вторник, 2 апреля 2013 г.

Games

Games

RightWebPage Pro 4.7 - Verify Web pages to ISO/IEC 23026-2006(E). (Free)

Posted: 02 Apr 2013 03:13 AM PDT



RightWebPage is a quality-assurance tool for Web applications. It can check Web sites against Internet best-practices standards such as HTML 5, CSS 3, WCAG, and ISO 23026.

Version 4.7:
  • GateKeeper-compatible Apple Developer-signed installer
  • All tests can run locally or on an intranet


  • OS X 10.8 or later


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Marine Drugs, Vol. 11, Pages 1113-1125: An HPLC Method for Microanalysis and Pharmacokinetics of Marine Sulfated Polysaccharide PSS-Loaded Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles in Rat Plasma

Posted: 02 Apr 2013 12:00 AM PDT

This study was aimed at developing a sensitive and selective HPLC method with postcolumn fluorescence derivatization for the detection of propylene glycol alginate sodium sulfate (PSS) in rat plasma. Plasma samples were prepared by a simple and fast ultrafiltration method. PSS was extracted from rat plasma with d-glucuronic acid as internal standard. Isocratic chromatographic separation was performed on a TSKgel G2500 PWxL column with the mobile phase of 0.1 M sodium sulfate at a flow rate of 0.5 mL/min. Analyte detection was achieved by fluorescence detection (FLD) at 250 nm (excitation) and 435 nm (emission) using guanidine hydrochloride as postcolumn derivatizing reagent in an alkaline medium at 120 °C. The calibration curve was linear over a concentration range of 1–500 μg/mL, and the lower limit of detection (LLOD) was found to be 250 ng/mL. This validated method was applied successfully to the pharmacokinetic study of PSS and PSS-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (PSS-NP) in rat plasma after a single intravenous (PSS only) and oral administration (PSS and PSS-NP). Significant differences in the main pharmacokinetic parameters of PSS and PSS-NP were observed. The relative bioavailability of PSS-NP was 190.10% compared with PSS which shows that PSS-NP can improve oral bioavailability.

Marine Drugs, Vol. 11, Pages 1104-1112: Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis

Posted: 02 Apr 2013 12:00 AM PDT

Three new dolastane diterpenes (1–3) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration.

Marine Drugs, Vol. 11, Pages 1087-1103: 6″-Debromohamacanthin A, a Bis (Indole) Alkaloid, Inhibits Angiogenesis by Targeting the VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways

Posted: 02 Apr 2013 12:00 AM PDT

Hamacanthins, bis (indole) alkaloids, are found in a few marine sponges, including Spongosorites sp. Hamacanthins have been shown to possess cytotoxic, antibacterial and antifungal activities. However, the precise mechanism for the biological activities of hamacanthins has not yet been elucidated. In the present study, the anti-angiogenic effects of 6″-debromohamacanthin A (DBHA), an active component of isolated hamacanthins, were evaluated in cultured human umbilical vascular endothelial cells (HUVEC) and endothelial-like cells differentiated from mouse embryonic stem (mES) cells. DBHA significantly inhibited vascular endothelial growth factor (VEGF)-induced cell proliferation, migration and tube formation in the HUVEC. DBHA also suppressed the capillary-like structure formation and the expression of platelet endothelial cell adhesion molecule (PECAM), an endothelial biomarker, in mES cell-derived endothelial-like cells. To further understand the precise molecular mechanism of action, VEGF-mediated signaling pathways were analyzed in HUVEC cells and mES cell-derived endothelial-like cells. DBHA suppressed the VEGF-induced expression of MAPKs (p38, ERK and SAPK/JNK) and the PI3K/AKT/mTOR signaling pathway. In addition, DBHA inhibited microvessel sprouting in mES/EB-derived embryoid bodies. In an ex vivo model, DBHA also suppressed the microvessel sprouting of mouse aortic rings. The findings suggest for the first time that DBHA inhibits angiogenesis by targeting the vascular endothelial growth factor receptor 2 (VEGFR2)-mediated PI3K/AKT/mTOR signaling pathway in endothelial cells.

