Games |
- Monster Loves You! - Screenshots
- Shade Basic 13.2.4 - Easiest way to get started with 3D graphics. (Demo)
- Shade Standard 13.2.4 - Tool for 3D design that works with your other graphics tools. (Demo)
- Shade Professional 13.2.4 - Ideal solution for broadcast ready 3D art and animation. (Demo)
- Remote Sensing, Vol. 5, Pages 1875-1893: Generating Virtual Images from Oblique Frames
- Remote Sensing, Vol. 5, Pages 1856-1874: Signal Classification of Submerged Aquatic Vegetation Based on the Hemispherical–Conical Reflectance Factor Spectrum Shape in the Yellow and Red Regions
- Remote Sensing, Vol. 5, Pages 1842-1855: A Sample-Based Forest Monitoring Strategy Using Landsat, AVHRR and MODIS Data to Estimate Gross Forest Cover Loss in Malaysia between 1990 and 2005
- Remote Sensing, Vol. 5, Pages 1809-1841: Image-Based Coral Reef Classification and Thematic Mapping
- IJMS, Vol. 14, Pages 8271-8290: Ovarian Cancer: Can Proteomics Give New Insights for Therapy and Diagnosis?
- iBackup Viewer 2.00 - Browse and manage iPhone backups. (Free)
- IJMS, Vol. 14, Pages 8252-8270: DNA Self-Assembly: From Chirality to Evolution
- IJMS, Vol. 14, Pages 8228-8251: Asymmetric Introgression in the Horticultural Living Fossil Cycas Sect. Asiorientales Using a Genome-Wide Scanning Approach
- IJMS, Vol. 14, Pages 8213-8227: The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer
- IJMS, Vol. 14, Pages 8188-8212: Endoplasmic Reticulum (ER) Stress Response and Its Physiological Roles in Plants
- IJMS, Vol. 14, Pages 8179-8187: Advances in the Techniques for the Prediction of microRNA Targets
- IJMS, Vol. 14, Pages 8164-8178: Monocyte Chemotactic Protein-1 Promotes the Myocardial Homing of Mesenchymal Stem Cells in Dilated Cardiomyopathy
- Molecules, Vol. 18, Pages 4451-4466: Phosphorus Dendrimers as Carriers of siRNA—Characterisation of Dendriplexes
- Molecules, Vol. 18, Pages 4437-4450: Hydrophobic Effect of Amphiphilic Derivatives of Chitosan on the Antifungal Activity against Aspergillus flavus and Aspergillus parasiticus
- Molecules, Vol. 18, Pages 4419-4436: Evaluation of the Biological Activity of Naturally Occurring 5,8-Dihydroxycoumarin
- Molecules, Vol. 18, Pages 4403-4418: Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides
| Monster Loves You! - Screenshots Posted: 15 Apr 2013 04:33 AM PDT As you approach elderhood, your choices become tougher. Do you encourage other monsters to understand and study their arch-enemies, the humans (requires Kindness)? Or do you use your cunning to lull the humans into a false sense of ease while gearing up for a slaughter (requires Cleverness)? 14 endings mean that there's a satisfying story both for players who like to rescue little children and for those who would eat them alive. |
| Shade Basic 13.2.4 - Easiest way to get started with 3D graphics. (Demo) Posted: 15 Apr 2013 03:30 AM PDT  Shade Basic helps you learn 3D modeling, rendering, and animation with a complete toolset by creating breathtakingly realistic art!
