Games |
- Former Sega employee reveals Sega Pluto prototype
- Metro: Last Light PC specs revealed
- Panky talks about his visit to NA LCS
- Dyrus discusses TSM internal tension at the LCS Super Week
- Bridge column, April 18: When side tricks have dried up
- Nokumo Lite 1.2.1 - Manage and track projects. (Free)
- Sustainability, Vol. 5, Pages 1661-1679: Spreading the Eco-Message: Using Proactive Coping to Aid Eco-Rep Behavior Change Programming
- Sustainability, Vol. 5, Pages 1645-1660: Locative Meaning-making: An Arts-based Approach to Learning for Sustainable Development
- Sensors, Vol. 13, Pages 5167-5180: Performance Evaluation of a Modular Detector Unit for X-Ray Computed Tomography
- Sensors, Vol. 13, Pages 5130-5166: Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections
- Sensors, Vol. 13, Pages 5117-5129: Caffeine as a Potential Quorum Sensing Inhibitor
- Sensors, Vol. 13, Pages 5109-5116: Performance Improvement of the One-Dot Lateral Flow Immunoassay for Aflatoxin B1 by Using a Smartphone-Based Reading System
- LEGO City Undercover: The Chase Begins - Screenshots
- Animal Crossing: New Leaf - Screenshots
- Molecules, Vol. 18, Pages 4613-4627: Synthesis of New 1,2,3-Triazole Derivatives of Uracil and Thymine with Potential Inhibitory Activity against Acidic Corrosion of Steels
- Molecules, Vol. 18, Pages 4599-4612: Functionalization of Multi-Walled Carbon Nanotubes with Thermo-Responsive Azide-Terminated Poly(N-isopropylacrylamide) via Click Reactions
- Molecules, Vol. 18, Pages 4588-4598: Chemical Composition, Cytotoxic and Antimicrobial Activity of Essential Oils from Cassia bakeriana Craib. against Aerobic and Anaerobic Oral Pathogens
- Molecules, Vol. 18, Pages 4573-4587: Triacylglyceride, Antioxidant and Antimicrobial Features of Virgin Camellia oleifera, C. reticulata and C. sasanqua Oils
- Molecules, Vol. 18, Pages 4561-4572: Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs
- Energies, Vol. 6, Pages 2204-2220: On the Feasibility of Using Poles Computed from Frequency Domain Spectroscopy to Assess Oil Impregnated Paper Insulation Conditions
| Former Sega employee reveals Sega Pluto prototype Posted: 17 Apr 2013 11:29 PM PDT Unreleased machine is a Sega Saturn with Netlink modem built into the device; still in working order.
An alleged former Sega employee under the online handle "Super Magnetic" has posted pictures of an unreleased Sega console on the Assembler Games forum.  A picture of the Sega Pluto prototype by forum member Super Magnetic (image credit: Assembler Gamer) The post states that the device is called the Sega Pluto, which is a Sega Saturn console with a Netlink modem built into the system. The system weighs in at 2.8kg and has two controller ports, a flip-top drive bay, and a cart slot. The machine has the Sega Saturn logo on top of it, which could infer that the device was to be marketed as a new SKU for the Sega Saturn. According to the forum member, there are only two known prototypes of the hardware in existence. The device the forum member is currently holding is in working order and can play NTSC US Sega Saturn games. The Netlink modem was compatible with a number of Sega Saturn titles like Saturn Bomberman and Virtual-On. Read and Post Comments | Get the full article at GameSpot "Former Sega employee reveals Sega Pluto prototype" was posted by Jonathan Toyad on Wed, 17 Apr 2013 23:29:08 -0700 |
| Metro: Last Light PC specs revealed Posted: 17 Apr 2013 11:25 PM PDT Publisher Deep Silver states that an Nvidia Titan graphic card is recommended.
Publisher Deep Silver and developer 4A has announced the PC specs for the upcoming shooter Metro: Last Light. Basically, the game will support Windows XP. The specs also recommend that users have a high-end graphics card like an Nvidia Titan to run the game to its fullest graphical capabilities. The specs are listed below: Minimum For 3D Vision Support: Recommended For 3D Vision Support: Optimum For 3D Vision Support: Read and Post Comments | Get the full article at GameSpot "Metro: Last Light PC specs revealed" was posted by Jonathan Toyad on Wed, 17 Apr 2013 23:25:13 -0700 |
| Panky talks about his visit to NA LCS Posted: 17 Apr 2013 10:39 PM PDT Travis catches up with his good friend Panky at the NA LCS super week.
