понедельник, 23 января 2012 г.

Games

Games

Prices Drop Monitor for Amazon 2.4 - Monitor specified product prices at Amazon.com.. (Free)

Posted: 23 Jan 2012 02:22 AM PST



Prices Drop Monitor for Amazon monitor any items you are interested in and alert you when price drops.

Amazon changes prices frequently. They go up and down constantly and very often the price is greatly reduced for short periods of time. Know exactly when it is the right time to buy and when you should probably wait. Never miss a deal again!

It is quick and easy. No sign-up, no configuration required. Just drag & drop items and start saving money.

It works on any Amazon of the world. And it is free.

Version 2.4:
  • Updated the icon to reflect the one of new the iPhone app, free from today on the App Store.
  • Growl notifications are now shown individually for each item which price is dropped.


  • Mac OS X 10.7 or later
  • 64-bit processor


Download Now

Future Internet, Vol. 4, Pages 83-91: When Atoms Meet Bits: Social Media, the Mobile Web and Augmented Revolution

Posted: 23 Jan 2012 12:00 AM PST

The rise of mobile phones and social media may come to be historically coupled with a growing atmosphere of dissent that is enveloping much of the globe. The Arab Spring, UK Riots, Occupy and many other protests and so-called "flash-mobs" are all massive gatherings of digitally-connected individuals in physical space; and they have recently become the new normal. The primary role of technology in producing this atmosphere has, in part, been to effectively link the on and the offline. The trend to view these as separate spaces, what I call "digital dualism", is faulty. Instead, I argue that the digital and physical enmesh to form an "augmented reality". Linking the power of the digital–creating and disseminating networked information–with the power of the physical–occupying geographic space with flesh-and-blood bodies–is an important part of why we have this current flammable atmosphere of augmented revolution.

Viruses, Vol. 4, Pages 167-183: The Development and Application of a Dot-ELISA Assay for Diagnosis of Southern Rice Black-Streaked Dwarf Disease in the Field

Posted: 23 Jan 2012 12:00 AM PST

Outbreaks of the southern rice black-streaked dwarf virus (SRBSDV) have caused significant crop losses in southern China in recent years, especially in 2010. There are no effective, quick and practicable methods for the diagnosis of rice dwarf disease that can be used in the field. Traditional reverse transcription-polymerase chain reaction (RT-PCR) methodology is accurate but requires expensive reagents and instruments, as well as complex procedures that limit its applicability for field tests. To develop a sensitive and reliable assay for routine laboratory diagnosis, a rapid dot enzyme-linked immunosorbent assay (dot-ELISA) method was developed for testing rice plants infected by SRBSDV. Based on anti-SRBSDV rabbit antiserum, this new dot-ELISA was highly reliable, sensitive and specific toward SRBSDV. The accuracy of two blotting media, polyvinylidene fluoride membrane (PVDF membrane) and nitrocellulose filter membrane (NC membrane), was compared. In order to facilitate the on-site diagnosis, three county laboratories were established in Shidian (Yunnan province), Jianghua (Hunan Province) and Libo (Guizhou province). Suspected rice cases from Shidian, Yuanjiang and Malipo in Yunnan province were tested and some determined to be positive for SRBSDV by the dot-ELISA and confirmed by the One Step RT-PCR method. To date, hundreds of suspected rice samples collected from 61 districts in southwestern China have been tested, among which 55 districts were found to have rice crops infected by SRBSDV. Furthermore, the test results in the county laboratories showed that Libo, Dehong (suspected samples were sent to Shidian) and Jianghua were experiencing a current SRBSDV outbreak.

Remote Sensing, Vol. 4, Pages 303-326: Exploring Simple Algorithms for Estimating Gross Primary Production in Forested Areas from Satellite Data

Posted: 23 Jan 2012 12:00 AM PST

Algorithms that use remotely-sensed vegetation indices to estimate gross primary production (GPP), a key component of the global carbon cycle, have gained a lot of popularity in the past decade. Yet despite the amount of research on the topic, the most appropriate approach is still under debate. As an attempt to address this question, we compared the performance of different vegetation indices from the Moderate Resolution Imaging Spectroradiometer (MODIS) in capturing the seasonal and the annual variability of GPP estimates from an optimal network of 21 FLUXNET forest towers sites. The tested indices include the Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), Leaf Area Index (LAI), and Fraction of Photosynthetically Active Radiation absorbed by plant canopies (FPAR). Our results indicated that single vegetation indices captured 50–80% of the variability of tower-estimated GPP, but no one index performed universally well in all situations. In particular, EVI outperformed the other MODIS products in tracking seasonal variations in tower-estimated GPP, but annual mean MODIS LAI was the best estimator of the spatial distribution of annual flux-tower GPP (GPP = 615 × LAI − 376, where GPP is in g C/m2/year). This simple algorithm rehabilitated earlier approaches linking ground measurements of LAI to flux-tower estimates of GPP and produced annual GPP estimates comparable to the MODIS 17 GPP product. As such, remote sensing-based estimates of GPP continue to offer a useful alternative to estimates from biophysical models, and the choice of the most appropriate approach depends on whether the estimates are required at annual or sub-annual temporal resolution.

Puzzlejuice

Posted: 22 Jan 2012 02:44 PM PST

[Platform: Mobile (iOS)] What a world we live in, where mankind can walk on the moon, salad can be purchased in cups, and falling block puzzles can be fused with word games. If you're ready for your brain to have a little run through the multitasking wringer, Puzzlejuice is without a doubt the best way to hurt your synapses. With a little Tetris-like block arranging and a little Spelltower-style word building, you, too, can drive yourself mad with delight!

Daily Sudoku - January 23 - Easy

Posted: 23 Jan 2012 02:12 AM PST

The key choices may seem unusual, but the navigation has to avoid key presses that are reserved for the browser, for example we couldn't use CTRL+1 to highlight all squares that contain a as this is opens the first window in Firefox, nor SHIFT+P as it is reserved for printing, etc.

SQLiteSync 1.0.1 - Compare, merge and keep in sync two sqlite databases.. (Demo)

Posted: 23 Jan 2012 01:54 AM PST



SQLiteSync is a very powerful and easy to use application to compare, merge and keep in sync two sqlite databases and thanks to its underline technology it is able to visualize the differences between millions of rows in few milliseconds.

SQLiteSync smart visualization technology is also able to detect BLOB columns and very large TEXT columns and display all of them in a preview panel. SQLiteSync is able to apply differences in data, tables, indexes, trigger and views. Synchronization code can be applied directly to the databases or an optional SQL text script can be generated.



Version 1.0.1: Release notes were unavailable when this listing was updated.

Mac OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

AnyToISO Lite 3.3 - Create ISO images from various file types.. (Free)

Posted: 23 Jan 2012 01:48 AM PST



AnyToISO Lite is the ultimate ISO Creator for Windows and Mac: create ISO from almost everything including all CD/DVD images formats popular in Internet, CD/DVD/Blue-ray disks or simply from a local folder. Complete command line support. Free Lite Version.

Version 3.3:
  • Create BIN/CUE images from disks (including Audio CDs)
  • Extract Audio CD images (BIN/CUE and NRG) to .WAV files
  • Improved CD/DVD/BD to ISO conversion
  • MDX files support
  • Number of small improvements and bug fixes


Mac OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

DesktopShelves 2.0 - Display folders as desktop shelves.. (Demo)

Posted: 23 Jan 2012 02:16 AM PST



DesktopShelves can help clean up a desktop cluttered by dozens of different files.

You can display any folder as a shelf on your Desktop. On a shelf the size of 5 normal Desktop items you can fit 20 files, because items on a shelf are slightly rotated like books on a real-world shelf. That saves a lot of screen real estate.

If you mouse-over your shelves, you can see a larger preview of the file. A double-click opens it.

You can use DesktopShelves in many different ways: to organize files by project, quickly access frequently used files, or to collect text snippets and templates. Other features include:

  • Finder integration: open folders as shelves from the Finder context menu
  • Shelf contents update automatically when the underlying folder changes (e.g. you add or remove a file in Finder)
  • Shelf width can be adjusted and shelves can be placed anywhere on the Desktop
  • Drag & drop support: drag files from the Finder on the shelves, drop files from a shelf directly into other applications like Mail.app or TextEdit (dragging with right mouse button inserts the file contents)


Version 2.0:
  • Added a hotkey to temporarily hide all shelves
  • Shelf item angle can now be changed all the way to a flat view
  • Now works with file labels set in Finder


Mac OS X 10.6.6 or later.

Download Now

This posting includes an audio/video/photo media file: Download Now

Remote Sensing, Vol. 4, Pages 271-302: Environmental and Sensor Limitations in Optical Remote Sensing of Coral Reefs: Implications for Monitoring and Sensor Design

Posted: 23 Jan 2012 12:00 AM PST

A generic method was developed for analysing the capabilities of optical remote sensing of aquatic systems in terms of environmental components and imaging sensor configurations. The method was based on a component based model of the entire system in which not only benthic composition but other environmental components such as water inherent optical properties (IOPs), bathymetry, sun elevation, wind speed and sensor noise characteristics were defined by datasets with the potential to include across-image variation. The model was applied to data from Pacific Ocean reefs in an airborne sensor context to estimate the primary environmental or sensor factors confounding discrimination of benthic mixtures of key reef types: live coral, bleached coral, dead coral and macroalgae. Results indicate that spectral variation of benthic types and sub-pixel mixing is the primary limiting factor for benthic mapping objectives, whereas instrument noise levels are a minor factor.

Polymers, Vol. 4, Pages 275-295: Dispersion of Carbon Nanotubes: Mixing, Sonication, Stabilization, and Composite Properties

Posted: 23 Jan 2012 12:00 AM PST

Advances in functionality and reliability of carbon nanotube (CNT) composite materials require careful formulation of processing methods to ultimately realize the desired properties. To date, controlled dispersion of CNTs in a solution or a composite matrix remains a challenge, due to the strong van der Waals binding energies associated with the CNT aggregates. There is also insufficiently defined correlation between the microstructure and the physical properties of the composite. Here, we offer a review of the dispersion processes of pristine (non-covalently functionalized) CNTs in a solvent or a polymer solution. We summarize and adapt relevant theoretical analysis to guide the dispersion design and selection, from the processes of mixing/sonication, to the application of surfactants for stabilization, to the final testing of composite properties. The same approaches are expected to be also applicable to the fabrication of other composite materials involving homogeneously dispersed nanoparticles.

SwiftRing 1.2 - Assign custom mouse shortcuts to any Mac application.. (Commercial)

Posted: 23 Jan 2012 01:36 AM PST



SwiftRing is a powerful productivity tool that allows you to assign custom mouse shortcuts to any Mac application.

The demo video and media articles on our website are the best way to get familiar with SwiftRing. A brief summary of SwiftRing's capabilities are outlined below.

The Basics:

Once SwiftRing is installed, using it is very simple:

  • Hold down the option key to bring up the ring.
  • The ring for the currently active application will pop up.
  • Touch a ring segment to perform an action, no clicking is required.
  • Extra action labels stacked on the top and bottom segments are activated using the mouse scroll wheel.
Customizing: Actions can be customized for any application - simply assign as many keystrokes and/or shortcuts as desired to a ring segment using the preferences panel. The ring activation key (option by default) can also be changed.

SwiftRing comes with built in support for Safari and iTunes. A generic ring is also supported to provide common actions for unrecognized applications.

Speed Demons: Power users can hold the activation key, quickly touch a segment, and release option without the ring ever popping up for maximum efficiency. The scroll wheel can also be used to perform highly repetitive actions.



Version 1.2:
  • Added a registration key system to simplify upgrade process and allow demos.
  • Added the 'Control' key and combinations back to launch options.


Mac OS X 10.5 or later (with access for assistive devices enabled)

Download Now

This posting includes an audio/video/photo media file: Download Now

MacTerm 4.0.0.b.20120121 - Terminal emulator for both local and remote shells.. (Free)

Posted: 23 Jan 2012 01:29 AM PST



MacTerm (was MacTelnet) on Mac OS X is now a complete replacement for Terminal, allowing access to both local and remote applications.

Its many features include powerful terminals (with or without tabs), a very flexible preferences system, TEK vector graphics, dynamic search, notifications and keep-alive, macros, a floating command line window, special keypads, a session manager, and even a basic Python scripting interface. It's also free software under the GPL.

Version 4.0.0.b.20120121:

  • This project has been renamed "MacTerm". This emphasizes the fact that the program is a full terminal on Mac OS X that is in no way limited to telnet sessions.
  • In the last few months there have been substantial changes! Major improvements have been made to the XTerm and VT220 emulators. Full Screen mode has been tweaked in several ways. The Local Echo interface has been enhanced, to better indicate "invisible" inputs such as control characters. Notification windows (when not using Growl) have a new appearance and behavior. Macros can now more easily use control characters. And, a number of bugs have been fixed. These changes are available now, in the latest daily build.
  • But there are even more features in the works...
  • The most significant feature under development is emulator-level support for UTF-8, instead of the "mostly UTF-8" translation mechanism that is currently used. This will fix a lot of apparent bugs that depend on exactly what text is displayed and how the text was encoded. It will also return to normal some features that were broken by simplistic UTF-8 support, like single-byte replacements for escape sequences.
  • Another task is to fix a variety of user interface problems that are frankly caused entirely by the simultaneous use of the Carbon and Cocoa frameworks; for example, tabbed windows are susceptible to bugs in sheets that cannot occur in windows where the tabs are turned off. A hybrid approach was absolutely necessary as an interim solution, but there is constant effort to peel away dependencies on older technologies and cure the "warts" in the user interface's behavior.


Mac OS X 10.3.9 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

iWatermark Pro 1.19 - Easily add watermarks to art, photos and more.. (Shareware)

Posted: 23 Jan 2012 01:33 AM PST



iWatermark Pro allows you to secure and protect your photos. iWatermark allows you to create watermarks within iPhoto and Aperture. If you are a photographer or artist iWatermark works for you to by adding a visible personal text or graphic watermark. Once added to a photo or graphic this visible watermark displays your creation and ownership. Its like signing your intellectual property. Its cheaper, faster and easier to use than Photoshop.

iWatermark works with all photo browsers and directly within iPhoto.

iWatermark, is the only watermarking tool available for iPhone, Mac, Windows, Android and iPhone/iPad. iWatermark is the most popular utility in the world to watermark photos for photographers.

Why Watermark?

  • Digitally sign your photos/artwork with iWatermark to claim, secure and maintain your intellectual property and reputation.
  • Build your company brand, by having your company logo on all your images.
  • Avoid the surprise of seeing your photos and/or artwork elsewhere on the web or in an ad.
  • Avoid the conflicts and headaches with plagiarists who claim they didn't know that you created it.
  • Avoid the costly litigation that can be involved in these cases of misuse of ip.
  • Avoid intellectual property squabbles.
iWatermark maintains meta tags, uses many input/output formats and can also create thumbnails. Can process single files or folders and more.

"The beauty of iWatermark is its combination of ease of use and functionality. If you've ever wanted to give watermarking a try, or if you're already doing it and you'd welcome a way to do it quickly and easily, iWatermark is an inexpensive and impressive utility. I've yet to see a better solution." Dan Frakes, Macworld, 4.5 of 5 mice.

Version 1.19:

  • now use Dropbox to backup your watermarks and settings and sync them between your Macs. from the advanced tab you can create a new dropbox account (2GB free) then upload to save settings and watermarks. If you have another Mac you can open iWatermark and download from Dropbox to sync watermarks between computers. Great for publishers and large photo workflows.
    • - also a fix for importing settings from the old iWatermark to deal with corrupt settings.


Mac OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

IJMS, Vol. 13, Pages 1258-1268: Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation

Posted: 23 Jan 2012 12:00 AM PST

Vascular inflammation is an important factor which can promote diabetic complications. In this study, the inhibitory effects of aqueous extract from Prunella vulgaris (APV) on high glucose (HG)-induced expression of cell adhesion molecules in human umbilical vein endothelial cells (HUVEC) are reported. APV decreased HG-induced expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. APV also dose-dependently inhibited HG-induced adhesion of HL-60 monocytic cells. APV suppressed p65 NF-κB activation in HG-treated cells. APV significantly inhibited the formation of intracellular reactive oxygen species (ROS). HG-stimulated HUVEC secreted gelatinases, however, APV inhibited it. APV induced Akt phosphorylation as well as activation of heme oxygenase-1 (HO-1), eNOS, and nuclear factor E2-related factor 2 (Nrf2), which may protect vascular inflammation caused by HG. In conclusion, APV exerts anti-inflammatory effect via inhibition of ROS/NF-κB pathway by inducing HO-1 and eNOS expression mediated by Nrf2, thereby suggesting that Prunella vulgaris may be a possible therapeutic approach to the inhibition of diabetic vascular diseases.

IJMS, Vol. 13, Pages 1239-1257: The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human Keratinocytes

Posted: 23 Jan 2012 12:00 AM PST

The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM) on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC—in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE)—has great merits for skin regeneration. In this study, human primary keratinocytes (HKs), which play fundamental roles in skin tissue, was used to examine how AAPE affects HK. HK proliferation was significantly higher in the experimental group (1.22 μg/mL) than in the control group. DNA gene chip demonstrated that AAPE in keratinocytes (p < 0.05) notably affected expression of 290 identified transcripts, which were associated with cell proliferation, cycle and migration. More keratinocyte wound healing and migration was shown in the experimental group (1.22 μg/mL). AAPE treatment significantly stimulated stress fiber formation, which was linked to the RhoA-ROCK pathway. We identified 48 protein spots in 2-D gel analysis and selected proteins were divided into 64% collagen components and 30% non-collagen components as shown by the MALDI-TOF analysis. Antibody array results contained growth factor/cytokine such as HGF, FGF-1, G-CSF, GM-CSF, IL-6, VEGF, and TGF-β3 differing from that shown by 2-D analysis. Conclusion: AAPE activates HK proliferation and migration. These results highlight the potential of the topical application of AAPE in the treatment of skin regeneration.

IJMS, Vol. 13, Pages 1225-1238: Disruption of Axonal Transport in Motor Neuron Diseases

Posted: 23 Jan 2012 12:00 AM PST

Motor neurons typically have very long axons, and fine-tuning axonal transport is crucial for their survival. The obstruction of axonal transport is gaining attention as a cause of neuronal dysfunction in a variety of neurodegenerative motor neuron diseases. Depletions in dynein and dynactin-1, motor molecules regulating axonal trafficking, disrupt axonal transport in flies, and mutations in their genes cause motor neuron degeneration in humans and rodents. Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS). Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS. Dynactin-1 mRNA is also reduced in the affected neurons of a mouse model of spinal and bulbar muscular atrophy, a motor neuron disease caused by triplet CAG repeat expansion in the gene encoding the androgen receptor. Pathogenic androgen receptor proteins also inhibit kinesin-1 microtubule-binding activity and disrupt anterograde axonal transport by activating c-Jun N-terminal kinase. Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias. These observations suggest that the impairment of axonal transport is a key event in the pathological processes of motor neuron degeneration and an important target of therapy development for motor neuron diseases.

Molecules, Vol. 17, Pages 1124-1137: New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

Posted: 23 Jan 2012 12:00 AM PST

Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a–e which differ from sorafenib in their amide part. A 4-step synthetic pathway includes preparation of 4-chloropyridine-2-carbonyl chloride hydrochloride (1), 4-chloro-pyridine-2-carboxamides 2a–e, 4-(4-aminophenoxy)-pyridine-2-carboxamides 3a–e and the target compounds 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-phenoxy]-pyridine-2-carboxamides 4a–e. All compounds were fully chemically characterized and evaluated for their cytostatic activity against a panel of carcinoma, lymphoma and leukemia tumour cell lines. In addition, their antimetabolic potential was investigated as well. The most prominent antiproliferative activity was obtained for compounds 4a–e (IC50 = 1-4.3 μmol·L−1). Their potency was comparable to the potency of sorafenib, or even better. The compounds inhibited DNA, RNA and protein synthesis to a similar extent and did not discriminate between tumour cell lines and primary fibroblasts in terms of their anti-proliferative activity.

XBMC 11.0.beta2 - Powerful media center tool for Mac or Apple TV.. (Free)

Posted: 22 Jan 2012 08:59 PM PST



XBMC is an award winning media center for Mac OS X. The ultimate High Definition hub for all your media, XBMC is easy to use, looks slick, and has a large helpful community.For PPC Version, download here:http://mirrors.xbmc.org/releases/osx/ppc/xbmc-10.1-ppc-repack.dmg

Version 11.0.beta2:
  • Since Beta 1, unencrypted bluray, dvd player, startup problems in OSX, airplay, subtitle issues, unofficial addon repository installations, and the frustrating TMDB scraper problems that have made it difficult for everyone to scrape new movies have all seen fixes. In addition, a great deal of progress has been made in the new XBMCBuntu build, which should be ready for the next preview release. Finally, all Beta 1 users are encouraged to update immediately to fix a scraper error that causes XBMC to crash.


  • Mac OS X 10.4.11 or later
  • Or Apple TV


Download Now

This posting includes an audio/video/photo media file: Download Now

Molecules, Vol. 17, Pages 1113-1123: Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

Posted: 23 Jan 2012 12:00 AM PST

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
Автор: на

Комментариев нет:

Отправить комментарий

Подписаться на: Комментарии к сообщению (Atom)