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- Sustainability, Vol. 4, Pages 2852-2861: Effect of Improving Environmental Sustainability in Developing Countries by Upgrading Solid Waste Management Techniques: A Case Study
- Proteomes, Vol. 1, Pages 1-2: Proteomes: A New Proteomic Journal
- IJGI, Vol. 1, Pages 242-255: Detecting Changes in Forest Structure over Time with Bi-Temporal Terrestrial Laser Scanning Data
- Crystals, Vol. 2, Pages 1483-1491: Simulation Design for Rutile-TiO2 Nanostructures with a Large Complete-Photonic Bandgap in Electrolytes
- Adobe Camera Raw 7.2.0.46 - Adds support for many new cameras.. (Updater)
- LE MANS: Toyota Tops Friday At Shanghai
- Paper Mario: Sticker Star trailer features the word 'nyarglebargle' and a screen-filling goat
- Tom Clancy's Ghost Recon Online - Introducing Clans
- Maestia: Rise of Keledus - Launch Trailer
- World of Warcraft: Mists of Pandaria Review
- Video Review - World of Warcraft: Mists of Pandaria
- Social Share: Express Edition
- Cancers, Vol. 4, Pages 1106-1145: RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis
- Molecules, Vol. 17, Pages 12734-12745: Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants
- Molecules, Vol. 17, Pages 12718-12733: 17O-Dynamic NMR and DFT Investigation of Bis(acyloxy)iodoarenes
- Molecules, Vol. 17, Pages 12704-12717: An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
- Molecules, Vol. 17, Pages 12665-12703: Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry
- Molecules, Vol. 17, Pages 12657-12664: Antioxidant Interactions between Major Phenolic Compounds Found in ‘Ataulfo’ Mango Pulp: Chlorogenic, Gallic, Protocatechuic and Vanillic Acids
- Molecules, Vol. 17, Pages 12651-12656: Two New Glycosides from the Fruits of Morinda citrifolia L.
- Molecules, Vol. 17, Pages 12642-12650: New Bioactive Alkyl Sulfates from Mediterranean Tunicates
| Posted: 26 Oct 2012 12:00 AM PDT The present research has focused on a contribution to the improvement of solid waste management in a waste collectors’ cooperative located in Brazil (Marcos Moura district, Santa Rita, Paraiba State) through a technical and organizational up-grading. Collection, processing and final disposal of wastes still represent a problem in some regions of Brazil. The proposed strategy foresaw the analysis of the local situation, the evaluation of the cooperative efficiency rate and then the introduction of technical and operational improvements to the service. Besides the technical activity, a social inclusion program was developed in order to include local scavengers (called Catadores) and to improve the social and economic conditions of populations involved in the process. The project also increased their environmental awareness. The workgroup is still monitoring the obtained results in order to check for the achievement of foreseen targets, to plan further improvements and to replicate this experience in other Brazilian areas. |
| Proteomes, Vol. 1, Pages 1-2: Proteomes: A New Proteomic Journal Posted: 26 Oct 2012 12:00 AM PDT In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis. The continuous development of the mass spectrometry techniques created a huge analytical potential allowing the study of nearly complete proteomes in single experiments. This evolution distanced proteomics from protein chemistry and placed it in a novel position. Its capability to identify and quantify in parallel thousands of proteins and their modifications at minute sample amount requirements is one of the most fascinating technological advances in biology today. |
| Posted: 26 Oct 2012 12:00 AM PDT Changes to stems caused by natural forces and timber harvesting constitute an essential input for many forestry-related applications and ecological studies, especially forestry inventories based on the use of permanent sample plots. Conventional field measurement is widely acknowledged as being time-consuming and labor-intensive. More automated and efficient alternatives or supportive methods are needed. Terrestrial laser scanning (TLS) has been demonstrated to be a promising method in forestry field inventories. Nevertheless, the applicability of TLS in recording changes in the structure of forest plots has not been studied in detail. This paper presents a fully automated method for detecting changes in forest structure over time using bi-temporal TLS data. The developed method was tested on five densely populated forest plots including 137 trees and 50 harvested trees in point clouds. The present study demonstrated that 90 percent of tree stem changes could be automatically located from single-scan TLS data. These changes accounted for 92 percent of the changed basal area. The results indicate that the processing of TLS data collected at different times to detect tree stem changes can be fully automated. |
| Posted: 26 Oct 2012 12:00 AM PDT The photonic bands of various TiO2 2D photonic crystals, i.e., cylindrical, square and hexagonal columns connected with/without walls and filled with acetonitrile, were investigated from the perspective of dye-sensitized solar cells. The finite-difference time-domain methods revealed that two-dimensional (2D) photonic crystals with rods connected with walls composed of TiO2 and electrolytes had complete photonic band gaps under specific conditions. This optimally designed bandgap reaches a large Δω/ωmid value, 1.9%, in a triangular array of square rods connected with walls, which is the largest complete 2D bandgap thus far reported for a photochemical system. These discoveries would promote the photochemical applications of photonic crystals. |
| Adobe Camera Raw 7.2.0.46 - Adds support for many new cameras.. (Updater) Posted: 26 Oct 2012 03:31 AM PDT  Adobe Camera Raw's latest plug-in replaces the original Camera Raw plug-in that was installed with Photoshop CS5. The Camera Raw 7 plug-in is not compatible with versions of Photoshop earlier than Photoshop CS6 or versions of Photoshop Elements earlier than Photoshop Elements 6 for Mac. Version 7.2.0.46: Camera Raw 7.2 is now available as a final release through the update mechanism in Photoshop CS6. The goal of this release is to provide additional camera raw support, lens profile support and address bugs that were introduced in previous releases of Camera Raw. Customers of previous versions of Photoshop can utilize DNG Converter 7.2 for raw file support for newly added cameras. Cameras:
Fixes:
Download Now This posting includes an audio/video/photo media file: Download Now |
| LE MANS: Toyota Tops Friday At Shanghai Posted: 26 Oct 2012 12:00 AM PDT  Alex Wurz tops time charts in Practice 2, quickest on Friday at Shanghai... |
| Paper Mario: Sticker Star trailer features the word 'nyarglebargle' and a screen-filling goat Posted: 26 Oct 2012 03:23 AM PDT Paper Mario: Sticker Star may well have featured in the 3DS sizzle reel from Nintendo Direct yesterday, but this full standalone trailer released |
| Tom Clancy's Ghost Recon Online - Introducing Clans Posted: 26 Oct 2012 01:39 AM PDT This video explains the the role clans play in Tom Clancy's Ghost Recon Online.
Read and Post Comments | Get the full article at GameSpot "Tom Clancy's Ghost Recon Online - Introducing Clans" was posted by MikeTao on Fri, 26 Oct 2012 01:39:07 -0700 |
| Maestia: Rise of Keledus - Launch Trailer Posted: 26 Oct 2012 12:11 AM PDT Check out the launch trailer for Maestia: Rise of Keledus, featuring the MAEstyle dance.
Read and Post Comments | Get the full article at GameSpot "Maestia: Rise of Keledus - Launch Trailer" was posted by MikeTao on Fri, 26 Oct 2012 00:11:41 -0700 |
| World of Warcraft: Mists of Pandaria Review Posted: 25 Oct 2012 10:33 PM PDT Mists of Pandaria's glittering forests and engaging activities feel fresh despite the game's reliance on familiar tropes.
Score: 7.5 / good Get the full article at GameSpot "World of Warcraft: Mists of Pandaria Review" was posted by Brittany Vincent on Thu, 25 Oct 2012 22:33:00 -0700 |
| Video Review - World of Warcraft: Mists of Pandaria Posted: 25 Oct 2012 10:20 PM PDT The continent of Pandaria goes to war with Brittany Vincent in this video review for World of Warcraft: Mists of Pandaria.
Read and Post Comments | Get the full article at GameSpot "Video Review - World of Warcraft: Mists of Pandaria" was posted by JimM on Thu, 25 Oct 2012 22:20:18 -0700 |
| Posted: 25 Oct 2012 05:41 PM PDT This week's social report takes on minecraft goodies, Halo wedding, cosplay, free to play games on the go, and more. Get the full article at GameSpot "Social Share: Express Edition" was posted by Staff on Thu, 25 Oct 2012 17:41:00 -0700 |
| Posted: 26 Oct 2012 12:00 AM PDT Prostate cancer is the third leading cause of male cancer deaths in the developed world. The current lack of highly specific detection methods and efficient therapeutic agents for advanced disease have been identified as problems requiring further research. The integrins play a vital role in the cross-talk between the cell and extracellular matrix, enhancing the growth, migration, invasion and metastasis of cancer cells. Progression and metastasis of prostate adenocarcinoma is strongly associated with changes in integrin expression, notably abnormal expression and activation of the β3 integrins in tumour cells, which promotes haematogenous spread and tumour growth in bone. As such, influencing integrin cell expression and function using targeted therapeutics represents a potential treatment for bone metastasis, the most common and debilitating complication of advanced prostate cancer. In this review, we highlight the multiple ways in which RGD-binding integrins contribute to prostate cancer progression and metastasis, and identify the rationale for development of multi-integrin antagonists targeting the RGD-binding subfamily as molecularly targeted agents for its treatment. |
| Posted: 26 Oct 2012 12:00 AM PDT The purpose of this work was the synthesis, characterization and efficacy evaluation of new biocompatible antioxidant polymers linking trans-ferulic acid or a-lipoic acid. In particular, ferulic or lipoic acid were introduced in the preformed polymeric backbone. The new antioxidant biopolymers were characterized by Fourier transform infrared spectroscopy and gel permeation chromatography. The degree of functionalization (moles of antioxidant per gram of polymer) was determined by the Gaur-Gupta method for free amino group determination and by the Folin method for the phenolic groups. Their ability to inhibit lipid peroxidation were estimated in rat liver microsomal membranes induced in vitro by tert-BOOH (tert-butyl hydroperoxide), as a source of free radicals. The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging effect was also evaluated. The obtained systems, with different solubility, showed strong antioxidant and antiradical activities, suggesting potential use as packaging materials for foods, cosmetics, pharmaceuticals and personal care products. Moreover, the cytotoxicity of the synthesized polymers was also evaluated on Caco-2 cell cultures in order to verify their biocompatibility when exposed to an absorptive epithelial cell line. |
| Posted: 26 Oct 2012 12:00 AM PDT Bis(acetoxy)iodobenzene and related acyloxy derivatives of hypervalent I(III) were studied by variable temperature solution-state 17O-NMR and DFT calculations. The 17O-NMR spectra reveal a dynamic process that interchanges the oxygen atoms of the acyloxy groups. For the first time, coalescence events could be detected for such compounds, allowing the determination of activation free energy data which are found to range between 44 and 47 kJ/mol. The analysis of the 17O linewidth measured for bis(acetoxy)iodobenzene indicates that the activation entropy is negligible. DFT calculations show that the oxygen atom exchange arises as a consequence of the [1,3]-sigmatropic shift of iodine. The calculated activation barriers are in excellent agreement with the experimental results. Both the 17O-NMR and DFT studies show that the solvent and chemical alterations, such as modification of the acyl groups or para- substitution of the benzene ring, hardly affect the energetics of the dynamic process. The low I-O Wiberg bond index (0.41–0.42) indicates a possible explanation of the invariance of both the energy barrier and the 17O chemical shift with para-substitution. |
| Posted: 26 Oct 2012 12:00 AM PDT A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. |
| Posted: 26 Oct 2012 12:00 AM PDT There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of novel triazole-modified nucleic acid derivatives for potential downstream DNA- and RNA-based applications. This review will focus on highlighting representative novel nucleic acid molecular structures that have been synthesized via the “click” azide-alkyne cycloaddition. Many of these derivatives show compatibility for various applications that involve enzymatic transformation, nucleic acid hybridization, molecular tagging and purification, and gene silencing. The details of these applications are discussed. In conclusion, the future of nucleic acid analogues functionalized with triazoles is promising. |
| Posted: 26 Oct 2012 12:00 AM PDT Phenolic compounds are known to have antioxidant capacity; however, there is little information about molecular interactions between particular phenolics found in fruits at different developmental stages. Therefore, the total antioxidant capacity of the phenolic compounds of a fruit may not correspond to the sum of individual antioxidant capacity given by antioxidants from that tissue. In this study, individual antioxidant capacity and the interactions of four major phenolic compounds (chlorogenic, gallic, protocatechuic and vanillic acid) found in 'Ataulfo' mango pulp were tested using the DPPH assay. Significant synergism was found in the majority of the all combinations, as well as the combination of the four phenolics. However, antagonism was also observed between some molecules. This work demonstrated particular interactions that may occur in a complex environment within the complex framework of a natural food. The present results may also assist in the future design of functional foods or ingredients based on their antioxidant activity and their synergistic or antagonist interactions. |
| Molecules, Vol. 17, Pages 12651-12656: Two New Glycosides from the Fruits of Morinda citrifolia L. Posted: 26 Oct 2012 12:00 AM PDT To study the chemical constituents of the fruits of noni (Morinda citrifolia L.), and find novel compounds, an n-butanol extract of the ethanol soluble fraction was subjected to repeated silica gel and ODS column chromatography and HPLC. Two new glycosides were isolated and their structures elucidated by NMR and HRFAB-MS spectrometry as (2E,4E,7Z)-deca-2,4,7-trienoate-2-O-β-D-glucopyranosyl-β-D-glucopyra-noside (1) and amyl-1-O-β-D-apio-furanosyl-1,6-O-β-D-glucopyranoside (2), respectively. |
| Molecules, Vol. 17, Pages 12642-12650: New Bioactive Alkyl Sulfates from Mediterranean Tunicates Posted: 26 Oct 2012 12:00 AM PDT Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells. |
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