вторник, 9 октября 2012 г.

Games

Games

Reversion: The Escape - Screenshots

Posted: 09 Oct 2012 04:28 AM PDT

Features:
-  An incredible atmosphere with a perfectly suited soundtrack
-  Original cartoon graphics
-  A mature story with charismatic characters: meet with Laura, the
   militaries and three other characters
-  Challenging enigmas that'll held you for about 4hours.
-  Free Hints
-  6 available languages (Chinese, English, French, German, Italian,
   Spanish)
-  Specific interface for each device (even the new iPhone 5)
-  Specially designed to be played by all ages

Divinity Anthology - Screenshots

Posted: 09 Oct 2012 04:22 AM PDT

Hungry Hungry Hippos - Screenshots

Posted: 09 Oct 2012 04:38 AM PDT

Choose from 3 ways to play:
1. Single Player: Choose your Hippo and see how fast you can chomp all the fruit! How'd you do? Think you can beat your time? Play again! Available via all iPhone, iPad or iPod Touch.

2. Hippo-vs-iDevice: Choose which Hippo you want to be, and be ready to race the machine! Whoever eats the most fruit first wins! Available via all iPhone, iPad or iPod Touch.

3. 4 player Hippo: Gather your friends together and start chomping at the Tiki Pond. This four player mode offers laughter and mango munching fun for all at the same time! Only available via iPad.

Road Trip Effect Pro 2.9.1 - Create visual travel log movies in iMovie.. (Shareware)

Posted: 09 Oct 2012 03:33 AM PDT



Road Trip Effect Pro can generate animated trails on maps in Quicktime format. Trails can be infinitely layered to allow complex actions by a limitless number of agents. Comes with many preset icons and maps for faster work, yet is fully customizable. Options and Specs:
  • Imports external images from these formats (.jpg, .bmp, .png, .pict or .tiff)
  • Supports infinite trip layers with arbitrary start times and lengths.
  • Supports infinite number of legs in each layer.
  • Each layer can have it's own color, width, opacity, icon, and fade length.
  • Points at the beginning and start of a leg can have formatted labels and can be made invisible.
  • Supports sizes and frame rates for (NTSC, PAL, 720p or 1080p)
  • Movie Lead-In/Lead-Out lengths can be configured.
  • Trails can automatically wrap if you drag past the edge of the map. This is perfect for showing around the world journeys.


Version 2.9.1:
  • Folders that end in end .rtep are now recognized again as Road Trip Effect Projects (broken in version 2.9). You may need to re-associate the file in the Finder.
  • Minor improvements to the users guide. You may need to restart your computer.


Mac OS X 10.4 or later

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This posting includes an audio/video/photo media file: Download Now

Fopydo 2.6.0 - Create PDF documents from images.. (Free)

Posted: 09 Oct 2012 03:23 AM PDT



Fopydo is short for photocopy documents - it creates PDF documents from images taken with digital cameras, cell phones or scanners. Results are very compact in size and can be saved or emailed securely (with 128-bit encryption). In addition to PDF related functions Fopydo can OCR texts in a number of languages and save results in a text document (open source Tesseract OCR engine is embedded in the application). Visit fopydo.com to learn more about the software and to see tutorials. Please leave your feedback about the program - this will be very helpful for the author.

Version 2.6:
  • PDF files from scanners etc. can be now used as input files in addition to previously supported input file formats (TIFF, JPEG, PNG, GIF, BMP).
  • If PDF file matching the document title (without .PDF suffix) exists in selected output folder, Fopydo will give you an option to append pages to the existing document or overwrite. This functionality is intended for keeping digitized copies of paper documents growing over time e.g. notebooks, bill receipts, statements etc.
  • Added detection of blank pages in input from scanners, to allow double-sided scanning without the need to remove blank pages by hand in case of mixed one sided/double sided input.
  • Functionality for re-ordering and automatic rotation of pages of bound documents was moved to the sampling phase to make it work better with barcode detection.
  • Added preview of all document pages before submitting images for processing.


Mac OS X 10.6 or later

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Pokémon developer confident it can keep making new pokémon forever

Posted: 09 Oct 2012 03:35 AM PDT

Worried that Pokemon developer Game Freak might run out of ideas for new monsters to catch? Don't be. In an interview with GameCentral, the Japanese

IJMS, Vol. 13, Pages 12890-12910: Fluorescence Lifetime Correlation Spectroscopy (FLCS): Concepts, Applications and Outlook

Posted: 09 Oct 2012 12:00 AM PDT

Fluorescence Lifetime Correlation Spectroscopy (FLCS) is a variant of fluorescence correlation spectroscopy (FCS), which uses differences in fluorescence intensity decays to separate contributions of different fluorophore populations to FCS signal. Besides which, FLCS is a powerful tool to improve quality of FCS data by removing noise and distortion caused by scattered excitation light, detector thermal noise and detector afterpulsing. We are providing an overview of, to our knowledge, all published applications of FLCS. Although these are not numerous so far, they illustrate possibilities for the technique and the research topics in which FLCS has the potential to become widespread. Furthermore, we are addressing some questions which may be asked by a beginner user of FLCS. The last part of the text reviews other techniques closely related to FLCS. The generalization of the idea of FLCS paves the way for further promising application of the principle of statistical filtering of signals. Specifically, the idea of fluorescence spectral correlation spectroscopy is here outlined.

IJMS, Vol. 13, Pages 12880-12889: Substrate Temperature Dependent Surface Morphology and Photoluminescence of Germanium Quantum Dots Grown by Radio Frequency Magnetron Sputtering

Posted: 09 Oct 2012 12:00 AM PDT

The visible luminescence from Ge nanoparticles and nanocrystallites has generated interest due to the feasibility of tuning band gap by controlling the sizes. Germanium (Ge) quantum dots (QDs) with average diameter ~16 to 8 nm are synthesized by radio frequency magnetron sputtering under different growth conditions. These QDs with narrow size distribution and high density, characterized using atomic force microscopy (AFM) and field emission scanning electron microscopy (FESEM) are obtained under the optimal growth conditions of 400 °C substrate temperature, 100 W radio frequency powers and 10 Sccm Argon flow. The possibility of surface passivation and configuration of these dots are confirmed by elemental energy dispersive X-ray (EDX) analysis. The room temperature strong visible photoluminescence (PL) from such QDs suggests their potential application in optoelectronics. The sample grown at 400 °C in particular, shows three PL peaks at around ~2.95 eV, 3.34 eV and 4.36 eV attributed to the interaction between Ge, GeOx manifesting the possibility of the formation of core-shell structures. A red shift of ~0.11 eV in the PL peak is observed with decreasing substrate temperature. We assert that our easy and economic method is suitable for the large-scale production of Ge QDs useful in optoelectronic devices.

Molecules, Vol. 17, Pages 11920-11930: Chemical Genetics — A Versatile Method to Combine Science and Higher Level Teaching in Molecular Genetics

Posted: 09 Oct 2012 12:00 AM PDT

Phosphorylation is a key event in many cellular processes like cell cycle, transformation of environmental signals to transcriptional activation or polar growth. The chemical genetics approach can be used to analyse the effect of highly specific inhibition in vivo and is a promising method to screen for kinase targets. We have used this approach to study the role of the germinal centre kinase Don3 during the cell division in the phytopathogenic fungus Ustilago maydis. Due to the easy determination of the don3 phenotype we have chosen this approach for a genetic course for M.Sc. students and for IMPRS (International Max-Planck research school) students. According to the principle of "problem-based learning" the aim of this two-week course is to transfer knowledge about the broad spectrum of kinases to the students and that the students acquire the ability to design their own analog-sensitive kinase of interest. In addition to these training goals, we benefit from these annual courses the synthesis of basic constructs for genetic modification of several kinases in our model system U. maydis.

Worm Air - Screenshots

Posted: 09 Oct 2012 03:46 AM PDT

East vs West: A Hearts of Iron Game - Screenshots

Posted: 09 Oct 2012 03:51 AM PDT

Features:
Choose your game style: Lead any nation in the Post-World War II Era and expand your nation's influence while the tension rises

Keep a watchful eye on the world: Experience a rich 3D topographic map that allows deep strategic decisions

Take control by all means: Use Diplomacy, Politics, Economy and Espionage to influence the policies of other nations or just outsmart the others in the new economical system.

