Games |
- Molecules, Vol. 16, Pages 4438-4450: Phytochemical Analysis and Antimicrobial Activities of Methanolic Extracts of Leaf, Stem and Root from Different Varieties of Labisa pumila Benth
- Molecules, Vol. 16, Pages 4428-4437: Microwave-Assisted Extraction of Polyphenols from Camellia oleifera Fruit Hull
- Materials, Vol. 4, Pages 980-990: Luminescent Afterglow Behavior in the M2Si5N8: Eu Family (M = Ca, Sr, Ba)
- Sensors, Vol. 11, Pages 5677-5694: Assessment of Acacia Koa Forest Health across Environmental Gradients in Hawai‘i Using Fine Resolution Remote Sensing and GIS
- Molecules, Vol. 16, Pages 4408-4427: Targeting Oncogenic Protein-Protein Interactions by Diversity Oriented Synthesis and Combinatorial Chemistry Approaches
- Irising business card
- Highlight of the Week: Crazy horses (PlayStation 3)
- SAGE 4.7 - Open source advanced mathematics software.. (Free)
- Molecules, Vol. 16, Pages 4401-4407: Two New Acridone Alkaloids from Glycosmis macrantha
- Panoply 3.0.2 - Plot raster images of latitude/longitude-gridded data.. (Free)
- SOHO Organizer 9.1.4 - Includes SOHO Organizer, SOHO Notes, and SOHO Print Essentials.. (Demo)
- SOHO Notes 9.1.4 - Premier digital note-taking application.. (Demo)
- SecureCRT 6.7 - Terminal emulation for computing professionals.. (Demo)
- Molecules, Vol. 16, Pages 4389-4400: In Vitro and In Vivo Antitumor Activity of Scutellaria Barbate Extract on Murine Liver Cancer
- Molecules, Vol. 16, Pages 4379-4388: Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins
- Klondike Forever 1.3.6 - Solitaire card game.. (Free)
- Solitaire Forever 1.3.5 - Over 100 solitaire card games.. (Shareware)
- Energies, Vol. 4, Pages 878-893: Impact of Turbulence Intensity and Equivalence Ratio on the Burning Rate of Premixed Methane–Air Flames
- Captain America: Super Soldier--Christos Gage Q&A
- On the Spot - Shadows of the Damned, Bastion
| Posted: 27 May 2011 12:00 AM PDT A local herb, Kacip Fatimah, is famous amongst Malay women for its uses in parturition; however, its phytochemical contents have not been fully documented. Therefore, a study was performed to evaluate the phenolics, flavonoids, and total saponin contents, and antibacterial and antifungal properties of the leaf, stem and root of three varieties of Labisia pumila Benth. Total saponins were found to be higher in the leaves of all three varieties, compared to the roots and stems. Leaves of var. pumila exhibited significantly higher total saponin content than var. alata and lanceolata, with values of 56.4, 43.6 and 42.3 mg diosgenin equivalent/g dry weight, respectively. HPLC analyses of phenolics and flavonoids in all three varieties revealed the presence of gallic acid, caffeic acid, rutin, and myricetin in all plant parts. Higher levels of flavonoids (rutin, quercitin, kaempferol) were observed in var. pumila compared with alata and lanceolata, whereas higher accumulation of phenolics (gallic acid, pyrogallol) was recorded in var. alata, followed by pumila and lanceolata. Antibacterial activities of leaf, stem and root extracts of all varieties determined against both Gram positive (Micrococcus luteus, Bacillus subtilis B145, Bacillus cereus B43, Staphylococcus aureus S1431) and Gram negative (Enterobacter aerogenes, Klebsiella pneumonia K36, Escherichia coli E256, Pseudomonas aeruginosa PI96) pathogens showed that crude methanolic extracts are active against these bacteria at low concentrations, albeit with lower antibacterial activity compared to kanamycin used as the control. Antifungal activity of methanolic extracts of all plant parts against Fusarium sp., Candida sp. and Mucor using the agar diffusion disc exhibited moderate to appreciable antifungal activities compared to streptomycin used as positive control. |
| Posted: 27 May 2011 12:00 AM PDT The abundant fruit hulls of tea-oil tree (Camellia oleifera) are still underutilized and wastefully discaded to pollute the environment. In order to solve this problem and better utilize the fruit hulls of C. oleifera, a microwave-assisted extraction system was used to extract their polyphenols using water as the extraction solvent. A central composite design (CCD) was used to monitor the effects of three extraction processing parameters – liquid:solid ratio (mL/g), extraction time (min) and extraction temperature (°C) – on the polyphenol yield (%). The results showed that the optimal conditions were liquid:solid ratio of 15.33:1 (mL/g), extraction time of 35 min and extraction temperature of 76 °C. Validation tests indicated that under the optimized conditions the actual yield of polyphenols was 15.05 ± 0.04% with RSD = 0.21% (n = 5), which was in good agreement with the predicted yield. Phenolic compounds in the extracts were analysed by HPLC, and gallic acid was found to be the predominant constituent. The total flavonoid content in the extracts was determined and high total flavonoid content was revealed (140.06 mg/g dry material). |
