четверг, 12 января 2012 г.

Games

Games

The Future of Tablet Gaming

Posted: 12 Jan 2012 01:00 AM PST

We scour the halls of CES 2012 to catch a glimpse of what's next in tablet and touchscreen gaming.

 

Read and Post Comments | Get the full article at GameSpot

"The Future of Tablet Gaming" was posted by Tyler on Thu, 12 Jan 2012 01:00:48 -0800

The Future of 3D - CES 2012

Posted: 12 Jan 2012 12:18 AM PST

Maxwell sifts through all the tech booths at CES 2012 to find out if 3D video is here to stay.

 

Read and Post Comments | Get the full article at GameSpot

"The Future of 3D - CES 2012" was posted by franka on Thu, 12 Jan 2012 00:18:26 -0800

Nyko Booth Tour at CES 2012

Posted: 11 Jan 2012 10:44 PM PST

Chris Arbogast shows us the VITA power kit pack, Kindle Fire power case and speaker stand, Yo Gabba Gabba Muno clock, and Brobee backpack.

 

Read and Post Comments | Get the full article at GameSpot

"Nyko Booth Tour at CES 2012" was posted by sampsona on Wed, 11 Jan 2012 22:44:00 -0800

Zombie Pinball

Posted: 12 Jan 2012 03:12 AM PST

Ping ghosts, kill zombies and fight bosses all with a pinball in a graveyard. Fun but challenging, can you kill the zombies before you fall? Origina..

The HotSpot - Mind the Generation Gap - 1/11/12

Posted: 11 Jan 2012 06:12 PM PST

Speculation about the next generation of consoles is heating up, but what do gamers actually want from it? And will Sony and Microsoft even show up for the fight?

 

Read and Post Comments | Get the full article at GameSpot

"The HotSpot - Mind the Generation Gap - 1/11/12" was posted by Brendan on Wed, 11 Jan 2012 18:12:10 -0800

Hands-On with the Razer Blade Gaming Laptop

Posted: 11 Jan 2012 05:35 PM PST

We check out the ambitious new gaming laptop from Razer, complete with touchscreen switchblade UI.

 

Read and Post Comments | Get the full article at GameSpot

"Hands-On with the Razer Blade Gaming Laptop" was posted by Tyler on Wed, 11 Jan 2012 17:35:25 -0800

Energies, Vol. 5, Pages 71-91: Is the Electric Vehicle an Attractive Option for Customers?

Posted: 12 Jan 2012 12:00 AM PST

As a new technology, electric mobility has the potential to achieve a reduction in CO2 emissions and contribute to the transition from the current transportation system to a better one, environmentally speaking. The objective of the paper is to aid the necessary decision-making for the adoption and development of electric vehicles in Spain, taking the time horizon of 2020. This will be achieved by building a System Dynamics model for various scenarios that will be used for the analysis and comparison of various dynamic variables, as well as to determine how, and to what extent, they will influence the number of electric vehicles that will run on Spanish roads in the coming years, focusing on the cost variable.

Administrative Sciences, Vol. 2, Pages 1-25: Race to the Future: Innovations in Gifted and Enrichment Education in Asia, and Implications for the United States

Posted: 12 Jan 2012 12:00 AM PST

How are Asian countries preparing children to have skills—including creativity, innovation, and technical capability—to compete in the 21st Century global economy? Countries including China, Korea, Japan and Singapore have begun to integrate education policy and practice into a key component if national innovation strategies: human capital development. Asian countries are developing an emphasis on innovation and creativity at all levels of education, while the United States continues (via No Child Left Behind testing and budget cut-backs) to move away from that model. Developments in China (including Hong Kong and Taiwan), Korea and Singapore are complemented with comparisons to trends in national policy and private sector practice in Japan and the United States. Preliminary findings indicate that while progress has been made towards establishing education practices that enrich student learning, helping children to reach their highest potential in some countries, cultural practices and budgetary constraints have limited reform in others. The paper concludes with a summary of comparative best practices in enrichment education policy and practice and implications for globally competitive national innovation systems.

