Games |
- NinJump Deluxe - iPhone - Screenshots
- Entropy, Vol. 13, Pages 778-789: Quantum Kolmogorov Complexity and Information-Disturbance Theorem
- Administrative Sciences, Vol. 1, Pages 3-13: Intra-Group Conflict and Teamwork Quality: The Moderating Role of Leadership Styles
- Monster Dash - iPhone - Screenshots
- Molecules, Vol. 16, Pages 2785-2795: Antifeedant Triterpenoids from the Seeds and Bark of Lansium domesticum cv Kokossan (Meliaceae)
- Information, Vol. 2, Pages 247-265: Designing Data Protection Safeguards Ethically
- Toxins, Vol. 3, Pages 356-368: Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells
- Cancers, Vol. 3, Pages 1691-1707: Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy
- Wilkie sets deadline for pokie plan
- Energies, Vol. 4, Pages 582-598: Evaluation of Lithium-Ion Battery Equivalent Circuit Models for State of Charge Estimation by an Experimental Approach
- Cancers, Vol. 3, Pages 1672-1690: Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression
- Cancers, Vol. 3, Pages 1639-1671: Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy
- Cancers, Vol. 3, Pages 1622-1638: Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
- Cancers, Vol. 3, Pages 1605-1621: The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells
- Cancers, Vol. 3, Pages 1593-1604: Role of Surgery in Stages II and III Pediatric Abdominal Non-Hodgkin Lymphoma: A 5-Years Experience
- Cancers, Vol. 3, Pages 1580-1592: Delineating an Epigenetic Continuum for Initiation, Transformation and Progression to Breast Cancer
- Game My little pony : 29/03/2011
- Game Oscar showcase : 29/03/2011
- Game Save the sea creatures : 29/03/2011
- Game Spongebob - pest of the west showdown : 29/03/2011
| NinJump Deluxe - iPhone - Screenshots Posted: 29 Mar 2011 03:02 AM PDT Features include: -Simple single-tap gameplay -Ninjas -Beautiful enhanced graphics -Witch Doctors -Awesome bonuses -Sea Monsters -Original sound and music -Ninja Pirates -Game Center leader boards -Ninja Pirate Parrots -Challenge a friend via email -Tropical Snakes -Post scores on Facebook or Twitter -Monkeys throwing bee-hives -Giant Beetles |
| Entropy, Vol. 13, Pages 778-789: Quantum Kolmogorov Complexity and Information-Disturbance Theorem Posted: 29 Mar 2011 12:00 AM PDT In this paper, a representation of the information-disturbance theorem based on the quantum Kolmogorov complexity that was defined by P. Vit´anyi has been examined. In the quantum information theory, the information-disturbance relationship, which treats the trade-off relationship between information gain and its caused disturbance, is a fundamental result that is related to Heisenberg's uncertainty principle. The problem was formulated in a cryptographic setting and the quantitative relationships between complexities have been derived. |
| Posted: 29 Mar 2011 12:00 AM PDT The study examines the extent to which task and relations oriented leadership moderate the impact of task and relationship conflict on teamwork quality. In a sample of 37 teams, the study shows that relationship oriented leadership is beneficial for dealing with relationship conflict, but it does not have the expected positive interaction effect with task conflict. The main practical implication of the results is that in order to mitigate the negative effects of intra-group conflict on teamwork quality the leadership style should fit the type of disagreement (task versus relational) predominantly experienced by the teams. |
| Monster Dash - iPhone - Screenshots Posted: 29 Mar 2011 02:28 AM PDT Instantly playable and simple to control, the action speeds up and changes gears with every new world. Best of all, there are weapon and health pickups to buff Steakfries into serious action mode! Blast your enemies with the one shot Pacifier, electro-charge your way to victory with Mr. Zappy, and look out for the ultimate in raining destruction -- the Machine Gun Jetpack! |
| Posted: 29 Mar 2011 12:00 AM PDT Two tetranortriterpenoids, kokosanolide A (1) and C (2) were isolated from the seeds and three onoceranoid-type triterpenoids: kokosanolide B (3), 8,14-secogammacera-7,14-diene-3,21-dione (4) and a 1.5:0.5 mixture of 8,14-secogammacera-7,14(27)-diene-3,21-dione (5) and compound 4 were isolated from the bark of kokossan (Lansium domesticum). Complete 1H- and 13C-NMR data of the triterpenoids 1-5 are reported. The triterpenoids' structures were elucidated primarily by means of high field 1D- and 2D-NMR, IR and HRMS spectral data. Triterpenoids 1-5 exhibited moderate to strong antifeedant activity against the fourth instar larvae of Epilachna vigintioctopunctata. |
