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- Molecules, Vol. 16, Pages 5437-5452: Recent Developments in Molecular Dynamics Simulations of Fluorescent Membrane Probes
- Molecules, Vol. 16, Pages 5422-5436: Synthesis of Key Fragments of Amphidinolide Q — A Cytotoxic 12-membered Macrolide
- Continuity 2: The Continuation
- Sharpshooter 2.0 - Rename screenshots as they are taken.. (Shareware)
- Sensors, Vol. 11, Pages 6593-6602: An Optical AC Voltage Sensor Based on the Transverse Pockels Effect
- Molecules, Vol. 16, Pages 5402-5421: Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma Susceptibility
- Molecules, Vol. 16, Pages 5387-5401: Enantioselective Addition of Allyltin Reagents to Amino Aldehydes Catalyzed with Bis(oxazolinyl)phenylrhodium(III) Aqua Complexes
- Energies, Vol. 4, Pages 998-1009: Energy Use in Day Care Centers and Schools
- Molecules, Vol. 16, Pages 5374-5386: Study of Organic Honey from the Northeast of Portugal
- Cancers, Vol. 3, Pages 2827-2843: Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy
- Cancers, Vol. 3, Pages 2811-2826: Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
- Sensors, Vol. 11, Pages 6575-6592: Polynomial Method for PLL Controller Optimization
- Molecules, Vol. 16, Pages 5362-5373: Isolation of a Bis-Iodurated Tetra-THF as a Trace Product from the Oxidation of Squalene with RuO4 and Its Double Ring Expansion to a Novel bis-THF-bis-THP Compound
- Game Celebrity fashion victim : 27/06/2011
- Game Easter egg hop : 27/06/2011
- Game Replicator : 27/06/2011
- Game Waynes world soundboard : 27/06/2011
- Game Cute autumn dressup : 27/06/2011
- Game Start The Leak : 27/06/2011
- Game Witchdance hexentanz : 27/06/2011
| Posted: 27 Jun 2011 12:00 AM PDT Due to their sensitivity and versatility, the use of fluorescence techniques in membrane biophysics is widespread. Because membrane lipids are non-fluorescent, extrinsic membrane probes are widely used. However, the behaviour of these probes when inserted in the bilayer is often poorly understood, and it can be hard to distinguish between legitimate membrane properties and perturbation resulting from probe incorporation. Atomistic molecular dynamics simulations present a convenient way to address these issues and have been increasingly used in recent years in this context. This article reviews the application of molecular dynamics to the study of fluorescent membrane probes, focusing on recent work with complex design fluorophores and ordered bilayer systems. |
| Posted: 27 Jun 2011 12:00 AM PDT b-Hydroxy aldehyde and alkyl ketone moieties were effectively synthesized as key intermediates of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp.. The asymmetric center of the former derivative was produced by Sharpless asymmetric epoxidation, followed by E-selective 1,4-addition to give the sp2 methyl group. Derivatization of the L-ascorbic acid derivative by Evans asymmetric alkylation and Peterson olefination provided the latter intermediate. The coupling reaction of the segments was examined. |
| Continuity 2: The Continuation Posted: 26 Jun 2011 05:36 PM PDT [Platform: Mobile (iPhone, iPod Touch)] Those of us adept at folding space-time (with or without the use of spice) are very familiar with the concept of moving chunks of the universe around so we can easily step from one area to another. For everyone else, there's Continuity 2: The Continuation, a sequel to the familiar Flash puzzle game Continuity. Combining a little bit of 2D platforming and a lot of sliding puzzle logic, Continuity 2 is a unique and challenging experience made better by the battery of almost 50 new levels packed into the iPhone's tiny little screen. It's all the space-time folding you could ever want, without the blue-in-blue eyes to show for it! |
| Sharpshooter 2.0 - Rename screenshots as they are taken.. (Shareware) Posted: 27 Jun 2011 03:14 AM PDT  Sharpshooter... Rename your screenshots with pinpoint accuracy. Sharpshooter is a small utility which aids the management of screenshots. Sharpshooter lets you manipulate and process the screenshot while it is still fresh on your mind. When you take a screenshot on Mac OS X with Command-Shift-3 (or with another variation) Sharpshooter will present a window where you can review the picture and choose what to do with it. You can either rename it from its default name to something more descriptive, move the screenshot to the Trash, or cancel the operation keeping the screenshot as it is. Version 2.0:
Mac OS X 10.6.6 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 27 Jun 2011 12:00 AM PDT This paper introduces an optical AC voltage sensor based on the transverse Pockels effect. The sensor utilizes a bulk Bi4Ge3O12 (BGO) crystal as the sensing element. The measurement principle has been described and prototype of the sensor has been constructed and evaluated. Good linearity and accuracy performance was obtained for AC voltage measurement. The proposed sensor can be thus applied to high AC voltage measurements in the electric power industry. |
| Posted: 27 Jun 2011 12:00 AM PDT MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG). The gene was identified as an up-regulated molecule in cultured trabecular meshwork (TM) cells after treatment with dexamethasone and was originally referred to as trabecular meshwork-inducible glucocorticoid response (TIGR). Elevated intraocular pressure (IOP), due to decreased aqueous outflow, is the strongest known risk factor for POAG. Increasing evidence showed that the modulation of the wild-type (wt) myocilin protein expression is not causative of glaucoma while some misfolded and self-assembly aggregates of mutated myocilin may be associated with POAG in related or unrelated populations. The etiology of the disease remains unclear. Consequently, a better understanding of the molecular mechanisms underlyingPOAG is required to obtain early diagnosis, avoid potential disease progression, and develop new therapeutic strategies. In the present study, we review and discuss the most relevant studies regarding structural characterizations, expressions, molecular interactions, putative functions of MYOC gene and/or its corresponding protein in POAG etiology. |
| Posted: 27 Jun 2011 12:00 AM PDT Bis(oxazolinyl)phenylrhodium(III) aqua complexes, (Phebox)RhX2(H2O) [X = Cl, Br], were found to be efficient Lewis acid catalysts for the enantioselective addition of allyl- and methallyltributyltin reagents to amino aldehydes. The reactions proceed smoothly in the presence of 5–10 mol % of (Phebox)RhX2(H2O) complex at ambient temperature to give the corresponding amino alcohols with modest to good enantioselectivity (up to 94% ee). |
| Energies, Vol. 4, Pages 998-1009: Energy Use in Day Care Centers and Schools Posted: 27 Jun 2011 12:00 AM PDT Typically the aim in the construction process is to calculate the energy, space and cost efficiency in the design phase. These factors' influence on decision making extends to the whole building process. How these decisions affect the use of the building and user satisfaction as well as maintenance is still not that well understood. This study analyses different schools and day care centers and their energy as well as primary energy use. The buildings are located in southern Finland. Each building has had different objectives with respect to energy efficiency in the design phase. Our objective was to find out how those decisions made in the design and construction phase have influenced the overall energy performance of the building compared to existing building stock of similar building type. The results show that the studied buildings had lower thermal energy consumption compared to existing building stock. Thus the special attention in the design phase allowed achieving the desired goal. However, for the electricity consumption such a correlation could not be found. One of the reasons could be also different service level of buildings (more equipment). Also other quality values could not be compared since such data were not available from the existing building stock. As many earlier studies have indicated users have a high influence on the energy consumption. In the future, when feed-back from the users are obtained it will be interesting to analyze the results and compare what kind of influence that user behavior will have on the overall energy consumption of the studied buildings. |
| Molecules, Vol. 16, Pages 5374-5386: Study of Organic Honey from the Northeast of Portugal Posted: 27 Jun 2011 12:00 AM PDT Concerns about traces of numerous toxic substances and authenticity have prompted consumer demand for honey that is certified as organic, based on strict ecological, natural principles and traceability. The present study aims to characterize organic honey samples (n = 73) from Northeast Portugal, with respect to floral nectar origin, physicochemical parameters and microbial safety. The phenols and flavonoids contents, often referred to as responsible for honey's bioactive properties, were also assessed. All organic honey samples were classified as monofloral lavender (Lavandula sp.), exceeded in quality the international physicochemical standards and showed low microbiological counts (yeast, moulds and aerobic mesophiles), with negative results in respect to fecal coliforms, Salmonella and sulphite-reducing Clostridium spp. Correlation of the palynological, physicochemical and microbiological results is necessary to check the authenticity, quality and sanitation of honey. Although not required by international legislation, results of those assessments provide a complete outlook and elucidation of the organic honey's properties, which could promote its valorisation. |
