Games |
- Deadbeat Gamblers Stiff Casinos
- LaFayette Senior Center happenings
- Sustainability, Vol. 3, Pages 531-540: Environmental Laws and Sustainability: An Introduction
- Molecules, Vol. 16, Pages 2726-2742: Essential Oils and Their Constituents: Anticonvulsant Activity
- Molecules, Vol. 16, Pages 2714-2725: Oxidative Decarboxylation of Levulinic Acid by Silver(I)/Persulfate
- Molecules, Vol. 16, Pages 2688-2713: Glycosides, Depression and Suicidal Behaviour: The Role of Glycoside-Linked Proteins
- Molecules, Vol. 16, Pages 2672-2687: Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences
- Molecules, Vol. 16, Pages 2658-2671: Investigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters—An In Vitro Model for Prodrug Activation
- Game Driving simulator : 23/03/2011
- Game Railway : 23/03/2011
- Game Rumble ball - field number 1 : 23/03/2011
- Game Locations movie : 23/03/2011
- Game Chitose line simulator : 23/03/2011
- Game Travel pursuit : 23/03/2011
- Game Fx2 : 23/03/2011
- Game Act on co2 : 23/03/2011
- Game A nice walk : 23/03/2011
- Game Rumble ball - field number 2 : 23/03/2011
- Game Hello my friends mario : 23/03/2011
- Game Fx simulation : 23/03/2011
| Deadbeat Gamblers Stiff Casinos Posted: 23 Mar 2011 02:34 AM PDT Two years ago, gambler Jerome Powers lost $1.2 million playing blackjack at Mohegan Sun, a Connecticut casino owned by the Pequot Indians. |
| LaFayette Senior Center happenings Posted: 23 Mar 2011 02:34 AM PDT The King was George York and the reigning Queen was Shelly Reynolds. slideshow Ken Menefee, our oldest member, turned 91 Feb. This posting includes an audio/video/photo media file: Download Now |
| Sustainability, Vol. 3, Pages 531-540: Environmental Laws and Sustainability: An Introduction Posted: 23 Mar 2011 12:00 AM PDT In this introduction to the special issue of Sustainability on environmental laws and sustainability, we attempt to synthesize key lessons from the issue's ten substantive articles. These lessons involve the use of law to achieve integrated decision-making, the use of pre-existing laws to foster sustainability, the centrality of sub-national governments in achieving sustainability, the background law of unsustainable development, the growing importance of climate change, the need to use law to protect and restore ecological integrity, the importance of judicial review and nongovernmental organizations, the need to translate sustainability into specific legal principles, the challenge of creating an appropriate national legal structure for sustainability, the importance of sustainability assessment tools and institutions before and after laws are adopted, and the importance of "soft" law. |
| Molecules, Vol. 16, Pages 2726-2742: Essential Oils and Their Constituents: Anticonvulsant Activity Posted: 23 Mar 2011 12:00 AM PDT A literature-based survey of plants species and their essential oils with anticonvulsant activity was carried out. As results, 30 species belonging to 13 families and 23 genera were identified for their activities in the experimental models used for anticonvulsant drug screening. Thirty chemical constituents of essential oils with anticonvulsant properties were described. Information on these 30 species is presented together with isolated bioactive compound studies. |
| Posted: 23 Mar 2011 12:00 AM PDT The oxidative decarboxylation of levulinic acid (LA) by silver(I)/persulfate [Ag(I)/S2O82−] has been investigated in this paper. The effects of buffer solution, initial pH value, time and temperature and dosages of Ag(I)/S2O82− on the decarboxylation of LA were examined in batch experiments and a reaction scheme was proposed on basis of the reaction process. The experimental results showed that a solution of NaOH-KH2PO4 was comparatively suitable for the LA decarboxylation reaction by silver(I)/persulfate. Under optimum conditions (temperature 160 °C, pH 5.0, and time 0.5 h), the rate of LA conversion in NaOH-KH2PO4 solutions with an initial concentration of 0.01 mol LA reached 70.2%, 2-butanone (methyl ethyl ketone) was the single product in the gas phase and the resulted molar yield reached 44.2%. |
| Posted: 23 Mar 2011 12:00 AM PDT Nowadays depression and suicide are two of the most important worldwide public health problems. Although their specific molecular mechanisms are still largely unknown, glycosides can play a fundamental role in their pathogenesis. These molecules act presumably through the up-regulation of plasticity-related proteins: probably they can have a presynaptic facilitatory effect, through the activation of several intracellular signaling pathways that include molecules like protein kinase A, Rap-1, cAMP, cADPR and G proteins. These proteins take part in a myriad of brain functions such as cell survival and synaptic plasticity. In depressed suicide victims, it has been found that their activity is strongly decreased, primarily in hippocampus and prefrontal cortex. These studies suggest that glycosides can regulate neuroprotection through Rap-1 and other molecules, and may play a crucial role in the pathophysiology of depression and suicide. |
| Posted: 23 Mar 2011 12:00 AM PDT Objects, goals, and main methods as well as perspectives of chemical biology are discussed. This review is focused on the fundamental aspects of this emerging field of life sciences: chemical space, the small molecule library and chemical sensibilization (small molecule microassays). |
| Posted: 23 Mar 2011 12:00 AM PDT In this study the solvolysis of newly synthesized fluocinolone acetonide C-21 esters was analysed in comparison with fluocinonide during a 24-hour period of time. The solvolysis was performed in an ethanol-water (90:10 v/v) mixture using the excess of NaHCO3. The solvolytic mixtures of each investigated ester have been assayed by a RP-HPLC method using isocratic elution with methanol-water (75:25 v/v); flow rate 1 mL/min; detection at 238 nm; temperature 25 °C. Solvolytic rate constants were calculated from the obtained data. Geometry optimizations and charges calculations were carried out by Gaussian W03 software. A good correlation (R = 0.9924) was obtained between solvolytic rate constants and the polarity of the C-O2 bond of those esters. The established relation between solvolytic rate constant (K) and lipophilicity (cLogP) with experimental anti-inflammatory activity could be indicative for topical corticosteroid prodrug activation. |
| Game Driving simulator : 23/03/2011 Posted: 02 Dec 2010 10:00 PM PST  |
| Posted: 02 Dec 2010 10:02 PM PST  |
| Game Rumble ball - field number 1 : 23/03/2011 Posted: 02 Dec 2010 11:02 PM PST  |
| Game Locations movie : 23/03/2011 Posted: 02 Dec 2010 09:00 PM PST  |
| Game Chitose line simulator : 23/03/2011 Posted: 02 Dec 2010 10:03 PM PST  |
| Game Travel pursuit : 23/03/2011 Posted: 02 Dec 2010 11:08 PM PST  |
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| Posted: 02 Dec 2010 09:06 PM PST  |
| Posted: 02 Dec 2010 10:08 PM PST  |
| Game Rumble ball - field number 2 : 23/03/2011 Posted: 02 Dec 2010 11:00 PM PST  |
| Game Hello my friends mario : 23/03/2011 Posted: 02 Dec 2010 11:06 PM PST  |
| Game Fx simulation : 23/03/2011 Posted: 02 Dec 2010 09:08 PM PST  |
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