пятница, 15 апреля 2011 г.

Games

Games

Games

IJERPH, Vol. 8, Pages 1126-1140: Assessment of Water Quality in a Subtropical Alpine Lake Using Multivariate Statistical Techniques and Geostatistical Mapping: A Case Study

Posted: 15 Apr 2011 12:00 AM PDT

Concerns about the water quality in Yuan-Yang Lake (YYL), a shallow, subtropical alpine lake located in north-central Taiwan, has been rapidly increasing recently due to the natural and anthropogenic pollution. In order to understand the underlying physical and chemical processes as well as their associated spatial distribution in YYL, this study analyzes fourteen physico-chemical water quality parameters recorded at the eight sampling stations during 2008–2010 by using multivariate statistical techniques and a geostatistical method. Hierarchical clustering analysis (CA) is first applied to distinguish the three general water quality patterns among the stations, followed by the use of principle component analysis (PCA) and factor analysis (FA) to extract and recognize the major underlying factors contributing to the variations among the water quality measures. The spatial distribution of the identified major contributing factors is obtained by using a kriging method. Results show that four principal components i.e., nitrogen nutrients, meteorological factor, turbidity and nitrate factors, account for 65.52% of the total variance among the water quality parameters. The spatial distribution of principal components further confirms that nitrogen sources constitute an important pollutant contribution in the YYL.

IJMS, Vol. 12, Pages 2518-2542: Functioning Nanomachines Seen in Real-Time in Living Bacteria Using Single-Molecule and Super-Resolution Fluorescence Imaging

Posted: 15 Apr 2011 12:00 AM PDT

Molecular machines are examples of "pre-established" nanotechnology, driving the basic biochemistry of living cells. They encompass an enormous range of function, including fuel generation for chemical processes, transport of molecular components within the cell, cellular mobility, signal transduction and the replication of the genetic code, amongst many others. Much of our understanding of such nanometer length scale machines has come from in vitro studies performed in isolated, artificial conditions. Researchers are now tackling the challenges of studying nanomachines in their native environments. In this review, we outline recent in vivo investigations on nanomachines in model bacterial systems using state-of-the-art genetics technology combined with cutting-edge single-molecule and super-resolution fluorescence microscopy. We conclude that single-molecule and super-resolution fluorescence imaging provide powerful tools for the biochemical, structural and functional characterization of biological nanomachines. The integrative spatial, temporal, and single-molecule data obtained simultaneously from fluorescence imaging open an avenue for systems-level single-molecule cellular biophysics and in vivo biochemistry.

JLPEA, Vol. 1, Pages 131-149: Path Specific Register Design to Reduce Standby Power Consumption

Posted: 15 Apr 2011 12:00 AM PDT

A methodology is proposed to design low leakage registers by considering the type of timing path, i.e., short or long, and type of register, i.e., launching or capturing. Three different dual threshold voltage registers are developed where each register trades, depending upon the timing path, a different timing constraint for reducing the leakage current. For example, the first proposed register is used as a launching register in a noncritical path, trading clock-to-Q delay for leakage current. Other timing constraints such as setup and hold times are maintained the same not to introduce any timing violations. Alternatively, the second and third registers, trade, respectively, setup time and hold time for leakage current while maintaining clock-to-Q delay constant. The effect of the proposed methodology on leakage current is investigated for four technology nodes. The overall reduction in the leakage current of a register can exceed 90% while maintaining the clock frequency and other design parameters such as area and dynamic power the same. Three ISCAS 89 benchmark circuits are utilized to evaluate the methodology, demonstrating, on average, 23% reduction in the overall leakage current.

Materials, Vol. 4, Pages 801-815: Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro

Posted: 15 Apr 2011 12:00 AM PDT

The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.

Micromachines, Vol. 2, Pages 129-149: Mori-Tanaka Based Estimates of Effective Thermal Conductivity of Various Engineering Materials

Posted: 15 Apr 2011 12:00 AM PDT

The purpose of this paper is to present a simple micromechanics-based model to estimate the effective thermal conductivity of macroscopically isotropic materials of matrix-inclusion type. The methodology is based on the well-established Mori-Tanaka method for composite media reinforced with ellipsoidal inclusions, extended to account for imperfect thermal contact at the matrix-inclusion interface, random orientation of particles and particle size distribution. Using simple ensemble averaging arguments, we show that the Mori-Tanaka relations are still applicable for these complex systems, provided that the inclusion conductivity is appropriately modified. Such conclusion is supported by the verification of the model against a detailed finite-element study as well as its validation against experimental data for a wide range of engineering material systems.

