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Molecules, Vol. 16, Pages 2802-2816: Effects of Panax ginseng on Tumor Necrosis Factor-α-Mediated Inflammation: A Mini-Review
Molecules, Vol. 16, Pages 2796-2801: Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila
Warstory - Europe in Flames - PC - Screenshots
Resident Evil: The Mercenaries 3D - 3DS - Screenshots
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Molecules, Vol. 16, Pages 2802-2816: Effects of Panax ginseng on Tumor Necrosis Factor-α-Mediated Inflammation: A Mini-Review

Posted: 30 Mar 2011 12:00 AM PDT

Panax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides. In this review, we summarize recent publications on the anti-inflammatory effects of ginseng extracts and ginsenosides on cellular responses triggered by different inducers including endotoxin, tumor necrosis factor-alpha (TNF-α), interferon-gamma and other stimuli. Proinflammatory cytokines, chemokines, adhesion molecules and mediators of inflammation including inducible nitric oxide synthase, cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response. Ginseng extracts and ginsenosides including Rb1, Rd, Rg1, Rg3, Rh1, Rh2, Rh3 and Rp1 have been reported to have anti-inflammatory properties in different studies related to inflammation. Ginsenosides inhibit different inducers-activated signaling protein kinases and transcription factor nuclear factor-kappaB leading to decreases in the production of cytokines and mediators of inflammation. The therapeutic potential of ginseng on TNF-α-mediated inflammatory diseases is also discussed. Taken together, this summary provides evidences for the anti-inflammatory effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their effects on inflammatory diseases.

Molecules, Vol. 16, Pages 2796-2801: Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila

Posted: 30 Mar 2011 12:00 AM PDT

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3–4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1–4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.

Warstory - Europe in Flames - PC - Screenshots

Posted: 30 Mar 2011 03:10 AM PDT

Features:
- Experience large scale cooperative and competitive gameplay in a fully persistent world and liberate Europe with thousands of players
- Choose your faction: Western Allies (US or UK forces) or Soviet Union
- Play dynamic real time battles on 50 unique battlefields and use powerful special abilities
- Create your own commander and collect achievements throughout many wars (seasons)
- Conquer cities occupied by the Wehrmacht in large scale operations and earn valuable medals and insignias
- Manage and improve your company out of over 50 different units and officers with thousands of equipment items
- Many social features, such as Clans, interactive friend lists and daily login bonuses

Resident Evil: The Mercenaries 3D - 3DS - Screenshots

Posted: 30 Mar 2011 03:09 AM PDT

While the gameplay will be familiar to those who have previously played Mercenaries, changes have been implemented to the stages and characters have been transformed to full 3D, the addition of the ability to move and shoot adds new gameplay tactics, and the addition of touch screen functionality improves access to the inventory and game map.
Features:
- Fan favorite Resident Evil Mercenaries mode, in 3D and on a handheld for the first time
- Fast-paced, combat-heavy Resident Evil action
- 2 player co-op gameplay with Ad Hoc and Nintendo Wi-Fi Connection
- Reworked missions from the original with new placement of enemies and objects
- Choose from legendary past and present Resident Evil characters, including for the first time in Mercenaries, Claire Redfield

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Posted: 02 Jan 2011 04:08 PM PST