| Information, Vol. 2, Pages 247-265: Designing Data Protection Safeguards Ethically Posted: 29 Mar 2011 12:00 AM PDT Since the mid 1990s, lawmakers and scholars have worked on the idea of embedding data protection safeguards in information and communication technology (ICT) with the aim to access and control personal data in compliance with current regulatory frameworks. This effort has been strengthened by the capacities of computers to draw upon the tools of artificial intelligence (AI) and operations research. However, work on AI and the law entails crucial ethical issues concerning both values and modalities of design. On one hand, design choices might result in conflicts of values and, vice versa, values may affect design features. On the other hand, the modalities of design cannot only limit the impact of harm-generating behavior but also prevent such behavior from occurring via self-enforcement technologies. In order to address some of the most relevant issues of data protection today, the paper suggests we adopt a stricter, yet more effective version of "privacy by design." The goal should be to reinforce people's pre-existing autonomy, rather than having to build it from scratch. |
| Posted: 29 Mar 2011 12:00 AM PDT Cycle inhibiting factors (Cifs) are type III secreted effectors produced by diverse pathogenic bacteria. Cifs are "cyclomodulins" that inhibit the eukaryotic host cell cycle and also hijack other key cellular processes such as those controlling the actin network and apoptosis. This review summarizes current knowledge on Cif since its first characterization in enteropathogenic Escherichia coli, the identification of several xenologues in distant pathogenic bacteria, to its structure elucidation and the recent deciphering of its mode of action. Cif impairs the host ubiquitin proteasome system through deamidation of ubiquitin or the ubiquitin-like protein NEDD8 that regulates Cullin-Ring-ubiquitin Ligase (CRL) complexes. The hijacking of the ubiquitin-dependent degradation pathway of host cells results in the modulation of various cellular functions such as epithelium renewal, apoptosis and immune response. Cif is therefore a powerful weapon in the continuous arm race that characterizes host-bacteria interactions. |
| Posted: 29 Mar 2011 12:00 AM PDT Estrogen receptor (ERa) signaling plays a key role in hormonal cancer progression. ERa is a ligand-dependent transcription factor that modulates gene transcription via recruitment to the target gene chromatin. Emerging evidence suggests that ERa signaling has the potential to contribute to epigenetic changes. Estrogen stimulation is shown to induce several histone modifications at the ERα target gene promoters including acetylation, phosphorylation and methylation via dynamic interactions with histone modifying enzymes. Deregulation of enzymes involved in the ERa-mediated epigenetic pathway could play a vital role in ERa driven neoplastic processes. Unlike genetic alterations, epigenetic changes are reversible, and hence offer novel therapeutic opportunities to reverse ERa driven epigenetic changes. In this review, we summarize current knowledge on mechanisms by which ERa signaling potentiates epigenetic changes in cancer cells via histone modifications. |
| Wilkie sets deadline for pokie plan Posted: 29 Mar 2011 01:30 AM PDT Key independent Andrew Wilkie has given Prime Minister Julia Gillard until budget day in May 2012 to put gambling limits on pokies or he'll withdraw his support for the government. |