Marine Drugs, Vol. 10, Pages 106-115: A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample

Posted: 12 Jan 2012 12:00 AM PST

A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.

Agriculture, Vol. 2, Pages 1-11: Levels of Sulfur as an Essential Nutrient Element in the Soil-Crop-Food System in Austria

Posted: 12 Jan 2012 12:00 AM PST

Total sulfur data of various agricultural and food items from the lab of the author, have been compiled to develop an understanding of sulfur levels and ecological cycling in Austria. As sulfur level is not an included factor among the quality criteria of soil and fertilizer composition, the database is rather small. Problems in analytical determinations of total sulfur, in particular digestions, are outlined. As a protein component, sulfur is enriched in matrices of animal origin, in particular in egg white. There is substantial excretion from animals and man via urine. Organic fertilizers (manures, composts) might contribute significantly to the sulfur budget of soils, which is important for organic farming of crops with high sulfur needs. For soils, drainage is a main route of loss of soluble sulfate, thus pot experiments may yield unrealistic sulfur budgets.

IJMS, Vol. 13, Pages 758-773: Mechanisms of Action of (Meth)acrylates in Hemolytic Activity, in Vivo Toxicity and Dipalmitoylphosphatidylcholine (DPPC) Liposomes Determined Using NMR Spectroscopy

Posted: 12 Jan 2012 12:00 AM PST

We investigated the quantitative structure-activity relationships between hemolytic activity (log 1/H50) or in vivo mouse intraperitoneal (ip) LD50 using reported data for α,β-unsaturated carbonyl compounds such as (meth)acrylate monomers and their 13C-NMR β-carbon chemical shift (δ). The log 1/H50 value for methacrylates was linearly correlated with the δCβ value. That for (meth)acrylates was linearly correlated with log P, an index of lipophilicity. The ipLD50 for (meth)acrylates was linearly correlated with δCβ but not with log P. For (meth)acrylates, the δCβ value, which is dependent on the π-electron density on the β-carbon, was linearly correlated with PM3-based theoretical parameters (chemical hardness, η; electronegativity, χ; electrophilicity, ω), whereas log P was linearly correlated with heat of formation (HF). Also, the interaction between (meth)acrylates and DPPC liposomes in cell membrane molecular models was investigated using 1H-NMR spectroscopy and differential scanning calorimetry (DSC). The log 1/H50 value was related to the difference in chemical shift (ΔδHa) (Ha: H (trans) attached to the β-carbon) between the free monomer and the DPPC liposome-bound monomer. Monomer-induced DSC phase transition properties were related to HF for monomers. NMR chemical shifts may represent a valuable parameter for investigating the biological mechanisms of action of (meth)acrylates.

Molecules, Vol. 17, Pages 728-739: Reaction Characteristics of Andrographolide and its Analogue AL-1 with GSH, as a Simple Chemical Simulation of NF-κB Inhibition

Posted: 12 Jan 2012 12:00 AM PST

14-α-Lipoic acid-3,19-dihydroxyandrographolide (AL-1, 2) is an analogue of andrographolide (Andro, 1) coupled to α-lipoic acid (LA, 4). AL-1 was at least 10-fold more potent than the natural parent compound Andro in inhibiting nuclear factor (NF)-κB activation in RIN-m cells. In the present study, glutathione (GSH, 3) was used as a simple chemical model molecule of NF-κB with cysteine 62. The characteristics of the reaction between AL-1 or Andro and GSH were investigated to trace some possible elucidation for the inhibitive mechanism and stronger inhibition of AL-1 to NF-κB activation. The results showed that the main reaction products of AL-1 and Andro were identical, sulfhydryl adduct and amino adduct. AL-1 reacted much faster than Andro with GSH. The product yield of AL-1 was much higher than that of Andro. It was speculated that AL-1 might inhibit NF-κB by the same mechanism as Andro. And the faster reaction rate and higher yield may account for the stronger NF-κB inhibition of AL-1 when compared with Andro.

Molecules, Vol. 17, Pages 716-727: Evaluation of the Immunity Activity of Glycyrrhizin in AR Mice

Posted: 12 Jan 2012 12:00 AM PST

In this study, we evaluated effect of glycyrrhizin on immunity function in allergic rhinitis (AR) mice. The AR mice model were induced by dripping ovalbumin in physiological saline (2 mg mL−1, 10 μL) into the bilateral nasal cavities using a micropipette. After the AR model was induced, mice were randomly divided into six groups: the normal control, model, lycopene 20 mg kg−1 (as positive control drug) group, and glycyrrhizin 10, 20, 30 mg kg−1 groups. After the sensitization day 14, lycopene (20 mg/kg BW) and glycyrrhizin (10, 20 and 30 mg/kg BW) were given orally for 20 days once a day. Mice in the normal control and model groups were given saline orally once a day for 20 days. Results showed that glycyrrhizin treatment could dose-dependently significantly reduce blood immunoglobulin E (IgE), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-6 (IL-6), nitrous oxide (NO), tumor necrosis factor-alpha (TNF-α) levels and nitrous oxide synthase (NOS) activity and enhance blood immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), interleukin-2 (IL-2) and interleukin-12 (IL-12) levels in AR mice. Furthermore, glycyrrhizin treatment could dose-dependently significantly enhance acetylcholinesterase (AchE) activity and reduce substance P (SP) level in peripheral blood and nasal mucosa of AR mice. We conclude that glycyrrhizin can improve immunity function in AR mice, suggesting a potential drug for the prevention and therapy of AR.

Molecules, Vol. 17, Pages 703-715: Controlled Fabrication of Flower-like Nickel Oxide Hierarchical Structures and Their Application in Water Treatment

Posted: 12 Jan 2012 12:00 AM PST

Flower-like NiO hierarchical structures with 2–5 μm diameter assembled from nanosheet building blocks have been successfully fabricated via a wet-chemical method combined with thermodecomposition technology. The template-free method is facile and effective in preparing flower-like NiO superstructures in high yield. The intermediate product and final hierarchical structures are characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform IR (FTIR), and thermogravimetric analysis (TGA). The effects of growth temperature and reaction time on the morphologies of the as-prepared structures were investigated by SEM characterization and a possible mechanism for the formation of flower-like NiO is proposed. Based on the nitrogen adsorption and desorption measurements, the BET surface area of the as-obtained sample is 55.7 m2/g and the pore-size distribution plot indicates a bimodal mesopore distribution, with pore sizes of ca. 2.6 nm and 7.4 nm, respectively. In comparison with sphere-like and rod-like structures, the flower-like NiO hierarchical structures show an excellent ability to rapidly remove various pollutants when used as adsorbent and photocatalyst in waste-water treatment, which may be attributed to its unique hierarchical and porous surface structures.

Molecules, Vol. 17, Pages 688-702: The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients

Posted: 12 Jan 2012 12:00 AM PST

β-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that β-carotene may inhibit or induce cytochrome P450 enzymes and transporters. The study objective was to investigate the effect of β-carotene on the steady-state pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1 infected individuals. Twelve hour nelfinavir pharmacokinetic analysis was conducted at baseline and after 28 days of β-carotene supplementation (25,000 IU twice daily). Nelfinavir and M8 concentrations were measured with validated assays. Non-compartmental methods were used to calculate the pharmacokinetic parameters. Geometric mean ratios comparing day 28 to day 1 area under the plasma concentration-time curve (AUC0–12 h), maximum (Cmax) and minimum (Cmin) concentrations of nelfinavir and M8 are presented with 90% confidence intervals. Eleven subjects completed the study and were included in the analysis. There were no significant differences in nelfinavir AUC0–12 h and Cmin (−10%, +4%) after β-carotene supplementation. The M8 Cmin was increased by 31% while the M8 AUC0–12 h and Cmax were unchanged. During the 28 day period, mean CD4+ % and CD4+:CD8+ ratio increased significantly (p < 0.01). β-carotene supplementation increased serum carotene levels but did not cause any clinically significant difference in the nelfinavir and M8 exposure.

