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Molecules, Vol. 16, Pages 4897-4911: Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
Molecules, Vol. 16, Pages 4884-4896: Comparison of Compositions and Antimicrobial Activities of Essential Oils from Chemically Stimulated Agarwood, Wild Agarwood and Healthy Aquilaria sinensis (Lour.) Gilg Trees
IJMS, Vol. 12, Pages 3989-3997: Metathesis of Fatty Acid Ester Derivatives in 1,1-Dialkyl and 1,2,3-Trialkyl Imidazolium Type Ionic Liquids
Molecules, Vol. 16, Pages 4861-4883: Recent Advances in the Studies on Luotonins
IJMS, Vol. 12, Pages 3966-3988: Applications and Implications of Neutral versus Non-neutral Markers in Molecular Ecology
Meet the GamesRadar UK team and play Child of Eden! (Child of Eden)
Game Chicken : 14/06/2011
Game Gem Defender : 14/06/2011
Game Gunfire : 14/06/2011
Game Ill mouse racer : 14/06/2011
Game Dada adventure : 14/06/2011
Game Necrorun : 14/06/2011
Game Space invaders defence : 14/06/2011
Game Higher : 14/06/2011
Game Thorenzitha 6 : 14/06/2011
Game Holiday Sim : 14/06/2011
Game Legend of surf : 14/06/2011
Game Space Hummer : 14/06/2011
Game Dance dance egypt queen : 14/06/2011
Game Stop the aliens! : 14/06/2011

Molecules, Vol. 16, Pages 4897-4911: Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

Posted: 14 Jun 2011 12:00 AM PDT

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

Molecules, Vol. 16, Pages 4884-4896: Comparison of Compositions and Antimicrobial Activities of Essential Oils from Chemically Stimulated Agarwood, Wild Agarwood and Healthy Aquilaria sinensis (Lour.) Gilg Trees

Posted: 14 Jun 2011 12:00 AM PDT

The composition and antimicrobial activity of the essential oils which were obtained from agarwood originated from Aquilaria sinensis (Lour.) Gilg stimulated by the chemical method (S1) were characterized, taking wild agarwood (S2) and healthy trees (S3) respectively as the positive and negative controls. The chemical composition of S1 was investigated by gas chromatography-mass spectrometry (GC-MS). The essential oil of S1 showed a similar composition to that of S2, being rich in sesquiterpenes and aromatic constituents. However, the essential oil of S3 was abundant in fatty acids and alkanes. Essential oils of S1 and S2 had better inhibition activities towards Bacillus subtilis and Staphyloccus aureus, compared with essential oil of S3. Escherichia coli was not sensitive to any of them.

IJMS, Vol. 12, Pages 3989-3997: Metathesis of Fatty Acid Ester Derivatives in 1,1-Dialkyl and 1,2,3-Trialkyl Imidazolium Type Ionic Liquids

Posted: 14 Jun 2011 12:00 AM PDT

The self-metathesis of methyl oleate and methyl ricinoleate was carried out in the presence of ruthenium alkylidene catalysts 1–4 in [bmim] and [bdmim][X] type ionic liquids (RTILs) (X = PF6−, BF4– and NTf2−) using the gas chromatographic technique. Best catalytic performance was obtained in [bdmim][X] type ionic liquids when compared with [bmim][X] type ionic liquids. Catalyst recycling studies were also carried out in the room temperature ionic liquids (RTILs) with catalysts 1–4 in order to explore their possible industrial application.

Molecules, Vol. 16, Pages 4861-4883: Recent Advances in the Studies on Luotonins

Posted: 14 Jun 2011 12:00 AM PDT

Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNA-cleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered.

IJMS, Vol. 12, Pages 3966-3988: Applications and Implications of Neutral versus Non-neutral Markers in Molecular Ecology

Posted: 14 Jun 2011 12:00 AM PDT

The field of molecular ecology has expanded enormously in the past two decades, largely because of the growing ease with which neutral molecular genetic data can be obtained from virtually any taxonomic group. However, there is also a growing awareness that neutral molecular data can provide only partial insight into parameters such as genetic diversity, local adaptation, evolutionary potential, effective population size, and taxonomic designations. Here we review some of the applications of neutral versus adaptive markers in molecular ecology, discuss some of the advantages that can be obtained by supplementing studies of molecular ecology with data from non-neutral molecular markers, and summarize new methods that are enabling researchers to generate data from genes that are under selection.

Meet the GamesRadar UK team and play Child of Eden! (Child of Eden)

Posted: 14 Jun 2011 02:53 AM PDT

OK, here's the deal. You HAVE to play Child of Eden. Got it? Everyone must experience this game. But what better way to experience it than with the GamesRadar UK team at your side? If playing Child of Eden and meeting the GamesRadar UK team are all you've ever dreamed about, then all your dreams could come true! We'll be at the Child of Eden Experience in London this Thursday afternoon (June 16) from 2pm until 8pm, basically doing what we do best. Playing games and talking with words. Perhaps into your very ears.