| Posted: 29 Mar 2011 12:00 AM PDT To improve the use of lithium-ion batteries in electric vehicle (EV) applications, evaluations and comparisons of different equivalent circuit models are presented in this paper. Based on an analysis of the traditional lithium-ion battery equivalent circuit models such as the Rint, RC, Thevenin and PNGV models, an improved Thevenin model, named dual polarization (DP) model, is put forward by adding an extra RC to simulate the electrochemical polarization and concentration polarization separately. The model parameters are identified with a genetic algorithm, which is used to find the optimal time constant of the model, and the experimental data from a Hybrid Pulse Power Characterization (HPPC) test on a LiMn2O4 battery module. Evaluations on the five models are carried out from the point of view of the dynamic performance and the state of charge (SoC) estimation. The dynamic performances of the five models are obtained by conducting the Dynamic Stress Test (DST) and the accuracy of SoC estimation with the Robust Extended Kalman Filter (REKF) approach is determined by performing a Federal Urban Driving Schedules (FUDS) experiment. By comparison, the DP model has the best dynamic performance and provides the most accurate SoC estimation. Finally, sensitivity of the different SoC initial values is investigated based on the accuracy of SoC estimation with the REKF approach based on the DP model. It is clear that the errors resulting from the SoC initial value are significantly reduced and the true SoC is convergent within an acceptable error. |
| Posted: 29 Mar 2011 12:00 AM PDT Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response. |
| Cancers, Vol. 3, Pages 1639-1671: Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy Posted: 29 Mar 2011 12:00 AM PDT Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major resistance factor and critical anti-apoptotic regulator that inhibits tumor necrosis factor-alpha (TNF-alpha), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis as well as chemotherapy-triggered apoptosis in malignant cells. c-FLIP is expressed as long (c-FLIPL), short (c-FLIPS), and c-FLIPR splice variants in human cells. c-FLIP binds to FADD and/or caspase-8 or -10 in a ligand-dependent and-independent fashion, which in turn prevents death-inducing signaling complex (DISC) formation and subsequent activation of the caspase cascade. Moreover, c-FLIPL and c-FLIPS are known to have multifunctional roles in various signaling pathways, as well as activating and/or upregulating several cytoprotective signaling molecules. Upregulation of c-FLIP has been found in various tumor types, and its downregulation has been shown to restore apoptosis triggered by cytokines and various chemotherapeutic agents. Hence, c-FLIP is an important target for cancer therapy. For example, small interfering RNAs (siRNAs) that specifically knockdown the expression of c-FLIPL in diverse human cancer cell lines augmented TRAIL-induced DISC recruitment and increased the efficacy of chemotherapeutic agents, thereby enhancing effector caspase stimulation and apoptosis. Moreover, small molecules causing degradation of c-FLIP as well as decreasing mRNA and protein levels of c-FLIPL and c-FLIPS splice variants have been found, and efforts are underway to develop other c-FLIP-targeted cancer therapies. This review focuses on (1) the functional role of c-FLIP splice variants in preventing apoptosis and inducing cytokine and drug resistance; (2) the molecular mechanisms that regulate c-FLIP expression; and (3) strategies to inhibit c-FLIP expression and function. |
| Posted: 29 Mar 2011 12:00 AM PDT It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β. |
| Posted: 29 Mar 2011 12:00 AM PDT The Nrf2 anti-oxidant response element (ARE) pathway plays an important role in regulating cellular anti-oxidants. Under normal cellular conditions Nrf2 can be described as an anti-tumor molecule due to its induction of cytoprotective genes which protect cells from electrophile and oxidative damage. However in cancerous cells, Nrf2 takes on a pro-tumoral identity as the same cytoprotective genes can enhance resistance of those cancer cells to chemotherapeutic drugs. Such Nrf2-regulated cytoprotective genes include heme oxygenase-1 (HO-1), which has been shown to protect human leukemia cells from apoptotic signals. Moreover, a relationship between Nrf2 and the nuclear factor-κB (NF-κB) signaling pathway has been recently identified, and is now recognized as an important cross-talk mechanism by which Nrf2 can overcome apoptosis and provide cells with reduced sensitivity towards chemotherapeutic agents. In recent years a number of important research papers have highlighted the role of Nrf2 in providing protection against both current and new chemotherapeutic drugs in blood cancer. This review will provide a synopsis of these research papers with an aim to carefully consider if targeting Nrf2 in combination with current or new chemotherapeutics is a viable strategy in the more effective treatment of blood cancers. |
| Posted: 29 Mar 2011 12:00 AM PDT Abdominal Non-Hodgkin lymphomas (NHL) are the most common extra nodal presentation of pediatric NHL. Our aim is to assess the role of surgery as a risk factor and to evaluate the impact of risk-adjusted systemic chemotherapy on survival of patients with stages II and III disease. This study included 35 pediatric patients with abdominal NHL treated over five years at South Egypt Cancer Institute (SECI), Assiut University, between January 2005 and January 2010. The data of every patient included: Age, sex, and presentation, staging work up to determine extent of the disease and the type of resection performed, histopathological examination, details of chemotherapy, disease free survival and overall survival. The study included 25 boys and 10 girls with a median age of six years (range: 2.5:15). Thirty patients (86%) presented with abdominal pain, 23 patients (66%) presented with abdominal mass and distention, 13 patients (34%) presented with weight loss, and intestinal obstruction occurred in six patients (17%). The ileo-cecal region and abdominal lymph nodes were the commonest sites (48.5%, 21% respectively). Burkitt's lymphoma was the most common histological type in 29 patients (83%). Ten (28.5%) stage II (group A) and 25 (71.5%) stage III (group B). Complete resections were performed in 10 (28.5%), debulking in 6 (17%) and imaging guided biopsy in 19 (54%). A11 patients received systemic chemotherapy. The median follow up duration was 63 months (range 51-78 months). The parameters that significantly affect the overall survival were stage at presentation complete resection for localized disease. In conclusion, the extent of disease at presentation is the most important prognostic factor in pediatric abdominal NHL. Surgery is restricted to defined situations such as; abdominal emergencies, diagnostic biopsy and total tumor extirpation in localized disease. Chemotherapy is the cornerstone in the management of pediatric abdominal NHL. |
| Posted: 29 Mar 2011 12:00 AM PDT Aberrant methylation of promoter CpG islands is a hallmark of human cancers and is an early event in carcinogenesis. We examined whether promoter hypermethylation contributes to the pathogenesis of benign breast lesions along a progression continuum to invasive breast cancer. The exploratory study cohort comprised 17 breast cancer patients with multiple benign and/or in situ lesions concurrently present with invasive carcinoma within a tumor biopsy. DNA from tumor tissue, normal breast epithelium when present, benign lesions (fibroadenoma, hyperplasia, papilloma, sclerosing adenosis, apocrine metaplasia, atypical lobular hyperplasia or atypical ductal hyperplasia), and in situ lesions of lobular carcinoma and ductal carcinoma were interrogated for promoter methylation status in 22 tumor suppressor genes using the multiplex ligation-dependent probe amplification assay (MS-MLPA). Methylation specific PCR was performed to confirm hypermethylation detected by MS-MLPA. Promoter methylation was detected in 11/22 tumor suppressor genes in 16/17 cases. Hypermethylation of RASSF1 was most frequent, present in 14/17 cases, followed by APC in 12/17, and GSTP1 in 9/17 cases with establishment of an epigenetic monocloncal progression continuum to invasive breast cancer. Hypermethylated promoter regions in normal breast epithelium, benign, and premalignant lesions within the same tumor biopsy implicate RASSF1, APC, GSTP1, TIMP3, CDKN2B, CDKN2A, ESR1, CDH13, RARB, CASP8, and TP73 as early events. DNA hypermethylation underlies the pathogenesis of step-wise transformation along a monoclonal continuum from normal to preneoplasia to invasive breast cancer. |
| Game My little pony : 29/03/2011 Posted: 02 Dec 2010 10:00 PM PST  |
| Game Oscar showcase : 29/03/2011 Posted: 02 Dec 2010 11:08 PM PST  |
| Game Save the sea creatures : 29/03/2011 Posted: 02 Dec 2010 09:00 PM PST  |
| Game Spongebob - pest of the west showdown : 29/03/2011 Posted: 02 Dec 2010 09:05 PM PST  |
| You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий