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- Cancers, Vol. 3, Pages 1405-1425: Breast Cancer-Initiating Cells: Insights into Novel Treatment Strategies
- Sensors, Vol. 11, Pages 3214-3226: Potentiometric Electronic Tongue to Resolve Mixtures of Sulfide and Perchlorate Anions
- IJERPH, Vol. 8, Pages 875-898: Life-long Programming Implications of Exposure to Tobacco Smoking and Nicotine Before and Soon After Birth: Evidence for Altered Lung Development
- IJMS, Vol. 12, Pages 1888-1907: Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment
- POLICE: Lehigh University student lied about armed robbery, lost money gambling
- A Better Finder Attributes 5.03 - Contextual menu item to change file creation/modification dates.. (Shareware)
- Cancers, Vol. 3, Pages 1383-1404: Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer
- Cancers, Vol. 3, Pages 1372-1382: The Potential Use of N-Myristoyltransferase as a Biomarker in the Early Diagnosis of Colon Cancer
- Toxins, Vol. 3, Pages 218-241: Arf6-Dependent Intracellular Trafficking of Pasteurella multocida Toxin and pH-Dependent Translocation from Late Endosomes
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- Game Henri 8 - dressed to kill : 16/03/2011
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- Game Osamagotchi : 16/03/2011
| Posted: 16 Mar 2011 12:00 AM PDT There is accumulating evidence that breast cancer may arise from mutated mammary stem/progenitor cells which have been termed breast cancer-initiating cells (BCIC). BCIC identified in clinical specimens based on membrane phenotype (CD44+/CD24−/low and/or CD133+ expression) or enzymatic activity of aldehyde dehydrogenase 1 (ALDH1+), have been demonstrated to have stem/progenitor cell properties, and are tumorigenic when injected in immunocompromized mice at very low concentrations. BCIC have also been isolated and in vitro propagated as non-adherent spheres of undifferentiated cells, and stem cell patterns have been recognized even in cancer cell lines. Recent findings indicate that aberrant regulation of self renewal is central to cancer stem cell biology. Alterations in genes involved in self-renewal pathways, such as Wnt, Notch, sonic hedgehog, PTEN and BMI, proved to play a role in breast cancer progression. Hence, targeting key elements mediating the self renewal of BCIC represents an attractive option, with a solid rationale, clearly identifiable molecular targets, and adequate knowledge of the involved pathways. Possible concerns are related to the poor knowledge of tolerance and efficacy of inhibiting self-renewal mechanisms, because the latter are key pathways for a variety of biological functions and it is unknown whether their interference would kill BCIC or simply temporarily stop them. Thus, efforts to develop BCIC-targeted therapies should not only be focused on interfering on self-renewal, but could seek to identify additional molecular targets, like those involved in regulating EMT-related pathways, in reversing the MDR phenotype, in inducing differentiation and controlling cell survival pathways. |
| Posted: 16 Mar 2011 12:00 AM PDT This work describes the use of an array of potentiometric sensors and an artificial neural network response model to determine perchlorate and sulfide ions in polluted waters, by what is known as an electronic tongue. Sensors used have been all-solid-state PVC membrane selective electrodes, where their ionophores were different metal-phtalocyanine complexes with specific and anion generic responses. The study case illustrates the potential use of electronic tongues in the quantification of mixtures when interfering effects need to be counterbalanced: relative errors in determination of individual ions can be decreased typically from 25% to less than 5%, if compared to the use of a single proposed ion-selective electrode. |
| Posted: 16 Mar 2011 12:00 AM PDT Tobacco smoking during pregnancy remains common, especially in indigenous communities, and likely contributes to respiratory illness in exposed offspring. It is now well established that components of tobacco smoke, notably nicotine, can affect multiple organs in the fetus and newborn, potentially with life-long consequences. Recent studies have shown that nicotine can permanently affect the developing lung such that its final structure and function are adversely affected; these changes can increase the risk of respiratory illness and accelerate the decline in lung function with age. In this review we discuss the impact of maternal smoking on the lungs and consider the evidence that smoking can have life-long, programming consequences for exposed offspring. Exposure to maternal tobacco smoking and nicotine intake during pregnancy and lactation changes the genetic program that controls the development and aging of the lungs of the offspring. Changes in the conducting airways and alveoli reduce lung function in exposed offspring, rendering the lungs more susceptible to obstructive lung disease and accelerating lung aging. Although it is generally accepted that prevention of maternal smoking during pregnancy and lactation is essential, current knowledge of the effects of nicotine on lung development does not support the use of nicotine replacement therapy in this group. |
| Posted: 16 Mar 2011 12:00 AM PDT Oxidative stress is implicated in the pathogenesis and/or complications of hypertension and/or diabetes mellitus. A combination of these disorders increases the risk of developing cardiovascular events. This study investigated the effects of streptozotocin (60 mg/kg; ip)-induced diabetes on blood pressure, oxidative stress and effects of honey on these parameters in the kidneys of streptozotocin-induced diabetic Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Diabetic WKY and SHR were randomized into four groups and received distilled water (0.5 mL) and honey (1.0 g/kg) orally once daily for three weeks. Control SHR had reduced malondialdehyde (MDA) and increased systolic blood pressure (SBP), catalase (CAT) activity, and total antioxidant status (TAS). SBP, activities of glutathione peroxidase (GPx) and glutathione reductase (GR) were elevated while TAS was reduced in diabetic WKY. In contrast, SBP, TAS, activities of GPx and GR were reduced in diabetic SHR. Antioxidant (honey) treatment further reduced SBP in diabetic SHR but not in diabetic WKY. It also increased TAS, GSH, reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, activities of GPx and GR in diabetic SHR. These data suggest that differences in types, severity, and complications of diseases as well as strains may influence responses to blood pressure and oxidative stress. |
| POLICE: Lehigh University student lied about armed robbery, lost money gambling Posted: 16 Mar 2011 02:11 AM PDT A Lehigh University graduate student who told Bethlehem police he was robbed at knifepoint Saturday and had $4,000 stolen has been charged with filing a false report after admitting he lost the money while gambling at the Sands casino, police said Tuesday. |
| Posted: 16 Mar 2011 02:22 AM PDT  A Better Finder Attributes 5 is the ultimate file tweaking tool for Mac OS X. A Better Finder Attributes 5 combines photo shooting date and file date changing along with a few unique tricks of its own. Change JPEG EXIF Timestamps at Will A Better Finder Attributes 5 allows you to manipulate JPEG EXIF timestamps at will by setting them to specific times or batch adjusting them by adding and removing time (useful for correcting the timestamps of images taken with a digital camera with a incorrectly set clock and to compensate for timezone changes). Correct Finder Sorting for JPEG EXIF and RAW Photo A Better Finder Attributes 5 also allows to synchronize the file creation and modification dates with the shooting dates of JPEG EXIF as well as a wide variety of RAW formats, so that files sort properly in the Finder and other systems. Total File and Folder Creation and Modification Date Control A Better Finder Attributes 5 gives you total control over file creation and modification dates, setting them to specific times and dates, adding or removing time or simply removing them altogether. More File Magic On top of these features, A Better Finder Attributes 5 gives you control over:
A Better Finder Attributes 5 features an elegant and intuitive interface with many advanced features. Simply drag & drop the files you want to change into the file list, select an action from the popup menu and modify the settings to your liking, then click on "Perform Changes". Automate with Droplets A Better Finder Attributes 5 allows you to save frequently used settings to separate "droplet" applications. Drag & drop files onto the droplet application to apply the changes stored in it. Double click the droplet to edit the stored settings. Other Noteworthy Features
Version 5.03:
