Games |
- Cancers, Vol. 3, Pages 1821-1843: Targeted Alpha Therapy Approach to the Management of Pancreatic Cancer
- Future Internet, Vol. 3, Pages 87-116: A Service Oriented Architecture for Personalized Universal Media Access
- IJMS, Vol. 12, Pages 2262-2274: Multi-Step Usage of in Vivo Models During Rational Drug Design and Discovery
- IJMS, Vol. 12, Pages 2242-2261: Improving the Accuracy of Density Functional Theory (DFT) Calculation for Homolysis Bond Dissociation Energies of Y-NO Bond: Generalized Regression Neural Network Based on Grey Relational Analysis and Principal Component Analysis
- Tap Zoo - iPhone - Screenshots
- Return of the Bots - iPhone - Screenshots
- Aladin and the Enchanted Lamp - iPhone - Screenshots
- Pilot Winds - iPhone - Screenshots
- Frog Toss! - iPhone - Screenshots
- Find Any File 1.5.3 - Search your disks for files using various criteria.. (Shareware)
- Adobe AIR 2.7 - Deploy web applications on the desktop.. (Free)
- Chicago officers accused of sex assault
- IJERPH, Vol. 8, Pages 985-1031: A Multidisciplinary, Science-Based Approach to the Economics of Climate Change
- IJERPH, Vol. 8, Pages 976-984: Intensity and Inhalation of Smoking in the Aetiology of Laryngeal Cancer
- Water, Vol. 3, Pages 479-494: Climate Change and Classic Maya Water Management
- Genes, Vol. 2, Pages 332-344: Effect of Culture Conditions on Viability of Mouse and Rat Embryos Developed In Vitro
- A Pawn With Hopes Of Castles, In Search Of A Gambit
- Cancers, Vol. 3, Pages 1798-1820: Apoptosis and DNA Methylation
- IJMS, Vol. 12, Pages 2232-2241: One-Dimensional Hydrogen-Bonded Infinite Chain from Nickel(II) Tetraaza Macrocyclic Complex and 1,2-Cyclopentanedicarboxylate Ligand
- Game Cupido in love : 01/04/2011
| Posted: 01 Apr 2011 12:00 AM PDT Evidence for the efficacy of targeted alpha therapy for the control of pancreatic cancer in preclinical models is reviewed. Results are given for in vitro pancreatic cancer cells and clusters and micro-metastatic cancer lesions in vivo. Two complementary targeting vectors are examined. These are the C595 monoclonal antibody that targets the MUC1 antigen and the PAI2 ligand that targets the uPA receptor. The expression of the tumor-associated antigen MUC-1 and the uPA receptor on three pancreatic cancer cell lines is reported for cell clusters, human mouse xenografts and lymph node metastases, as well as for human pancreatic cancer tissues, using immuno-histochemistry, confocal microscopy and flow cytometry. The targeting vectors C595 and PAI2 were labeled with the alpha emitting radioisotope 213Bi using the chelators cDTPA and CHX-A″ to form the alpha-conjugates (AC). Cell clusters were incubated with the AC and examined at 48 hours. Apoptosis was documented using the TUNEL assay. In vivo, the anti-proliferative effect for tumors was tested at two days post-subcutaneous cell inoculation. Mice were injected with different concentrations of AC by local or systemic administration. Changes in tumor progression were assessed by tumor size. MUC-1 and uPA are strongly expressed on CFPAC-1, PANC-1 and moderate expression was found CAPAN-1 cell clusters and tumor xenografts. The ACs can target pancreatic cells and regress cell clusters (~100 µm diameter), causing apoptosis in some 70–90 % of cells. At two days post-cell inoculation in mice, a single local injection of 74 MBq/kg of AC causes complete inhibition of tumor growth. Systemic injections of 111, 222 and 333 MBq/kg of alpha-conjugate caused significant tumor growth delay in a dose dependent manner after 16 weeks, compared with the non-specific control at 333 MBq/kg. Cytotoxicity was assessed by the MTS and TUNEL assays. The C595 and PAI2-alpha conjugates are indicated for the treatment of micro-metastatic pancreatic cancer with over-expression of MUC1 and uPA receptors in post-surgical patients with minimal residual disease. The observation of tumor regression in a Phase I clinical trial of targeted alpha therapy for metastatic melanoma indicates that alpha therapy can regress tumors by a process called tumor anti-vascular alpha therapy (TAVAT). As a consequence, this therapy could be indicated for the management of non-surgical pancreatic cancer tumors. |
| Posted: 01 Apr 2011 12:00 AM PDT Multimedia streaming means delivering continuous data to a plethora of client devices. Besides the actual data transport, this also needs a high degree of content adaptation respecting the end users' needs given by content preferences, transcoding constraints, and device capabilities. Such adaptations can be performed in many ways, usually on the media server. However, when it comes to content editing, like mixing in subtitles or picture-in-picture composition, relying on third party service providers may be necessary. For economic reasons this should be done in a service-oriented way, because a lot of adaptation modules can be reused within different adaptation workflows. Although service-oriented architectures have become widely accepted in the Web community, the multimedia environment is still dominated by monolithic systems. The main reason is the insufficient support for working with continuous data: generally the suitability of Web services for handling complex data types and state-full applications is still limited. In this paper we discuss extensions of Web service frameworks, and present a first implementation of a service-oriented framework for media streaming and digital item adaptation. The focus lies on the technical realization of the services. Our experimental results show the practicality of the actual deployment of service-oriented multimedia frameworks. |