Read and Post Comments | Get the full article at GameSpot "Panky talks about his visit to NA LCS" was posted by erickt on Wed, 17 Apr 2013 22:39:13 -0700 |
| Dyrus discusses TSM internal tension at the LCS Super Week Posted: 17 Apr 2013 10:00 PM PDT Travis sits down with Dyrus at the LCS super week to learn more about the internal tension currently within the team.
Read and Post Comments | Get the full article at GameSpot "Dyrus discusses TSM internal tension at the LCS Super Week" was posted by erickt on Wed, 17 Apr 2013 22:00:55 -0700 |
| Bridge column, April 18: When side tricks have dried up Posted: 18 Apr 2013 02:37 AM PDT Alija Izetbegovic, the first president of Bosnia and Herzegovina, said, "We play an active role and try to influence our destiny; we have our own trump cards and we use them." So far this week, we have been looking at defenses in no-trump contracts aided by placing declarer's high-card points based on the bidding and play. This posting includes an audio/video/photo media file: Download Now |
| Nokumo Lite 1.2.1 - Manage and track projects. (Free) Posted: 18 Apr 2013 02:48 AM PDT  Nokumo Lite is a productivity app that combines a myriad of organizational capabilities into a single app. Feature Highlights:
Version 1.2.1: Bug Fixes:
OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 18 Apr 2013 12:00 AM PDT Making pro-environmental behavior changes can be difficult, particularly when these changes challenge daily routines and comfortable lifestyles. We designed and implemented an eco-representative intervention program to help students reduce their energy use by proactively coping with barriers to pro-environmental behavior change, and then communicate effective behavior change strategies to student peers. Twenty-nine first-year college students participated in a four-week proactive coping training to change five environmentally impactful behaviors and then spread behavior change messages to fellow residents during a two-week energy challenge. Eco-reps successfully changed their own behaviors in a pro-environmental direction by generating important barriers and successful facilitators for behavior change, and eco-rep residence halls were more likely to reduce energy and maintain reductions compared to non-eco-rep halls. Implications for future environmental behavior change interventions are discussed. |
| Posted: 18 Apr 2013 12:00 AM PDT The term sustainable development is often criticized for having lost credibility due to a lack of clear-cut delineation. The same holds true for education designed to foster sustainable development often referred to as education for sustainable development (ESD). This contribution agrees that the term suffers from a want of meaning, but argues that the persistent hunt for a definition—i.e., a fixed generic description—produces rather than resolves this deficit. What sustainable development means is context and time dependent and is therefore necessarily ambiguous, open-ended and dynamic. Hence, the success of ESD depends on the paradoxical imperative of reducing vagueness while at the same time maintaining ambiguity. This paper explores how this can be established and proposes a process informed by the arts. Drawing from dialogic practices, site-specific theatre and a project conducted in a British village, this writing discusses elements that constitute a process of "context-based meaning finding". It concludes that ESD essentially starts with and revolves around re-embedding SD in life and the act of living, engaging people in place through processes in which communities yield their own, context and time specific interpretations of sustainable development. |
| Posted: 18 Apr 2013 12:00 AM PDT A research prototype CT scanner is currently under development in our lab. One of the key components in this project is the CT detector. This paper describes the design and performance evaluation of the modular CT detector unit for our proposed scanner. It consists of a Photodiode Array Assembly which captures irradiating X-ray photons and converts the energy into electrical current, and a mini Data Acquisition System which performs current integration and converts the analog signal into digital samples. The detector unit can be easily tiled together to form a CT detector. Experiments were conducted to characterize the detector performance both at the single unit level and system level. The noise level, linearity and uniformity of the proposed detector unit were reported and initial imaging studies were also presented which demonstrated the potential application of the proposed detector unit in actual CT scanners. |
| Posted: 18 Apr 2013 12:00 AM PDT Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positive pathogens is just beginning to be understood. Intriguingly, other significant human pathogens, including Clostridium perfringens, Listeria monocytogenes, and Enterococcus faecalis contain agr or analogues linked to virulence. Moreover, other significant human Gram-positive pathogens use peptide based quorum sensing systems to establish or maintain infection. The potential for commonality in aspects of these signaling systems across different species raises the prospect of identifying therapeutics that could target multiple pathogens. Here, we review the status of research into these agr homologues, analogues, and other peptide based quorum sensing systems in Gram-positive pathogens as well as the potential for identifying common pathways and signaling mechanisms for therapeutic discovery. |
| Sensors, Vol. 13, Pages 5117-5129: Caffeine as a Potential Quorum Sensing Inhibitor Posted: 18 Apr 2013 12:00 AM PDT Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs. |
| Posted: 18 Apr 2013 12:00 AM PDT This study was conducted to develop a simple, rapid, and accurate lateral flow immunoassay (LFIA) detection method for point-of-care diagnosis. The one-dot LFIA for aflatoxin B1 (AFB1) was based on the modified competitive binding format using competition between AFB1 and colloidal gold-AFB1-BSA conjugate for antibody binding sites in the test zone. A Smartphone-based reading system consisting of a Samsung Galaxy S2 Smartphone, a LFIA reader, and a Smartphone application for the image acquisition and data analysis. The detection limit of one-dot LFIA for AFB1 is 5 μg/kg. This method provided semi-quantitative analysis of AFB1 samples in the range of 5 to 1,000 μg/kg. Using combination of the one-dot LFIA and the Smartphone-based reading system, it is possible to conduct a more fast and accurate point-of-care diagnosis. |
| LEGO City Undercover: The Chase Begins - Screenshots Posted: 18 Apr 2013 03:15 AM PDT As an emerging undercover investigator learning the art of disguise, Chase McCain will need to adopt a variety of disguises – including a fireman, a robber, a construction worker and a miner - in order to blend into his surroundings. With this in mind, and beginning the week after the launch of the game, Nintendo of Europe will be releasing unlock codes for extra Chase McCain costumes on its Nintendo 3DS Facebook and Twitter accounts, including a mime artist and a zombie, to ensure Chase can remain anonymous wherever he goes! In addition, within the game you have the chance to collect over 70 mini figures that are assigned to the different disguise categories, opening up the possibility to play as some of the more unusual characters of LEGO CITY. As part of the post-launch offering, Nintendo of Europe will also be releasing on social media an unlock code for a very handy vehicle to call upon when criminals are making a hasty retreat. Once unlocked, vehicles are available at Vehicle Call-in Points located around LEGO CITY, but for Chase a set of wheels is never far away, with over 50 different vehicles available to commandeer. Pesky criminals are not even safe whilst airborne or at sea, as speedboats and helicopters will become available as the storyline unfolds. |
| Animal Crossing: New Leaf - Screenshots Posted: 18 Apr 2013 02:59 AM PDT Fact sheet pending. |
| Posted: 18 Apr 2013 12:00 AM PDT Ten 1,4-disubstituted 1,2,3-triazoles were synthesized from one of 1-(azido-methyl)benzene, 1-(azidomethyl)-4-fluorobenzene, 1-(azidomethyl)-4-chlorobenzene, 1-(azidomethyl)-4-bromobenzene or 1-(azidomethyl)-4-iodobenzene, generated in situ from sodium azide and the corresponding benzyl halide, and dipropargyl uracil or dipropargyl thymine. Optimal experimental conditions were established for the conventional click chemistry. The corrosion inhibiting properties of some of these compounds, which were determined by means of an electrochemical technique, are also presented. |
| Posted: 18 Apr 2013 12:00 AM PDT Covalently functionalized multi-walled carbon nanotubes (MWNTs) were prepared by grafting well-defined thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) via click reactions. First, azide-terminated poly(N-isopropylacrylamide) (N3-PNIPAM) was synthesized by reversible addition fragmentation chain-transfer (RAFT) polymerization, and then the N3-PNIPAM moiety was connected onto MWNTs by click chemistry. The products were characterized by means of FT-IR, TGA and TEM. The results show that the modification of MWNTs is very successful and MWNTs functionalized by N3-PNIPAM (MWNTs-PNIPAM) have good solubility and stability in water. TEM images show the functionalized MWNTs are dispersed individually, indicating that the bundles of original MWNTs are separated into individual tubes by surface modification with polymer chains. These MWNTs modified with PNIPAM represent a potential nano-material for preparation of hydrophilic composite materials. |
| Posted: 18 Apr 2013 12:00 AM PDT The chemical composition of the essential oils from leaves, bark and wood of Cassia bakeriana Craib. was determined by gas chromatography (GC) and gas chromatography–mass spectrometry (GC-MS). Alcohols, aldehydes and fatty acids were the major components in leaf and bark oil, while wood essential oil was rich in fatty acids. Terpenes such as linalool, (E)-nerolidol and phytol were present in low concentrations. The antimicrobial activity against aerobic and anaerobic oral bacteria was evaluated using the microdilution method, as was the cell viability test carried out with Vero cells. The oils from leaves and bark showed high antimicrobial activity, with minimum inhibitory concentrations between 62.5 and 125 µg·mL−1 for most of the tested bacteria, including Streptococcus mutans, the main etiological agent of dental caries. Leaves oil displayed the lowest cytotoxic effect (EC50 of 153 µg·mL−1), while wood oil exhibited the highest toxicity to Vero cells. C. bakeriana oils are thus a source of biologically active compounds against aerobic and anaerobic oral microorganisms. This study is the first report on the chemical composition, antimicrobial activity and cytotoxicity of C. bakeriana. |
| Posted: 18 Apr 2013 12:00 AM PDT Virgin oils obtained from seeds of Camellia oleifera (CO), Camellia reticulata (CR) and Camellia sasanqua (CS) were studied for their triacylglyceride composition, antioxidant and antimicrobial activities. Levels of fatty acids determined by 1H-nuclear magnetic resonance analysis were similar to those reported for olive oils (82.30%–84.47%; 5.69%–7.78%; 0.26%–0.41% and 8.04%–11.2%, for oleic, linoleic, linolenic and saturated acids, respectively). The CR oil showed the best antioxidant potential in the three in vitro models tested. With regard to EC50 values (µg/mL), the order in DPPH radical-scavenging was CR (33.48) < CO (35.20) < CS (54.87). Effectiveness in reducing power was CR (2.81) < CO (3.09) < CS (5.32). IC50 for LPO inhibition were 0.37, 0.52 and 0.75 µg/mL for CR, CO and CS, respectively. All the oils showed antimicrobial activity, and exhibited different selectivity and MICs for each microorganism tested (E. coli, B. cereus and C. albicans). B. cereus was the less sensitive species (MIC: 52.083 ± 18.042 for CO; 41.667 ± 18.042 for CR; 104.167 ± 36.084 for CS mg/mL) and the E. coli was the most sensitive to camellia oil's effect. The standard gentamicin presented higher MIC for E. coli (4.2) than the CR (MIC= 2.6) and CO (MIC = 3.9) oils. |
| Posted: 18 Apr 2013 12:00 AM PDT Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of the parent drug LZDO (1a) in vivo. Prodrugs 3–5 were found to display a potent positive inotropic effect on the myocardium, without the risk of arrhythmia. Prodrugs 3–5 rapidly underwent enzymatic hydrolysis to release the parent compound LZDO in 1–3 h in rat liver microsomes and rat plasma. The half-life of the parent compound was prolonged after intragastric administration of prodrug 3, which was found to be a superior prodrug candidate for increasing myocardial contractility. |
| Posted: 18 Apr 2013 12:00 AM PDT Frequency Domain Spectroscopy (FDS) is an effective tool allowing assessing the condition of oil-paper insulation system in power equipment. However, results from these measurements are known to be greatly influenced by various parameters, including insulation aging, moisture content, and insulation geometry/volume, together with environmental condition such as temperature. In this contribution, a series of experiments have been performed under controlled laboratory conditions. The dielectric response of the oil impregnated paper, along with the degree of polymerization and moisture content, were monitored. Since dielectric parameters are geometry dependent, poles (independent of the geometry) which depends on resistivity and permittivity, were considered to assess the condition of the insulation. From the investigations performed on new and aged samples, it is shown that poles (P) can be regarded as insulation aging indicator. It is also shown that a per unit value based on the Dielectric Dissipation Factor (DDF), measured in the frequency range from 1 to 1000 Hz can be correlated to moisture content in the insulation paper. |
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