| Posted: 27 May 2011 12:00 AM PDT Persistent luminescent materials are able to emit light for hours after being excited. The majority of persistent phosphors emit in the blue or green region of the visible spectrum. Orange- or red-emitting phosphors, strongly desired for emergency signage and medical imaging, are scarce. We prepared the nitrido-silicates Ca2Si5N8:Eu (orange), Sr2Si5N8:Eu (reddish), Ba2Si5N8:Eu (yellowish orange), and their rare-earth codoped variants (R = Nd, Dy, Sm, Tm) through a solid state reaction, and investigated their luminescence and afterglow properties. In this paper, we describe how the persistent luminescence is affected by the type of codopant and the choice and ratio of the starting products. All the materials exhibit some form of persistent luminescence, but for Sr2Si5N8:Eu,R this is very weak. In Ba2Si5N8:Eu the afterglow remains visible for about 400 s, and Ca2Si5N8:Eu,Tm shows the brightest and longest afterglow, lasting about 2,500 s. For optimal persistent luminescence, the dopant and codopant should be added in their fluoride form, in concentrations below 1 mol%. A Ca3N2 deficiency of about 5% triples the afterglow intensity. Our results show that Ba2Si5N8:Eu(,R) and Ca2Si5N8:Eu(,R) are promising persistent phosphors for applications requiring orange or red light. |
| Posted: 27 May 2011 12:00 AM PDT Koa (Acacia koa) forests are found across broad environmental gradients in the Hawai'ian Islands. Previous studies have identified koa forest health problems and dieback at the plot level, but landscape level patterns remain unstudied. The availability of high-resolution satellite images from the new GeoEye1 satellite offers the opportunity to conduct landscape-level assessments of forest health. The goal of this study was to develop integrated remote sensing and geographic information systems (GIS) methodologies to characterize the health of koa forests and model the spatial distribution and variability of koa forest dieback patterns across an elevation range of 600–1,000 m asl in the island of Kaua'i, which correspond to gradients of temperature and rainfall ranging from 17–20 °C mean annual temperature and 750–1,500 mm mean annual precipitation. GeoEye1 satellite imagery of koa stands was analyzed using supervised classification techniques based on the analysis of 0.5-m pixel multispectral bands. There was clear differentiation of native koa forest from areas dominated by introduced tree species and differentiation of healthy koa stands from those exhibiting dieback symptoms. The area ratio of healthy koa to koa dieback corresponded linearly to changes in temperature across the environmental gradient, with koa dieback at higher relative abundance in warmer areas. A landscape-scale map of healthy koa forest and dieback distribution demonstrated both the general trend with elevation and the small-scale heterogeneity that exists within particular elevations. The application of these classification techniques with fine spatial resolution imagery can improve the accuracy of koa forest inventory and mapping across the islands of Hawai'i. Such findings should also improve ecological restoration, conservation and silviculture of this important native tree species. |
| Posted: 27 May 2011 12:00 AM PDT We are currently witnessing a decline in the development of efficient new anticancer drugs, despite the salient efforts made on all fronts of cancer drug discovery. This trend presumably relates to the substantial heterogeneity and the inherent biological complexity of cancer, which hinder drug development success. Protein-protein interactions (PPIs) are key players in numerous cellular processes and aberrant interruption of this complex network provides a basis for various disease states, including cancer. Thus, it is now believed that cancer drug discovery, in addition to the design of single-targeted bioactive compounds, should also incorporate diversity-oriented synthesis (DOS) and other combinatorial strategies in order to exploit the ability of multi-functional scaffolds to modulate multiple protein-protein interactions (biological hubs). Throughout the review, we highlight the chemistry driven approaches to access diversity space for the discovery of small molecules that disrupt oncogenic PPIs, namely the p53-Mdm2, Bcl-2/Bcl-xL-BH3, Myc-Max, and p53-Mdmx/Mdm2 interactions. |
| Posted: 27 May 2011 02:32 AM PDT The latest animated business-card from Cardnetics is this card with a built-in irising mechanism. The card is available as a finished product, a kit, or a Thingiverse object to download and cut yourself. It's also available in other sizes, including greeting-cards. Iris Business Card by clide (Thingiverse) (via Reddit) This posting includes an audio/video/photo media file: Download Now |
| Highlight of the Week: Crazy horses (PlayStation 3) Posted: 27 May 2011 02:36 AM PDT This week's video highlight is brought to you by Japan World Cup 3 - a racing game in the more genteel sense of the word 'racing'. That's right - horses. GGs. Kebabs. Whatever, there's nothing genteel about the content of the game. Japan is famous for producing some of the most touchingly crazy creations in the world of gaming, but this takes the sugarlump. The game's been out for a while and we're amazed its charms have only just now come to our attention, but we're so glad they did. Observe: |
| SAGE 4.7 - Open source advanced mathematics software.. (Free) Posted: 27 May 2011 01:40 AM PDT  SAGE is open source mathematics software which creates a viable free open source alternative to Magma, Maple, Mathematica, and Matlab. General and Advanced Pure and Applied Mathematics Use an Open Source Alternative Use Most Mathematics Software from Within SAGE Use a Standard Programming Language Version 4.7:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Molecules, Vol. 16, Pages 4401-4407: Two New Acridone Alkaloids from Glycosmis macrantha Posted: 27 May 2011 12:00 AM PDT Extraction and chromatographic separation of the extracts of dried stem barks of Glycosmis macrantha lead to isolation of two new acridone alkaloids, macranthanine (1) and 7-hydroxynoracronycine (2), and a known acridone, atalaphyllidine (3). The structures of these alkaloids were determined by detailed spectral analysis and also by comparison with reported data. |
| Panoply 3.0.2 - Plot raster images of latitude/longitude-gridded data.. (Free) Posted: 27 May 2011 01:18 AM PDT  Panoply plots geo-gridded arrays of latitude-longitude, latitude-vertical or time-latitude data encoded in netCDF, HDF and GRIB format. Features include:
Version 3.0.2:
Download Now This posting includes an audio/video/photo media file: Download Now |
| SOHO Organizer 9.1.4 - Includes SOHO Organizer, SOHO Notes, and SOHO Print Essentials.. (Demo) Posted: 27 May 2011 01:22 AM PDT  SOHO Organizer is the official successor to Personal Organizer and Group Organizer and represents a 100% Cocoa rewrite of the former products. This means SOHO Organizer presents a first-class Mac OS X experience complete with all the features Mac OS X users expect: Aqua interface, Unicode compliance, built-in spell checking, Service support, etc. Finally, the true benefit of a complete Cocoa rewrite is that SOHO Organizer is built for the future and can easily accommodate future technologies (think Intel-based Macs). SOHO Organizer makes managing customer relationships from phone calls and notes to appointments and to-dos easy. It embraces and leverages popular Mac OS X technologies and applications instead of trying to replace them. For example, it synchronizes seamlessly with the Address Book and iCal so that users can continue to use them and other applications that rely on their data. Users can thus use Apple's iSync to synchronize their contacts and calendars in SOHO Organizer to cell phones, iPods, Palm handhelds, and even .Mac. Version 9.1.4:
Mac OS X 10.5.8 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| SOHO Notes 9.1.4 - Premier digital note-taking application.. (Demo) Posted: 27 May 2011 01:26 AM PDT  SOHO Notes is the premier digital note-taking application for Macintosh. Use it to capture, organize, and share all of your personal and workgroup information. It can store rich text, PDF's, images, files, movies, audio, bookmarks, and web archives. Synchronize notes between multiple computers, iPod's, and Palm handhelds. Single And Multi-User Capable - SOHO Notes is as equally suitable for the sole proprietor with a single computer as the small business with a few dozen networked computers. This all new note manager is based on a commercial database engine for high-performance and reliability. Its client/server design makes SOHO Notes ideal for anything that needs to be shared such as meeting notes, confidential company documents, employee handbooks, approved company artwork and logos, product plans, marketing campaign documents, etc. Sharing notes is easy with its manageable user access privileges.
Mac OS X 10.5.8 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| SecureCRT 6.7 - Terminal emulation for computing professionals.. (Demo) Posted: 27 May 2011 01:07 AM PDT SecureCRT provides rock-solid terminal emulation for computing professionals, raising productivity with advanced session management and a host of ways to save time and streamline repetitive tasks. SecureCRT provides secure remote access, file transfer, and data tunneling for everyone in your organization. Version 6.7:
Mac OS X 10.5 or later Download Now |
| Posted: 27 May 2011 12:00 AM PDT In the present study, we investigated the in vitro and in vivo antitumor effects of crude extract of Scutellaria Barbate (CE-SB) on mouse hepatoma H22 cells. The MTT assay was used to determine the growth inhibition of H22 cells in vitro. The in vivo therapeutic effects of CE-SB were determined using H22 tumor bearing mice. Besides, the body weight, tumor weight, thymus index and spleen index of H22 bearing mice were also measured. The tumor inhibitory rate (IR) was calculated according to the mean weight of tumor (MWT). The phagocytotic function of macrophages was examined by observing peritoneal macrophages phagocytize chicken RBC. The results showed that CE-SB could inhibit the growth of hepatoma H22 Cells in vitro and in vivo. Furthermore, CE-SB could improve immune function of H22 tumor bearing mice. Together these results indicate that CE-SB has antitumor activity and seems to be safe and effective for the use of anti-tumor therapy. |
| Molecules, Vol. 16, Pages 4379-4388: Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins Posted: 27 May 2011 12:00 AM PDT The ionic liquid 1,3-dimethylimidazolium methyl sulfate, [MMIm][MSO4], together with a small amount of water (the amount taken up by the ionic liquid upon exposure to air), acts efficiently as both solvent and catalyst of the Knoevenagel condensation reactions of malononitrile with 4-substituted benzaldehydes, without the need for any other solvent or promoter, affording yields of 92%–99% within 2–7 min at room temperature. When L-proline is used as an additional promoter to obtain coumarins from o-hydroxybenzaldehydes, the reaction also proceeds in high yields. Work-up is very simple and the ionic liquid can be reused several times. Some of the coumarins obtained are described for the first time. |
| Klondike Forever 1.3.6 - Solitaire card game.. (Free) Posted: 27 May 2011 12:53 AM PDT  Klondike Forever... Enjoy everyone's favorite solitaire game, fast, smooth, and beautiful, for free! Features include:
Version 1.3.6:
Mac OS X 10.4 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Solitaire Forever 1.3.5 - Over 100 solitaire card games.. (Shareware) Posted: 27 May 2011 12:49 AM PDT  Solitaire Forever is a solitaire card game with the following features:
Version 1.3.5:
Mac OS X 10.4 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 27 May 2011 12:00 AM PDT Direct Numerical Simulations (DNS) have been conducted to study the response of initially laminar spherical premixed methane–air flame kernels to successively higher turbulence intensities at five different equivalence ratios. The numerical experiments include a 16-species/25-step skeletal mechanism for methane oxidation and a multicomponent molecular transport model. Highly turbulent conditions (with integral Reynolds numbers up to 4513) have been accessed. The effect of turbulence on the physical properties of the flame, in particular its consumption speed Sc, which is an interesting measure of the turbulent flame speed ST has been investigated. Local quenching events are increasingly observed for highly turbulent conditions, particularly for lean mixtures. The obtained results qualitatively confirm the expected trend regarding correlations between u′/SL and the consumption speed: Sc first increases, roughly linearly, with u′/SL (low turbulence zone), then levels off (bending zone) before decreasing again (quenching limit) for too intense turbulence. For a fixed value of u′/SL, Sc/SL varies with the mixture equivalence ratio, showing that additional parameters should probably enter phenomenological expressions relating these two quantities. |
