Games |
- iBackup Viewer 1.40 - Browse and manage iPhone backups.. (Free)
- AppShelf 2.3.5 - Keep track of your software registrations and serial numbers.. (Shareware)
- CatHide 0.9.1 - Build games compatible with many operating systems.. (Demo)
- Sony sues Kevin Butler actor and Bridgestone after Kevin Butler actor appears in Nintendo-related Bridgestone ad
- Ondesoft iTunes Converter 1.25.1 - Unlock DRM-protected music files.. (Shareware)
- Sensors, Vol. 12, Pages 13480-13490: Design of a New Sensor for Determination of the Effects of Tractor Field Usage in Southern Spain: Soil Sinkage and Alterations in the Cone Index and Dry Bulk Density
- Ondesoft AudioBook Converter 1.25.1 - Convert your audio books to MP3 or AAC.. (Shareware)
- Sensors, Vol. 12, Pages 13471-13479: A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles
- IJMS, Vol. 13, Pages 12773-12856: Theoretical Models for Surface Forces and Adhesion and Their Measurement Using Atomic Force Microscopy
- IJMS, Vol. 13, Pages 12761-12772: Proteins of Unknown Function in the Protein Data Bank (PDB): An Inventory of True Uncharacterized Proteins and Computational Tools for Their Analysis
- Call of Duty: Black Ops Declassified - Activision says "No" to Zombies mode
- IJMS, Vol. 13, Pages 12747-12760: Protective Effect of Tulbaghia violacea Harv. on Aortic Pathology, Tissue Antioxidant Enzymes and Liver Damage in Diet-Induced Atherosclerotic Rats
- Molecules, Vol. 17, Pages 11748-11762: Optimization of Ultrasound-Assisted Extraction of Crude Oil from Winter Melon (Benincasa hispida) Seed Using Response Surface Methodology and Evaluation of Its Antioxidant Activity, Total Phenolic Content and Fatty Acid Composition
- Molecules, Vol. 17, Pages 11729-11747: Mechanical, Thermal and Morphological Properties of Poly(lactic acid)/Epoxidized Palm Olein Blend
- Metabolites, Vol. 2, Pages 648-666: Structural Identification of O-Linked Oligosaccharides Using Exoglycosidases and MSn Together with UniCarb-DB Fragment Spectra Comparison
- With Ligambi trial, will feds kneecap the mob?
- Pathogens, Vol. 1, Pages 65-82: Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors
- Forests, Vol. 3, Pages 896-902: Plant Invasions: Symptoms and Contributors Rather Than Causes of Environmental Degradation
- Religions, Vol. 3, Pages 922-949: The New Internationalists: World Vision and the Revival of American Evangelical Humanitarianism, 1950–2010
- Pharmaceutics, Vol. 4, Pages 501-516: Development Strategies for Herbal Products Reducing the Influence of Natural Variance in Dry Mass on Tableting Properties and Tablet Characteristics
| iBackup Viewer 1.40 - Browse and manage iPhone backups.. (Free) Posted: 08 Oct 2012 03:43 AM PDT  iBackup Viewer manages to extract information from iPhone / iPad backups, including contacts, call history, SMS messages, Web visits, website bookmarks, photos and iPhone Apps. How does it work? iTunes backs up iPhone and iPad contents into unreadable database and files. This makes it difficult to get necessary information for the backed up files. iBackup Viewer does load and parse the iPhone backups, and extract those useful data, and convert them to readable format for viewing. What can iBackup Viewer do? With iBackup Viewer, you can get most of the important and useful data from iOS backups, including:
Version 1.40:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| AppShelf 2.3.5 - Keep track of your software registrations and serial numbers.. (Shareware) Posted: 08 Oct 2012 03:30 AM PDT  AppShelf is for you if you've bought apps in the last several months - or even years ago - and now have no idea where the serial number is. Have you ever found yourself digging through archived emails in search of registration info? With AppShelf you can bundle all the "stuff" related to a software purchase into one place. It's easy, just drag and drop! |
| CatHide 0.9.1 - Build games compatible with many operating systems.. (Demo) Posted: 08 Oct 2012 03:38 AM PDT  CatHide is a cross-platform mobile development tool. It uses a modified version of the Cocos2d-x library to allow developers to build games for iOS, Android, Blackberry QNX and WebOS from a single codebase and with a single click. I features its own built in simulator for testing the apps and can deploy to various platform specific simulators and devices for real life testing. The software is in beta form and is free to download and try for 30 days. The trial period will be reset with new updates until the product reaches release status. During the beta period, it can be purchased for a discounted price of $29.99. After the beta period, the price will be $49.95. A tutorial on the basics of using CatHide and its version of Cocos2d-x is available on the website. More tutorials are planned.
This posting includes an audio/video/photo media file: Download Now |
| Posted: 08 Oct 2012 03:34 AM PDT It was perhaps inevitable. Sony is now officially suing both Bridgestone Tires and the company owned by Kevin Butler actor Jerry Lawler over Lawler's |
| Ondesoft iTunes Converter 1.25.1 - Unlock DRM-protected music files.. (Shareware) Posted: 08 Oct 2012 03:08 AM PDT  Ondesoft iTunes Converter is designed to convert iTunes DRM-protected music files or audio books to unprotected MP3 or AAC files in batch with ID tags preserved. In addition, the iTunes-to-MP3 Converter extracts audio from iTunes video files and saves it in all the most common audio types. It is also an M4P-to-MP3 converter and Audible-AA-files-to-MP3 converter. Features:
Version 1.25.1:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 08 Oct 2012 12:00 AM PDT Variations in sinkage and cone index are of crucial importance when planning fieldwork, and for determining the trafficability of farm machinery. Many studies have highlighted the link between higher values of these parameters and dramatic decreases in crop yield. Variations in the dry bulk density and cone index of clayey soil in Southern Spain were measured following each of five successive passes over the same land with the three types of tractor most widely used in the area (tracked, two-wheel drive and four-wheel drive). In addition, sinkage (rut depth) of the running gear was measured using a laser microrelief profile meter. This device, which integrates three sensors, was specifically designed for these experiments, as was an electrical penetrometer to determine the cone index, and both instruments proved reliable and accurate in the field. The main goal of this study was to design, manufacture and test these new devices. The first pass caused most soil alteration when compared to successive passes for all types of tractor tested and soil conditions prevailing during the tests. (Heavier) four-wheel drive tractors were found to cause greater soil damage (sinkage, cone index and dry bulk density) than two-wheel drive and track tractors. There was no statistically significant difference between the two latter types. The greatest alterations were recorded in the top 10 cm of the soil. The results show that soil compaction should be avoided as much as possible. This can be achieved by ensuring that tractors always travel along the same tracks, especially in the wet season. At present these aspects are not considered by farmers in this area. |
| Ondesoft AudioBook Converter 1.25.1 - Convert your audio books to MP3 or AAC.. (Shareware) Posted: 08 Oct 2012 03:04 AM PDT  Ondesoft AudioBook Converter is an AA converter that can batch convert purchased Audio books or AA flies from iTunes or Audible on Mac OS X to MP3 or AAC format. Then DRM protections on audio book will be removed. The conversion with CD output quality is at up to 16x speeds! Convert purchased Audio Book playable on iTunes Convert audible aa to MP3 to Play anywhere Remove DRM protections 16X conversion speed Preserve ID Tags Output MP3 or AAC files with CD Quality Convert DRM audiobooks in batch Silent Recording Quick access to iTunes folder Unlimited converting times Version 1.25.1:
This posting includes an audio/video/photo media file: Download Now |
| Posted: 08 Oct 2012 12:00 AM PDT CD105 is a well-known tumor metastasis marker and useful for early monitoring of metastasis and cancer relapse. It is important to generate rapid, reliable and precise analytical information regarding CD105 levels. To establish a simple, selective and sensitive detection method, we prepared an immunosensor with novel bioconjugates based on Pt nanoparticles, thionin acetate and antibodies. The proposed immunosensor displayed a broader linear response to CD105, with a working range of 1.3 to 200.0 ng/mL and a detection limit of 0.9 ng/mL under optimal conditions. Moreover, the studied immunosensor exhibited high sensitivity, fast analysis and adequate stability. The proposed methodology could readily be extended to other clinical- or environment-related biospecies. |
| Posted: 08 Oct 2012 12:00 AM PDT The increasing importance of studies on soft matter and their impact on new technologies, including those associated with nanotechnology, has brought intermolecular and surface forces to the forefront of physics and materials science, for these are the prevailing forces in micro and nanosystems. With experimental methods such as the atomic force spectroscopy (AFS), it is now possible to measure these forces accurately, in addition to providing information on local material properties such as elasticity, hardness and adhesion. This review provides the theoretical and experimental background of afs, adhesion forces, intermolecular interactions and surface forces in air, vacuum and in solution. |
| Posted: 08 Oct 2012 12:00 AM PDT Proteins of uncharacterized functions form a large part of many of the currently available biological databases and this situation exists even in the Protein Data Bank (PDB). Our analysis of recent PDB data revealed that only 42.53% of PDB entries (1084 coordinate files) that were categorized under "unknown function" are true examples of proteins of unknown function at this point in time. The remainder 1465 entries also annotated as such appear to be able to have their annotations re-assessed, based on the availability of direct functional characterization experiments for the protein itself, or for homologous sequences or structures thus enabling computational function inference. |
| Call of Duty: Black Ops Declassified - Activision says "No" to Zombies mode Posted: 08 Oct 2012 02:30 AM PDT Activision has confirmed Vita shooter Call of Duty: Black Ops Declassified won't feature Zombies mode. In response to questions about the presence of |
| Posted: 08 Oct 2012 12:00 AM PDT The protective effect Tulbaghia violacea rhizomes (TVR) against derangements in serum lipid profile, tissue antioxidant enzyme depletion, endothelium dysfunction and histopathological changes in the aorta and liver of rats fed with an atherosclerogenic (Ath) diet (4% cholesterol, 1% cholic acid and 0.5% thiouracil) was investigated in this study. Co-treatment with the TVR extracts (250 and 500 mg/kg body weight for two weeks significantly (p < 0.05) protected against elevated serum triglyceride (TG), total cholesterol (TC), LDL-cholesterol, VLDL-cholesterol and decreased HDL-cholesterol in a dose-dependent manner when compared with the atherogenic control. The extracts also reduced (p < 0.05) elevated thiobabutric reacting substance (TBARS) and reversed endothelial dysfunction parameters (fibrinogen and total NO levels) and tissue antioxidant enzyme activities to near normal. The protective ability of the extract was confirmed by the significant (p < 0.05) reduction in the activities of serum markers of liver (LDH, AST, ALT, ALP, bilirubin) and kidney damage (creatinine and bilirubin) in extract-treated groups compared with the atherogenic control group. Also, histopathology evaluations of aorta sections revealed that the extracts protected against the development of fatty streak plaques (aorta) and fatty changes in hepatocytes. The observed activities of the extracts compared favorably with standard drug atorvastatin. Our study thus showed that the methanolic extract of TVR could protect against the early onset of atherosclerosis. |
| Posted: 08 Oct 2012 12:00 AM PDT In the present study, ultrasound-assisted extraction of crude oil from winter melon seeds was investigated through response surface methodology (RSM). Process variables were power level (25–75%), temperature (45–55 °C) and sonication time (20–40 min). It was found that all process variables have significant (p < 0.05) effects on the response variable. A central composite design (CCD) was used to determine the optimum process conditions. Optimal conditions were identified as 65% power level, 52 °C temperature and 36 min sonication time for maximum crude yield (108.62 mg-extract/g-dried matter). The antioxidant activity, total phenolic content and fatty acid composition of extract obtained under optimized conditions were determined and compared with those of oil obtained by the Soxhlet method. It was found that crude extract yield (CEY) of ultrasound-assisted extraction was lower than that of the Soxhlet method, whereas antioxidant activity and total phenolic content of the extract obtained by ultrasound-assisted extraction were clearly higher than those of the Soxhlet extract. Furthermore, both extracts were rich in unsaturated fatty acids. The major fatty acids of the both extracts were linoleic acid and oleic acid. |
