среда, 8 июня 2011 г.

Games

Games

Molecules, Vol. 16, Pages 4775-4785: Biologically Important Eremophilane Sesquiterpenes from Alaska Cedar Heartwood Essential Oil and Their Semi-Synthetic Derivatives

Posted: 08 Jun 2011 12:00 AM PDT

The essential oil of Alaska cedar heartwood is known to contain compounds which contribute to the remarkable durability of this species. While previous research has identified several compounds, a complete description of this oil has not been undertaken. In this research a profile of the oil is given in which the major components are identified by GC, isolation and spectroscopic techniques. The major components of the steam distilled essential oil were identified as nootkatin, nootkatone, valencene, nootaktene, carvacrol, methyl carvacrol, nootkatol (2), and eremophil-1(10),11-dien-13-ol (3). The last two compounds were isolated for the first time from Alaska cedar in this research. The absolute stereochemistry at C-2 of nootkatol was shown to have the (S) configuration using the Mosher ester method. Assignment of stereochemistry for valencene-13-ol (3) was established by synthesis from valencene (6). Finally, two related sesquiterpenoids were synthesized from nootkatone and valencene. These sesquiterpenoids were nootkatone-1,10-11,12-diepoxide (5) and valencene-13-aldehyde (4), respectively.

IJERPH, Vol. 8, Pages 2074-2089: Spatial Pattern Analysis of Heavy Metals in Beijing Agricultural Soils Based on Spatial Autocorrelation Statistics

Posted: 08 Jun 2011 12:00 AM PDT

This study explored the spatial pattern of heavy metals in Beijing agricultural soils using Moran's I statistic of spatial autocorrelation. The global Moran's I result showed that the spatial dependence of Cr, Ni, Zn, and Hg changed with different spatial weight matrixes, and they had significant and positive global spatial correlations based on distance weight. The spatial dependence of the four metals was scale-dependent on distance, but these scale effects existed within a threshold distance of 13 km, 32 km, 50 km, and 29 km, respectively for Cr, Ni, Zn, and Hg. The maximal spatial positive correlation range was 57 km, 70 km, 57 km, and 55 km for Cr, Ni, Zn, and Hg, respectively and these were not affected by sampling density. Local spatial autocorrelation analysis detected the locations of spatial clusters and spatial outliers and revealed that the pollution of these four metals occurred in significant High-high spatial clusters, Low-high, or even High-low spatial outliers. Thus, three major areas were identified and should be receiving more attention: the first was the northeast region of Beijing, where Cr, Zn, Ni, and Hg had significant increases. The second was the southeast region of Beijing where wastewater irrigation had strongly changed the content of metals, particularly of Cr and Zn, in soils. The third area was the urban fringe around city, where Hg showed a significant increase.

Molecules, Vol. 16, Pages 4764-4774: Synthesis and Antimicrobial Activity of Some Novel 5-Alkyl-6-Substituted Uracils and Related Derivatives

Posted: 08 Jun 2011 12:00 AM PDT

6-Chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloro-pyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes. The reaction of compounds 5a-c with 1-substituted piperazines yielded the corresponding 5-alkyl-6-(4-substituted-1-piperazinyl)uracils 6a-j. The target 8-alkyltetrazolo[1,5-f]pyrimidine-5,7(3H,6H)-diones 7a-c were prepared via the reaction of 5a-c with sodium azide. Compounds 6a-j and 7a-c were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Compound 6h displayed potent broad-spectrum antibacterial activity, while compound 6b showed moderate activity against the Gram-positive bacteria. All the tested compounds were practically inactive against Candida albicans.

IJERPH, Vol. 8, Pages 2020-2073: Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and Potential Air Pollutant Interactions

Posted: 08 Jun 2011 12:00 AM PDT

Regulatory agencies are under increased pressure to consider broader public health concerns that extend to multiple pollutant exposures, multiple exposure pathways, and vulnerable populations. Specifically, cumulative risk assessment initiatives have stressed the importance of considering both chemical and non-chemical stressors, such as socioeconomic status (SES) and related psychosocial stress, in evaluating health risks. The integration of non-chemical stressors into a cumulative risk assessment framework has been largely driven by evidence of health disparities across different segments of society that may also bear a disproportionate risk from chemical exposures. This review will discuss current efforts to advance the field of cumulative risk assessment, highlighting some of the major challenges, discussed within the construct of the traditional risk assessment paradigm. Additionally, we present a summary of studies of potential interactions between social stressors and air pollutants on health as an example of current research that supports the incorporation of non-chemical stressors into risk assessment. The results from these studies, while suggestive of possible interactions, are mixed and hindered by inconsistent application of social stress indicators. Overall, while there have been significant advances, further developments across all of the risk assessment stages (i.e., hazard identification, exposure assessment, dose-response, and risk characterization) are necessary to provide a scientific basis for regulatory actions and effective community interventions, particularly when considering non-chemical stressors. A better understanding of the biological underpinnings of social stress on disease and implications for chemical-based dose-response relationships is needed. Furthermore, when considering non-chemical stressors, an appropriate metric, or series of metrics, for risk characterization is also needed. Cumulative risk assessment research will benefit from coordination of information from several different scientific disciplines, including, for example, toxicology, epidemiology, nutrition, neurotoxicology, and the social sciences.