| Posted: 01 Apr 2011 12:00 AM PDT In this article we propose a systematic development method for rational drug design while reviewing paradigms in industry, emerging techniques and technologies in the field. Although the process of drug development today has been accelerated by emergence of computational methodologies, it is a herculean challenge requiring exorbitant resources; and often fails to yield clinically viable results. The current paradigm of target based drug design is often misguided and tends to yield compounds that have poor absorption, distribution, metabolism, and excretion, toxicology (ADMET) properties. Therefore, an in vivo organism based approach allowing for a multidisciplinary inquiry into potent and selective molecules is an excellent place to begin rational drug design. We will review how organisms like the zebrafish and Caenorhabditis elegans can not only be starting points, but can be used at various steps of the drug development process from target identification to pre-clinical trial models. This systems biology based approach paired with the power of computational biology; genetics and developmental biology provide a methodological framework to avoid the pitfalls of traditional target based drug design. |
| Posted: 01 Apr 2011 12:00 AM PDT We propose a generalized regression neural network (GRNN) approach based on grey relational analysis (GRA) and principal component analysis (PCA) (GP-GRNN) to improve the accuracy of density functional theory (DFT) calculation for homolysis bond dissociation energies (BDE) of Y-NO bond. As a demonstration, this combined quantum chemistry calculation with the GP-GRNN approach has been applied to evaluate the homolysis BDE of 92 Y-NO organic molecules. The results show that the full-descriptor GRNN without GRA and PCA (F-GRNN) and with GRA (G-GRNN) approaches reduce the root-mean-square (RMS) of the calculated homolysis BDE of 92 organic molecules from 5.31 to 0.49 and 0.39 kcal mol−1 for the B3LYP/6-31G (d) calculation. Then the newly developed GP-GRNN approach further reduces the RMS to 0.31 kcal mol−1. Thus, the GP-GRNN correction on top of B3LYP/6-31G (d) can improve the accuracy of calculating the homolysis BDE in quantum chemistry and can predict homolysis BDE which cannot be obtained experimentally. |
| Tap Zoo - iPhone - Screenshots Posted: 01 Apr 2011 02:58 AM PDT LOADED WITH FEATURES: - More than 50 new animals to care for! - Make choices about how to expand your zoo - Breed animals - Place sidewalks and rivers to encourage visitors to see all your different animals and attractions - Unlock new animals and zoo attractions - Collect money your animals have earned for your zoo - Build stores, restaurants, and attractions to encourage more people to come visit your zoo. - Hire rangers to help you care for your animals when you're not there - Plant trees to make your park more beautiful. - Visit your friends' Zoos and play together! - Very fun to play! - Works on iPod Touch and iPhones 3G, 3GS, and 4. - Crossbreed animals! |
| Return of the Bots - iPhone - Screenshots Posted: 01 Apr 2011 02:58 AM PDT Complete 9 intense missions to unlock 2 survival arenas. Collect credits with your score and unlock up to 7 characters. 11 challenging scenarios to explore, in a dual-stick 3D action experience with classic gameplay, sudden enemy attacks and massive boss battles. |
| Aladin and the Enchanted Lamp - iPhone - Screenshots Posted: 01 Apr 2011 02:58 AM PDT A THRILLING ADVENTURE: Look for food, avoid the stallholders, find the marvels' cavern lost in the desert, enjoy the Genius' magic powers and find out what the mysterious secret kept in the Palace is! USEFUL HINTS: Use the Hint: a shiny halo helps you to find one of the objects. No more hints? Not enough time? Find the bonus stars hidden in the scenes to get more hints or time! MAGNIFICIENT SETS: Escape in the oriental deserts, explore the souks, admire the marvels in the famous cavern or the prestigious Palace. CONTENT: - 40 places to observe - Mini-games: puzzle games - 3 profiles management - 2 game modes: Classics and Time Attack - Best scores on line - Search of objects (list, to collect) - Help: zoom on selected screens, limited number of reloading hints, bonus stars - Magnificent sets: high resolution images |
| Pilot Winds - iPhone - Screenshots Posted: 01 Apr 2011 02:58 AM PDT REASONS PILOT WINDS IS AWESOME • You can play for free • Fast and skilful gameplay • Compete with your friends' highscores: for free • Tons of game modes and a secret character to unlock • Many score bonuses to discover and unlock • Guaranteed updates - At least two new game modes to be released soon! |
