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- Molecules, Vol. 18, Pages 398-407: Efficient Indium-Mediated Dehalogenation of Aromatics in Ionic Liquid Media
- Toxins, Vol. 5, Pages 25-48: Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP
- Sensors, Vol. 13, Pages 500-515: Repeatability, Reproducibility and Standardisation of a Laser Doppler Imaging Technique for the Evaluation of Normal Mouse Hindlimb Perfusion
- Sensors, Vol. 13, Pages 484-499: Disposable Fluorescence Optical pH Sensor for Near Neutral Solutions
- Sensors, Vol. 13, Pages 463-483: What is a Fresh Scent in Perfumery? Perceptual Freshness is Correlated with Substantivity
- IJMS, Vol. 14, Pages 611-624: Disruption of the Expression of a Non-Coding RNA Significantly Impairs Cellular Differentiation in Toxoplasma gondii
- Polymers, Vol. 5, Pages 1-18: Plastic Degradation and Its Environmental Implications with Special Reference to Poly(ethylene terephthalate)
- Entropy, Vol. 15, Pages 113-143: The Relation between Granger Causality and Directed Information Theory: A Review
- Symmetry, Vol. 5, Pages 1-46: Taylor–Socolar Hexagonal Tilings as Model Sets
- Toxins, Vol. 5, Pages 16-24: Onabotulinumtoxin A for Treating Overactive/Poor Compliant Bladders in Children and Adolescents with Neurogenic Bladder Secondary to Myelomeningocele
- Metals, Vol. 3, Pages 49-57: Permeability of Aluminium Foams Produced by Replication Casting
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- Airfoil 4.7.5 - Send audio from any app to AirPort Express/Apple TV and more.. (Demo)
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| Posted: 28 Dec 2012 12:00 AM PST An efficient indium-mediated dehalogenation reaction of haloaromatics and haloheteroaromatics in ionic liquids has been studied. This method is simple and effective in the presence of [bmim]Br. Furthermore, this methodology is environmentally friendly compared with conventional ones. |
| Posted: 28 Dec 2012 12:00 AM PST Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural properties and functionality. EspP has been used to investigate mechanistic details of autotransport, and recent studies indicate that this transport mechanism is not autonomous but rather dependent on additional factors. Currently, five subtypes have been identified (EspPα-EspPε), with EspPα being associated with highly virulent EHEC serotypes and isolates from patients with severe disease. EspPα has been shown to degrade major proteins of the complement cascade, namely C3 and C5 and probably interferes with hemostasis by cleavage of coagulation factor V. Furthermore, EspPα is believed to contribute to biofilm formation perhaps by polymerization to rope-like structures. Together with the proteolytic activity, EspPα might ameliorate host colonization and interfere with host response. |
| Posted: 28 Dec 2012 12:00 AM PST Background. Preclinical perfusion studies are useful for the improvement of diagnosis and therapy in dermatologic, cardiovascular and rheumatic human diseases. The Laser Doppler Perfusion Imaging (LDPI) technique has been used to evaluate superficial alterations of the skin microcirculation in surgically induced murine hindlimb ischemia. We assessed the reproducibility and the accuracy of LDPI acquisitions and identified several critical factors that could affect LDPI measurements in mice. Methods. Twenty mice were analysed. Statistical standardisation and a repeatability and reproducibility analysis were performed on mouse perfusion signals with respect to differences in body temperature, the presence or absence of hair, the type of anaesthesia used for LDPI measurements and the position of the mouse body. Results. We found excellent correlations among measurements made by the same operator (i.e., repeatability) under the same experimental conditions and by two different operators (i.e., reproducibility). A Bland-Altman analysis showed the absence of bias in repeatability (p = 0.29) or reproducibility (p = 0.89). The limits of agreement for repeatability were –0.357 and –0.033, and for reproducibility, they were –0.270 and 0.238. Significant differences in perfusion values were observed in different experimental groups. Conclusions. Different experimental conditions must be considered as a starting point for the evaluation of new drugs and strategic therapies. |
| Posted: 28 Dec 2012 12:00 AM PST The design, development and performance evaluation of a fluorescence-based pH sensor for on-line measurements is presented. The pKa of the sensing element has been calculated to be 7.9, thus the sensor is suitable for measurement of near neutral solutions. The sensor consists of a low-cost disposable polymer sensing probe, in contact with the solution under test, interrogated by an optoelectronic transduction system. The pH sensitive dye is based on fluorescein O-methacrylate, which has been covalently linked to a hydrogel matrix, realized through the use of HEMA (2-hydroxyethyl methacrylate), HDDA (1,6-hexanediol diacrylate) and PEGDA (polyethylene glycol diacrylate). The optical interrogation setup, together with the electronics, has been developed to acquire and process the fluorescence signal. The sensor works over a pH range between 6.5 and 9.0. In the range between 7.0 and 8.0, the sensor shows a linear behavior with a maximum linearity error of 5%. Thanks to the good performance of the sensing element and transduction system, the short term drift of the reading (measured over 40 min) is lower than 0.15%. The measuring system also exhibits good performance in terms of response time and reproducibility. |