Sensors, Vol. 13, Pages 4468-4484: Formaldehyde Gas Sensors: A Review

Posted: 02 Apr 2013 12:00 AM PDT

Many methods based on spectrophotometric, fluorometric, piezoresistive, amperometric or conductive measurements have been proposed for detecting the concentration of formaldehyde in air. However, conventional formaldehyde measurement systems are bulky and expensive and require the services of highly-trained operators. Accordingly, the emergence of sophisticated technologies in recent years has prompted the development of many microscale gaseous formaldehyde detection systems. Besides their compact size, such devices have many other advantages over their macroscale counterparts, including a real-time response, a more straightforward operation, lower power consumption, and the potential for low-cost batch production. This paper commences by providing a high level overview of the formaldehyde gas sensing field and then describes some of the more significant real-time sensors presented in the literature over the past 10 years or so.

Sensors, Vol. 13, Pages 4450-4467: SAR Image Simulation in the Time Domain for Moving Ocean Surfaces

Posted: 02 Apr 2013 12:00 AM PDT

This paper presents a fundamental simulation method to generate synthetic aperture radar (SAR) images for moving ocean surfaces. We have designed the simulation based on motion induced modulations and Bragg scattering, which are important features of ocean SAR images. The time domain simulation is able to obtain time series of microwave backscattering modulated by the orbital motions of ocean waves. Physical optics approximation is applied to calculate microwave backscattering. The computational grids are smaller than transmit microwave to demonstrate accurate interaction between electromagnetic waves and ocean surface waves. In this paper, as foundations for SAR image simulation of moving ocean surfaces, the simulation is carried out for some targets and ocean waves. The SAR images of stationary and moving targets are simulated to confirm SAR signal processing and motion induced modulation. Furthermore, the azimuth signals from the regular wave traveling to the azimuth direction also show the azimuthal shifts due to the orbital motions. In addition, incident angle dependence is simulated for irregular wind waves to compare with Bragg scattering theory. The simulation results are in good agreement with the theory. These results show that the simulation is applicable for generating numerical SAR images of moving ocean surfaces.

Sensors, Vol. 13, Pages 4428-4449: Dosimeter-Type NOx Sensing Properties of KMnO4 and Its Electrical Conductivity during Temperature Programmed Desorption

Posted: 02 Apr 2013 12:00 AM PDT

An impedimetric NOx dosimeter based on the NOx sorption material KMnO4 is proposed. In addition to its application as a low level NOx dosimeter, KMnO4 shows potential as a precious metal free lean NOx trap material (LNT) for NOx storage catalysts (NSC) enabling electrical in-situ diagnostics. With this dosimeter, low levels of NO and NO2 exposure can be detected electrically as instantaneous values at 380 °C by progressive NOx accumulation in the KMnO4 based sensitive layer. The linear NOx sensing characteristics are recovered periodically by heating to 650 °C or switching to rich atmospheres. Further insight into the NOx sorption-dependent conductivity of the KMnO4-based material is obtained by the novel eTPD method that combines electrical characterization with classical temperature programmed desorption (TPD). The NOx loading amount increases proportionally to the NOx exposure time at sorption temperature. The cumulated NOx exposure, as well as the corresponding NOx loading state, can be detected linearly by electrical means in two modes: (1) time-continuously during the sorption interval including NOx concentration information from the signal derivative or (2) during the short-term thermal NOx release.

Torchlight II releases mod tools and Steam Workshop support

Posted: 02 Apr 2013 02:15 AM PDT

Runic Games' RPG can now be flooded with all sorts of modifications.

 

RPG Torchlight II has been updated with the inclusion of GUTS, developer Runic Games' custom editor for the game, and full integration with the Steam Workshop.