Note: Users must obtain a trial license to evaluate Shade Basic. See here for details. Version 13.2.4:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Shade Standard 13.2.4 - Tool for 3D design that works with your other graphics tools. (Demo) Posted: 15 Apr 2013 03:24 AM PDT  Shade Standard brings together advanced 3D modeling, rendering, and animation into an integrated, flexible suite on OS X and Windows. Use Shade as a complete, standalone tool set, or as a key design tool in your existing workflow. Shade Standard includes 2 GB of tutorials, materials and scene data to help you get started in 3D. Creating a model or a finished, rendered image or animation takes time. Every feature of Shade lets you work faster to produce high-resolution, high-quality art and animation. You can accomplish so many things with Shade Standard:
Note: Users must obtain a trial license to evaluate Shade Standard. See here for details. Version 13.2.4:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Shade Professional 13.2.4 - Ideal solution for broadcast ready 3D art and animation. (Demo) Posted: 15 Apr 2013 03:19 AM PDT  Shade Professional brings together advanced 3D modeling, rendering, and animation into an integrated, flexible suite on OS X and Windows. Use Shade as a complete, standalone tool set, or as a key design tool in your existing workflow. Shade Standard includes 2 GB of tutorials, materials, and scene data to help you get started in 3D. Creating a model or a finished, rendered image or animation takes time. Every feature of Shade lets you work faster to produce high-resolution, high-quality art and animation. You can accomplish so many things with Shade Professional:
Note: Users must obtain a trial license to evaluate Shade Professional. See here for details. Version 13.2.4:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Remote Sensing, Vol. 5, Pages 1875-1893: Generating Virtual Images from Oblique Frames Posted: 15 Apr 2013 12:00 AM PDT Image acquisition systems based on multi-head arrangement of digital cameras are attractive alternatives enabling a larger imaging area when compared to a single frame camera. The calibration of this kind of system can be performed in several steps or by using simultaneous bundle adjustment with relative orientation stability constraints. The paper will address the details of the steps of the proposed approach for system calibration, image rectification, registration and fusion. Experiments with terrestrial and aerial images acquired with two Fuji FinePix S3Pro cameras were performed. The experiments focused on the assessment of the results of self-calibrating bundle adjustment with and without relative orientation constraints and the effects to the registration and fusion when generating virtual images. The experiments have shown that the images can be accurately rectified and registered with the proposed approach, achieving residuals smaller than one pixel. |
| Posted: 15 Apr 2013 12:00 AM PDT The water column overlying the submerged aquatic vegetation (SAV) canopy presents difficulties when using remote sensing images for mapping such vegetation. Inherent and apparent water optical properties and its optically active components, which are commonly present in natural waters, in addition to the water column height over the canopy, and plant characteristics are some of the factors that affect the signal from SAV mainly due to its strong energy absorption in the near-infrared. By considering these interferences, a hypothesis was developed that the vegetation signal is better conserved and less absorbed by the water column in certain intervals of the visible region of the spectrum; as a consequence, it is possible to distinguish the SAV signal. To distinguish the signal from SAV, two types of classification approaches were selected. Both of these methods consider the hemispherical–conical reflectance factor (HCRF) spectrum shape, although one type was supervised and the other one was not. The first method adopts cluster analysis and uses the parameters of the band (absorption, asymmetry, height and width) obtained by continuum removal as the input of the classification. The spectral angle mapper (SAM) was adopted as the supervised classification approach. Both approaches tested different wavelength intervals in the visible and near-infrared spectra. It was demonstrated that the 585 to 685-nm interval, corresponding to the green, yellow and red wavelength bands, offered the best results in both classification approaches. However, SAM classification showed better results relative to cluster analysis and correctly separated all spectral curves with or without SAV. Based on this research, it can be concluded that it is possible to discriminate areas with and without SAV using remote sensing. |