Spy on your opponents: Make good use of your superspies from a collection of Spy Cards

Get support from United Nations: If all else fails, bring your issues in front of the UN General Assembly and hope for a resolution to pass

Feel the pressure when the Doomsday clock rises: Do you push another issue to get more prestige, or will you back down to prevent an escalation to a possible World War III?

Take part of the arms race: Fight globally for Ideological Domination and challenge the dynamic military AI. Wage war, secure resources and make sure to control your military production so you are prepared for the worst possible outcome – a global nuclear war.

Explore a flexible technology system - Research new technologies to give your nation technological superiority and nuclear supremacy. Take part in the exciting space race or try to develop your own nuclear defense systems.

Control the land, air, sea and beyond: Explore the Strategic warfare system to crush your enemies if the situation arises or use guerillas to do the job for you. Freely customize your ships for your own personal strategies in the brand new naval editor.

Relive history or change it: Experience historical accuracy that offers unparalleled level of freedom of choice and a large re-playability value
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Golden Joystick Awards 2012: Best Mobile/Tablet category – who are you voting for?

Posted: 09 Oct 2012 02:33 AM PDT

As voting for the Golden Joystick Awards 2012 enters its final weeks, we take a look at each of the individual categories. Today is the turn of Best

Rocketbirds: Hardboiled Chicken - Screenshots

Posted: 09 Oct 2012 03:20 AM PDT

Fact sheet pending.

Molecules, Vol. 17, Pages 11897-11919: Evaluation of the Antioxidant and Anti-glication Effects of the Hexane Extract from Piper auritum Leaves in Vitro and Beneficial Activity on Oxidative Stress and Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats

Posted: 09 Oct 2012 12:00 AM PDT

The aim of this study was to investigate the antioxidant activity of hexane extracts from leaves of Piper auritum (HS). Eight complementary in vitro test methods were used, including inhibition of DPPH· radicals, nitric oxide, superoxide anion, ion-chelating, ABTS, oxygen radical absorbance capacity, β-carotene bleaching and peroxy radical scavenging. The results indicated that HS possesses high antioxidant activity. To add to these finding we tested the effect against oxidative stress in liver, pancreas and kidney in diabetic rats. Low levels of SOD, CAT, GPx and GSH in diabetic rats were reverted to near normal values after treatment with HS. These results suggest that P. auritum prevents oxidative stress, acting as a suppressor of liver cell damage. Given the link between glycation and oxidation, we proposed that HS might possess significant in vitro antiglycation activity. Our data confirmed the inhibitory effect of HS on bovine serum albumin, serum glycosylated protein, glycation of LDL, and glycation hemoglobin. The effect of HS on diabetic renal damage was investigated using streptozotocin-induced diabetic rats. The oral administration of HS at a dose of 200 and 400 mg/kg body weight/day for 28 days significantly reduced advanced glycation endproduct (AGE) formation, elevated renal glucose and thiobarbituric acid-reactive substance levels in the kidneys of diabetic rats. This implies that HS would alleviate the oxidative stress under diabetes through the inhibition of lipid peroxidation. These findings indicate that oxidative stress is increased in the diabetic rat kidney and that HS can prevent renal damage associated with diabetes by attenuating the oxidative stress.

Molecules, Vol. 17, Pages 11877-11896: Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation

Posted: 09 Oct 2012 12:00 AM PDT

A series of novel glycol-clusters containing sulfonated N-acetyl-D-glucosamine (GlcNAc) have been synthesized using click chemistry. Three dendrimers with aromatic dendrons were synthesized using chlorination, azidation and click chemistries. The resulting dendrimers were modified with azide-terminated sulfonated GlcNAc using click chemistry. The sulfonated dendrimers showed affinity for proteins, including the lectin wheat germ agglutinin and amyloid beta peptide (1-42). The dendrimers of G1 and G2 in particular showed the largest affinity for the proteins. The addition of the sulfonated GlcNAc dendrimers of G1 and G2 exhibited an inhibition effect on the aggregation of the amyloid beta peptide, reduced the b-sheet conformation, and led to a reduction in the level of nanofiber formation.