Sensors, Vol. 12, Pages 863-877: Real Time Corner Detection for Miniaturized Electro-Optical Sensors Onboard Small Unmanned Aerial Systems

Posted: 12 Jan 2012 12:00 AM PST

This paper describes the target detection algorithm for the image processor of a vision-based system that is installed onboard an unmanned helicopter. It has been developed in the framework of a project of the French national aerospace research center Office National d'Etudes et de Recherches Aérospatiales (ONERA) which aims at developing an air-to-ground target tracking mission in an unknown urban environment. In particular, the image processor must detect targets and estimate ground motion in proximity of the detected target position. Concerning the target detection function, the analysis has dealt with realizing a corner detection algorithm and selecting the best choices in terms of edge detection methods, filtering size and type and the more suitable criterion of detection of the points of interest in order to obtain a very fast algorithm which fulfills the computation load requirements. The compared criteria are the Harris-Stephen and the Shi-Tomasi, ones, which are the most widely used in literature among those based on intensity. Experimental results which illustrate the performance of the developed algorithm and demonstrate that the detection time is fully compliant with the requirements of the real-time system are discussed.

Sensors, Vol. 12, Pages 839-862: A Low-Complexity Geometric Bilateration Method for Localization in Wireless Sensor Networks and Its Comparison with Least-Squares Methods

Posted: 12 Jan 2012 12:00 AM PST

This research presents a distributed and formula-based bilateration algorithm that can be used to provide initial set of locations. In this scheme each node uses distance estimates to anchors to solve a set of circle-circle intersection (CCI) problems, solved through a purely geometric formulation. The resulting CCIs are processed to pick those that cluster together and then take the average to produce an initial node location. The algorithm is compared in terms of accuracy and computational complexity with a Least-Squares localization algorithm, based on the Levenberg–Marquardt methodology. Results in accuracy vs. computational performance show that the bilateration algorithm is competitive compared with well known optimized localization algorithms.

WowWee Puts Real Toys in Digital Games, Creates 'appcessories'

Posted: 11 Jan 2012 11:41 PM PST

IDG News Service - WowWee showed an upcoming game platform at the Consumer Electronics Show called AppGear, which combines real toys with on-screen animation to create a new product category it calls "appcessories." Each AppGear game will be offered as a free download for iOS and Android tablets, and children will buy at retail the corresponding ... (more)

Sensors, Vol. 12, Pages 806-838: Reliability and Availability Evaluation ofWireless Sensor Networks for Industrial Applications

Posted: 12 Jan 2012 12:00 AM PST

Wireless Sensor Networks (WSN) currently represent the best candidate to be adopted as the communication solution for the last mile connection in process control and monitoring applications in industrial environments. Most of these applications have stringent dependability (reliability and availability) requirements, as a system failure may result in economic losses, put people in danger or lead to environmental damages. Among the different type of faults that can lead to a system failure, permanent faults on network devices have a major impact. They can hamper communications over long periods of time and consequently disturb, or even disable, control algorithms. The lack of a structured approach enabling the evaluation of permanent faults, prevents system designers to optimize decisions that minimize these occurrences. In this work we propose a methodology based on an automatic generation of a fault tree to evaluate the reliability and availability of Wireless Sensor Networks, when permanent faults occur on network devices. The proposal supports any topology, different levels of redundancy, network reconfigurations, criticality of devices and arbitrary failure conditions. The proposed methodology is particularly suitable for the design and validation of Wireless Sensor Networks when trying to optimize its reliability and availability requirements.

Powerball Winning Numbers for 01/11/2012

Posted: 11 Jan 2012 08:33 PM PST

5 - 19 - 29 - 45 - 47 Powerball 25 Power Play 2
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