вторник, 4 декабря 2012 г.

Games

Games

Contract Killer Zombies 2 - Screenshots

Posted: 04 Dec 2012 03:22 AM PST

FREE-ROAMING THIRD-PERSON ACTION!
Explore numerous locations both inside and out.

HIGH-QUALITY 3D GRAPHICS!
Experience beautiful graphics on the latest devices

SURVIVAL MODE!
Get the highest score by protecting the civilian from waves of zombies!

TONS OF MISSIONS TO COMPLETE!
Save civilians, find provisions and clear escape routes to open new locations.

KILL ZOMBIES!
Use a variety of deadly guns, grenades and melee weapons!

COLLECT ITEMS!
Shotguns, Machine Guns, Sniper Rifles, Grenades, Axes, Chainsaws, Health Packs and MORE!

MULTIPLE ZOMBIE BOSSES!
Can you take them all down?

Graphics Comparison - Far Cry 3

Posted: 03 Dec 2012 10:44 PM PST

Which version of Far Cry 3 has the juiciest-looking boar meat, you ask? We did a quick side-by-side comparison of Far Cry 3's opening scene to get quick idea of which one looks the best. What do you think? (Spoiler: It's PC)

 

Read and Post Comments | Get the full article at GameSpot

"Graphics Comparison - Far Cry 3" was posted by edmondt on Mon, 03 Dec 2012 22:44:18 -0800

Court Results: Cases involving defendants from Boston

Posted: 04 Dec 2012 02:29 AM PST

Andrew Lindsay, 26, of Granville Street, Boston. Trespassing and theft of a mobile phone.

This posting includes an audio/video/photo media file: Download Now

The Last of Us: Teaser trailer for Naughty Dog’s PS3 exclusive is short but sinister

Posted: 04 Dec 2012 03:10 AM PST

Sony has released a teaser trailer for developer Naughty Dog's upcoming PS3 exclusive, The Last of Us. The purpose of the teaser is to promote a story

Writer Rumble - Screenshots

Posted: 04 Dec 2012 02:54 AM PST

Features:
• Choose from 6 literary legends
• Use special powers to triple your word damage or black out your opponent's board
• Challenge your friends in local or online multiplayer
• Play against your friends with split-screen multiplayer for iPad
• Game Center and Facebook integration to set up matches and compare scores
• Play survival mode to increase your ability and set new high scores

Orc Attack - Screenshots

Posted: 04 Dec 2012 02:39 AM PST

In Orc Attack, players will enjoy a variety of gameplay features, including:
- Two different gameplay modes: The Magic Mode, in which orcs perform magical spells with devastating effects on their enemies; and The Dirty Mode, in which orcs produce vile and dangerous gasses creating explosions and other devastating effects on their enemies.
- Local and online 2-4 person cooperative play.
- An intelligent new camera system enabling players to share the same camera without losing sight of their co-op friends.
- 15 different levels across four expansive environments.
- As players progress, they gain experience and unlock new attack combinations, more efficient gas powers, additional strength, and increase in speed.
- Using runes (the game's currency), players can buy new equipment, weapons, power-ups, armor, and magic elixirs at the Orc Store.
-  Gamers can evolve their orc avatars and distribute experience points to different characteristics such as strength, speed, and resistance to differentiate fighting styles.

Bubble Island - Screenshots

Posted: 04 Dec 2012 03:02 AM PST

Play 60 second rounds and challenge your friends in weekly tournaments by dropping as many bubbles as possible.

The lovable Raccoon is at your side to feed your bubble shooter and help you get the high score! Unlock four exciting boosts to enhance your play, and discover Firemode when your skills are unstoppable.

Login with Facebook to compete with your friends, collect your Daily Bonus, and experience the amazing fireballs that destroy everything in your way.

Crazy Bowl - Screenshots

Posted: 04 Dec 2012 02:46 AM PST

There are two arenas to choose to play in: Wild Wild West, and Haunted Arena. Each come fully equipped with a randomly selected ball with special abilities at the beginning of each round, like the Electric, Canon, Curse, and Fire Ball. Dodge obstacles and hit the moving pins in Easy Mode or Hard Mode. Once you are victorious, a bonus round begins where you can finish the job by finger flicking the pin into oblivion. After the pin is thoroughly defeated, you can snapshot it for all to see.

Toxins, Vol. 4, Pages 1440-1450: Occurrence of Ochratoxin A in the Wild Boar (Sus scrofa): Chemical and Histological Analysis

Posted: 04 Dec 2012 12:00 AM PST

Ochratoxins are fungal secondary metabolites that may contaminate a broad variety of foodstuffs, such as grains, vegetables, coffee, dried fruits, beer, wine and meats. Ochratoxins are nephrotoxins, carcinogens, teratogens and immunotoxins in rats and are also likely to be in humans. In 2009/2010, a survey of the presence of Ochratoxin A (OTA) in regularly hunted wild boars in the Calabria region of southern Italy detected OTA in 23 animals in the kidney, urinary bladder, liver and muscles: 1.1 ± 1.15, 0.6 ± 0.58, 0.5 ± 0.54 and 0.3 ± 0.26 μg/kg, respectively. Twelve tissue samples showed levels of OTA higher than the guideline level (1 μg/kg) established by the Italian Ministry of Health. In five wild boars, gross-microscopic lesions were described for the organs displaying the highest concentrations of OTA determined by HPLC-FLD analysis, i.e., the kidney, liver and urinary bladder.

Water, Vol. 4, Pages 983-994: Regulation of Water Pollution from Hydraulic Fracturing in Horizontally-Drilled Wells in the Marcellus Shale Region, USA

Posted: 04 Dec 2012 12:00 AM PST

Hydraulic fracturing is an industrial process used to extract fossil fuel reserves that lie deep underground. With the introduction of horizontal drilling, new commercial sources of energy have become available. Wells are drilled and injected with large quantities of water mixed with specially selected chemicals at high pressures that allow petroleum reserves to flow to the surface. While the increased economic activities and the outputs of domestic energy are welcomed, there is growing concern over negative environmental impacts from horizontal drilling in shale formations. The potential for water contamination, land destruction, air pollution, and geologic disruption has raised concerns about the merits of production activities used during extraction. This paper looks at the impacts of horizontal drilling using hydraulic fracturing on water supplies and takes a comprehensive look at legislative and regulatory approaches to mitigate environmental risks in the Marcellus shale region. The overview identifies shortcomings associated with regulatory controls by local and state governments and offers two policy suggestions to better protect waters of the region.

Sensors, Vol. 12, Pages 16685-16694: Development of a One-Step Immunocapture Real-Time RT-PCR Assay for Detection of Tobacco Mosaic Virus in Soil

Posted: 04 Dec 2012 12:00 AM PST

Tobacco mosaic virus (TMV) causes significant losses in many economically important crops. Contaminated soils may play roles as reservoirs and sources of transmission for TMV. In this study we report the development of an immunocapture real-time RT-PCR (IC-real-time RT-PCR) assay for direct detection of TMV in soils without RNA isolation. A series of TMV infected leaf sap dilutions of 1:101, 1:102, 1:103, 1:104, 1:105 and 1:106 (w/v, g/mL) were added to one gram of soil. The reactivity of DAS-ELISA and conventional RT-PCR was in the range of 1:102 and 1:103 dilution in TMV-infested soils, respectively. Meanwhile, the detection limit of IC-real-time RT-PCR sensitivity was up to 1:106 dilution. However, in plant sap infected by TMV, both IC-real-time RT-PCR and real-time RT-PCR were up to 1:106 dilution, DAS-ELISA could detect at least 1:103 dilution. IC-real-time RT-PCR method can use either plant sample extracts or cultivated soils, and show higher sensitivity than RT-PCR and DAS-ELISA for detection of TMV in soils. Therefore, the proposed IC-real-time RT-PCR assay provides an alternative for quick and very sensitive detection of TMV in soils, with the advantage of not requiring a concentration or RNA purification steps while still allowing detection of TMV for disease control.

Sensors, Vol. 12, Pages 16673-16684: Influence of Parasitic Capacitance on Output Voltage for Series-Connected Thin-Film Piezoelectric Devices

Posted: 04 Dec 2012 12:00 AM PST

Series-connected thin film piezoelectric elements can generate large output voltages. The output voltage ideally is proportional to the number of connections. However, parasitic capacitances formed by the insulation layers and derived from peripheral circuitry degrade the output voltage. Conventional circuit models are not suitable for predicting the influence of the parasitic capacitance. Therefore we proposed the simplest model of piezoelectric elements to perform simulation program with integrated circuit emphasis (SPICE) circuit simulations). The effects of the parasitic capacitances on the thin-film Pb(Zr, Ti)O3, (PZT) elements connected in series on a SiO2 insulator are demonstrated. The results reveal the negative effect on the output voltage caused by the parasitic capacitances of the insulation layers. The design guidelines for the devices using series-connected piezoelectric elements are explained.

