Games |
- Meadows contributes to statewide gain in table games revenue
- Excentro 1.9.9 - Create guilloche illustration designs. (Shareware)
- Excentro Lite 1.9.9 - Create guilloche illustration designs. (Shareware)
- Admiral Nemo - Screenshots
- IJMS, Vol. 14, Pages 8491-8495: Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases
- IJMS, Vol. 14, Pages 8479-8490: Identification of a Genomic Region Containing a Novel Promoter Resistant to Glucose Repression and Over-Expression of β-Glucosidase Gene in Hypocrea orientalis EU7-22
- IJMS, Vol. 14, Pages 8467-8478: Role of UPR Pathway in Defense Response of Aedes aegypti against Cry11Aa Toxin from Bacillus thuringiensis
- Molecules, Vol. 18, Pages 4544-4560: Deuterium Isotope Effects on 13C-NMR Chemical Shifts of 10-Hydroxybenzo[h]quinolines
- Molecules, Vol. 18, Pages 4526-4543: Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
- Molecules, Vol. 18, Pages 4510-4525: The Use of Bio-Guided Fractionation to Explore the Use of Leftover Biomass in Dutch Flower Bulb Production as Allelochemicals against Weeds
- Entropy, Vol. 15, Pages 1408-1415: General Formula for the Efficiency of Quantum-Mechanical Analog of the Carnot Engine
- Entropy, Vol. 15, Pages 1388-1407: Capacitive Mixing for Harvesting the Free Energy of Solutions at Different Concentrations
- Ace Attorney 5 out this July in Japan
- Entropy, Vol. 15, Pages 1375-1387: Classification of Knee Joint Vibration Signals Using Bivariate Feature Distribution Estimation and Maximal Posterior Probability Decision Criterion
- IJMS, Vol. 14, Pages 8456-8466: Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells
- IJMS, Vol. 14, Pages 8437-8455: Dual Role of MicroRNAs in NAFLD
- IJMS, Vol. 14, Pages 8422-8436: MiR199b Suppresses Expression of Hypoxia-Inducible Factor 1α (HIF-1α) in Prostate Cancer Cells
- Apple Canon Laser Printer Drivers 2.0 - For OS X 10.6, 10.7 and 10.8. (Updater)
- Apple Java 2013-003 - For OS X 10.7 and 10.8. (Updater)
- Spotify 0.9.0.117. - Stream music, create playlists and more. (Free)
| Meadows contributes to statewide gain in table games revenue Posted: 17 Apr 2013 02:34 AM PDT Donna LaPia, a poker room shift manager at The Meadows Racetrack & Casino, wins a third straight hand of poker as dealer Michael Santangelo slides chips her way during a media demonstration in July 2010. |
| Excentro 1.9.9 - Create guilloche illustration designs. (Shareware) Posted: 17 Apr 2013 02:51 AM PDT  Excentro is an easy-to-use yet advanced tool that can create guilloche designs such as backgrounds, borders, or rosettes. The guilloches are vintage design elements that were frequently used for anti-counterfeiting security purposes on banknotes, passports, checks, and certificates over the past two hundred years. As the times changed and digital copy and printing technologies were perfected, guilloches no longer presented sufficient security measures that could prevent the forging and counterfeiting of valuable papers. Today the main part of security technology lies in the special paper or tricky inks used in printing. Still, it is too early to say that the days of guilloche designs are over. They can still be used to prevent the counterfeiting of products that do not require the highest level of security (e.g., theater tickets, diplomas, or gift certificates). Or, they can just be used to decorate and add some aesthetic value to a product giving it a 'money-like' look and value.
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Excentro Lite 1.9.9 - Create guilloche illustration designs. (Shareware) Posted: 17 Apr 2013 02:47 AM PDT  Excentro Lite is a simple but advanced tool that can create guilloche designs like backgrounds, borders, or rosettes. Excentro Lite is a simplified version with the features set close to the original Excentro from the mid-90's. It does not have the Tiles, Frames, Reliefs, or Pen tools of the full Excentro version, but it has a very affordable price point, and is made for the users who need to create designs for occasional jobs or just to do some guilloche experiments. Version 1.9.9:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 17 Apr 2013 03:38 AM PDT Features: • Unstoppable land-to-sea action in the best old-school arcade style • Unique Steampunk atmosphere • 60 scenes • 6 ruthless opponents • 18 different types of attackers from water and air • 5 powerful weapons • 28 buildings (for rebuilding the capital city) |
| Posted: 17 Apr 2013 12:00 AM PDT The seemingly disparate areas of oxygen toxicity, radiation exposure, and aging are now recognized to share a common feature—the aberrant production and/or removal of biologically derived free radicals and other reactive oxygen and nitrogen species (ROS/RNS). Advances in our understanding of the effects of free radicals in biology and medicine have been, and continue to be, actively translated into clinically tractable diagnostic and therapeutic applications. This issue is dedicated to recent advances, both basic discoveries and clinical applications, in the field of free radicals in biology and medicine. As more is understood about the proximal biological targets of aberrantly produced or removed reactive species, their sensors, and effectors of compensatory response, a great deal more will be learned about the commonalities in mechanisms underlying seemingly disparate disease states. Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan. |
| Posted: 17 Apr 2013 12:00 AM PDT A high concentration of glucose in the medium could greatly inhibit the expression of cellulase in filamentous fungi. The aspartic protease from fungus Hypocrea orientalis EU7-22 could efficiently express under both induction condition and glucose repression condition. Based on the sequence of structure gene of aspartic protease, the upstream sequence harboring the putative promoter proA for driving the expression of aspartic protease was obtained by genome walking. The upstream sequence contained the typical promoter motifs "TATA" and "CAAT". The β-glucosidase gene (Bgl1) from H. orientalis was cloned and recombined with promoter proA and terminator trpC. The expression cassette was ligated to the binary vector to form pUR5750-Bgl1, and then transferred into the host strain EU7-22 via Agrobacterium tumefaciens mediated transformation (ATMT), using hygromycin B resistance gene as the screening marker. Four transformants Bgl-1, Bgl-2, Bgl-3 and Bgl-4 were screened. Compared with the host strain EU7-22, the enzyme activities of filter paper (FPA) and β-glucosidase (BG) of transformant Bgl-2 increased by 10.6% and 19.1% under induction condition, respectively. The FPA and BG activities were enhanced by 22.2% and 700% under 2% glucose repression condition, respectively, compared with the host strain. The results showed that the putative promoter proA has successfully driven the over-expression of Bgl1 gene in H. orientalis under glucose repression condition. |
| Posted: 17 Apr 2013 12:00 AM PDT The insecticidal Cry toxins are pore-forming toxins produced by the bacteria Bacillus thuringiensis that disrupt insect-midgut cells. Cells can trigger different survival mechanisms to counteract the effects of sub-lytic doses of pore forming toxins. Particularly, two signaling pathways have been demonstrated to play a role in the defense mechanism to other toxins in Caenorhabditis elegans and in mammalian cells. These are the unfolded protein response (UPR) and the sterol regulatory element binding proteins (SREBP) pathways, which are proposed to facilitate membrane repair responses. In this work we analyzed the role of these pathways in Aedes aegypti response to intoxication with Cry11Aa toxin. We show that UPR is activated upon toxin ingestion. The role of these two pathways was analyzed in vivo by using RNA interference. We silenced the expression of specific proteins in A. aegypti larvae. Gene silencing of Ire-1 and Xbp-1 proteins from UPR system, resulted in hypersensitive to Cry11Aa toxin action. In contrast, silencing of Cas-1, Scap and S2P from SREBP pathway had no affect on Cry11Aa toxicity in A. aegypti larvae. However, the role of SREBP pathway requires further studies to be conclusive. Our data indicate that the UPR pathway is involved in the insect defense against Cry toxins. |