| Frog Toss! - iPhone - Screenshots Posted: 01 Apr 2011 02:58 AM PDT Features: - Easy to play yet still a test of your amphibian aiming skills! - Grab 5 different power-ups to enhance your frog launching prowess! - Collect 20 different prizes to earn special bonuses, making your power-ups even stronger! - The lilies change color! Match all the lilies to the same color for more bonuses, like extra frogs or even a shot at a rare prize! - Your frogs are hungry! Nab the buzzing flies and you'll attract more frogs for your catapult! GAMEPLAY TIP: It is the length of your swipe that determines how far the frog is launched. The speed of the swipe is not important. Long swipes shoot far. Short swipes for short launches. |
| Find Any File 1.5.3 - Search your disks for files using various criteria.. (Shareware) Posted: 01 Apr 2011 02:25 AM PDT  Find Any File searches your local disks for files by name, creation or modification date, size, or type and creator code (not by content, though). As there are other tools with a similar search operation, here are the special features unique to Find Any File:
Unlike Spotlight (i.e. the Finder's Find command), it does not access a pre-built database but searches the chosen volume directly. This allows you to find any file, even those inside packages and others excluded from Spotlight search. Hence it is great for finding system files, for example. On the other hand, it may take a little longer than Spotlight, and it is only fast on HFS(+) volumes. But even on mounted network volumes of a Mac OS X server it can still be surprisingly fast. Hence, this is not an entire replacement for Spotlight but it can come handy in certain, if not many, situations.
Mac OS X 10.4.1 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Adobe AIR 2.7 - Deploy web applications on the desktop.. (Free) Posted: 01 Apr 2011 02:23 AM PDT  Adobe AIR is a cross-operating system runtime that allows web application developers to use their existing web development skills (HTML, Javascript, Adobe Flash, Adobe Flex, Ajax) to build and deploy rich Internet applications on the desktop. Adobe AIR enables developers to create applications that combine the benefits of web applications - network and user connectivity, rich media content, ease of development, and broad reach - with the strengths of desktop applications - application interactions, local resource access, personal settings, powerful functionality, and rich interactive experiences. Adobe AIR enables familiar application interaction models, including drag-and-drop support, rich clipboard access, and desktop and system shortcuts. Adobe AIR applications run as regular applications, and do not have to run within another application or shell (as web applications do by running within the browser).
Mac OS X 10.4.9 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Chicago officers accused of sex assault Posted: 01 Apr 2011 01:33 AM PDT Two Chicago police officers are accused of playing strip poker and sexually assaulting a 22-year-old woman. This posting includes an audio/video/photo media file: Download Now |
| Posted: 01 Apr 2011 12:00 AM PDT Economic analyses of environmental mitigation and other interdisciplinary public policy issues can be much more useful if they critically examine what other disciplines have to say, insist on using the most relevant observational data and the scientific method, and examine lower cost alternatives to the change proposed. These general principles are illustrated by applying them to the case of climate change mitigation, one of the most interdisciplinary of public policy issues. The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO2 emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO2 emissions reductions on atmospheric CO2 appear to be short rather than long lasting. The costs of CO2 emissions reductions are very much higher than usually estimated because of technological and implementation problems recently identified. Geoengineering such as solar radiation management is a controversial alternative to CO2 emissions reductions that offers opportunities to greatly decrease these large costs, change global temperatures with far greater assurance of success, and eliminate the possibility of low probability, high consequence risks of rising temperatures, but has been largely ignored by economists. CO2 emissions reductions are economically unattractive since the very modest benefits remaining after the corrections for the above effects are quite unlikely to economically justify the much higher costs unless much lower cost geoengineering is used. The risk of catastrophic anthropogenic global warming appears to be so low that it is not currently worth doing anything to try to control it, including geoengineering. |
| Posted: 01 Apr 2011 12:00 AM PDT The carcinogenic effect of smoking on laryngeal cancer is well established; however, the risk pattern for detailed smoking characteristics is less clear. Thus, the aim of this analysis was to quantify the impact of different inhalation behaviours on the risk of laryngeal cancer. We conducted a population-based case control study in Germany, frequency-matched for sex and age, using a standardized questionnaire covering lifelong smoking details, including age at start, time since quitting, types of smoking products, duration, intensity and inhalation behaviour. We found higher risks for increasing duration and intensity of smoking. A clear dose-response relationship was found in all inhalation subgroups, i.e., not only for deep inhalers, but also for those puffing on a cigarette. Clearly reduced risks could be observed for quitting smoking. Changing inhalation habits might be considered as a first step to reducing the risk of developing laryngeal cancer. However, the best way to effectively reduce laryngeal cancer risk is to quit smoking. |
