Games

Molecules, Vol. 16, Pages 3875-3884: Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder
Molecules, Vol. 16, Pages 3869-3874: Two New Iridoid Glycosides from the Root Barks of Sambucus williamsii Hance
Game Destroy all cars : 09/05/2011
Game Mine mine mine : 09/05/2011
Game Penalty final 06 : 09/05/2011
Game Flash empires 3 : 09/05/2011
Game Waluigi game : 09/05/2011
Game Jet ski : 09/05/2011
Game Cascade 2 : 09/05/2011
Game Sonic pacman : 09/05/2011
Game Cargo truck express : 09/05/2011
Game The eva project : 09/05/2011
Game Critter capture : 09/05/2011
Game Emo ti jon : 09/05/2011
Game Hug a bear : 09/05/2011
Game Red : 09/05/2011
Molecules, Vol. 16, Pages 3855-3868: RuCl3·3H2O Catalyzed Reactions: Facile Synthesis of Bis(indolyl)methanes under Mild Conditions
Cancers, Vol. 3, Pages 2286-2301: Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach?
Papers 2.0.6 - Your personal library of Science.. (Shareware)
IncognitoRAT: Java-based, cross-platform botnet is equal-opportunity crimeware

Molecules, Vol. 16, Pages 3875-3884: Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder

Posted: 09 May 2011 12:00 AM PDT

Gaultheria yunnanensis (Franch.) Rehder is a kind of traditional Chinese herbal medicine used for the treatments of rheumatoid arthritis, swelling and pain. Two methyl salicylate glycosides, namely methyl benzoate-2-O-b-D-xylopyranosyl(1-6)-O-b-D-gluco-pyranoside (J12122) and methyl benzoate-2-O-β-D-xylopyranosyl(1-2)[O-β-D-xylopyranosyl(1-6)]-O-β-D-glucopyranoside (J12123), are natural salicylic derivatives isolated from Gaultheria yunnanensis. In this study, we investigated the anti-inflammatory activity of J12122 and J12123 on LPS-induced RAW264.7 macrophage cells by measuring the production of pro-inflammatory cytokines, accumulation of nitric oxide (NO), and level of reactive oxygen species (ROS). The results showed that both methyl salicylate glycosides dose-dependently inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, respectively. Consistent with these observations, J12122 and J12123 significantly suppressed the accumulation of NO, with an inhibitory rate of 56.20% and 51.72% at 3.0 μg/mL concentration, respectively. Furthermore, the two methyl salicylate glycosides reduced the level of ROS induced by LPS. These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS.

Molecules, Vol. 16, Pages 3869-3874: Two New Iridoid Glycosides from the Root Barks of Sambucus williamsii Hance

Posted: 09 May 2011 12:00 AM PDT

Chemical investigation of the ethanol extract of the root barks of Sambucus williamsii Hance collected in the Heilongjiang province of China resulted in the isolation of two new iridoid glycosides, williamsoside A (1) and williamsoside B (2). Their structures were elucidated on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies. Iridoid glycosides have for a long time been considered as characteristic ingredients of S. williamsii. However, the presence of iridoid glycosides with apiofuranosyl moieties in S. williamsii is reported for the first time in this study.

Game Destroy all cars : 09/05/2011

Posted: 04 Jan 2011 05:00 PM PST

Game Mine mine mine : 09/05/2011

Posted: 04 Jan 2011 04:05 PM PST

Game Penalty final 06 : 09/05/2011

Posted: 04 Jan 2011 04:03 PM PST

Game Flash empires 3 : 09/05/2011

Posted: 04 Jan 2011 04:09 PM PST

Game Waluigi game : 09/05/2011

Posted: 05 Dec 2010 12:06 AM PST

Game Jet ski : 09/05/2011

Posted: 04 Jan 2011 03:01 PM PST

Game Cascade 2 : 09/05/2011

Posted: 04 Jan 2011 03:05 PM PST

Game Sonic pacman : 09/05/2011

Posted: 04 Jan 2011 03:06 PM PST

Game Cargo truck express : 09/05/2011

Posted: 04 Jan 2011 04:00 PM PST

Game The eva project : 09/05/2011

Posted: 05 Dec 2010 12:02 AM PST

Game Critter capture : 09/05/2011

Posted: 04 Jan 2011 04:00 PM PST

Game Emo ti jon : 09/05/2011

Posted: 05 Dec 2010 12:08 AM PST

Game Hug a bear : 09/05/2011

Posted: 04 Jan 2011 03:01 PM PST

Game Red : 09/05/2011

Posted: 05 Dec 2010 12:03 AM PST

Molecules, Vol. 16, Pages 3855-3868: RuCl3·3H2O Catalyzed Reactions: Facile Synthesis of Bis(indolyl)methanes under Mild Conditions

Posted: 09 May 2011 12:00 AM PDT

RuCl3·3H2O was found to be an effective catalyst for reactions of indoles, 2-methylthiophene, and 2-methylfuran with aldehydes to afford the corresponding bis(indolyl)methanes, bis(thienyl)methanes, and bis(fur-2-yl)methanes in moderate to excellent yields. Experimental results indicated that mono(indolyl)methanol is not the reaction intermediate under these reaction conditions.

Cancers, Vol. 3, Pages 2286-2301: Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach?

Posted: 09 May 2011 12:00 AM PDT

Pancreatic cancer is a devastating disease. It is the fourth leading cause of cancer-related death in Germany. The incidence in 2003/2004 was 16 cases per 100.000 inhabitants. Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis. These low survival rates demonstrate the poor prognosis of this carcinoma. Previous therapeutic approaches including surgical resection combined with adjuvant therapy or palliative chemoradiation have not achieved satisfactory results with respect to overall survival. Therefore, it is necessary to evaluate new therapeutic approaches. Neoadjuvant therapy is an interesting therapeutic option for patients with pancreatic cancer. For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging, increasing the probability of a margin-negative resection and decreasing the occurrence of lymph node metastasis. Currently, there is no universally accepted approach for treating patients with pancreatic cancer in the neoadjuvant setting. In this review, the most common neoadjuvant strategies will be described, compared and discussed.

Papers 2.0.6 - Your personal library of Science.. (Shareware)

Posted: 09 May 2011 02:45 AM PDT

Papers bundles all the great technologies that come with Mac OS X Tiger to give you a complete new workflow for reading scientific articles.

You find, download, archive, and organize all your articles within a single application. But that is just the start, using spotlight you instantly find back the paper you are looking for.

Read it fullscreen, add your notes, send a copy to a colleague. These are just a few of the many features that after using them yourself you will never want to give up again.

Version 2.0.6: Release notes were unavailable when this listing was updated.

Mac OS X 10.6 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

IncognitoRAT: Java-based, cross-platform botnet is equal-opportunity crimeware

Posted: 08 May 2011 09:34 PM PDT

IncognitoRAT is the first known Java-based, cross-platform botnet. It can infect Java virtual machines on MacOS and Windows machines, as well as iPads and iPhones. Presumably, GNU/Linux machines are vulnerable, too, but this isn't mentioned in the article.

"The original propagation vector of IncognitoRAT is a Windows executable, but apparently it was created using the tool JarToExe, which includes, among other features, the ability to convert .jar files into .exe files, to add program icons and version information, and protect and encrypt Java programs.
Once the .jar file is converted, it is executed and downloads a number of Java-based libraries that allow the attacker to remotely control the keyboard and mouse of the affected computer, to play MP3 files and videos, to record images taken by the computer's webcam, and to send stolen information to a predefined email account.