Marine Drugs, Vol. 9, Pages 984-993: DedA Protein Relates to Action-Mechanism of Halicyclamine A, a Marine Spongean Macrocyclic Alkaloid, as an Anti-dormant Mycobacterial Substance

Posted: 08 Jun 2011 12:00 AM PDT

A macrocyclic alkaloid, halicyclamine A, was re-discovered from an Indonesian marine sponge of Haliclona sp. 05A08 as an anti-dormant mycobacterial substance. To clarify action-mechanism of halicyclamine A, halicyclamine A-resistant strains were screened from the transformants of Mycobacterium smegmatis with the genomic DNA library of M. bovis BCG, which were constructed in the multi-copy shuttle cosmid pYUB145. Sequencing analysis of the cosmids isolated from the halicyclamine A-resistant transformants revealed that the responsible gene was involved in the genome region between 2920.549 kb and 2933.210 kb. Further experiments using the transformants over-expressing individual gene contained in the responsible region were executed, and the transformant, which over-expressed BCG2664 gene assigned as dedA gene, was found to become halicyclamine A-resistant. This evidence strongly suggested that DedA protein correlates with the action-mechanism of halicyclamine A as an anti-dormant mycobacterial substance.

E3 2011: See Nintendo's crazy new Wii U controller being held and fiddled with by a woman on the showfloor (Batman: Arkham City)

Posted: 08 Jun 2011 02:40 AM PDT

So the big talking point of E3 is Nintendo's new controller. Which is certainly dividing opinion like wood on a chopping block. It's another piece of radical Nintendo genius/madness that could be the best/worst thing ever. We love/hate it already. Have you made up your mind about it? While you're having a think, check out this video direct from E3 of a woman paid to demonstrate the Wii U controller earning her money.

Pac-Man Party 3D - 3DS - Screenshots

Posted: 08 Jun 2011 02:18 AM PDT

Fact sheet pending.

Ninja Gaiden 3 - PS3 - Screenshots

Posted: 08 Jun 2011 02:18 AM PDT

Featuring a new story, new gameplay and new modes, Ninja Gaiden 3 marks a new direction in this fan-favorite franchise. Team NINJA will change the way fans think about ninja and Hayabusa in this game, and promise that they'll know what
it feels like to "cut someone down" through their experiences in the game.
The game will also feature online multiplayer, both co-op and competitive, that will add a completely new experience to Ninja Gaiden. The shadowy world of ninja has never been presented this way, and Ninja Gaiden will never be the same!
Pick up the Dragon Sword once more, sharpen its blade and hone your skills. An adventure unlike any other awaits you.
FEATURES:
- Cutting Down your Enemy: Through new gameplay mechanics and presentation, players will feel what it's like to cut through an enemy's flesh and bone, along with the consequence that comes with it.
- A Hero Unmasked: With a new story and new characters, players will learn more about Hayabusa's past and present life than ever before. Once seen only as a mindless killing machine, players will unravel layers of their hero as they see his motivations and learn about the man behind the mask.
- High-Octane Ninja Action: Built upon the same intense action that the series is renowned for, Ninja Gaiden 3 will challenge players while still remaining accessible for players new to the franchise.
- Online Action: A rich and challenging set of online modes are being implemented, giving players the option to play cooperatively or competitively. New challenges, characters and missions await those who choose to join the Shadows of the World online!

Ninja Gaiden 3 - Xbox360 - Screenshots

Posted: 08 Jun 2011 02:18 AM PDT

Featuring a new story, new gameplay and new modes, Ninja Gaiden 3 marks a new direction in this fan-favorite franchise. Team NINJA will change the way fans think about ninja and Hayabusa in this game, and promise that they'll know what
it feels like to "cut someone down" through their experiences in the game.
The game will also feature online multiplayer, both co-op and competitive, that will add a completely new experience to Ninja Gaiden. The shadowy world of ninja has never been presented this way, and Ninja Gaiden will never be the same!
Pick up the Dragon Sword once more, sharpen its blade and hone your skills. An adventure unlike any other awaits you.
FEATURES:
- Cutting Down your Enemy: Through new gameplay mechanics and presentation, players will feel what it's like to cut through an enemy's flesh and bone, along with the consequence that comes with it.
- A Hero Unmasked: With a new story and new characters, players will learn more about Hayabusa's past and present life than ever before. Once seen only as a mindless killing machine, players will unravel layers of their hero as they see his motivations and learn about the man behind the mask.
- High-Octane Ninja Action: Built upon the same intense action that the series is renowned for, Ninja Gaiden 3 will challenge players while still remaining accessible for players new to the franchise.
- Online Action: A rich and challenging set of online modes are being implemented, giving players the option to play cooperatively or competitively. New challenges, characters and missions await those who choose to join the Shadows of the World online!