| Captain America: Super Soldier--Christos Gage Q&A Posted: 26 May 2011 11:21 PM PDT Captain America: Super Soldier is being penned by renowned comics writer Christos Gage, and we spoke to Gage to find out how the game links to the movie, comics canon, and more.
For its game tie-in in to the upcoming Captain America: The First Avenger film, Sega has brought in the big guns story-wise, hiring comic book writer and screenwriter Christos Gage to write the plot powering Captain America: Super Soldier. GameSpot AU spoke to Gage--who has written for Marvel on such titles as Avengers: The Initiative, Civil War: House of M, War Machine: Weapon of Shield, and more--on how the game ties into the film, what makes Captain America appealing, and what other characters from the Marvel universe we can expect to see in the upcoming title.
 GameSpot AU: Tell us about the story you penned for Captain America: Super Soldier. How does it tie in to the movie? Christos Gage: Well it's actually cool because we're not tied in to the movie. It's set in the movie universe, because that's the version of Captain America that most people will be familiar with, but there was no edict to retell the story of the movie, they just said to go ahead and make the best game you can make. The premise of the game is that it's set in WWII, and Hydra has this mountain base where they're manufacturing weapons of mass destruction that can turn the tide of war. It's an old medieval castle that's been turned into a base and manufacturing centre, and Captain America has to infiltrate and put a stop to it. And, of course, there are all these cool bosses and villains that people will recognise from the comics. The Red Skull is in there, but then there's also Madame Hydra, Arnim Zola, and Baron Strucker. GS AU: So was that a good thing, not being tied in to the film's narrative? CG: Yeah, the making of movies is a very fluid thing. Whole scenes can get cut, it can be rethought because they can't get a particular location, or they can't get the budget, and that way you're consistently worrying about what changes the movie is making. Like I said, it's set in the movie universe, so people who see the movie and want to play the game will recognise Captain America. Plus, the other benefit is people who have seen the movie and then play the game won't feel like they're playing through something they've already seen. GS AU: How closely does the game stick to comic book canon? CG: Much in the same way that Batman: Arkham Asylum is not the comic book continuity or the movie continuity per se, it's sort of its own thing. For instance, in the comics, Madame Hydra was not a WWII-era villain. She came along in our time in the '60s after Cap awoke in the future. But we just liked the idea that there always is a Madame Hydra, it's a title and there's always been one, and hence there's one in our WWII version. So we've taken some liberties like that, but it's always in the interest of fun and not getting too bogged down in one particular continuity. We're just giving the player the best possible gaming experience. We don't want people to have to have a degree in Captain America to play the game, even though I happen to have one, it was my major in college [laughs]. The idea is, the casual fan can go in and just play the game, but a long-time comic fan like myself who's been reading the comics for 30 years will find some funny strands and think this is true to the comics. GS AU: So you've told us about the rogues gallery. What about other Marvel heroes? Will we see any cameos in the game? CG: Aside from Bucky, there are no other Marvel heroes. In the WWII era, the heroes that people associate with Captain America are the Invaders, but they're like Human Torch and Sub-Mariner. And Human Torch is in movie-land as part of the Fantastic Four, so we couldn't have used him anyway. Sub-Mariner is his own franchise. Really, there weren't a lot of options to throw in other heroes simply because of the timeframe it was set in. But there is going to be Bucky, and I think they've revealed there will be an incarnation of the Howling Commandos in there. GS AU: So does that mean Nick Fury maybe? CG: So as we've seen in the present movies, Nick Fury is Samuel Jackson in the present day, so… GS AU: Was it more challenging or interesting for you to write a Captain America set in the past?