Pharmaceutics, Vol. 4, Pages 517-530: Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers

Posted: 09 Oct 2012 12:00 AM PDT

Numerous publications have reported the significant pharmacodynamic activity of Curcumin (CRM) despite low or undetectable levels in plasma. The objective of the present study was to perform a detailed pharmacokinetic evaluation of CRM after the oral administration of a highly bioavailable lipidic formulation of CRM (CRM-LF) in human subjects. Cmax, Tmax and AUC0–¥ were found to be 183.35 ± 37.54 ng/mL, 0.60 ± 0.05 h and 321.12 ± 25.55 ng/mL respectively, at a dose of 750 mg. The plasma profile clearly showed three distinct phases, viz., absorption, distribution and elimination. A close evaluation of the primary pharmacokinetic parameters provided valuable insight into the behavior of the CRM after absorption by CRM-LF. CRM-LF showed a lag time (Tlag) of 0.18 h (around 12 min). Pharmacokinetic modeling revealed that CRM-LF followed a two-compartment model with first order absorption, lag time and first order elimination. A high absorption rate constant (K01, 4.51/h) signifies that CRM-LF ensured rapid absorption of the CRM into the central compartment. This was followed by the distribution of CRM from the central to peripheral compartment (K12, 2.69/h). The rate of CRM transfer from the peripheral to central compartment (K21, 0.15/h) was slow. This encourages higher tissue levels of CRM as compared with plasma levels. The study provides an explanation of the therapeutic efficacy of CRM, despite very low/undetectable levels in the plasma.

Viruses, Vol. 4, Pages 2016-2030: Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

Posted: 09 Oct 2012 12:00 AM PDT

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

Axioms, Vol. 1, Pages 291-323: The Hecke Bicategory

Posted: 09 Oct 2012 12:00 AM PDT

We present an application of the program of groupoidification leading up to a sketch of a categorification of the Hecke algebroid—the category of permutation representations of a finite group. As an immediate consequence, we obtain a categorification of the Hecke algebra. We suggest an explicit connection to new higher isomorphisms arising from incidence geometries, which are solutions of the Zamolodchikov tetrahedron equation. This paper is expository in style and is meant as a companion to Higher Dimensional Algebra VII: Groupoidification and an exploration of structures arising in the work in progress, Higher Dimensional Algebra VIII: The Hecke Bicategory, which introduces the Hecke bicategory in detail.

Molecules, Vol. 17, Pages 11864-11876: Pumpkin (Cucurbita moschata) Fruit Extract Improves Physical Fatigue and Exercise Performance in Mice

Posted: 09 Oct 2012 12:00 AM PDT

Pumpkin (Cucurbita moschata) is a popular and nutritious vegetable consumed worldwide. The overall purpose of this study was to evaluate the effects of C. moschata fruit extract (CME) on anti-fatigue and ergogenic functions following physiological challenges. Male ICR mice from four groups designated vehicle, CME-50, CME-100 and CME-250, respectively (n = 8 per group in each test) were orally administered CME for 14 days at 0, 50, 100 and 250 mg/kg/day. The anti-fatigue activity and exercise performance were evaluated using exhaustive swimming time, forelimb grip strength, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. The resting muscular and hepatic glycogen was also analyzed after 14-day supplementation with CME. Trend analysis revealed that CME treatments increased grip strength. CME dose-dependently increased 5% body weight loaded swimming time, blood glucose, and muscular and hepatic glycogen levels. CME dose-dependently decreased plasma lactate and ammonia levels and creatine kinase activity after a 15-min swimming test. The mechanism was relevant to the increase in energy storage (as glycogen) and release (as blood glucose), and the decrease of plasma levels of lactate, ammonia, and creatine kinase. Therefore, CME may be potential for the pharmacological effect of anti-fatigue.

Penguins Attack 4

Posted: 09 Oct 2012 01:39 AM PDT

The evil penguin invaders are coming and it's up to you and your defense towers to do stop them, will you prevail?
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