| Posted: 27 Jun 2011 12:00 AM PDT Glioblastoma multiforme (GBM) is a lethal type of cancer mainly resistant to radio- and chemotherapy. Since the tumor suppressor p53 functions as a transcription factor regulating the expression of genes involved in growth inhibition, DNA repair and apoptosis, we previously assessed whether specific differences in the modulation of gene expression are responsible for the anti-tumor properties of a dominant positive p53, chimeric tumor suppressor (CTS)-1. CTS-1 is based on the sequence of p53 and designed to resist various mechanisms of inactivation which limit the activity of p53. To identify CTS-1-regulated cell death-inducing genes, we generated a CTS-1-resistant glioma cell line (229R). We used Affymetrix whole-genome microarray expression analysis to analyze alterations in gene expression and identified a variety of CTS-1 regulated genes involved in cancer-linked processes. 313 genes were differentially expressed in Adeno-CTS-1 (Ad-CTS-1)-infected and 700 genes in uninfected 229R cells compared to matching parental cells. Ingenuity Pathway Analysis (IPA) determined a variety of differentially expressed genes in Ad-CTS-1-infected cells that were members of the intracellular networks with central tumor-involved players such as nuclear factor kappa B (NF-κB), protein kinase B (PKB/AKT) or transforming growth factor beta (TGF-β). Differentially regulated genes include secreted factors as well as intracellular proteins and transcription factors regulating not only cell death, but also processes such as tumor cell motility and immunity. This work gives an overview of the pathways differentially regulated in the resistant versus parental glioma cells and might be helpful to identify candidate genes which could serve as targets to develop novel glioma specific therapy strategies. |
| Posted: 27 Jun 2011 12:00 AM PDT The connection between inflammation and tumorigenesis has been well established, based on a great deal of supporting evidence obtained from epidemiological, pharmacological, and genetic studies. One representative example is inflammatory bowel disease, because it is an important risk factor for the development of colon cancer. Moreover, intratumoral infiltration of inflammatory cells suggests the involvement of inflammatory responses also in other forms of sporadic as well as heritable colon cancer. Inflammatory responses and tumorigenesis activate similar sets of transcription factors such as NF-kB, Stat3, and hypoxia inducible factor and eventually enhances the expression of inflammatory cytokines including tumor necrosis factor (TNF) and chemokines. The expression of TNF and chemokines is aberrantly expressed in a mouse model of colitis-associated carcinogenesis as well as in inflammatory bowel disease and colon cancer in humans. Here, after summarizing the presumed actions of TNF and chemokines in tumor biology, we will discuss the potential roles of TNF and chemokines in chronic inflammation-associated colon cancer in mice. |
| Sensors, Vol. 11, Pages 6575-6592: Polynomial Method for PLL Controller Optimization Posted: 27 Jun 2011 12:00 AM PDT The Phase-Locked Loop (PLL) is a key component of modern electronic communication and control systems. PLL is designed to extract signals from transmission channels. It plays an important role in systems where it is required to estimate the phase of a received signal, such as carrier tracking from global positioning system satellites. In order to robustly provide centimeter-level accuracy, it is crucial for the PLL to estimate the instantaneous phase of an incoming signal which is usually buried in random noise or some type of interference. This paper presents an approach that utilizes the recent development in the semi-definite programming and sum-of-squares field. A Lyapunov function will be searched as the certificate of the pull-in range of the PLL system. Moreover, a polynomial design procedure is proposed to further refine the controller parameters for system response away from the equilibrium point. Several simulation results as well as an experiment result are provided to show the effectiveness of this approach. |
| Posted: 27 Jun 2011 12:00 AM PDT A novel bis-iodurated polyether compound, based on an unprecedented tetra-THF backbone, has been isolated as a trace by-product of the oxidation of squalene with the catalytic system RuO2(cat.)/NaIO4. The double erythro configuration of the central portion of the molecule furnishes the first indirect support of the previously postulated pathway operating in the oxidative pentacyclization of the isoprenoid substrate. A bidirectional double oxidative bis-cyclization is invoked to explain the formation of this compound. The isolated substance was successfully subjected to a double rearrangement-ring expansion to give a novel bis-THF-bis-THP compound. |
| Game Celebrity fashion victim : 27/06/2011 Posted: 06 Dec 2010 12:02 AM PST
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| Game Easter egg hop : 27/06/2011 Posted: 05 Jan 2011 03:01 PM PST
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| Posted: 05 Jan 2011 04:00 PM PST
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| Game Waynes world soundboard : 27/06/2011 Posted: 05 Jan 2011 03:03 PM PST
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| Game Cute autumn dressup : 27/06/2011 Posted: 05 Jan 2011 04:04 PM PST
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| Game Start The Leak : 27/06/2011 Posted: 05 Jan 2011 05:00 PM PST
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| Game Witchdance hexentanz : 27/06/2011 Posted: 06 Dec 2010 12:05 AM PST
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