| Posted: 15 Apr 2013 12:00 AM PDT Insular Southeast Asia is a hotspot of humid tropical forest cover loss. A sample-based monitoring approach quantifying forest cover loss from Landsat imagery was implemented to estimate gross forest cover loss for two eras, 1990–2000 and 2000–2005. For each time interval, a probability sample of 18.5 km × 18.5 km blocks was selected, and pairs of Landsat images acquired per sample block were interpreted to quantify forest cover area and gross forest cover loss. Stratified random sampling was implemented for 2000–2005 with MODIS-derived forest cover loss used to define the strata. A probability proportional to x (πpx) design was implemented for 1990–2000 with AVHRR-derived forest cover loss used as the x variable to increase the likelihood of including forest loss area in the sample. The estimated annual gross forest cover loss for Malaysia was 0.43 Mha/yr (SE = 0.04) during 1990–2000 and 0.64 Mha/yr (SE = 0.055) during 2000–2005. Our use of the πpx sampling design represents a first practical trial of this design for sampling satellite imagery. Although the design performed adequately in this study, a thorough comparative investigation of the πpx design relative to other sampling strategies is needed before general design recommendations can be put forth. |
| Remote Sensing, Vol. 5, Pages 1809-1841: Image-Based Coral Reef Classification and Thematic Mapping Posted: 15 Apr 2013 12:00 AM PDT This paper presents a novel image classification scheme for benthic coral reef images that can be applied to both single image and composite mosaic datasets. The proposed method can be configured to the characteristics (e.g., the size of the dataset, number of classes, resolution of the samples, color information availability, class types, etc.) of individual datasets. The proposed method uses completed local binary pattern (CLBP), grey level co-occurrence matrix (GLCM), Gabor filter response, and opponent angle and hue channel color histograms as feature descriptors. For classification, either k-nearest neighbor (KNN), neural network (NN), support vector machine (SVM) or probability density weighted mean distance (PDWMD) is used. The combination of features and classifiers that attains the best results is presented together with the guidelines for selection. The accuracy and efficiency of our proposed method are compared with other state-of-the-art techniques using three benthic and three texture datasets. The proposed method achieves the highest overall classification accuracy of any of the tested methods and has moderate execution time. Finally, the proposed classification scheme is applied to a large-scale image mosaic of the Red Sea to create a completely classified thematic map of the reef benthos. |
| Posted: 15 Apr 2013 12:00 AM PDT The study of the ovarian proteomic profile represents a new frontier in ovarian cancer research, since this approach is able to enlighten the wide variety of post-translational events (such as glycosylation and phosphorylation). Due to the possibility of analyzing thousands of proteins, which could be simultaneously altered, comparative proteomics represent a promising model of possible biomarker discovery for ovarian cancer detection and monitoring. Moreover, defining signaling pathways in ovarian cancer cells through proteomic analysis offers the opportunity to design novel drugs and to optimize the use of molecularly targeted agents against crucial and biologically active pathways. Proteomic techniques provide more information about different histological types of ovarian cancer, cell growth and progression, genes related to tumor microenvironment and specific molecular targets predictive of response to chemotherapy than sequencing or microarrays. Estimates of specificity with proteomics are less consistent, but suggest a new role for combinations of biomarkers in early ovarian cancer diagnosis, such as the OVA1 test. Finally, the definition of the proteomic profiles in ovarian cancer would be accurate and effective in identifying which pathways are differentially altered, defining the most effective therapeutic regimen and eventually improving health outcomes. |
| iBackup Viewer 2.00 - Browse and manage iPhone backups. (Free) Posted: 15 Apr 2013 03:00 AM PDT  iBackup Viewer manages to extract information from iPhone / iPad backups, including contacts, call history, SMS messages, Web visits, website bookmarks, photos, and iPhone Apps. How does it work? What can iBackup Viewer do?
Version 2.00:
OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| IJMS, Vol. 14, Pages 8252-8270: DNA Self-Assembly: From Chirality to Evolution Posted: 15 Apr 2013 12:00 AM PDT Transient or long-term DNA self-assembly participates in essential genetic functions. The present review focuses on tight DNA-DNA interactions that have recently been found to play important roles in both controlling DNA higher-order structures and their topology. Due to their chirality, double helices are tightly packed into stable right-handed crossovers. Simple packing rules that are imposed by DNA geometry and sequence dictate the overall architecture of higher order DNA structures. Close DNA-DNA interactions also provide the missing link between local interactions and DNA topology, thus explaining how type II DNA topoisomerases may sense locally the global topology. Finally this paper proposes that through its influence on DNA self-assembled structures, DNA chirality played a critical role during the early steps of evolution. |