 CG: I enjoyed it for a variety of reasons. One, it's because that's when the movie is set, and also because that's when you associate the genesis of the character of Captain America, being in WWII. For the first real big Captain America game--and now, obviously, you had the Captain America and the Avengers arcade game in the '90s, which I played--but for the first big modern game, I thought it should be set in WWII, and the fun thing would be to have future games based on the present day. So it wasn't so much a challenge, as it's actually very interesting because in the comics I've written Captain America in the present day. He's this grizzled veteran who's seen it all and done it all. This Captain America I was writing [for the game] is a much younger guy who's still discovering the full extent of his abilities. So it was really interesting to write the same character at a younger age. GS AU: This is the first time you've written for a game, right? CG: That's right. I had previously written a comic book adaptation of the game Dante's Inferno. GS AU: So what's it like? How does it compare to something comics, or film and TV? CG: You know, it's interesting because games are halfway between comics and screenwriting. On the one hand, comics have the ultimate freedom, because you don't have to worry about budget--anything that can be drawn, you can do. Every screen writer who writes comic books say they can literally do anything, and that's why it's so much fun. On the flipside, the great thing about movies and TV, even though you have a budget to deal with, is that you do get the benefit of live actors who can bring things to life. Games are in the middle because you have voice actors--and they do have some amazing actors--and while there's some constraints with how many characters you can animate and locations and things like that, there aren't as many as in movies and TV. So it's just a matter of how many different things you can do. So, yes, you can blow up an entire skyscraper in a game, whereas you may not be able to do that in a movie. GS AU: Let's talk about the character of Captain America. If you're not American, it would be easy to assume that the concept of a character named Captain America would be foreign, even a bit laughable. But the idea works--the character resonates. Why is that?
 CG: What resonates about Captain America is, and this was established long ago, that the character is not tied into any particular administration or government--he stands for the American dream. And the American dream is something that people all around the world believe in. They may not call it the American dream, but they believe in the ideals of it--freedom, life, liberty, and the pursuit of happiness. You see it going on in the Middle East right now, with people calling for democracy. So the ideals behind Captain America transcend the nationalistic aspect of it. So people look at Captain America not as a symbol of a country or a political administration, but rather a set of ideals that are universal. GS AU: Christos Gage, thanks for your time. Captain America: Super Soldier will be released on the Xbox 360, PS3, PSP, DS, and Wii in mid-July, 2011. Read and Post Comments | Get the full article at GameSpot "Captain America: Super Soldier--Christos Gage Q&A" was posted by Randolph Ramsay on Thu, 26 May 2011 23:21:52 -0700 |
| On the Spot - Shadows of the Damned, Bastion Posted: 26 May 2011 10:53 PM PDT Do you want guns, destruction, and maybe a wee bit of madness? Then join us today for Duke Nukem Forever, Red Faction: Armageddon, Shadows of the Damned, and more!
Read and Post Comments | Get the full article at GameSpot "On the Spot - Shadows of the Damned, Bastion" was posted by DanM on Thu, 26 May 2011 22:53:32 -0700 |
| You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий