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Molecules, Vol. 18, Pages 7661-7674: 1,2,3-Triazole-Substituted Oleanolic Acid Derivatives: Synthesis and Antiproliferative Activity
File Juicer 4.35 - Extract images, video, or sound from files and folders. (Shareware)
Molecules, Vol. 18, Pages 7646-7660: Eco-Friendly Chitosan Production by Syncephalastrum racemosum and Application to the Removal of Acid Orange 7 (AO7) from Wastewaters
Molecules, Vol. 18, Pages 7631-7645: Synthesis and Characterization of Some New Complexes of Magnesium (II) and Zinc (II) with the Natural Flavonoid Primuletin
Molecules, Vol. 18, Pages 7609-7630: Hepatoprotective Effects of Mushrooms
BootChamp 1.5 - Quickly boot into Windows via Boot Camp. (Free)
Laws, Vol. 2, Pages 150-168: Labeling Genetically Engineered Food in the United States: Suggestions for a New Approach
July/August 2013
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Molecules, Vol. 18, Pages 7661-7674: 1,2,3-Triazole-Substituted Oleanolic Acid Derivatives: Synthesis and Antiproliferative Activity

Posted: 01 Jul 2013 12:00 AM PDT

Hybrid compounds are relevant products when searching for structure-activity relationships of natural products. Starting from the naturally occurring triterpene oleanolic acid, alkyl esters were prepared and treated with different aromatic azides using click chemistry to produce hybrid compounds. Some 18 new oleanolic acid derivatives were synthesized and the structures were confirmed by spectroscopic and spectrometric means. The antiproliferative activity of the new derivatives was evaluated towards normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), promyelocytic leukemia (HL-60), lung cancer (SK-MES-1) and bladder carcinoma (J82) cells. The alkyne esters 1 and 3 showed activity on all cell lines but without selectivity (19.6–23.1 μM and 14.1–56.2 μM, respectively), their respective methyl esters were inactive. Compounds with a benzene and p-anisole attached to the triazole ring, showed no antiproliferative effect. Introduction of a chlorine atom into the benzene ring (compound 9) elicited a selective effect against AGS cells (IC50 value: 8.9 μM). The activity was lost when the COOH function at C-28 was methylated. Better antiproliferative effect was found for compounds 11 and 15 bearing a p-toluenesulphonyl group, with values in the range of 10.8–47.1 μM and 11.5–22.2 μM, respectively. The effect, however, was not associated with selectivity.

File Juicer 4.35 - Extract images, video, or sound from files and folders. (Shareware)

Posted: 01 Jul 2013 02:09 AM PDT

File Juicer is a drag-and-drop can opener and data archaeologist. Its specialty is to find and extract images, video, audio or text from files which are hard to open in other ways.

It finds and extracts: JPEG, JP2, PNG, GIF, PDF, BMP, WMF, EMF, PICT, TIFF, Flash, ZIP, HTML, WAV, AVI, MOV, MP4, MPG, MP3, AIFF, AU, WMV, or text from files which contain data in those formats.

Lossless extraction... File Juicer does't convert the images/sounds/videos it finds, but saves them unchanged in their original format if possible. See the manual for details.

This is useful:

if you want to extract the images/sounds/videos from a PDF or Word document;
if you have old files you can no longer open with current applications;
if you receive emails with attachments you can not open;
if you have corrupt files or databases;
if you have damaged or acidentally erased flash cards for your digital camera;
if you receive "self extracting" EXE files designed for Windows;
or if this is just faster than copying and pasting from the file.

When you have extracted some files -- for instance from an accidentally erased flash card, you can then check that they are intact with QuickTime Player or convert them with other applications. For images, checking validity is done by letting File Juicer generate icons for the files. Then the files with icons are the ones which are intact.

File Juicer has Automator support so you can save just the settings you need and use them directly from Finder.

Version 4.35:

Improved: Raised limit for when File Juicer switches juicing Office documents to recovery mode to 512 MB. Some have Office documents this size, but I am not sure how many. If you happen to have any larger than 512 MB, please tell me more about it!

OS X 10.5.8 or later

More information

Download Now

Molecules, Vol. 18, Pages 7646-7660: Eco-Friendly Chitosan Production by Syncephalastrum racemosum and Application to the Removal of Acid Orange 7 (AO7) from Wastewaters

Posted: 01 Jul 2013 12:00 AM PDT

Due to the existence of new methodologies that have reduced the production costs of microbiological chitosan, this paper puts forward the use of agro-industrial residues in order to produce microbiological chitosan and to apply chitosan as an innovative resource for removing acid orange 7 (AO7) from wastewaters. The best culture conditions were selected by a full 24 factorial design, and the removal of the dye was optimized by a 23 central composite rotational design. The results showed that corn steep liquor (CSL) is an agro-industrial residue that can be advantageously used to produce microbiological chitosan with yields up to 7.8 g/kg of substrate. FT-IR spectra of the product showed typical peak distributions like those of standard chitosan which confirmed the extracted product was chitosan-like. The efficiency of removing low concentrations of AO7 by using microbiological chitosan in distilled water (up to 89.96%) and tap water (up to 80.60%) was significantly higher than the efficiency of the control (chitosan obtained from crustaceans), suggesting that this biopolymer is a better economic alternative for discoloring wastewater where a low concentration of the dye is considered toxic. The high percentage recovery of AO7 from the microbiological chitosan particles used favors this biopolymer as a possible bleaching agent which may be reusable.

Molecules, Vol. 18, Pages 7631-7645: Synthesis and Characterization of Some New Complexes of Magnesium (II) and Zinc (II) with the Natural Flavonoid Primuletin

Posted: 01 Jul 2013 12:00 AM PDT

Two new metal complexes formulated as [Mg(L)2(H2O)2]·H2O (1) and [Zn(L)2(H2O)2]·0.5H2O (2), where HL = 5-hydroxyflavone (primuletin), have been synthesized and characterized by elemental and thermal analyses, molar conductance, IR, UV-Vis, 1H- and 13C-NMR, fluorescence and mass spectra. In solid state, complexes had shown higher fluorescence intensities comparing to the free ligand, and this behavior is appreciated as a consequence of the coordination process.

Molecules, Vol. 18, Pages 7609-7630: Hepatoprotective Effects of Mushrooms

Posted: 01 Jul 2013 12:00 AM PDT

The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, b-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

BootChamp 1.5 - Quickly boot into Windows via Boot Camp. (Free)

Posted: 01 Jul 2013 01:52 AM PDT

BootChamp is a small utility for quickly booting into Windows.

How is this different than selecting your Windows volume from within Startup Disk in System Preferences?

Well, using Startup Disk actually changes your startup disk permanently so that each time you restart, it boots into whatever you have selected. What this program is doing is the same thing that happens when you hold down Option at startup and select Windows. However, the app only requires a single click and your admin password, and then it restarts your computer into Windows without further input from you. It will not actually change your startup disk.

Version 1.5:

Improved detection of a Windows volume
Fixed potential crash
Added Croatian localization
BootChamp now requires a 64-bit computer

OS X 10.6.8 or later

More information

Download Now

Laws, Vol. 2, Pages 150-168: Labeling Genetically Engineered Food in the United States: Suggestions for a New Approach

Posted: 01 Jul 2013 12:00 AM PDT

The Federal Food, Drug, and Cosmetic Act (FFDCA) provides that a food is misbranded if the label accompanying the product is false or misleading in any particular. Congress provided minimal guidance to assist the FDA in making these determinations. When challenged, courts have granted substantial deference to FDA's various interpretations of what constitute a material fact. However, when confronted with the regulatory question of whether or how to label products derived from genetically engineered (GE) crops, the FDA adopted a narrow reading of the statute that focused on changes in the product itself, rather than the act of genetic engineering. Only those GE products that possessed characteristics significantly different from their conventional counterparts would require labels. This "process versus product" distinction in food labels lies at the heart of the FDA's resistance to repeated calls for mandatory labeling of foods derived from genetic engineering. Consumer interest in GE food, according to the agency, is not a material fact to trigger mandatory labeling under the statute. In contrast to its approach to GE labels, the agency has long required (since 1966) process-based labels for foods treated with irradiation. As recently as 1986, the FDA affirmed that materiality of information under it misbranding analysis is not limited to product safety or even the abstract worth of the information, but whether consumers view the information as important and whether the omission of a labeling statement would mislead the consumer. Accordingly, mere consumer interest can give rise to a mandatory labeling regime under the FFDCA. In the irradiation context, whole foods and single-ingredient products treated with irradiation must bear a label indicating the process. The irradiation of components in a multi-ingredient food product, however, need not bear a label. This distinction between processed, multi-ingredient and whole or single-ingredient foods provides a potential pathway for the agency to revise its approach to mandatory GE labeling. Exempting highly processed, multi-ingredient foods from a labeling regime would minimize traceability and segregation-generated disruptions in the commodity supply chain, thereby minimizing potential compliance costs, while also empowering consumers to express their preferences for non-GE whole and single-ingredient food products.

July/August 2013

Posted: 30 Jun 2013 11:55 PM PDT

Actor and musician Jeff Bridges has brought an understated style to the silver screen for decades, but a love of music turned him into the guitarist of his boyhood dreams.

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