| Posted: 28 Dec 2012 12:00 AM PST Perfumes are manufactured by mixing odorous materials with different volatilities. The parameter that measures the lasting property of a material when applied on the skin is called substantivity or tenacity. It is well known by perfumers that citrus and green notes are perceived as fresh and they tend to evaporate quickly, while odors most dissimilar to ‘fresh’ (e.g., oriental, powdery, erogenic and animalic scents) are tenacious. However, studies aimed at quantifying the relationship between fresh odor quality and substantivity have not received much attention. In this work, perceptual olfactory ratings on a fresh scale, estimated in a previous study, were compared with substantivity parameters and antierogenic ratings from the literature. It was found that the correlation between fresh odor character and odorant substantivity is quite strong (r = −0.85). ‘Fresh’ is sometimes interpreted in perfumery as ‘cool’ and the opposite of ‘warm’. This association suggests that odor freshness might be somehow related to temperature. Assuming that odor perception space was shaped throughout evolution in temperate climates, results reported here are consistent with the hypothesis that ‘fresh’ evokes scents typically encountered in the cool season, while ‘warm’ would be evoked by odors found in nature during summer. This hypothesis is rather simplistic but it may provide a new insight to better understand the perceptual space of scents. |
| Posted: 28 Dec 2012 12:00 AM PST The protozoan parasite Toxoplasma gondii is an important human and veterinary pathogen. Asexual replication of T. gondii in humans and intermediate hosts is characterized by two forms: rapidly growing “tachyzoites” and latent “bradyzoite” tissue cysts. Tachyzoites are responsible for acute illness and congenital neurological birth defects, while the more slowly dividing bradyzoite form can remain latent within the tissues for many years, representing a threat to immunocompromised patients. We have developed a genetic screen to identify regulatory genes that control parasite differentiation and have isolated mutants that fail to convert to bradyzoites. One of these mutants has an insertion disrupting a locus that encodes a developmentally regulated non-coding RNA transcript, named Tg-ncRNA-1. Microarray hybridizations suggest that Tg-ncRNA-1 is involved in the early steps of bradyzoite differentiation. Since Tg-ncRNA-1 does not contain an open reading frame, we used the algorithm Coding Potential Calculator (CPC) that evaluates the protein-coding potential of a transcript, to classify Tg-ncRNA-1. The CPC results strongly indicate that Tg-ncRNA-1 is a non-coding RNA (ncRNA). Interestingly, a previously generated mutant also contains an insertion in Tg-ncRNA-1. We show that both mutants have a decreased ability to form bradyzoites, and complementation of both mutants with wild-type Tg-ncRNA-1 restores the ability of the parasites to differentiate. It has been shown that an important part of bradyzoite differentiation is transcriptionally controlled, but this is the first time that a non-coding RNA is implicated in this process. |
| Posted: 28 Dec 2012 12:00 AM PST With increasing global consumption and their natural resistance to degradation, plastic materials and their accumulation in the environment is of increasing concern. This review aims to present a general overview of the current state of knowledge in areas that relate to biodegradation of polymers, especially poly(ethylene terephthalate) (PET). This includes an outline of the problems associated with plastic pollution in the marine environment, a description of the properties, commercial manufacturing and degradability of PET, an overview of the potential for biodegradation of conventional polymers and biodegradable polymers already in production. |
| Posted: 28 Dec 2012 12:00 AM PST This report reviews the conceptual and theoretical links between Granger causality and directed information theory. We begin with a short historical tour of Granger causality, concentrating on its closeness to information theory. The definitions of Granger causality based on prediction are recalled, and the importance of the observation set is discussed. We present the definitions based on conditional independence. The notion of instantaneous coupling is included in the definitions. The concept of Granger causality graphs is discussed. We present directed information theory from the perspective of studies of causal influences between stochastic processes. Causal conditioning appears to be the cornerstone for the relation between information theory and Granger causality. In the bivariate case, the fundamental measure is the directed information, which decomposes as the sum of the transfer entropies and a term quantifying instantaneous coupling. We show the decomposition of the mutual information into the sums of the transfer entropies and the instantaneous coupling measure, a relation known for the linear Gaussian case. We study the multivariate case, showing that the useful decomposition is blurred by instantaneous coupling. The links are further developed by studying how measures based on directed information theory naturally emerge from Granger causality inference frameworks as hypothesis testing. |