Sensors, Vol. 12, Pages 16660-16672: Nucleic Acid Sandwich Hybridization Assay with Quantum Dot-Induced Fluorescence Resonance Energy Transfer for Pathogen Detection

Posted: 04 Dec 2012 12:00 AM PST

This paper reports a nucleic acid sandwich hybridization assay with a quantum dot (QD)-induced fluorescence resonance energy transfer (FRET) reporter system. Two label-free hemagglutinin H5 sequences (60-mer DNA and 630-nt cDNA fragment) of avian influenza viruses were used as the targets in this work. Two oligonucleotides (16 mers and 18 mers) that specifically recognize two separate but neighboring regions of the H5 sequences were served as the capturing and reporter probes, respectively. The capturing probe was conjugated to QD655 (donor) in a molar ratio of 10:1 (probe-to-QD), and the reporter probe was labeled with Alexa Fluor 660 dye (acceptor) during synthesis. The sandwich hybridization assay was done in a 20 μL transparent, adhesive frame-confined microchamber on a disposable, temperature-adjustable indium tin oxide (ITO) glass slide. The FRET signal in response to the sandwich hybridization was monitored by a homemade optical sensor comprising a single 400 nm UV light-emitting diode (LED), optical fibers, and a miniature 16-bit spectrophotometer. The target with a concentration ranging from 0.5 nM to 1 μM was successfully correlated with both QD emission decrease at 653 nm and dye emission increase at 690 nm. To sum up, this work is beneficial for developing a portable QD-based nucleic acid sensor for on-site pathogen detection.

Sensors, Vol. 12, Pages 16641-16659: Experimental Investigation of the Cross-Sensitivity and Size Effects of Polyvinylidene Fluoride Film Sensors on Modal Testing

Posted: 04 Dec 2012 12:00 AM PST

Due to advantages such as light weight, flexibility, and low cost, polyvinylidene fluoride (PVDF) films have been widely used in engineering applications as sensors for detecting strain, pressure, or micro-force. However, it is known that PVDF strain sensors have strain cross-sensitivity in mutually orthogonal directions. Furthermore, the size of the PVDF film sensor would also affect the dynamic strain sensing performance. In this paper, to investigate the cross-sensitivity and size effects experimentally, we employ PVDF film sensors to perform dynamic measurements on a cantilever beam. Since the vibrations of the cantilever beam are excited by impacts of a steel ball, the induced highly repeatable transient responses contain a wide range of resonant frequencies and thus can be used to investigate both the size and cross-sensitivity effects of the PVDF film sensors in a dynamic sensing environment. Based on the experimental results of the identified resonant frequencies compared with results obtained from a strain gauge, finite element calculations, and theoretical predictions, suggestions for the use of the PVDF strain sensor in modal testing are given in this paper.

Materials, Vol. 5, Pages 2621-2636: Polydopamine-Supported Lipid Bilayers

Posted: 04 Dec 2012 12:00 AM PST

We report the formation of lipid membranes supported by a soft polymeric cushion of polydopamine. First, 20 nm thick polydopamine films were formed on mica substrates. Atomic force microscopy imaging indicated that these films were also soft with a surface roughness of 2 nm under hydrated conditions. A zwitterionic phospholipid bilayer was then deposited on the polydopamine cushion by fusion of dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) vesicles. Polydopamine films preserved the lateral mobility of the phospholipids as shown by fluorescence microscopy recovery after photobleaching (FRAP) experiments. Diffusion coefficients of ~5.9 and 7.2 µm2 s−1 were respectively determined for DMPC and DOPC at room temperature, values which are characteristic of lipids in a free standing bilayer system.