| Posted: 08 Oct 2012 12:00 AM PDT Poly(lactic acid) (PLA) is known to be a useful material in substituting the conventional petroleum-based polymer used in packaging, due to its biodegradability and high mechanical strength. Despite the excellent properties of PLA, low flexibility has limited the application of this material. Thus, epoxidized palm olein (EPO) was incorporated into PLA at different loadings (1, 2, 3, 4 and 5 wt%) through the melt blending technique and the product was characterized. The addition of EPO resulted in a decrease in glass transition temperature and an increase of elongation-at-break, which indicates an increase in the PLA chain mobility. PLA/EPO blends also exhibited higher thermal stability than neat PLA. Further, the PLA/1 wt% EPO blend showed enhancement in the tensile, flexural and impact properties. This is due to improved interaction in the blend producing good compatible morphologies, which can be revealed by Scanning Electron Microscopy (SEM) analysis. Therefore, PLA can be efficiently plasticized by EPO and the feasibility of its use as flexible film for food packaging should be considered. |
| Posted: 08 Oct 2012 12:00 AM PDT The availability of specific exoglycosidases alongside a spectral library of O-linked oligosaccharide collision induced dissociation (CID) MS fragments, UniCarb-DB, provides a pathway to make the elucidation of O-linked oligosaccharides more efficient. Here, we advise an approach of exoglycosidase-digestion of O-linked oligosaccharide mixtures, for structures that do not provide confirmative spectra. The combination of specific exoglycosidase digestion and MS2 matching of the exoglycosidase products with structures from UniCarb-DB, allowed the assignment of unknown structures. This approach was illustrated by treating sialylated core 2 O-linked oligosaccharides, released from the human synovial glycoprotein (lubricin), with a α2–3 specific sialidase. This methodology demonstrated the exclusive 3 linked nature of the sialylation of core 2 oligosaccharides on lubricin. When specific exoglycosidases were not available, MS3 spectral matching using standards was used. This allowed the unusual 4-linked terminal GlcNAc epitope in a porcine stomach to be identified in the GlcNAc1-4Galb1–3(GlcNAcb1-6)GalNAcol structure, indicating the antibacterial epitope GlcNAca1–4. In total, 13 structures were identified using exoglycosidase and MSn, alongside UniCarb-DB fragment spectra comparison. UniCarb-DB could also be used to identify the specificity of unknown exoglycosidases in human saliva. Endogenous salivary exoglycosidase activity on mucin oligosaccharides could be monitored by comparing the generated tandem MS spectra with those present in UniCarb-DB, showing that oral exoglycosidases were dominated by sialidases with a higher activity towards 3-linked sialic acid rather than 6-linked sialic acid. |
| With Ligambi trial, will feds kneecap the mob? Posted: 08 Oct 2012 12:51 AM PDT JURY SELECTION begins Tuesday in the racketeering trial of reputed acting Philadelphia mob boss Joseph "Uncle Joe" Ligambi and six lieutenants. |
| Posted: 08 Oct 2012 12:00 AM PDT We previously proved that a histone deacetylase inhibitor (valproate, VPA) decreases the number of leukemic cells in bovine leukemia virus (BLV)-infected sheep. Here, we characterize the mechanisms initiated upon interruption of treatment. We observed that VPA treatment is followed by a decrease of the B cell counts and proviral loads (copies per blood volume). However, all sheep eventually relapsed after different periods of time and became refractory to further VPA treatment. Sheep remained persistently infected with BLV. B lymphocytes isolated throughout treatment and relapse were responsive to VPA-induced apoptosis in cell culture. B cell proliferation is only marginally affected by VPA ex vivo. Interestingly, in four out of five sheep, ex vivo viral expression was nearly undetectable at the time of relapse. In two sheep, a new tumoral clone arose, most likely revealing a selection process exerted by VPA in vivo. We conclude that the interruption of VPA treatment leads to the resurgence of the leukemia in BLV-infected sheep and hypothesize that resistance to further treatment might be due to the failure of viral expression induction. The development of more potent HDAC inhibitors and/or the combination with other compounds can overcome chemoresistance. These observations in the BLV model may be important for therapies against the related Human T-lymphotropic virus type 1. |
| Posted: 08 Oct 2012 12:00 AM PDT Native or exotic woody plants can proliferate in dry and moist eucalypt ecosystems shading out many other native species, contributing to chronic decline of eucalypts and reinforcing unnatural fire regimes and nutrient cycling processes. Whether native or exotic, they proliferate as a consequence of disturbances which impact directly on these ecosystems. The most extensive ongoing disturbance since European occupation of Australia has been the disruption of frequent mild burning by humans. This burning maintained dynamically stable nutrient cycling processes and a competitive balance in dry and moist eucalypt systems and prevented plant "invasions". |
| Posted: 08 Oct 2012 12:00 AM PDT International relief and development agencies consistently rank among the largest evangelical organizations, and in recent decades, they have gained increased exposure and influence within the greater humanitarian community. World Vision, the largest evangelical agency, is also the largest Christian humanitarian organization in the world. Themes of politics and culture wars have led many to scholars to categorize American evangelicals into distinct conservative and liberal parties. Yet the history of American evangelicals' humanitarianism demonstrates how they often resisted such dichotomies. As evangelical humanitarian agencies expanded exponentially over the past five decades, they came to embrace a "holistic gospel" that helped shape evangelical mission debates concerning the relationship between evangelism and social action; they engaged international evangelicals that forced Americans to reconsider their own categories; and many modeled a practical ecumenism that allowed evangelicals to expand beyond a limited subculture to work alongside other religious and even secular NGOs. While other evangelical progressives fragmented over identity politics or remained tethered to small alterative communities, the leading aid agencies have achieved broad support across evangelicalism, making them some of the most influential voices. |
| Posted: 08 Oct 2012 12:00 AM PDT One "Quality by Design" approach is the focus on the variability of the properties of the active substance. This is crucially important for active substances that are obtained from natural resources such as herbal plant material and extracts. In this paper, we present various strategies for the development of herbal products especially taking into account the natural batch-to-batch variability (mainly of the dry mass) of tablets that contain a fixed amount of tincture. The following steps in the development have been evaluated for the outcome of the physico-chemical properties of the resulting tablets and intermediates: concentration of the tincture extracted from Echinacea fresh plant, loading of the concentrate onto an inert carrier, the respective wet granulation and drying step, including milling, and the adjuvant excipients for the tablet compression step. The responses that were investigated are the mean particle size of the dried and milled granulates, compaction properties and disintegration time of the tablets. Increased particle size showed a significant increase of the disintegration time and a decrease of the compaction properties. In addition, our results showed that the particle size has a great dependency on the ratio of liquid to carrier during the wet granulation process. Thus, the variability of the respective parameters tested was influenced by the performed strategies, which is how the tincture correlated to its dry mass and the relation of the amount of carrier used. In order to optimize these parameters, a strategy considering the above-mentioned points has to be chosen. |
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