| Symmetry, Vol. 5, Pages 1-46: Taylor–Socolar Hexagonal Tilings as Model Sets Posted: 28 Dec 2012 12:00 AM PST The Taylor–Socolar tilings are regular hexagonal tilings of the plane but are distinguished in being comprised of hexagons of two colors in an aperiodic way. We place the Taylor–Socolar tilings into an algebraic setting, which allows one to see them directly as model sets and to understand the corresponding tiling hull along with its generic and singular parts. Although the tilings were originally obtained by matching rules and by substitution, our approach sets the tilings into the framework of a cut and project scheme and studies how the tilings relate to the corresponding internal space. The centers of the entire set of tiles of one tiling form a lattice Q in the plane. If XQ denotes the set of all Taylor–Socolar tilings with centers on Q, then XQ forms a natural hull under the standard local topology of hulls and is a dynamical system for the action of Q.The Q-adic completion Q of Q is a natural factor of XQ and the natural mapping XQ → Q is bijective except at a dense set of points of measure 0 in Q. We show that XQ consists of three LI classes under translation. Two of these LI classes are very small, namely countable Q-orbits in XQ. The other is a minimal dynamical system, which maps surjectively to Q and which is variously 2 : 1, 6 : 1, and 12 : 1 at the singular points. We further develop the formula of what determines the parity of the tiles of a tiling in terms of the coordinates of its tile centers. Finally we show that the hull of the parity tilings can be identified with the hull XQ; more precisely the two hulls are mutually locally derivable. |
| Posted: 28 Dec 2012 12:00 AM PST This retrospective study was performed to verify the efficacy and safety of Onabotulinumtoxin A (BTX-A) in treating children with neurogenic bladder (NB) secondary to myelomeningocele (MMC) with detrusor overactivity/low compliance. From January 2002 to June 2011, 47 patients out of 68 with neuropathic bladder were selected (22 females, 25 males, age range 5–17 years; mean age 10.7 years at first injection). They presented overactive/poor compliant neurogenic bladders on clean intermittent catheterization, and were resistant or non compliant to pharmacological therapy. Ten patients presented second to fourth grade concomitant monolateral/bilateral vesicoureteral reflux (VUR). All patients were incontinent despite catheterization. In the majority of patients Botulinum-A toxin was administered under general/local anesthesia by the injection of 200 IU of toxin, without exceeding the dosage of 12IU/kg body weight, diluted in 20 cc of saline solution in 20 sites, except in the periureteral areas. Follow-up included clinical and ultrasound examination, urodynamics performed at 6, 12 and 24 weeks, and annually thereafter. Seven patients remained stable, 21 patients required a second injection after 6–9 months and 19 a third injection. VUR was corrected, when necessary, in the same session after the BT-A injection, by 1–3 cc of subureteral Deflux®. Urodynamic parameters considered were leak point pressure (LPP), leak point volume (LPV) and specific volume at 20 cm H2O pressure. The results were analyzed using the Wilcoxon test. All patients experienced a significant 66.45% average increase of LPV (Wilcoxon paired rank test = 7169 × 10 −10) and a significant 118.57% average increase of SC 20 (Wilcoxon paired rank test = 2.466 × 10 −12). The difference between preoperative and postoperative LPP resulted not significant (Wilcoxon paired rank test = 0.8858) No patient presented severe systemic complications; 38/47 patients presented slight hematuria for 2–3 days. Two patients had postoperative urinary tract infection. All patients were hospitalized for 24 h with catheterization. Thirty-eight out of 47 patients achieved dryness between CIC; nine patients improved their incontinence but still need pads. Ten patients have resumed anticholinergic agents. Our results suggest that the use of BTX-A is safe and effective in patients with MMC with a positive effect on their dryness and quality of life. |
| Metals, Vol. 3, Pages 49-57: Permeability of Aluminium Foams Produced by Replication Casting Posted: 28 Dec 2012 12:00 AM PST The replication casting process is used for manufacturing open-pore aluminum foams with advanced performances, such as stability and repeatability of foam structure with porosity over 60%. A simple foam structure model based on the interaction between sodium chloride solid particles poorly wetted by melted aluminum, which leads to the formation of air pockets (or “air collars”), is proposed for the permeability of porous material. The equation for the minimum pore radius of replicated aluminum foam is derived. According to the proposed model, the main assumption of the permeability model consists in a concentration of flow resistance in a circular aperture of radius rmin. The permeability of aluminum open-pore foams is measured using transformer oil as the fluid, changing the fractions of initial sodium chloride. Measured values of minimum pore size are close to theoretically predicted ones regardless of the particle shape. The expression for the permeability of replicated aluminum foam derived on the basis of the “bottleneck” model of porous media agrees well with the experimental data. The obtained data can be applied for commercial filter cells and pneumatic silencers. |
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| Airfoil 4.7.5 - Send audio from any app to AirPort Express/Apple TV and more.. (Demo) Posted: 27 Dec 2012 08:59 PM PST  Airfoil allows you to send any audio to AirPort Express units, Apple TVs, and even other Macs and PCs, all in sync! It's your audio - everywhere. With Airfoil you can take audio from any application and send to your AirPort Express units, as well as Apple TVs, and even other Macs and PCs running Airfoil Speakers! Transmit audio from RealPlayer, Windows Media Player, QuickTime Player, and other media players. Send audio from web-based applications like Pandora, Last.fm, and other to the AirPort Express. You can even stream audio from audio devices like RadioSHARK, XM and Sirius radios, around your house. Version 4.7.5:
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