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Economist: Nevada can gain millions in revenue with online poker
Cancers, Vol. 3, Pages 1566-1579: Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences
Cancers, Vol. 3, Pages 1550-1565: Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer
Sensors, Vol. 11, Pages 3418-3438: A QoS-Guaranteed Coverage Precedence Routing Algorithm for Wireless Sensor Networks
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Economist: Nevada can gain millions in revenue with online poker

Posted: 25 Mar 2011 02:24 AM PDT

An economist says ailing Nevada stands to gain millions in tax revenue if it regulates and develops the multibillion-dollar online poker industry, but detractors - including some of the most powerful Las Vegas casinos - called the bill on the table premature and said it could chew away at brick-and-mortar businesses.

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Cancers, Vol. 3, Pages 1566-1579: Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences

Posted: 25 Mar 2011 12:00 AM PDT

The concept of cancer stem cells has revolutionized our current vision of cancer development and was validated in solid tumors and cancers of the primitive hematopoietic compartment. Proof of the principle is still lacking, however, in malignancies of differentiated B-cells. We review here the current literature, which nevertheless suggests hierarchical organizations of the tumor clone for mostly incurable B-cell cancers such as multiple myeloma, lymphomas and B-chronic lymphocytic leukemia. We propose two models accounting for cancer stem cells in these contexts: a "top-to-bottom" clonal hierarchy from memory B-cells and a "bottom-to-top" model of clonal reprogramming. Selection pressure on the growing tumor can drive such reprogramming and increase its genetic diversity.

Cancers, Vol. 3, Pages 1550-1565: Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer

Posted: 25 Mar 2011 12:00 AM PDT

Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, overexpression of the insulin receptor in non-small cell lung cancer (NSCLC) is associated with an increased risk of metastasis and decreased survival. The uptake of glucose into cells is carried out via glucose transporters or GLUTs. Of these, GLUT-4 is essential for insulin-stimulated glucose uptake. Following treatment with the epigenetic targeting agents histone deacetylase inhibitors (HDACi), GLUT-3 and GLUT-4 expression were found to be induced in NSCLC cell lines, with minimal responses in transformed normal human bronchial epithelial cells (HBECs). Similar results for GLUT-4 were observed in cells derived from liver, muscle, kidney and pre-adipocytes. Bioinformatic analysis of the promoter for GLUT-4 indicates that it may also be regulated by several chromatin binding factors or complexes including CTCF, SP1 and SMYD3. Chromatin immunoprecipitation studies demonstrate that the promoter for GLUT-4 is dynamically remodeled in response to HDACi. Overall, these results may have value within the clinical setting as (a) it may be possible to use this to enhance fluorodeoxyglucose (18F) positron emission tomography (FDG-PET) imaging sensitivity; (b) it may be possible to target NSCLC through the use of HDACi and insulin mediated uptake of the metabolic targeting drugs such as 2-deoxyglucose (2-DG); or (c) enhance or sensitize NSCLC to chemotherapy.

Sensors, Vol. 11, Pages 3418-3438: A QoS-Guaranteed Coverage Precedence Routing Algorithm for Wireless Sensor Networks

Posted: 24 Mar 2011 12:00 AM PDT

For mission-critical applications of wireless sensor networks (WSNs) involving extensive battlefield surveillance, medical healthcare, etc., it is crucial to have low-power, new protocols, methodologies and structures for transferring data and information in a network with full sensing coverage capability for an extended working period. The upmost mission is to ensure that the network is fully functional providing reliable transmission of the sensed data without the risk of data loss. WSNs have been applied to various types of mission-critical applications. Coverage preservation is one of the most essential functions to guarantee quality of service (QoS) in WSNs. However, a tradeoff exists between sensing coverage and network lifetime due to the limited energy supplies of sensor nodes. In this study, we propose a routing protocol to accommodate both energy-balance and coverage-preservation for sensor nodes in WSNs. The energy consumption for radio transmissions and the residual energy over the network are taken into account when the proposed protocol determines an energy-efficient route for a packet. The simulation results demonstrate that the proposed protocol is able to increase the duration of the on-duty network and provide up to 98.3% and 85.7% of extra service time with 100% sensing coverage ratio comparing with LEACH and the LEACH-Coverage-U protocols, respectively.

Game Salems story : 25/03/2011

Posted: 02 Dec 2010 11:01 PM PST