GamesRadar UK's totally at E3 interviews: the very important studio manager (Xbox 360)

Posted: 08 Jun 2011 02:10 AM PDT

All this week the GamesRadar UK team is definitely in Los Angeles attending what is generally regarded as the biggest deal when it comes to video games. It's the big one. So we're absolutely there. There's no question of us still being in the office. No way. And because we're totally at E3, we're interviewing other people that are also definitely at E3. Seriously. We're not bullshitting.

And today's GamesRadar UK totally at E3 interview is with... a very important studio manager.

Hitman: Absolution - PC - Screenshots

Posted: 08 Jun 2011 01:57 AM PDT

HITMAN ABSOLUTION combines much loved classic gameplay with completely new gameplay features for the Hitman franchise. Fact sheet pending.

Hitman: Absolution - PS3 - Screenshots

Posted: 08 Jun 2011 01:57 AM PDT

HITMAN ABSOLUTION combines much loved classic gameplay with completely new gameplay features for the Hitman franchise. Fact sheet pending.

Hitman: Absolution - Xbox360 - Screenshots

Posted: 08 Jun 2011 01:57 AM PDT

HITMAN ABSOLUTION combines much loved classic gameplay with completely new gameplay features for the Hitman franchise. Fact sheet pending.

Crystals, Vol. 1, Pages 59-68: Barium Oxalates Combined with Oxo-Anions and Organic Cations: Syntheses and Structures of Ba2(C2O4)(H2PO3)2 and C2H10N2·Ba(H2O)2(HC2O4)4

Posted: 08 Jun 2011 12:00 AM PDT

The syntheses and single-crystal structures of Ba2(C2O4)(H2PO3)2 (1) and C2H10N2·Ba(H2O)2(HC2O4)4 (2) are described. Compound 1 is a three-dimensional mixed-anion framework containing BaO9 coordination polyhedra, which approximate to monocapped square anti-prisms: the connectivity of the BaO9 units via edges and triangular faces leads to a sheet structure. The oxalate ion in 1 is substantially twisted about its C–C bond [dihedral angle between the CO2 groups = 33.8 (3)°]. Compound 2 is a molecular salt containing ethylenediammonium dications and [Ba(HC2O4)4(H2O)2]2– dianions, which are linked by O–HLO and N–HLO hydrogen bonds. The BaO10 coordination polyhedron can be described as a distorted pentagonal anti-prism. Crystal data: 1 (C2H4Ba2O10P2), Mr = 524.68, monoclinic, C2/c (No. 15), Z = 4, a = 12.3829 (3) Å, b = 7.9124 (2) Å, c = 11.0858 (3) Å, b = 114.788 (2)°, V = 986.10 (4) Å3, R(F) = 0.016, wR(F2) = 0.040. 2 (C10H18BaN2O10), Mr = 591.60, monoclinic, C2/m (No. 12), Z = 2, a = 12.7393 (7) Å, b = 13.0111 (7) Å, c = 5.6050 (3) Å, b = 104.208 (4)°, V = 900.62 (8) Å3, R(F) = 0.027, wR(F2) = 0.054.

Cancers, Vol. 3, Pages 2540-2553: Tumor Cell Seeding During Surgery—Possible Contribution to Metastasis Formations

Posted: 08 Jun 2011 12:00 AM PDT

In spite of optimal local control in breast cancer, distant metastases can develop as a systemic part of this disease. Surgery is suspected to contribute to metastasis formation activating dormant tumor cells. Here we add data that seeding of cells during surgery may add to the risk of metastasis formation. The change in circulating epithelial tumor cells (CETC) was monitored in 66 breast cancer patients operated on with breast conserving surgery or mastectomy and during the further course of the disease, analyzing CETC from unseparated white blood cells stained with FITC-anti-EpCAM. An increase in cell numbers lasting until the start of chemotherapy was observed in about one third of patients. It was more preeminent in patients with low numbers of CETC before surgery and, surprisingly, in patients without involved lymph nodes. Patients with the previously reported behavior—Reincrease in cell numbers during adjuvant chemotherapy and subsequent further increase during maintenance therapy—were at increased risk of relapse. In addition to tumor cells already released during growth of the tumor, cell seeding during surgery may contribute to the early peak of relapses observed after removal of the primary tumor and chemotherapy may only marginally postpone relapse in patients with aggressively growing tumors.