F1: Vettel Keeps Pouring It On In China P2

Posted: 15 Apr 2011 12:00 AM PDT


Sebastian Vettel led both of Friday's practices in Shanghai...

Sudoku OneTouch 1.2 - Logic puzzle game.. (Commercial)

Posted: 15 Apr 2011 12:23 AM PDT



Sudoku OneTouch is the most popular and addictive logic puzzle game in the world has never looked and played this good on the Mac!



Brainium Studios brings you the most polished and intuitive Sudoku game with Sudoku OneTouch! Get ready for the best Sudoku experience on your Mac with a variety of keyboard, mouse and touchpad controls that make entering solutions and notes magically simple for everyone.


    

  • Four difficulty levels to challenge players of all skill levels
  • Thousands of masterfully crafted puzzles
  • Five gorgeous themes with high resolution graphics
  • Leader boards to challenge your best records

  • Great variety of controls with keyboard or mouse

  • OneTouch system for magically simple number entry with your mouse
  • Game statistics to keep track of your progress
  • Advanced game options, notes, and hint system
  • Five star support from Brainium Studios

Sudoku OneTouch is also available on iPad and iPhone as a universal App for your on the go puzzle pleasure!

Version 1.2:
  • Several important performance and stability optimizations

  • Older Mac hardware (such as older Macbooks) using Intel graphics hardware should no longer crash at startup due to limited texture size

  • Added "Full Screen" toggle checkbox to Options menu

  • Misc resizing screen polish and fixes


Mac OS X 10.6.6 or later.

Download Now

Molecules, Vol. 16, Pages 3197-3211: Antioxidant Properties and Antioxidant Compounds of Various Extracts from the Edible Basidiomycete Grifola Frondosa (Maitake)

Posted: 15 Apr 2011 12:00 AM PDT

Grifola frondosa is an edible mushroom currently available in Taiwan. Ethanolic, cold-water and hot-water extracts were prepared and their antioxidant properties were investigated. At 1 mg/mL, G. frondosa T1 and T2 cold-water extracts showed high reducing powers of 1.02 and 0.50, respectively. Chelating abilities on ferrous ions of G. frondosa T1 and T2 were higher for cold-water extracts than for ethanolic and hot-water extracts. For the scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, G. frondosa T1 and T2 extracts were effective in the following order: ethanolic > hot-water > cold-water. The G. frondosa hot-water extract showed high scavenging ability on superoxide anions. Total phenols, flavonoids, ascorbic acid and α-tocopherol are the major antioxidant components found in the various G. frondosa extracts. Based on EC50 values (

Molecules, Vol. 16, Pages 3179-3196: Induction of Intracellular Ca2+ and pH Changes in Sf9 Insect Cells by Rhodojaponin-III, A Natural Botanic Insecticide Isolated from Rhododendron molle

Posted: 15 Apr 2011 12:00 AM PDT

Many studies on intracellular calcium ([Ca2+]i) and intracellular pH (pHi) have been carried out due to their importance in regulation of different cellular functions. However, most of the previous studies are focused on human or mammalian cells. The purpose of the present study was to characterize the effect of Rhodojaponin-III (R-III) on [Ca2+]i and pHi and the proliferation of Sf9 cells. R-III strongly inhibited Sf9 cells proliferation with a time- and dose-dependent manner. Flow cytometry established that R-III interfered with Sf9 cells division and arrested them in G2/M. By using confocal scanning technique, effects of R-III on intracellular free calcium ([Ca2+]i) and intracellular pH (pHi) in Sf9 cells were determined. R-III induced a significant dose-dependent (1, 10, 100, 200 μg/mL) increase in [Ca2+]i and pHi of Sf9 cells in presence of Ca2+-containing solution (Hanks) and an irreversible decrease in the absence of extra cellular Ca2+. We also found that both extra cellular Ca2+ and intracellular Ca2+ stores contributed to the increase of [Ca2+]i, because completely treating Sf9 cells with CdCl2 (5 mM), a Ca2+ channels blocker, R-III (100 μg/mL) induced a transient elevation of [Ca2+]i in case of cells either in presence of Ca2+ containing or Ca2+ free solution. In these conditions, pHi showed similar changes with that of [Ca2+]i on the whole. Accordingly, we supposed that there was a certain linkage for change of [Ca2+]i, cell cycle arrest, proliferation inhibition in Sf9 cells induced by R-III.

TXTcrypt 1.3 - General purpose text encryption utility.. (Free)

Posted: 15 Apr 2011 12:02 AM PDT



TXTcrypt is a general purpose text encryption application for sms/email/notes etc. focused on ease of use and interoperability between mobile and desktop versions.