| Posted: 17 Apr 2013 12:00 AM PDT Deuterium isotope effects on 13C-NMR chemical shifts are investigated in a series of 10-hydroxybenzo[h]quinolines (HBQ's) The OH proton is deuteriated. The isotope effects on 13C chemical shifts in these hydrogen bonded systems are rather unusual. The formal four-bond effects are found to be negative, indicating transmission via the hydrogen bond. In addition unusual long-range effects are seen. Structures, NMR chemical shifts and changes in nuclear shieldings upon deuteriation are calculated using DFT methods. Two-bond deuterium isotope effects on 13C chemical shifts are correlated with calculated OH stretching frequencies. Isotope effects on chemical shifts are calculated for systems with OH exchanged by OD. Hydrogen bond potentials are discussed. New and more soluble nitro derivatives are synthesized. |
| Posted: 17 Apr 2013 12:00 AM PDT A new series of betulin derivatives containing one or two pharmacophores bearing an acetylenic and carbonyl function at the C-3 and/or C-28 positions has been synthesized and characterized by 1H- and 13C-NMR, IR, MS and elemental analyses. The crystal structure of 28-O-propynoylbetulin was determined by X-ray structural analysis. All new compounds, as well as betulin, were tested in vitro for their antiproliferative activity against human SW707 colorectal, CCRF/CEM leukemia, T47D breast cancer, and against murine P388 leukemia and Balb3T3 normal fibroblasts cell lines. Most of the compounds showed better cytotoxicity than betulin and cisplatin used as reference agent. 28-O-Propynoylbetulin was the most potent derivative, being over 500 times more potent than betulin and about 100 times more cytotoxic than cisplatin against the human leukemia (CCRF/CEM) cell line, with an ID50 value of 0.02 μg/mL. |
| Posted: 17 Apr 2013 12:00 AM PDT A major problem in flower bulb cultivation is weed control. Synthetic herbicides are mainly used, although they cause a range of problems, and integrated weed control through application of naturally occurring allelochemicals would be highly desirable. Flower bulb production creates large amounts of leftover biomass. Utilizing this source for weed control may provide new applications of the bulb crops. We therefore screened 33 flower bulb extracts for allelochemical activity against weeds. Several methanol and chloroform extracts were observed to inhibit germination and growth of Senecio vulgaris L. and Lolium perenne L., as representatives of di- and mono-cotyledonous weeds, respectively. Narciclasine was identified as the bioactive compound in Narcissus. The extract of Amaryllis belladonna L. was equally active, but did not contain any narciclasine. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC50 measured for radicle growth inhibition was 0.10 µM for narciclasine and 0.93 µM for lycorine, compared to 0.11 mM of chlorpropham, a synthetic herbicide. Therefore, the leftover biomass from the spring bulb industry represents an interesting potential source for promising allelochemicals for further studies on weed growth inhibition. |
| Posted: 17 Apr 2013 12:00 AM PDT An analog of the Carnot engine reversibly operating within the framework of pure-state quantum mechanics is discussed. A general formula is derived for the efficiency of such an engine with an arbitrary confining potential. Its expression is given in terms of an energy spectrum and shows how the efficiency depends on a potential as the analog of a working material in thermodynamics, in general. This non-universal nature results from the fact that there exists no analog of the second law of thermodynamics in pure-state quantum mechanics where the von Neumann entropy identically vanishes. A special class of spectra, which leads to a common form of the efficiency, is identified. |
| Posted: 17 Apr 2013 12:00 AM PDT An enormous dissipation of the order of 2 kJ/L takes place during the natural mixing process of fresh river water entering the salty sea. "Capacitive mixing" is a promising technique to efficiently harvest this energy in an environmentally clean and sustainable fashion. This method has its roots in the ability to store a very large amount of electric charge inside supercapacitor or battery electrodes dipped in a saline solution. Three different schemes have been studied so far, namely, Capacitive Double Layer Expansion (CDLE), Capacitive Donnan Potential (CDP) and Mixing Entropy Battery (MEB), respectively based on the variation upon salinity change of the electric double layer capacity, on the Donnan membrane potential, and on the electrochemical energy of intercalated ions. |
| Ace Attorney 5 out this July in Japan Posted: 16 Apr 2013 09:30 PM PDT Fifth game in courtroom adventure game series to feature free in-game outfit DLC and the return of protagonists Phoenix Wright and Apollo Justice.