| Posted: 15 Apr 2013 12:00 AM PDT The Asian cycads are mostly allopatric, distributed in small population sizes. Hybridization between allopatric species provides clues in determining the mechanism of species divergence. Horticultural introduction provides the chance of interspecific gene flow between allopatric species. Two allopatrically eastern Asian Cycas sect. Asiorientales species, C. revoluta and C. taitungensis, which are widely distributed in Ryukyus and Fujian Province and endemic to Taiwan, respectively, were planted in eastern Taiwan for horticultural reason. Higher degrees of genetic admixture in cultivated samples than wild populations in both cycad species were detected based on multilocus scans by neutral AFLP markers. Furthermore, bidirectional but asymmetric introgression by horticultural introduction of C. revoluta is evidenced by the reanalyses of species associated loci, which are assumed to be diverged after species divergence. Partial loci introgressed from native cycad to the invaders were also detected at the loci of strong species association. Consistent results tested by all neutral loci, and the species-associated loci, specify the recent introgression from the paradox of sharing of ancestral polymorphisms. Phenomenon of introgression of cultivated cycads implies niche conservation among two geographic-isolated cycads, even though the habitats of the extant wild populations of two species are distinct. |
| Posted: 15 Apr 2013 12:00 AM PDT Ovarian cancer is the fifth most common cause of death due to cancer in women despite being the tenth in incidence. Unfortunately, the five-year survival rate is only 45%, which has not improved much in the past 30 years. Even though the majority of women have successful initial therapy, the low rate of survival is due to the eventual recurrence and succumbing to their disease. With the recent release of the Cancer Genome Atlas for ovarian cancer, it was shown that the PI3K/AKT/mTOR pathway was one of the most frequently mutated or altered pathways in patients' tumors. Researching how the PI3K/AKT/mTOR pathway affects the progression and tumorigensis of ovarian cancer will hopefully lead to new therapies that will increase survival for women. This review focuses on recent research on the PI3K/AKT/mTOR pathway and its role in the progression and tumorigensis of ovarian cancer. |
| Posted: 15 Apr 2013 12:00 AM PDT The endoplasmic reticulum (ER) stress response is a highly conserved mechanism that results from the accumulation of unfolded or misfolded proteins in the ER. The response plays an important role in allowing plants to sense and respond to adverse environmental conditions, such as heat stress, salt stress and pathogen infection. Since the ER is a well-controlled microenvironment for proper protein synthesis and folding, it is highly susceptible to stress conditions. Accumulation of unfolded or misfolded proteins activates a signaling pathway, called the unfolded protein response (UPR), which acts to relieve ER stress and, if unsuccessful, leads to cell death. Plants have two arms of the UPR signaling pathway, an arm involving the proteolytic processing of membrane-associated basic leucine zipper domain (bZIP) transcription factors and an arm involving RNA splicing factor, IRE1, and its mRNA target. These signaling pathways play an important role in determining the cell's fate in response to stress conditions. |
| IJMS, Vol. 14, Pages 8179-8187: Advances in the Techniques for the Prediction of microRNA Targets Posted: 15 Apr 2013 12:00 AM PDT MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that play important roles in a variety of normal and diseased biological processes by post-transcriptionally regulating the expression of target genes. They can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs have been found to actively regulate a variety of cellular processes, including cell proliferation, death, and metabolism. Therefore, their study is crucial for the better understanding of cellular functions in eukaryotes. To better understand the mechanisms of miRNA: mRNA interaction and their cellular functions, it is important to identify the miRNA targets accurately. In this paper, we provide a brief review for the advances in the animal miRNA target prediction methods and available resources to facilitate further study of miRNAs and their functions. |
| Posted: 15 Apr 2013 12:00 AM PDT Dilated cardiomyopathy (DCM) is the most common form of non-ischemic cardiomyopathy that leads to heart failure. Mesenchymal stem cells (MSCs) are under active investigation currently as a potential therapy for DCM. However, little information is available about the therapeutic potential of intravenous administration of MSCs for DCM. Moreover, how MSCs home to the myocardium in DCM is also unclear. DCM was induced by intraperitoneally administering Doxorubicin and MSCs or vehicles were infused through the internal jugular vein. Cardiac functions including the percentage of fractional shortening, left ventricular diastolic dimension, left ventricular end-diastolic pressure, and left ventricular maximum dp/dt were evaluated by echocardiographic and hemodynamic studies. Fibrosis was determined by Masson's trichrome staining. The mRNA expression levels of monocyte chemotactic protein-1 (MCP-1), stromal cell-derived factor-1 (SDF-1), macrophage inflammatory protein-1α (MIP-1α), and monocyte chemotactic protein-3 (MCP-3) were determined using real time polymerase chain reactions and the protein expression level of MCP-1 was detected with Western blot. The MSCs