With TXTcrypt just enter your message and a password for it , now the encrypted message can only be decoded with that password , just tell it to someone , and send them message encrypted with it , they can use TXTcrypt to decode it.



TXTcrypt works with any character set being unicode compliant , the encryption used is as strong as encryption export regulations allow , not military grade but namely RC4 with keys as big as 64bit depending on the length of your password as such providing a decent amount of security.

Mac OS X 10.6.6 or later.

Download Now

On the Spot - SOCOM 4, Killzone 3, Twisted Metal

Posted: 14 Apr 2011 10:42 PM PDT

Coming up next On The Spot we've got two PS3 Demos for SOCOM 4 and the Steel Rain DLC for Killzone 3. Next we check in on SSX, and get a wrap up from all the Capcom action at Captivate 2011! All that and more, On The Spot.

 

Read and Post Comments | Get the full article at GameSpot

"On the Spot - SOCOM 4, Killzone 3, Twisted Metal" was posted by DanM on Thu, 14 Apr 2011 22:42:19 -0700

Capcom Captivate 2011 Wrap Up Video Feature

Posted: 14 Apr 2011 07:59 PM PDT

Ricardo and Shaun wrap up Capcom's Captivate and the repective upcoming titles from Miami

Read and Post Comments | Get the full article at GameSpot

"Capcom Captivate 2011 Wrap Up Video Feature" was posted by takeshi on Thu, 14 Apr 2011 19:59:10 -0700

SOCOM 4: U.S. Navy SEALs Video Review

Posted: 14 Apr 2011 07:08 PM PDT

Chris Watters preps his team before he breaches this video review for SOCOM 4: U.S. Navy SEALs.

 

Read and Post Comments | Get the full article at GameSpot

"SOCOM 4: U.S. Navy SEALs Video Review" was posted by JimM on Thu, 14 Apr 2011 19:08:19 -0700

SOCOM 4: U.S. Navy SEALs Daily Demo

Posted: 14 Apr 2011 06:56 PM PDT

Chris Watters demo SOCOM 4: U.S. Navy SEALs on the PS3 On The Spot.

 

Read and Post Comments | Get the full article at GameSpot

"SOCOM 4: U.S. Navy SEALs Daily Demo" was posted by Homer on Thu, 14 Apr 2011 18:56:30 -0700

Killzone 3 Daily Demo

Posted: 14 Apr 2011 06:55 PM PDT

Kevin VanOrd demos the Steel Rain DLC for Killzone 3 On The Spot.

 

Read and Post Comments | Get the full article at GameSpot

"Killzone 3 Daily Demo" was posted by Homer on Thu, 14 Apr 2011 18:55:08 -0700

Super Button Mashing: Round 2 Memory Leak

Posted: 14 Apr 2011 06:42 PM PDT

Chris Watters, David Jaffe and Shaun McInnis go head to head in Round 2 of Button Mashing: Memory Leak

 

Read and Post Comments | Get the full article at GameSpot

"Super Button Mashing: Round 2 Memory Leak" was posted by Homer on Thu, 14 Apr 2011 18:42:51 -0700

Rio Review

Posted: 14 Apr 2011 06:41 PM PDT

Rio is inconsistent and short on personality, but there's some enjoyment to be had in this multiplayer party game.

     

Score: 6.0 / fair

Get the full article at GameSpot

"Rio Review" was posted by Carolyn Petit on Thu, 14 Apr 2011 18:41:10 -0700

Twisted Metal Daily Demo

Posted: 14 Apr 2011 06:37 PM PDT

Shaun McInnis and Chris Watters talk about Twisted Metal On The Spot.

 

Read and Post Comments | Get the full article at GameSpot

"Twisted Metal Daily Demo" was posted by Homer on Thu, 14 Apr 2011 18:37:36 -0700

Might & Magic: Clash of Heroes Review

Posted: 14 Apr 2011 06:23 PM PDT

Addictive puzzle battles and a ton of content make Might & Magic: Clash of Heroes hard to put down.

 

Score: 8.0 / great

Get the full article at GameSpot

"Might & Magic: Clash of Heroes Review" was posted by Brett Todd on Thu, 14 Apr 2011 18:23:05 -0700

Might & Magic: Clash of Heroes Review

Posted: 14 Apr 2011 06:22 PM PDT

Addictive puzzle battles and a ton of content make Might & Magic: Clash of Heroes hard to put down.

 

Score: 8.0 / great

Get the full article at GameSpot

"Might & Magic: Clash of Heroes Review" was posted by Brett Todd on Thu, 14 Apr 2011 18:22:49 -0700
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