| Water, Vol. 3, Pages 479-494: Climate Change and Classic Maya Water Management Posted: 01 Apr 2011 12:00 AM PDT The critical importance of water is undeniable. It is particularly vital in semitropical regions with noticeable wet and dry seasons, such as the southern Maya lowlands. Not enough rain results in decreasing water supply and quality, failed crops, and famine. Too much water results in flooding, destruction, poor water quality, and famine. We show not only how Classic Maya (ca. A.D. 250–950) society dealt with the annual seasonal extremes, but also how kings and farmers responded differently in the face of a series of droughts in the Terminal Classic period (ca. A.D. 800–950). Maya farmers are still around today; kings, however, disappeared over 1,000 years ago. There is a lesson here on how people and water managers responded to long-term climate change, something our own society faces at present. The basis for royal power rested in what kings provided their subjects materially—that is, water during annual drought via massive artificial reservoirs, and spiritually—that is, public ceremonies, games, festivals, feasts, and other integrative activities. In the face of rulers losing their powers due to drought, people left. Without their labor, support and services, the foundation of royal power crumbled; it was too inflexible and little suited to adapting to change. |
| Posted: 01 Apr 2011 12:00 AM PDT Currently in vitro culture of mouse preimplantation embryos has become a very important technique to investigate different mechanisms of early embryogenesis. However, there is a big difference in the preimplantation development between mammalian species. Despite close relatedness to mice, in vitro cultivation of rat preimplantation embryos is still delicate and needs further investigation and optimizations. In this study we have compared the in vitro developmental potential of mouse and rat embryos cultured at different culture conditions in parallel experiments. Interestingly, mouse zygotes developed in vitro until blastocyst stage even in inadequate medium without any phosphates and with low osmolarity which was formulated especially for cultivation of rat embryos. Rat parthenotes and zygotes developed in M16 medium formulated for mouse embryos only till 2-cell stage and further development is blocked completely at this stage. Moreover, developmental ability of rat embryos in vitro was significantly lower in comparison with mouse even in special rat mR1ECM medium. Mouse and rat embryos at 2-cell stage obtained in vivo developed until blastocyst stages significantly more efficiently compared to zygotes. Culture of mouse zygotes in glass capillaries resulted in a significantly higher rate of morula and blastocyst development compared with dishes. The Well-of-the-Well system resulted in a significant improvement when compared with dishes for the culture of rat zygotes only until morula stage. Reduced oxygen tension increased the developmental rate of rat but not mouse zygotes until blastocyst stage. This study demonstrates that development of early preimplantation embryos is altered by different culture conditions and show strong differences even between two related species such as mice and rats. Therefore, for understanding the fundamental mechanisms of early mammalian development it is very important to use embryos of various species. |
| A Pawn With Hopes Of Castles, In Search Of A Gambit Posted: 01 Apr 2011 12:28 AM PDT Her Move: Sandrine Bonnaire plays a smart but shy woman who develops a passion for chess - and an appetite for a life beyond her experience. This posting includes an audio/video/photo media file: Download Now |
| Cancers, Vol. 3, Pages 1798-1820: Apoptosis and DNA Methylation Posted: 01 Apr 2011 12:00 AM PDT Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG. |
| Posted: 01 Apr 2011 12:00 AM PDT The reaction of [Ni(L)]Cl2·2H2O (L = 3,14-dimethyl-2,6,13,17-tetraazatricyclo [14,4,01.18,07.12]docosane) with trans-1,2-cyclopentanedicarboxylic acid (H2-cpdc) yields a 1D hydrogen-bonded infinite chain with formula [Ni(L)(H-cpdc-)2] (1). This complex has been characterized by X-ray crystallography, spectroscopy and cyclic voltammetry. The crystal structure of 1 exhibits a distorted octahedral geometry about Ni atom with four nitrogen atoms of the macrocycle and two oxygen atoms of the H-cpdc- ligand at the axial position. Compound 1 crystallizes in the monoclinic system P21/c with a = 8.7429(17), b = 10.488(2), c = 18.929(4) Å, β = 91.82(2), V = 1734.8(6) Å3, Z = 2. Electronic spectrum of 1 reveals a high-spin octahedral environment. Cyclic voltammetry of 1 undergoes two waves of a one-electron transfer corresponding to NiII/NiIII and NiII/NiI processes. |
| Game Cupido in love : 01/04/2011 Posted: 03 Dec 2010 10:04 PM PST  |
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