Interested modders can now create and distribute custom Torchlight II maps, quests, skills, and items. A mod manager is included, which gives players the ability to automatically obtain and subscribe to collections of mods.

When playing modded games, players can set the loading order of mods, view the mod history, and be told the potential impact of disabling any modifications before doing so.

Runic Games has put together a Wiki with tutorials and documentation for using the Torchlight II editor.

GameSpot awarded Torchlight II an 8.5 when it released in September 2012.

For more information on Torchlight II, check out GameSpot's previous coverage.

Read and Post Comments | Get the full article at GameSpot

"Torchlight II releases mod tools and Steam Workshop support" was posted by Martin Gaston on Tue, 02 Apr 2013 02:15:19 -0700

Big in Asia - Continent of the Ninth Seal (C9)

Posted: 01 Apr 2013 10:36 PM PDT

Jonathan and Randy delve into the high-flying combative theatrics of Korean origin in this MMO created by Webzen. Features shotguns, egyptian scorpion-dog hybrids, and a GameSpot editor losing badly at PvP.

 

Read and Post Comments | Get the full article at GameSpot

"Big in Asia - Continent of the Ninth Seal (C9)" was posted by rreydebarros on Mon, 01 Apr 2013 22:36:25 -0700

Injustice: Gods Among Us free demo hits April 4

Posted: 01 Apr 2013 10:32 PM PDT

Warner Bros. confirms free demo of NetherRealm's DC fighter for Xbox 360 and PS3 starting April 4; Black Adam confirmed as in-game character.

 

Warner Bros. has confirmed a free demo for the upcoming NetherRealm DC fighter, Injustice: Gods Among Us.

The demo--to be released on the Xbox 360 and PS3--will feature Batman, Wonder Woman and Lex Luthor in the Gotham City arena.

The demo will be available from April 4 on the PlayStation Network and Xbox Live Marketplace.

The publisher also announced Black Adam will feature as an in-game character when Injustice: Gods Among Us is released in North America on April 16. The game will launch on the Xbox 360, PS3, and Wii U.

For more on Injustice: Gods Among Us, check out GameSpot's previous coverage.

Read and Post Comments | Get the full article at GameSpot

"Injustice: Gods Among Us free demo hits April 4" was posted by Laura Parker on Mon, 01 Apr 2013 22:32:29 -0700

DesktopUtility 1.3 - Quickly access useful system tasks. (Free)

Posted: 02 Apr 2013 02:57 AM PDT



DesktopUtility is a tiny menubar application that allows you to hide your Desktop, toggle file visibility, show your User Library (OS X 10.7 or later), or force-empty the trash easily and conveniently from the system menu bar.

Version 1.3:
  • updated restart at login to use modern Apple API's
  • fixed Command-Q behaviour
  • menubar icon tweaks
  • updated copyright
  • fixed some memory leaks
  • fixed erroneous console messages


OS X 10.6.6 or later

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Sensors, Vol. 13, Pages 4404-4427: Pressure-Sensitive Paint Measurements of Transient Shock Phenomena

Posted: 02 Apr 2013 12:00 AM PDT

Measurements of the global pressure field created by shock wave diffraction have been captured optically using a porous pressure-sensitive paint. The pressure field created by a diffracting shock wave shows large increases and decreases in pressure and can be reasonably accurately captured using CFD. The substrate, a thin-layer chromatography (TLC) plate, has been dipped in a luminophore solution. TLC plates are readily available and easy to prepare. Illumination comes from two high-intensity broadband Xenon arc light sources with short-pass filters. The sample is imaged at 100 kHz using a Vision Research Phantom V710 in conjunction with a pair of long and short pass filters, creating a band. The PSP results are compared with numerical simulations of the flow using the commercial CFD package Fluent as part of ANSYS 13 for two Mach numbers.