Capcom has announced the Japanese release date for Gyakuten Saiban 5, which is better known as Ace Attorney 5 to Western audiences. According to a recent issue of Japanese game magazine Famitsu, the 3DS courtroom adventure game will be out in July 25 in Japan. The game features the return of main protagonist Phoenix Wright and fourth game protagonist Apollo Justice. Wright will be assisted by a new character named Kokone Kizuki throughout his court cases. Kizuki can use her glove and earrings to detect emotions displayed by witnesses that can be used to Wright's advantage during interrogations. The Japanese copy of the game will come with a code for free DLC that features Wright's original suit from the first three games and a few new outfits for Justice and Kizuki. The offer will last until August 15. Although there is no confirmation on a North American localization and release date, an eventual release seems likely given that the first four Ace Attorney games and its spin-off, Ace Attorney Investigations: Miles Edgeworth, made it way to the West. However, the sequel to the latter game has yet to be localized at this point in time. Read and Post Comments | Get the full article at GameSpot "Ace Attorney 5 out this July in Japan" was posted by Jonathan Toyad on Tue, 16 Apr 2013 21:30:22 -0700 |
| Posted: 17 Apr 2013 12:00 AM PDT Analysis of knee joint vibration or vibroarthrographic (VAG) signals using signal processing and machine learning algorithms possesses high potential for the noninvasive detection of articular cartilage degeneration, which may reduce unnecessary exploratory surgery. Feature representation of knee joint VAG signals helps characterize the pathological condition of degenerative articular cartilages in the knee. This paper used the kernel-based probability density estimation method to model the distributions of the VAG signals recorded from healthy subjects and patients with knee joint disorders. The estimated densities of the VAG signals showed explicit distributions of the normal and abnormal signal groups, along with the corresponding contours in the bivariate feature space. The signal classifications were performed by using the Fisher's linear discriminant analysis, support vector machine with polynomial kernels, and the maximal posterior probability decision criterion. The maximal posterior probability decision criterion was able to provide the total classification accuracy of 86.67% and the area (Az) of 0.9096 under the receiver operating characteristics curve, which were superior to the results obtained by either the Fisher's linear discriminant analysis (accuracy: 81.33%, Az: 0.8564) or the support vector machine with polynomial kernels (accuracy: 81.33%, Az: 0.8533). Such results demonstrated the merits of the bivariate feature distribution estimation and the superiority of the maximal posterior probability decision criterion for analysis of knee joint VAG signals. |
| IJMS, Vol. 14, Pages 8456-8466: Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells Posted: 17 Apr 2013 12:00 AM PDT Ultraviolet radiation (UVR) is known to be one of the most important environmental hazards acting on the skin. It was revealed that chronic exposure to UVR accelerates skin aging, induces immunosuppression and may lead to the development of skin cancers. On the other hand, UVR has been shown to be effective in the treatment of numerous skin diseases and thus, various phototherapy modalities have been developed to date. Narrow-band ultraviolet B (NB-UVB) emitting a light with a peak around 311 nm has been demonstrated to be effective in the treatment of various skin disorders; currently it is one of the most commonly used phototherapy devices. Despite NB-UVB has been developed more than 30 years ago, the exact mechanism of its therapeutic action remains poorly understood. To date, most of NB-UVB effects were attributed to its influence on immune cells; however, nearly 90% of NB-UVB irradiation is absorbed by epidermis and keratinocytes seem to be important players in mediating NB-UVB biological activity. Here, we have reviewed the current data about the influence of NB-UVB on epidermal cells, with a special emphasis on cell proliferation and death. |