expression of C-C chemokine receptor type 2 (CCR2), a MCP-1 receptor, was confirmed by Western blot and flow cytometry analysis. The chemotactic effects of MCP-1/CCR2 were checked by assessing the migration in vitro and in vivo. MSCs transplantation improved the cardiac function and decreased the myocardial fibrosis of mice with DCM. MCP-1 was up-regulated in dilated myocardial tissue both at the mRNA and protein level while SDF-1, MIP-1α and MCP-3 remain unchanged. CCR2 was present in MSCs. MCP-1 promoted MSCs migration in vitro while CCR2 inhibition decreased the migration of MCP-1 to the dilated heart. This study provides direct evidences that peripheral intravenous infusion of MSCs can support the functional recovery of DCM. In addition, novel insights into the myocardial homing factor of MSCs in DCM are presented. Modulation of MCP-1/CCR2 signaling system might be a novel therapeutic strategy for DCM. |
| Posted: 15 Apr 2013 12:00 AM PDT There are many types of dendrimers used as nanomolecules for gene delivery but there is still an ongoing search for ones that are able to effectively deliver drugs to cells. The possibility of gene silencing using siRNA gives hope for effective treatment of numerous diseases. The aim of this work was to investigate in vitro biophysical properties of dendriplexes formed by siRNA and cationic phosphorus dendrimers of 3rd and 4th generation. First, using the ethidium bromide intercalation method, it was examined whether dendrimers have an ability to form complexes with siRNA. Next, the characterisation of dendriplexes formed at different molar ratios was carried out using biophysical methods. The effects of zeta potential, size and changes of siRNA conformation on the complexation with dendrimers were examined. It was found that both phosphorus dendrimers interacted with siRNA. The zeta potential values of dendriplexes ranged from negative to positive and the hydrodynamic diameter depended on the number of dendrimer molecules in the complex. Furthermore, using circular dichroism spectroscopy it was found that cationic phosphorus dendrimers changed only slightly the shape of siRNA CD spectra, thus they did not induce significant changes in the nucleic acid secondary structure during complex formation. |
| Posted: 15 Apr 2013 12:00 AM PDT Low molecular weight amphiphilic derivatives of chitosan were synthesized, characterized and their antifungal activities against Aspergillus flavus and Aspergillus parasiticus were tested. The derivatives were synthesized using as starting material a deacetylated chitosan sample in a two step process: the reaction with propyltrimethyl-ammonium bromide (Pr), followed by reductive amination with dodecyl aldehyde. Aiming to evaluate the effect of the hydrophobic modification of the derivatives on the antifungal activity against the pathogens, the degree of substitution (DS1) by Pr groups was kept constant and the proportion of dodecyl (Dod) groups was varied from 7 to 29% (DS2). The derivatives were characterized by 1H-NMR and FTIR and their antifungal activities against the pathogens were tested by the radial growth of the colony and minimum inhibitory concentration (MIC) methods. The derivatives substituted with only Pr groups exhibited modest inhibition against A. flavus and A. parasiticus, like that obtained with deacetylated chitosan. Results revealed that the amphiphilic derivatives grafted with Dod groups exhibited increasing inhibition indexes, depending on polymer concentration and hydrophobic content. At 0.6 g/L, all amphiphilic derivatives having from 7.0 to 29% of Dod groups completely inhibited fungal growth and the MIC values were found to decrease from 4.0 g/L for deacetylated chitosan to 0.25–0.50 g/L for the derivatives. These new derivatives open up the possibility of new applications and avenues to develop effective biofungicides based on chitosan. |
| Posted: 15 Apr 2013 12:00 AM PDT 5,8-Dihydroxycoumarin (5,8-DHC) was isolated from aerial parts of sweet grass (Hierochloë odorata L.) and screened for antioxidant and genotoxic activities. A clear linear dependency of radical scavenging capacity in DPPH• and ABTS•+ assays was determined. 5,8-DHC was very efficient in retarding rapeseed oil oxidation (Oxipress test). TPC (total phenols content) and FRAP (the ability to reduce ferric ion to ferrous ion) assays revealed a somewhat lower antioxidant capacity of 5,8-DHC as compared with gallic acid. Genotoxic activity was tested using different genetic end-points: chromosome aberrations (CAs) and micronuclei (MN) in Wistar rat bone marrow in vivo, CAs and sister chromatid exchanges (SCEs) in human lymphocytes in vitro, and somatic mutations and recombination in Drosophila melanogaster wing cells in vivo. 5,8-DHC did not increase frequency of CAs in rat bone marrow cells, but induced a significant increase of MN. It was slightly mutagenic in the Drosophila melanogaster assay after 120 h of treatment, but not after 48 h of treatment. 5,8-DHC induced both CAs and SCEs in vitro in human lymphocytes in a clear dose-dependent manner. Thus, 5,8-DHC may be classified as weakly genotoxic both in vivo and in vitro. |
| Posted: 15 Apr 2013 12:00 AM PDT A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield. |
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