Sensors, Vol. 13, Pages 4390-4403: Numerical Analysis of Piezoelectric Active Repair in the Presence of Frictional Contact Conditions

Posted: 02 Apr 2013 12:00 AM PDT

The increasing development of smart materials, such as piezoelectric and shape memory alloys, has opened new opportunities for improving repair techniques. Particularly, active repairs, based on the converse piezoelectric effect, can increase the life of a structure by reducing the crack opening. A deep characterization of the electromechanical behavior of delaminated composite structures, actively repaired by piezoelectric patches, can be achieved by considering the adhesive layer between the host structure and the repair and by taking into account the frictional contact between the crack surfaces. In this paper, Boundary Element (BE) analyses performed on delaminated composite structures repaired by active piezoelectric patches are presented. A two-dimensional boundary integral formulation for piezoelectric solids based on the multi-domain technique to model the composite host damaged structures and the bonded piezoelectric patches is employed. An interface spring model is also implemented to take into account the finite stiffness of the bonding layers and to model the frictional contact between the delamination surfaces, by means of an iterative procedure. The effect of the adhesive between the plies of piezoelectric bimorph devices on the electromechanical response is first pointed out for both sensing and actuating behavior. Then, the effect of the frictional contact condition on the fracture mechanics behavior of actively repaired delaminated composite structures is investigated.

Sensors, Vol. 13, Pages 4378-4389: A Novel Flexible Room Temperature Ethanol Gas Sensor Based on SnO2 Doped Poly-Diallyldimethylammonium Chloride

Posted: 02 Apr 2013 12:00 AM PDT

A novel flexible room temperature ethanol gas sensor was fabricated and demonstrated in this paper. The polyimide (PI) substrate-based sensor was formed by depositing a mixture of SnO2 nanopowder and poly-diallyldimethylammonium chloride (PDDAC) on as-patterned interdigitated electrodes. PDDAC acted both as the binder, promoting the adhesion between SnO2 and the flexible PI substrate, and the dopant. We found that the response of SnO2-PDDAC sensor is significantly higher than that of SnO2 alone, indicating that the doping with PDDAC effectively improved the sensor performance. The SnO2-PDDAC sensor has a detection limit of 10 ppm at room temperature and shows good selectivity to ethanol, making it very suitable for monitoring drunken driving. The microstructures of the samples were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscope (TEM) and Fourier transform infrared spectra (FT-IR), and the sensing mechanism is also discussed in detail.

Sensors, Vol. 13, Pages 4367-4377: A Solid-Contact Ion Selective Electrode for Copper(II) Using a Succinimide Derivative as Ionophore

Posted: 02 Apr 2013 12:00 AM PDT

All-solid-state sensors with polyvinyl chloride (PVC)-based membranes using off-the-shelf N-hydroxysuccinimide (NHS) and succinimide (Succ) ionophores were prepared using DOP (dioctyl phthalate) and NPOE (ortho-nitrophenyloctyl ether) as plasticizers. Good responses were obtained when NHS was used. The potentiometric response of the proposed electrode is independent of pH over the range 2–6. The electrode shows a fast response time of 0.25 s. The electrode exhibits a Super-Nernstian response, with 37.5 mV/decade, with a potentiometric detection limit of 4.4 µM. The proposed sensor revealed good selectivity towards a group of transition metal ions.

Sensors, Vol. 13, Pages 4348-4366: Camera Sensor Arrangement for Crop/Weed Detection Accuracy in Agronomic Images

Posted: 02 Apr 2013 12:00 AM PDT

In Precision Agriculture, images coming from camera-based sensors are commonly used for weed identification and crop line detection, either to apply specific treatments or for vehicle guidance purposes. Accuracy of identification and detection is an important issue to be addressed in image processing. There are two main types of parameters affecting the accuracy of the images, namely: (a) extrinsic, related to the sensor's positioning in the tractor; (b) intrinsic, related to the sensor specifications, such as CCD resolution, focal length or iris aperture, among others. Moreover, in agricultural applications, the uncontrolled illumination, existing in outdoor environments, is also an important factor affecting the image accuracy. This paper is exclusively focused on two main issues, always with the goal to achieve the highest image accuracy in Precision Agriculture applications, making the following two main contributions: (a) camera sensor arrangement, to adjust extrinsic parameters and (b) design of strategies for controlling the adverse illumination effects.

IJMS, Vol. 14, Pages 7433-7444: A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China

Posted: 02 Apr 2013 12:00 AM PDT

NEDD4L is a candidate gene for hypertension, both functionally and genetically. Recently, studies showed evidence for the association of NEDD4L with obesity, a key intermediate phenotype in hypertension. To further investigate the relationship between NEDD4L and body mass-related phenotypes, we genotyped three common variants (rs2288774, rs3865418 and rs4149601) in a population-based study of 892 unrelated Han Cantonese using the Sequenom MALDI-TOF-MS platform. Allele frequencies and genotype distribution were calculated in lean controls and overweight/obese cases and analyzed for association by the Chi-squared test and Logistic regression. Linear regression analysis was used to analyze the effect of individual genotypes on quantitative traits. Multivariate analyses demonstrated that the minor allele of rs4149601(A = 20.9%) was associated with a 2.60 kg, 2.78 cm and 0.97 kg/m2 decrease per allele copy in weight, waist and BMI, respectively. Carriers of this allele also had a significant lower risk of overweight/obesity (p < 0.0001, OR = 0.52, 95% CI: 0.37–0.74) as compared to non-carriers. However, no significant association between genotypes at rs2288774 and rs3865418 and covariate-adjusted overweight/obesity or any related phenotypes was observed. These results suggested that the functional variant of NEDD4L, rs4149601, may be associated with obesity and related phenotypes, and further genetic and functional studies are required to understand its role in the manifestation of obesity.

IJMS, Vol. 14, Pages 7405-7432: A Central Role for Thiols in Plant Tolerance to Abiotic Stress

Posted: 02 Apr 2013 12:00 AM PDT

Abiotic stress poses major problems to agriculture and increasing efforts are being made to understand plant stress response and tolerance mechanisms and to develop new tools that underpin successful agriculture. However, the molecular mechanisms of plant stress tolerance are not fully understood, and the data available is incomplete and sometimes contradictory. Here, we review the significance of protein and non-protein thiol compounds in relation to plant tolerance of abiotic stress. First, the roles of the amino acids cysteine and methionine, are discussed, followed by an extensive discussion of the low-molecular-weight tripeptide, thiol glutathione, which plays a central part in plant stress response and oxidative signalling and of glutathione-related enzymes, including those involved in the biosynthesis of non-protein thiol compounds. Special attention is given to the glutathione redox state, to phytochelatins and to the role of glutathione in the regulation of the cell cycle. The protein thiol section focuses on glutaredoxins and thioredoxins, proteins with oxidoreductase activity, which are involved in protein glutathionylation. The review concludes with a brief overview of and future perspectives for the involvement of plant thiols in abiotic stress tolerance.

Graeme Devine takes off with Rocket Patrol

Posted: 02 Apr 2013 02:15 AM PDT

Graeme Devine is a veteran game developer who's turned his attention to iOS recently, putting together touch-based games meant for gamers of all ages.

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Stack Overload

Posted: 01 Apr 2013 09:09 PM PDT

Platform: Android, Javascript/HTML5 — Stack Overload Stack Overload is a mobile puzzle game from Bonus Level that feels like a cross between WarGames: WOPR and a memory game. It's your job to crash a series of increasingly complex programs by causing memory overloads one block at a time. This isn't as complicated as it sounds, as all you have to do is match pairs of tiles by turning them over one at a time. Overload the stack and you'll move on to the next level! Tagged as: android, bonuslevel, browser, free, game, html5, memory, mobile, puzzle, rating-g, tablet
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