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| Posted: 16 Mar 2011 12:00 AM PDT Similar to genetic alterations, epigenetic aberrations contribute significantly to tumor initiation and progression. In many cases, these changes are caused by activation or inactivation of the regulators that maintain epigenetic states. Here we review our current knowledge on the KDM5/JARID1 family of histone demethylases. This family of enzymes contains a JmjC domain and is capable of removing tri- and di- methyl marks from lysine 4 on histone H3. Among these proteins, RBP2 mediates drug resistance while JARID1B is required for melanoma maintenance. Preclinical studies suggest inhibition of these enzymes can suppress tumorigenesis and provide strong rationale for development of their inhibitors for use in cancer therapy. |
| Posted: 16 Mar 2011 12:00 AM PDT Colon cancer is one of the most common malignant diseases and a major cause of mortality in the Western world. Metastasis to lymph nodes and other gastrointestinal organs, especially to the liver and lungs, is most common and occurs in up to 25% of cancer patients when initially diagnosed. The majority of colon cancers develop from noncancerous adenomatous polyps on the lining of the colon which grow over the years to become cancerous. If detected early, the surgical resections of the growth, often in combination with chemotherapy, significantly increases life expectancy. We have shown that the enzyme N-myristoyltransferase (NMT) which carries out lipid modification of several proteins (including many of those involved in oncogenesis) is expressed at higher levels in cancerous tissues from the colon. We have also shown that in peripheral blood mononuclear cells (PBMC) and bone marrow (BM) cells collected from colon cancer patients and from azoxymethane-induced rats the expression and localization of NMT is altered. We have observed strong positivity for NMT in immunohistochemical analysis for PBMC from colon cancer patients as compared to control groups. Furthermore, in the bone marrow (BM) mononuclear cells, NMT was found to be confined to the nuclei whereas in control groups it was observed to be located in the cytoplasm. In conclusion, this strikingly differential localization offers the basis of a potential investigational tool for screening or diagnosis of individuals at risk for or suspected of having colon cancer. |
| Posted: 16 Mar 2011 12:00 AM PDT The potent mitogenic toxin from Pasteurella multocida (PMT) is the major virulence factor associated with a number of epizootic and zoonotic diseases caused by infection with this respiratory pathogen. PMT is a glutamine-specific protein deamidase that acts on its intracellular G-protein targets to increase intracellular calcium, cytoskeletal, and mitogenic signaling. PMT enters cells through receptor-mediated endocytosis and then translocates into the cytosol through a pH-dependent process that is inhibited by NH4Cl or bafilomycin A1. However, the detailed mechanisms that govern cellular entry, trafficking, and translocation of PMT remain unclear. Co-localization studies described herein revealed that while PMT shares an initial entry pathway with transferrin (Tfn) and cholera toxin (CT), the trafficking pathways of Tfn, CT, and PMT subsequently diverge, as Tfn is trafficked to recycling endosomes, CT is trafficked retrograde to the ER, and PMT is trafficked to late endosomes. Our studies implicate the small regulatory GTPase Arf6 in the endocytic trafficking of PMT. Translocation of PMT from the endocytic vesicle occurs through a pH-dependent process that is also dependent on both microtubule and actin dynamics, as evidenced by inhibition of PMT activity in our SRE-based reporter assay, with nocodazole and cytochalasin D, respectively, suggesting that membrane translocation and cytotoxicity of PMT is dependent on its transfer to late endosomal compartments. In contrast, disruption of Golgi-ER trafficking with brefeldin A increased PMT activity, suggesting that inhibiting PMT trafficking to non-productive compartments that do not lead to translocation, while promoting formation of an acidic tubulovesicle system more conducive to translocation, enhances PMT translocation and activity. |
| Game Magnet towers : 16/03/2011 Posted: 02 Dec 2010 10:08 PM PST  |
| Posted: 02 Dec 2010 10:02 PM PST  |
| Game Ultimate goal : 16/03/2011 Posted: 02 Dec 2010 09:02 PM PST  |
| Game Gorillaz grooves : 16/03/2011 Posted: 02 Dec 2010 10:05 PM PST  |
| Game Henri 8 - dressed to kill : 16/03/2011 Posted: 02 Dec 2010 10:09 PM PST  |
| Posted: 02 Dec 2010 09:08 PM PST  |
| Posted: 02 Dec 2010 11:09 PM PST  |
| Game Madness punishment : 16/03/2011 Posted: 02 Dec 2010 10:03 PM PST  |
| Posted: 02 Dec 2010 11:08 PM PST  |
| Posted: 02 Dec 2010 11:02 PM PST  |
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