Molecules, Vol. 16, Pages 4748-4763: Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives

Posted: 08 Jun 2011 12:00 AM PDT

A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study.

Sustainability, Vol. 3, Pages 809-822: Modern Biotechnology—Potential Contribution and Challenges for Sustainable Food Production in Sub-Saharan Africa

Posted: 08 Jun 2011 12:00 AM PDT

Modern biotechnology, including the application of transgenic techniques to produce Genetically Modified Organisms (GMOs), can play a significant role in increasing agricultural production in a sustainable way, but its products need to be tailored for the developing world. In sub-Saharan Africa, the capacity to develop GMOs and ensure they meet stringent regulatory requirements is somewhat limited. Most African governments contribute little to science and technology either financially or through strong policies. This leaves the determination of research and development priorities in the hands of international funding agencies. Whereas funding from the United States is generally supportive of GM technology, the opposite is true of funding from European sources. African countries are thus pulled in two different directions. One alternative to this dilemma might be for countries in the sub-Saharan Africa region to develop stronger South-South collaborations, but these need to be supported with adequate funding. African governments as well as external funding agencies are urged to consider the important role that biotechnology, including GM technology, can play in contributing to sustainable development in Africa, and to provide adequate support to the development of capacity to research, develop and commercialize GMOs in the region.

Crystals, Vol. 1, Pages 47-58: Short Intramolecular N–H⋯C(carbonyl) Interactions in Mixed-Ligand Molybdenum Hexacarbonyl Derivatives

Posted: 08 Jun 2011 12:00 AM PDT

The syntheses and single-crystal structures of Mo(CO)3(phen)(dipy) (1), Mo(CO)3(biquin)(dipy) (2) and Mo(CO)3(dpme)(dipy) (3), (phen = 1,10-phenanthroline, C12H8N2; dipy = 2,2'-dipyridylamine, C10H9N3; biquin = 2,2'-biquinoline, C18H12N2; dpme = 2,2'-dipyridylmethane, C11H10N2) are described. In each case, distorted fac-MoC3N3 octahedral coordination geometries arise for the metal atoms. Short intramolecular N–H…C interactions from the dipy N–H group to a carbonyl carbon atom occur in each structure. Crystal data: 1 (C25H17MoN5O3), Mr = 531.38, monoclinic, P21/n (No. 14), Z = 4, a = 11.0965 (5) Å, b = 13.0586 (6) Å, c = 16.6138 (8) Å, b = 108.324 (1)°, V = 2285.31 (18) Å3, R(F) = 0.035, wR(F2) = 0.070. 2 (C31H21MoN5O3), Mr = 607.47, monoclinic, P21/n (No. 14), Z = 4, a = 11.4788 (6) Å, b = 19.073 (1) Å, c = 11.9881 (6) Å, b = 95.179 (1)°, V = 2613.9 (2) Å3, R(F) = 0.030, wR(F2) = 0.076. 3 (C24H19MoN5O3), Mr = 521.38, monoclinic, P21/n (No. 14), Z = 4, a = 8.4222 (3) Å, b = 21.5966 (9) Å, c = 12.5011 (5) Å, b = 94.065 (1)°, V = 2268.12 (15) Å3, R(F) = 0.025, wR(F2) = 0.065.

Pro Evolution Soccer 2012 - Xbox360 - Preview

Posted: 08 Jun 2011 12:26 AM PDT

Futbole Excitante!!!


[That's not a misspelling of the Spanish. Our dear Eduardo is Portuguese. ~Ed.]

The Pro Evolution Soccer series has been steadily losing ground to FIFA. But from the looks of it, the 2012 edition of Pro Evo might just take that yearly battle at least as far as the penalty kicks. For the soccer (*cough* futebol *cough*) layman, that means that from the limited time I spent with it at E3, Pro Evo 2012 looks very good.

[image1]Konami is touting a huge overhaul in the way your matches play out with a set of new features for PES 2012 that sets it apart from last year's game. Special attention has been given to your teammates' artificial intelligence. For instance, the way computer controlled players keep up with you as you pass them the ball has been significantly improved. If you're a more tactical player, the so called "dummy runs" now work as a distraction tactic in real-time, where your computer-controlled players create diversions to give you openings for goal opportunities.

The one feature that has me scratching my head as of this writing, since I didn't actually see it in action, is what Konami calls "zonal defense". As it was described to me, it's basically a feature that makes the rest of your team "flow" across the pitch in a more natural way, closer to an actual match of soccer.

Graphics-wise, Pro Evo 2012 looks on par with recent sports game releases. Player models from the team I ...

Game Agent Combat : 08/06/2011

Posted: 05 Dec 2010 11:03 PM PST

Agent Combat
Автор: на

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