as if it's part of the wallpaper. This is just a demo, functionality available is limited. Full version is available in the Mac App Store. Information available to integrate using the full version:
Version 1.2: Note: The downloadable version is 1.1. The Mac App Store version is currently 1.2.
Download Now This posting includes an audio/video/photo media file: Download Now |
| Pattern Digger 1.2 - Manage projects with internal notes and reminders. (Demo) Posted: 16 Apr 2013 02:52 AM PDT  With Pattern Digger you can add special notes to your source code comments and Pattern Digger will remind you later of stuff you need to do. Working on a large project it is quite usual to leave some code refactoring or improvement tasks to be done later, have some code left to be reviewed by your colleagues or just mark some places you still have questions about. Pattern Digger will detect and maintain a list of project notes. Version 1.2:
Download Now This posting includes an audio/video/photo media file: Download Now |
| BookMacster 1.14.5 - Organize and manage bookmarks and sync across browsers. (Demo) Posted: 16 Apr 2013 02:47 AM PDT  BookMacster is the Bookmarks Master for the Mac. In addition to being able to use BookMacster directly via a global shortcut key or Status Menulet, BookMacster can keep bookmarks in sync among Safari, Firefox, Chrome, Camino, iCab, Roccat, Opera, and OmniWeb, on the Web with Diigo, Delicious, Pinboard, and Google Bookmarks, and on into your iPhone, iPad, or iPod Touch via Apple's iCloud. Used with an online file-syncing service such as Dropbox, BookMacster takes cross-browser bookmark syncing to all of your Macs. BookMacster keeps bookmarks alphabetized (sorted), verified, and checked for duplicates. BookMacster supports tags, comments, and shortcuts. BookMacster users can add bookmarks directly from within browsers, access all bookmarks while in any app from the menu bar and, under OS X 10.7 Lion, access past bookmarks via Lion's Auto Save and Versions features. Version 1.14.5:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 16 Apr 2013 12:00 AM PDT Bark beetles cause widespread damages in the coniferous-dominated forests of central Europe and North America. In the future, areas affected by bark beetles may further increase due to climate change. However, the early detection of the bark beetle green attack can guide management decisions to prevent larger damages. For this reason, a field-based bark beetle monitoring program is currently implemented in Germany. The combination of remote sensing and field data may help minimizing the reaction time and reducing costs of monitoring programs covering large forested areas. In this case study, RapidEye and TerraSAR-X data were analyzed separately and in combination to detect bark beetle green attack. The remote sensing data were acquired in May 2009 for a study site in south-west Germany. In order to distinguish healthy areas and areas affected by bark beetle green attack, three statistical approaches were compared: generalized linear models (GLM), maximum entropy (ME) and random forest (RF). The spatial scale (minimum mapping unit) was 78.5 m2. TerraSAR-X data resulted in fair classification accuracy with a cross-validated Cohen's Kappa Coefficient (kappa) of 0.23. RapidEye data resulted in moderate classification accuracy with a kappa of 0.51. The highest classification accuracy was obtained by combining the TerraSAR-X and RapidEye data, resulting in a kappa of 0.74. The accuracy of ME models was considerably higher than the accuracy of GLM and RF models. |
| Posted: 16 Apr 2013 12:00 AM PDT Temperature and precipitation have been separately reported to be the main factors affecting the Normalized Difference Vegetation Index (NDVI) in the Tibetan Plateau. The effects of the main climatic factors on the yearly maximum NDVI (MNDVI) in the Tibetan Plateau were examined on different scales. The result underscored the observation that both precipitation and temperature affect MNDVI based on weather stations or physico-geographical regions. Precipitation is the main climatic factor that affects the vegetation cover in the entire Tibetan Plateau. Both annual mean precipitation and annual mean precipitation of the growing period are related with MNDVI, and the positive correlations are manifested in a linear manner. By comparison, the weakly correlated current between MNDVI and all the temperature indexes is observed in the study area. |
| Posted: 16 Apr 2013 12:00 AM PDT Small brown planthopper (SBPH) and rice stripe virus (RSV) disease transmitted by SBPH cause serious damage to rice (Oryza sativa L.) in China. In the present study, we screened 312 rice accessions for resistance to SBPH. The indica variety, N22, is highly resistant to SBPH. One hundred and eighty two recombinant inbred lines (RILs) derived from a cross of N22 and the highly susceptible variety, USSR5, were used for quantitative trait locus (QTL) analysis of resistances to SBPH and RSV. In a modified seedbox screening test, three QTLs for SBPH resistance, qSBPH2, qSBPH3 and qSBPH7.1, were mapped on chromosomes 2, 3 and 7, a total explaining 35.1% of the phenotypic variance. qSBPH7.2 and qSBPH11.2, conferring antibiosis against SBPH, were detected on chromosomes 7 and 11 and accounted for 20.7% of the total phenotypic variance. In addition, qSBPH5 and qSBPH7.3, expressing antixenosis to SBPH, were detected on chromosomes 5 and 7, explaining 23.9% of the phenotypic variance. qSBPH7.1, qSBPH7.2 and qSBPH7.3, located in the same region between RM234 and RM429 on chromosome 7, using three different phenotyping methods indicate that the locus or region plays a major role in conferring resistance to SBPH in N22. Moreover, three QTLs, qSTV4, qSTV11.1 and qSTV11.2, for RSV resistance were detected on chromosomes 4 and 11. qSTV11.1 and qSTV11.2 are located in the same region between RM287 and RM209 on chromosome 11. Molecular markers spanning these QTLs should be useful in the development of varieties with resistance to SBPH and RSV. |
| Posted: 16 Apr 2013 12:00 AM PDT A new approach for encoding DNA sequences as input for DNA sequence analysis is proposed using the error correction coding theory of communication engineering. The encoder was designed as a convolutional code model whose generator matrix is designed based on the degeneracy of codons, with a codon treated in the model as an informational unit. The utility of the proposed model was demonstrated through the analysis of twelve prokaryote and nine eukaryote DNA sequences having different GC contents. Distinct differences in code distances were observed near the initiation and termination sites in the open reading frame, which provided a well-regulated characterization of the DNA sequences. Clearly distinguished period-3 features appeared in the coding regions, and the characteristic average code distances of the analyzed sequences were approximately proportional to their GC contents, particularly in the selected prokaryotic organisms, presenting the potential utility as an added taxonomic characteristic for use in studying the relationships of living organisms. |
| Posted: 16 Apr 2013 12:00 AM PDT We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860). However, these genes are involved in the pharmacology of both nicotine, through which they alter smoking behaviours, and carcinogenic nitrosamines. Herein, we separated participants by CYP2B6 genotype into a high- vs. low-risk group (*1/*1 + *1/*6 vs. *6/*6). Odds ratios estimated through logistic regression modeling were 1.25 (95% CI 0.68–2.30), 1.27 (95% CI 0.89–1.79) and 1.56 (95% CI 1.04–2.31) for CYP2B6, CYP2A6 and CHRNA5-CHRNA3-CHRNB4, respectively, with negligible differences when all genes were evaluated concurrently. Modeling the combined impact of high-risk genotypes yielded odds ratios that rose from 2.05 (95% CI 0.39–10.9) to 2.43 (95% CI 0.47–12.7) to 3.94 (95% CI 0.72–21.5) for those with 1, 2 and 3 vs. 0 high-risk genotypes, respectively. Findings from this pilot point to genetic variation in CYP2B6 as a lung cancer risk factor supporting a role for nitrosamine metabolic activation in the molecular mechanism of lung carcinogenesis |
| Posted: 16 Apr 2013 12:00 AM PDT SUMOylation plays an important role in regulating a wide range of cellular processes. Previously, we showed that ATF3, a stress response mediator, can be SUMOylated and lysine 42 is the major SUMO site. However, the significance of ATF3 SUMOylation in biological processes is still poorly understood. In the present study, we investigated the role of ATF3 SUMOylation on CCND activity and cellular proliferation in human prostate cancer cells. First, we showed that ATF3 can be SUMOylated endogenously in the overexpression system, and lysine 42 is the major SUMO site. Unlike normal prostate tissue and androgen-responsive LNCaP cancer cells, androgen-independent PC3 and DU145 cancer cells did not express ATF3 endogenously. Overexpression of ATF3 increased CCND1/2 expression in PC3 and DU145 cancer cells. Interestingly, we observed that SUMOylation is essential for ATF3-mediated CCND1/2 activation. Finally, we observed that SUMOylation plays a functional role in ATF3-mediated cellular proliferation in PC3 and DU145 cells. Taken together, our results demonstrate that SUMO modification of ATF3 influences CCND1/2 activity and cellular proliferation of prostate cancer PC3 and DU145 cells and explains at least in part how ATF3 functions to regulate cancer development. |
| Posted: 16 Apr 2013 12:00 AM PDT Methods of fluorescence spectroscopy and microscopy—including intensity and lifetime (FLIM) images—are used to examine uptake, intracellular location and interaction of the chemotherapeutic drug doxorubicin in MCF-7 human breast cancer cells as a function of cholesterol content. By comparing cells with natural and decreased cholesterol levels after 2 h or 24 h incubation with doxorubicin, we observed that higher fluorescence intensities and possibly shortened fluorescence lifetimes—reflecting increased uptake of the drug and more pronounced drug response—are concomitant with higher membrane fluidity. |
| Posted: 16 Apr 2013 12:00 AM PDT Neurons interact closely with astrocytes via glutamate; this neuron-glia circuit may play a pivotal role in synaptic transmission. On the other hand, astrocytes contact vascular endothelial cells with their end-feet. It is becoming obvious that non-neuronal cells play a critical role in regulating the neuronal activity in the brain. We find that kainic acid (KA) administration induces the expression of microsomal prostaglandin E synthase-1 (mPGES-1) in venous endothelial cells and the prostaglandin E2 (PGE2) receptor prostaglandin E receptor (EP)-3 on astrocytes. Endothelial mPGES-1 exacerbates KA-induced neuronal damage in in vivo experiments. In in vitro experiments, mPGES-1 produces PGE2, which enhances astrocytic Ca2+ levels via the EP3 receptor and increases Ca2+-dependent glutamate release, thus aggravating neuronal injury. This novel endothelium-astrocyte-neuron signaling pathway may be crucial for driving neuronal damage after repetitive seizures and could be a new therapeutic target for epilepsy and other brain disorders. |
| Posted: 16 Apr 2013 12:00 AM PDT In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones was designed and synthesized with the goal of improving the biological activity as 17b-hydroxysteroid dehydrogenase type 2 inhibitors of the corresponding amidothiophene derivatives. Two moderately active compounds were discovered and this allowed the identification of the biologically active open conformer as well as the extension of the enzyme binding site characterisation. |
| Boca Raton man was a bookie for 'enormous' Internet gambling operation, feds say Posted: 16 Apr 2013 12:27 AM PDT A Boca Raton man acted as a bookie for a massive Internet gambling operation, once boasting on a wiretapped phone call that he was pulling in $150,000 a day, federal prosecutors said Monday. This posting includes an audio/video/photo media file: Download Now |
| Posted: 16 Apr 2013 12:00 AM PDT In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM. |
| Molecules, Vol. 18, Pages 4467-4476: H/D Isotope Effects in Hydrogen Bonded Systems Posted: 16 Apr 2013 12:00 AM PDT An extremely strong H/D isotope effect observed in hydrogen bonded A-H…B systems is connected with a reach diversity of the potential shape for the proton/deuteron motion. It is connected with the anharmonicity of the proton/deuteron vibrations and of the tunneling effect, particularly in cases of short bridges with low barrier for protonic and deuteronic jumping. Six extreme shapes of the proton motion are presented starting from the state without possibility of the proton transfer up to the state with a full ionization. The manifestations of the H/D isotope effect are best reflected in the infra-red absorption spectra. A most characteristic is the run of the relationship between the isotopic ratio nH/nD and position of the absorption band shown by using the example of NHN hydrogen bonds. One can distinguish a critical range of correlation when the isotopic ratio reaches the value of ca. 1 and then increases up to unusual values higher than . The critical range of the isotope effect is also visible in NQR and NMR spectra. In the critical region one observes a stepwise change of the NQR frequency reaching 1.1 MHz. In the case of NMR, the maximal isotope effect is reflected on the curve presenting the dependence of Δd (1H,2H) on d (1H). This effect corresponds to the range of maximum on the correlation curve between dH and ΔpKa that is observed in various systems. There is a lack in the literature of quantitative information about the influence of isotopic substitution on the dielectric properties of hydrogen bond except the isotope effect on the ferroelectric phase transition in some hydrogen bonded crystals. |
| Posted: 16 Apr 2013 12:00 AM PDT Crop production of the important legume, the common bean (Phaseolus vulgaris), is often limited by low phosphorus (P) in the soil. The genotypes, BAT477 and DOR364, of the common bean have contrasting responses to P starvation. Plants from the BAT477 P deficiency tolerant genotype showed higher phosphate content and root biomass as compared to the DOR364 plants under P starvation. The PvPHR1 transcription factor-signaling pathway plays an essential role in the response to P starvation. PvPHO2, a negative regulator of this pathway, encodes an ubiquitin E2 conjugase that promotes degradation of P-responsive proteins and is the target gene of PvmiR399. PvPHO2 is downregulated in BAT477 plants under P deficiency, while such a response is not observed in P-starved DOR364 plants. Five putative PvmiR399 binding sites were identified in the 5' UTR region in both genotypes. While four sites showed an identical DNA sequence, the fifth (binding site of PvPHO2 one) showed three base changes and higher complementarity scores in DOR364 as compared to BAT477. Modified 5'RACE experiments indicated that PvmiR399 binding and/or processing was affected in DOR364 P-starved plants. We propose that a less efficient cleavage of the PvPHO2 mRNA directed by PvmiR399 would result in a higher PvPHO2-mediated degradation of P-responsive proteins in the DOR364 genotype with decreased P deficiency tolerance. |
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