| IJMS, Vol. 14, Pages 8437-8455: Dual Role of MicroRNAs in NAFLD Posted: 17 Apr 2013 12:00 AM PDT MicroRNAs are important post-transcriptional regulators in different pathophysiological processes. They typically affect the mRNA stability or translation finally leading to the repression of target gene expression. Notably, it is thought that microRNAs are crucial for regulating gene expression during metabolic-related disorders, such as nonalcoholic fatty liver disease (NAFLD). Several studies identify specific microRNA expression profiles associated to different histological features of NAFLD, both in animal models and in patients. Therefore, specific assortments of certain microRNAs could have enormous diagnostic potentiality. In addition, microRNAs have also emerged as possible therapeutic targets for the treatment of NAFLD-related liver damage. In this review, we discuss the experimental evidence about microRNAs both as potential non-invasive early diagnostic markers and as novel therapeutic targets in NAFLD and its more severe liver complications. |
| Posted: 17 Apr 2013 12:00 AM PDT MicroRNAs (miRNAs) are a class of small noncoding RNAs that post-transcriptionally repress expression of target genes via imperfect base-pairing with the 3'-untranslated region (3'-UTR). The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays important roles in physiology and pathology. Constitutive over-expression of HIF-1α is observed in many types of cancers including prostate carcinoma, but the mechanisms underlying this event remain largely unknown. Here we investigated the expression of miR199b and HIF-1α in normal prostate tissue, prostate cancer tissues and prostate carcinoma (PCa) cell lines LNCaP, PC-3 and DU145.We found that miR-199b expression level was decreased in prostate cancer while HIF-1α was significantly over-expressed. Furthermore, we postulated the posttranscriptional regulation of HIF-1α by miR199b through bioinformatics analysis, and herein we experimentally demonstrated that miR199b negatively regulated HIF-1α by targeting its 3'-untranslated region. Artificial over-expression of miR199b by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly down-regulated HIF-1α, together with reduced cell growth and increased cell death. |
| Apple Canon Laser Printer Drivers 2.0 - For OS X 10.6, 10.7 and 10.8. (Updater) Posted: 16 Apr 2013 08:59 PM PDT Apple Canon Laser Printer Drivers is the latest Canon Laser printing and scanning software for Mac OS X 10.6, 10.7 and 10.8. For information about supported printer models, see this page. Version 2.0:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Apple Java 2013-003 - For OS X 10.7 and 10.8. (Updater) Posted: 16 Apr 2013 08:59 PM PDT  Apple Java for OS X 2013-003 delivers improved security, reliability, and compatibility by updating Java SE 6 to 1.6.0_45. This update uninstalls the Apple-provided Java applet plug-in from all web browsers. To use applets on a webpage, click on the region labeled "Missing plug-in" to go download the latest version of the Java applet plug-in from Oracle. This update also removes the Java Preferences application, which is no longer required to configure applet settings. Please quit any web browsers and Java applications before installing this update.
OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Spotify 0.9.0.117. - Stream music, create playlists and more. (Free) Posted: 16 Apr 2013 08:59 PM PDT  Spotify is a new way to enjoy music. Simply download and install. Before you know it you'll be singing along to the genre, artist, or song of your choice. With Spotify you are never far away from the song you want. There are no restrictions in terms of what you can listen to or when. Forget about the hassle of waiting for files to download and fill up your hard drive before you get round to organising them. Spotify is instant, fun, and simple. Because music is social, Spotify allows you to share songs and playlists with friends, and even work together on collaborative playlists, Friday afternoon in the office might never be the same again! We're music lovers like everyone else. We want to connect millions of people with their favorite songs by creating a product that people love to use. We respect creativity and believe in fairly compensating artists for their work. We've cleared the rights to use the music you'll listen to in Spotify. Version 0.9.0.117.: Release notes were unavailable when this listing was updated. OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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