понедельник, 10 декабря 2012 г.

Games

Games

Toxins, Vol. 4, Pages 1468-1481: A Saccharomyces cerevisiae Wine Strain Inhibits Growth and Decreases Ochratoxin A Biosynthesis by Aspergillus carbonarius and Aspergillus ochraceus

Posted: 10 Dec 2012 12:00 AM PST

The aim of this study was to select wine yeast strains as biocontrol agents against fungal contaminants responsible for the accumulation of ochratoxin A (OTA) in grape and wine and to dissect the mechanism of OTA detoxification by a Saccharomyces cerevisiae strain (DISAABA1182), which had previously been reported to reduce OTA in a synthetic must. All of the yeast strains tested displayed an ability to inhibit the growth of Aspergillus carbonarius both in vivo and in vitro and addition of culture filtrates from the tested isolates led to complete inhibition of OTA production. S. cerevisiae DISAABA1182 was selected and further tested for its capacity to inhibit OTA production and pks (polyketide synthase) transcription in A. carbonarius and Aspergillus ochraceus in vitro. In order to dissect the mechanism of OTA detoxification, each of these two fungi was co-cultured with living yeast cells exposed to yeast crude or to autoclaved supernatant: S. cerevisiae DISAABA1182 was found to inhibit mycelial growth and OTA production in both Aspergilli when co-cultured in the OTA-inducing YES medium. Moreover, a decrease in pks transcription was observed in the presence of living cells of S. cerevisiae DISAABA1182 or its supernatant, while no effects were observed on transcription of either of the constitutively expressed calmodulin and β-tubulin genes. This suggests that transcriptional regulation of OTA biosynthetic genes takes place during the interaction between DISAABA1182 and OTA-producing Aspergilli.

OnyX 2.6.5b2 - Maintenance and optimization tool.. (Free)

Posted: 10 Dec 2012 03:23 AM PST



OnyX is a multifunctional utility for Mac OS X. It allows you to verify the startup disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock, Spotlight, and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more.

Version 2.6.5b2: Release notes were unavailable when this listing was updated.

  • OS X 10.8 only
  • 64-bit processor


Download Now

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Graphmatica 2.2.2 - Equation plotter.. (Demo)

Posted: 10 Dec 2012 02:59 AM PST



Graphmatica is a powerful, easy-to-use, equation plotter with numerical and calculus features. Graph Cartesian functions, relations, and inequalities, plus polar, parametric, and ordinary differential equations. Numerically solve and graphically display tangent lines and integrals. Find critical points, solutions to equations, and intersections between Cartesian functions. In summary, a great tool for students and teachers of anything from high-school algebra through college calculus.

Version 2.2.2: Release notes were unavailable when this listing was updated.

Mac OS X 10.6 or later

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Ask Marilyn: Ignoring Evacuation Orders

Posted: 10 Dec 2012 02:16 AM PST

Don Benson of Chicago writes : Marilyn: With modern weather-prediction technology, we can give endangered residents plenty of warning ahead of a hurricane.

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Color Alchemy

Posted: 09 Dec 2012 10:12 PM PST

Platform: iOS, Android — Color Alchemy Color Alchemy is a sparsely-styled mobile puzzle game from Element Modulus that challenges your ability to mix, split and alter beams of color. By dragging paths and adding special tiles to manipulate colors, you'll create some complex scenes that look like a truck carrying rainbows crashed into a Skittles factory. Just, you know, not as tragic. And with loads of levels and some painfully mind-bending puzzles, you've definitely got your work cut out for you. Tagged as: android, elementmodulus, game, ios, ipad, iphone, logic, mobile, puzzle, rating-g, tablet

Colonel Cortez Party - Grand Theft Auto: Vice City iOS Gameplay

Posted: 10 Dec 2012 02:07 AM PST

Time to pay Colonel Cortez a visit, but not before smartening up for the occasion.

 

Read and Post Comments | Get the full article at GameSpot

"Colonel Cortez Party - Grand Theft Auto: Vice City iOS Gameplay" was posted by markwalton on Mon, 10 Dec 2012 02:07:44 -0800

Opening Cut Scene - Grand Theft Auto: Vice City iOS Gameplay

Posted: 10 Dec 2012 02:05 AM PST

Want to know what GTA: VIce City looks like on iOS? Check out this clip of the opening sequence.

 

Read and Post Comments | Get the full article at GameSpot

"Opening Cut Scene - Grand Theft Auto: Vice City iOS Gameplay" was posted by markwalton on Mon, 10 Dec 2012 02:05:42 -0800

Day9 talks about NASL Season 4 Finals, HoTS and more

Posted: 10 Dec 2012 01:33 AM PST

Slasher catches up with Day9 as they clean out the theater after an exciting award ceremony.

 

Read and Post Comments | Get the full article at GameSpot

"Day9 talks about NASL Season 4 Finals, HoTS and more" was posted by erickt on Mon, 10 Dec 2012 01:33:20 -0800

Gretorp and Frodan share their thoughts about the NASL S4 Finals

Posted: 10 Dec 2012 01:31 AM PST

Slasher catches up with the caster combo Gretorp and Frodan to learn more about their thoughts on the finals, HoTS, 2012, predictions and more.

 

Read and Post Comments | Get the full article at GameSpot

"Gretorp and Frodan share their thoughts about the NASL S4 Finals" was posted by erickt on Mon, 10 Dec 2012 01:31:06 -0800

NASL Season 4 Champion Interview

Posted: 10 Dec 2012 01:28 AM PST

Slasher catches up with the Season 4 champion after the award ceremony to learn more about the matches.

 

Read and Post Comments | Get the full article at GameSpot

"NASL Season 4 Champion Interview" was posted by erickt on Mon, 10 Dec 2012 01:28:56 -0800

AU Shippin’ Out December 10-14: Marvel Avengers: Battle for Earth

Posted: 09 Dec 2012 10:26 PM PST

Avengers assemble! The Marvel and Disney universes are yours to explore in this week's new releases. Who will you assist?

 

Will you assemble the Avengers team and defend Earth or side with iconic Disney characters to unlock the power of two?

Wii U owners will be happy to see more games for the console available for sale this week. Marvel Avengers: Battle for Earth is a game inspired by the iconic Marvel comics and is based on the Secret Invasion storyline.

Developed by Ubisoft Quebec, the third-person action game features twenty playable characters from the Marvel universe, including characters that did not appear in The Avengers film.

Each character possesses four unique super powers that can be executed via the Wii U's touch-enabled gamepad. The game offers a variety of modes for play, including co-operative, campaign, arcade, and versus.

Disney Interactive Studios' new game Epic Mickey 2: The Power of Two will also be out on the Wii U this week. Sequel to the 2010 Wii-exclusive Disney Epic Mickey, the game boasts a co-op mode, full voice acting, and a tilt toward music. Players will be able to assume the role of Mickey Mouse or Oswald the Lucky Rabbit as they work together to combat a new enemy.

Spector spoke out against the game industry's focus on shooters and violence earlier this year, so expect co-operative family-friendly fun.

Don't own a Wii U? PC expansion Tropico 4: Modern Times will be on sale this week. Modern Times is an expansion to 2011's simulation game, Tropico 4, in which players took on the responsibility of constructing and managing islands from the ground up.

Tropico 4: Modern Times features a new single-player campaign that takes place a year after the events of the original title. Players once again assume the role of El Presidente, and must modernise their island nation whilst battling opposing forces.

Other titles out this week include Pro Evolution Soccer 2013 3D and Sonic & All-Stars Racing Transformed for the PlayStation Vita. Check out the full list of new releases below.

December 13, 2012
Disney Epic Mickey 2: The Power of Two (Wii U)
Kylie: Sing & Dance (Wii)
Marvel Avengers: Battle for Earth (Wii U)
Pro Evolution Soccer 2013 3D (3DS)
Sonic & All-Stars Racing Transformed (Vita)
Tropico 4: Modern Times (PC)

Read and Post Comments | Get the full article at GameSpot

"AU Shippin' Out December 10-14: Marvel Avengers: Battle for Earth" was posted by Zorine Te on Sun, 09 Dec 2012 22:26:28 -0800

Valve preparing living room PCs to compete with next-gen - Report

Posted: 09 Dec 2012 09:50 PM PST

Gabe Newell says he expects to see PC packages for the living room running Steam for TVs as early as next year; says this set-up will compete with next-gen hardware from Sony and Microsoft.

Valve co-founder and managing director Gabe Newell has revealed his expectations for custom PC packages that will allow users to run Steam from their living room TV sets as early as next year.

Speaking to Kotaku, Newell said these PC packages would compete with next-generation consoles from Sony and Microsoft.

Newell told the site that Valve would be looking to develop these kinds of packages, but that other PC companies would jump in as well.

"Certainly our hardware will be a very controlled environment," Newell said. "If you want more flexibility, you can always buy a more general purpose PC. For people who want a more turnkey solution, that's what some people are really gonna want for their living room."

Newell also hinted Valve is working on an updated engine which will reportedly work with next-generation consoles.

Valve launched its Steam Big Picture mode earlier this month. The TV interface for Windows and Mac allows users to access and play Steam games on their TV sets.

In March it was reported that Valve is working on a "Steam Box" TV set-top console, said to operate more like a platform along the lines of Google's Android operating system.

Read and Post Comments | Get the full article at GameSpot

"Valve preparing living room PCs to compete with next-gen - Report" was posted by Laura Parker on Sun, 09 Dec 2012 21:50:05 -0800

Super Street Fighter II Turbo Champion Interview

Posted: 09 Dec 2012 08:18 PM PST

Gootecks talks to Damien " Damdai" Dailidenas the champion of the Super Street Fighter II Turbo tournament at the Street Fighter 2 25th Anniversary event.

 

Read and Post Comments | Get the full article at GameSpot

"Super Street Fighter II Turbo Champion Interview" was posted by benitog on Sun, 09 Dec 2012 20:18:35 -0800

Street Fighter III 3rd Strike Champion Interview

Posted: 09 Dec 2012 07:00 PM PST

Gootecks talks to Jo "MOV" Egami, the Street Fighter III 3rd Strike Champion at the Street Fighter 2 25th Anniversary tournament.

 

Read and Post Comments | Get the full article at GameSpot

"Street Fighter III 3rd Strike Champion Interview" was posted by benitog on Sun, 09 Dec 2012 19:00:52 -0800

Molbank, Vol. 2012, Pages M789: 2-Bromophenyl Salicylate

Posted: 10 Dec 2012 12:00 AM PST

2-Bromophenyl salicylate is synthesized from 2-benzyloxybenzoic acid in two steps. The final compound has been characterized by IR, 1H-NMR, 13C-NMR and HRMS. The melting point for 2-bromophenyl salicylate is provided.

Diversity, Vol. 4, Pages 453-574: Aboveground Deadwood Deposition Supports Development of Soil Yeasts

Posted: 10 Dec 2012 12:00 AM PST

Unicellular saprobic fungi (yeasts) inhabit soils worldwide. Although yeast species typically occupy defined areas on the biome scale, their distribution patterns within a single type of vegetation, such as forests, are more complex. In order to understand factors that shape soil yeast communities, soils collected underneath decaying wood logs and under forest litter were analyzed. We isolated and identified molecularly a total of 25 yeast species, including three new species. Occurrence and distribution of yeasts isolated from these soils provide new insights into ecology and niche specialization of several soil-borne species. Although abundance of typical soil yeast species varied among experimental plots, the analysis of species abundance and community composition revealed a strong influence of wood log deposition and leakage of organic carbon. Unlike soils underneath logs, yeast communities in adjacent areas harbored a considerable number of transient (phylloplane-related) yeasts reaching 30% of the total yeast quantity. We showed that distinguishing autochthonous community members and species transient in soils is essential to estimate appropriate effects of environmental factors on soil fungi. Furthermore, a better understanding of species niches is crucial for analyses of culture-independent data, and may hint to the discovery of unifying patterns of microbial species distribution.

JFB, Vol. 3, Pages 879-894: Extracellular Matrix is an Important Component of Limbal Stem Cell Niche

Posted: 10 Dec 2012 12:00 AM PST

Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data suggest that these components are part of the stem cell niche and play a role in the homeostasis of limbal stem cells. The extracellular matrix provides a mechanical and structural support as well as regulates cellular functions such as adhesion, migration, proliferation, self-renewal and differentiation. Optimization of the extracellular matrix components might be able to recreate an ex vivo stem cell niche to expand limbal stem cells.

Pharmaceuticals, Vol. 5, Pages 1372-1392: The Liver as a Target Organ for Gene Therapy: State of the Art, Challenges, and Future Perspectives

Posted: 10 Dec 2012 12:00 AM PST

The liver is a target for gene therapy of inborn errors of metabolism, of hemophilia, and of acquired diseases such as liver cancer and hepatitis. The ideal gene transfer strategy should deliver the transgene DNA to parenchymal liver cells with accuracy and precision in the absence of side effects. Liver sinusoids are highly specialized capillaries with a particular endothelial lining: the endothelium contains open fenestrae, whereas a basal lamina is lacking. Fenestrae provide a direct access of gene transfer vectors to the space of Disse, in which numerous microvilli from parenchymal liver cells protrude. The small diameter of fenestrae in humans constitutes an anatomical barrier for most gene transfer vectors with the exception of adeno-associated viral (AAV) vectors. Recent studies have demonstrated the superiority of novel AAV serotypes for hepatocyte-directed gene transfer applications based on enhanced transduction, reduced prevalence of neutralizing antibodies, and diminished capsid immune responses. In a landmark clinical trial, hemophilia B was successfully treated with an AAV8 human factor IX expressing vector. Notwithstanding significant progress, clinical experience with these technologies remains very limited and many unanswered questions warrant further study. Therefore, the field should continue to progress as it has over the past decade, cautiously and diligently.

IJERPH, Vol. 9, Pages 4606-4614: The Relationship between Skin Symptoms and Allergic Reactions to Asian Dust

Posted: 10 Dec 2012 12:00 AM PST

Asian dust events result from displacement of atmospheric pollutants from the Chinese and Mongolian deserts, causing associated health issues throughout Northeast Asia. We investigated the relationship between skin symptoms in Asian dust events and contact allergy to Asian dust and associated metals. Increases in atmospheric levels of heavy metals such as Ni, Al, and Fe occurred during the severe Asian dust event on March 21, 2010. We conducted a case–control study (n = 62) with patch testing to compare skin symptoms on an Asian dust day with metal allergic reactions. Skin symptoms were observed in 18/62 subjects. Nine subjects with skin symptoms (group A) and 11 without (group B) were patch tested for six metals and Asian dust particles. Metal and dust samples were applied to the subjects’ backs for 2 days and the reactions were scored according to the International Contact Dermatitis Research Group guidelines. Differences in the positive rates between the groups were analyzed. Skin reactions to ferric chloride (p = 0.015), aluminum chloride (p = 0.047), nickel sulfate (p = 0.008), and Asian dust particles (p = 0.047) were more common in group A than in group B. Skin symptoms during Asian dust events may be allergic reactions to Asian dust particle-bound metals.

Chemosensors, Vol. 1, Pages 1-2: Chemosensors — Welcome to a New Open Access Journal Intended to Cover All Aspects of Chemical Sensing

Posted: 10 Dec 2012 12:00 AM PST

It gives me great pleasure to welcome you to Chemosensors, a new online-only journal established by the Multidisciplinary Digital Publishing Institute (MDPI, Basel, Switzerland) with the intent of covering all aspects of chemical sensing. The ability to sense or detect/identify and quantitate a chemical entity, and in particular accomplish this through the use of chemical means, has never been a more important part of our society. Chemosensing permeates diverse fields including healthcare (e.g., blood chemistry analysis), food safety (e.g., detecting contamination and spoilage), environmental monitoring (e.g., air and water quality), product and manufacturing assurance (e.g., purity and efficacy), household safety (e.g., smoke detection), forensics (e.g., drug analysis), and biological research (e.g., quantitating DNA or monitoring intracellular homeostasis), to name but a paltry few areas. Indeed, the application of chemosensing has become such an integrated aspect of modern society that trying to compile a comprehensive list of where it is utilized or relied on is almost impossible. Equally daunting is trying to compile a comprehensive list of all the different sensing techniques, types of analysis, modes of signal transduction, instruments and similar type aspects. The pace of new developments in this field is both remarkable and continuously accelerating with new products and applications being developed on an almost unceasing basis. [...]
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