Materials, Vol. 5, Pages 2609-2620: Properties of PEMA-NH4CF3SO3 Added to BMATSFI Ionic Liquid

Posted: 04 Dec 2012 12:00 AM PST

Polymer electrolyte films, comprising ammonium trifluoromethanesulfonate salt and butyl-trimethyl ammonium bis(trifluoromethylsulfonyl)imide ionic liquid immobilized in poly (ethyl methacrylate) was studied. Structural, morphological, thermal and electrical properties of the polymer electrolyte films were investigated by differential scanning calorimetry, scanning electron microscopy, and impedance spectroscopy, respectively. Interactions of the salt and ionic liquid with the host polymer were investigated by Fourier transform infra-red spectroscopy. Electrochemical stability of the electrolytes was determined using linear sweep voltammetry and transference numbers corresponding to ionic transport has been evaluated by means of the Wagner polarization technique. The highest conductivity achieved is in the order of 10−4 S cm−1 for the film added with 35 wt % butyl trimethylammonium bis (trifluoromethanesulfonyl)imide. The film has high amorphicity and low glass transition temperature of 2 °C. The film is electrochemically stable up to 1.8 V. The ion transference number in the polymer film is 0.82 and the conductivity behavior obeys Vogel-Tamman-Fulcher equation.

Materials, Vol. 5, Pages 2597-2608: Spectroscopy of Deep Traps in Cu2S-CdS Junction Structures

Posted: 04 Dec 2012 12:00 AM PST

Cu2S-CdS junctions of the polycrystalline material layers have been examined by combining the capacitance deep level transient spectroscopy technique together with white LED light additional illumination (C-DLTS-WL) and the photo-ionization spectroscopy (PIS) implemented by the photocurrent probing. Three types of junction structures, separated by using the barrier capacitance characteristics of the junctions and correlated with XRD distinguished precipitates of the polycrystalline layers, exhibit different deep trap spectra within CdS substrates.

IJERPH, Vol. 9, Pages 4433-4451: Contribution to Surface Water Contamination Understanding by Pesticides and Pharmaceuticals, at a Watershed Scale

Posted: 04 Dec 2012 12:00 AM PST

This study aims at understanding the presence of regulated and emerging micropollutants, particularly pesticides and pharmaceuticals, in surface water, regarding spatial and temporal influences at a watershed scale. The study of relations between micropollutants and other water quality and hydroclimatic parameters was carried out from a statistical analysis on historical and experimental data of different sampling sites from the main watershed of Brittany, western France. The outcomes point out the influence of urban and rural areas of the watershed as well as the impact of seasons on contamination variations. This work contributes to health risk assessment related to surface water contamination by micropollutants. This approach is particularly interesting in the case of agricultural watersheds such as the one studied, where more than 80% of surface water is used to produce drinking water.

IJERPH, Vol. 9, Pages 4403-4432: Comparing Sociodemographic Factors Associated with Disability Between Immigrants and the Chilean-Born: Are There Different Stories to Tell?

Posted: 04 Dec 2012 12:00 AM PST

This study explored a range of sociodemographic factors associated with disability among international immigrants in Chile, and compared them to the Chilean-born. Secondary data analysis of the Chilean population-based survey CASEN-2006 was conducted (268,873 participants). Main health outcomes: any disability and six different types of disability: visual, hearing, learning, physical, psychiatric and speaking (binary outcomes). Sociodemographic variables: Demographic factors (age, sex, marital status, urban/rural, ethnicity), socioeconomic status (SES: income, education, employment status, and an integrated indicator combining the SES measures through cluster analysis for the immigrant population), material factors (overcrowding, sanitation, housing quality) and migration related (country of origin and length of stay). Immigrants reported a significantly lower prevalence of any disability (3.55%), visual (1.00%) and physical disability (0.38%). Factors associated with any disability among immigrants were age, low SES or over 20 years duration of residence in Chile; while a range of sociodemographic factors were associated with disability in the Chilean-born. Conditional regression models by age group varied between populations, but SES remained significantly associated with disability across immigrants and the Chilean-born. However, there are no similar patterns of factors associated to different types of disability between the populations under study. Factors associated with disability varied between populations under study, but SES showed a consistent association with any disability in immigrants and the Chilean-born. Types of disability showed different patterns of factors associated to them between populations, which suggest the great complexity of underlying mechanisms related to disability in Chile.

IJMS, Vol. 13, Pages 16472-16488: 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways

Posted: 04 Dec 2012 12:00 AM PST

In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. BPB induced upregulation of Bax, Bad and Bak, downregulation of Bcl-2, Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and Endo G. Furthermore, it triggered extrinsic death receptor-dependent pathway, which was characterized by activating Fas, FADD and caspase-8. Most importantly, animal studies revealed a dramatic 40% reduction in tumor volume after 21 days of treatment. Thus, BPB may be a novel anticancer agent for the treatment of chondrosarcoma.
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